Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD95_LEIBR

TriTrypDb:

LbrM.24.0390 , LBRM2903_240008900

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HD95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.473
CLV_C14_Caspase3-7	308	312	PF00656	0.537
CLV_MEL_PAP_1	539	545	PF00089	0.703
CLV_NRD_NRD_1	155	157	PF00675	0.504
CLV_NRD_NRD_1	269	271	PF00675	0.688
CLV_NRD_NRD_1	321	323	PF00675	0.644
CLV_NRD_NRD_1	451	453	PF00675	0.643
CLV_NRD_NRD_1	552	554	PF00675	0.630
CLV_PCSK_KEX2_1	155	157	PF00082	0.504
CLV_PCSK_KEX2_1	269	271	PF00082	0.688
CLV_PCSK_KEX2_1	552	554	PF00082	0.630
CLV_PCSK_SKI1_1	128	132	PF00082	0.574
CLV_PCSK_SKI1_1	204	208	PF00082	0.666
CLV_PCSK_SKI1_1	328	332	PF00082	0.639
DEG_APCC_DBOX_1	430	438	PF00400	0.408
DEG_Nend_UBRbox_2	1	3	PF02207	0.656
DEG_SPOP_SBC_1	348	352	PF00917	0.431
DOC_CDC14_PxL_1	132	140	PF14671	0.466
DOC_CKS1_1	107	112	PF01111	0.514
DOC_CKS1_1	295	300	PF01111	0.456
DOC_CKS1_1	69	74	PF01111	0.565
DOC_CYCLIN_RxL_1	339	350	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	414	420	PF00134	0.398
DOC_MAPK_gen_1	300	307	PF00069	0.444
DOC_MAPK_JIP1_4	257	263	PF00069	0.590
DOC_MAPK_MEF2A_6	300	307	PF00069	0.444
DOC_PP1_RVXF_1	340	347	PF00149	0.346
DOC_PP1_RVXF_1	404	411	PF00149	0.541
DOC_PP1_RVXF_1	540	546	PF00149	0.529
DOC_PP1_RVXF_1	583	589	PF00149	0.428
DOC_PP2B_LxvP_1	502	505	PF13499	0.567
DOC_PP4_FxxP_1	465	468	PF00568	0.547
DOC_PP4_FxxP_1	500	503	PF00568	0.453
DOC_USP7_MATH_1	205	209	PF00917	0.455
DOC_USP7_MATH_1	210	214	PF00917	0.474
DOC_USP7_MATH_1	291	295	PF00917	0.461
DOC_USP7_MATH_1	494	498	PF00917	0.546
DOC_USP7_MATH_1	531	535	PF00917	0.430
DOC_USP7_MATH_1	80	84	PF00917	0.430
DOC_WW_Pin1_4	106	111	PF00397	0.417
DOC_WW_Pin1_4	294	299	PF00397	0.524
DOC_WW_Pin1_4	394	399	PF00397	0.453
DOC_WW_Pin1_4	68	73	PF00397	0.486
LIG_14-3-3_CanoR_1	175	184	PF00244	0.352
LIG_14-3-3_CanoR_1	204	210	PF00244	0.547
LIG_14-3-3_CanoR_1	217	224	PF00244	0.484
LIG_14-3-3_CanoR_1	257	262	PF00244	0.487
LIG_14-3-3_CanoR_1	300	306	PF00244	0.592
LIG_14-3-3_CanoR_1	392	399	PF00244	0.501
LIG_14-3-3_CanoR_1	542	546	PF00244	0.436
LIG_14-3-3_CanoR_1	585	589	PF00244	0.428
LIG_Actin_WH2_2	437	454	PF00022	0.471
LIG_APCC_ABBA_1	564	569	PF00400	0.368
LIG_BRCT_BRCA1_1	496	500	PF00533	0.541
LIG_deltaCOP1_diTrp_1	407	413	PF00928	0.454
LIG_FHA_1	14	20	PF00498	0.363
LIG_FHA_1	177	183	PF00498	0.511
LIG_FHA_1	201	207	PF00498	0.519
LIG_FHA_1	302	308	PF00498	0.439
LIG_FHA_1	40	46	PF00498	0.522
LIG_FHA_1	47	53	PF00498	0.460
LIG_FHA_1	520	526	PF00498	0.451
LIG_FHA_1	69	75	PF00498	0.499
LIG_FHA_2	288	294	PF00498	0.485
LIG_FHA_2	306	312	PF00498	0.560
LIG_FHA_2	32	38	PF00498	0.540
LIG_FHA_2	402	408	PF00498	0.524
LIG_LIR_Apic_2	104	110	PF02991	0.406
LIG_LIR_Apic_2	335	341	PF02991	0.418
LIG_LIR_Apic_2	497	503	PF02991	0.542
LIG_LIR_Gen_1	544	551	PF02991	0.428
LIG_LIR_Gen_1	569	578	PF02991	0.514
LIG_LIR_Gen_1	587	594	PF02991	0.337
LIG_LIR_Nem_3	517	521	PF02991	0.475
LIG_LIR_Nem_3	544	549	PF02991	0.432
LIG_LIR_Nem_3	569	574	PF02991	0.532
LIG_LIR_Nem_3	587	591	PF02991	0.330
LIG_MYND_1	480	484	PF01753	0.560
LIG_NBox_RRM_1	92	102	PF00076	0.527
LIG_NRBOX	238	244	PF00104	0.491
LIG_PCNA_TLS_4	552	559	PF02747	0.422
LIG_Pex14_1	554	558	PF04695	0.416
LIG_Pex14_1	588	592	PF04695	0.350
LIG_Pex14_2	545	549	PF04695	0.457
LIG_SH2_CRK	129	133	PF00017	0.378
LIG_SH2_CRK	191	195	PF00017	0.300
LIG_SH2_GRB2like	548	551	PF00017	0.428
LIG_SH2_GRB2like	77	80	PF00017	0.418
LIG_SH2_NCK_1	77	81	PF00017	0.422
LIG_SH2_SRC	567	570	PF00017	0.429
LIG_SH2_STAP1	119	123	PF00017	0.353
LIG_SH2_STAP1	62	66	PF00017	0.584
LIG_SH2_STAT5	22	25	PF00017	0.343
LIG_SH2_STAT5	521	524	PF00017	0.455
LIG_SH2_STAT5	548	551	PF00017	0.438
LIG_SH3_3	354	360	PF00018	0.517
LIG_SH3_3	395	401	PF00018	0.442
LIG_SH3_3	465	471	PF00018	0.555
LIG_SH3_3	474	480	PF00018	0.544
LIG_SH3_3	498	504	PF00018	0.487
LIG_SH3_3	66	72	PF00018	0.480
LIG_SUMO_SIM_anti_2	386	391	PF11976	0.538
LIG_SUMO_SIM_par_1	383	388	PF11976	0.489
LIG_TRAF2_1	505	508	PF00917	0.396
LIG_TRFH_1	500	504	PF08558	0.449
LIG_UBA3_1	434	438	PF00899	0.414
MOD_CDK_SPxK_1	294	300	PF00069	0.455
MOD_CK1_1	212	218	PF00069	0.561
MOD_CK1_1	227	233	PF00069	0.451
MOD_CK1_1	234	240	PF00069	0.533
MOD_CK1_1	294	300	PF00069	0.622
MOD_CK1_1	350	356	PF00069	0.413
MOD_CK1_1	83	89	PF00069	0.530
MOD_CK2_1	140	146	PF00069	0.366
MOD_CK2_1	401	407	PF00069	0.530
MOD_CK2_1	75	81	PF00069	0.449
MOD_CMANNOS	410	413	PF00535	0.635
MOD_CMANNOS	554	557	PF00535	0.622
MOD_GlcNHglycan	132	135	PF01048	0.681
MOD_GlcNHglycan	140	143	PF01048	0.533
MOD_GlcNHglycan	243	246	PF01048	0.813
MOD_GlcNHglycan	276	279	PF01048	0.816
MOD_GlcNHglycan	334	337	PF01048	0.682
MOD_GlcNHglycan	484	487	PF01048	0.784
MOD_GlcNHglycan	81	85	PF01048	0.647
MOD_GSK3_1	102	109	PF00069	0.517
MOD_GSK3_1	200	207	PF00069	0.479
MOD_GSK3_1	209	216	PF00069	0.527
MOD_GSK3_1	227	234	PF00069	0.542
MOD_GSK3_1	237	244	PF00069	0.464
MOD_GSK3_1	287	294	PF00069	0.532
MOD_GSK3_1	301	308	PF00069	0.516
MOD_GSK3_1	572	579	PF00069	0.412
MOD_GSK3_1	90	97	PF00069	0.447
MOD_LATS_1	255	261	PF00433	0.571
MOD_N-GLC_1	10	15	PF02516	0.480
MOD_N-GLC_1	348	353	PF02516	0.668
MOD_N-GLC_1	90	95	PF02516	0.616
MOD_NEK2_1	10	15	PF00069	0.348
MOD_NEK2_1	138	143	PF00069	0.462
MOD_NEK2_1	177	182	PF00069	0.470
MOD_NEK2_1	184	189	PF00069	0.481
MOD_NEK2_1	235	240	PF00069	0.502
MOD_NEK2_1	458	463	PF00069	0.527
MOD_NEK2_1	558	563	PF00069	0.415
MOD_NEK2_1	572	577	PF00069	0.413
MOD_NEK2_2	301	306	PF00069	0.508
MOD_NEK2_2	541	546	PF00069	0.533
MOD_PIKK_1	216	222	PF00454	0.563
MOD_PIKK_1	237	243	PF00454	0.552
MOD_PIKK_1	444	450	PF00454	0.539
MOD_PIKK_1	531	537	PF00454	0.364
MOD_PKA_2	184	190	PF00069	0.380
MOD_PKA_2	216	222	PF00069	0.531
MOD_PKA_2	287	293	PF00069	0.635
MOD_PKA_2	301	307	PF00069	0.569
MOD_PKA_2	391	397	PF00069	0.488
MOD_PKA_2	541	547	PF00069	0.432
MOD_PKA_2	584	590	PF00069	0.428
MOD_Plk_1	10	16	PF00069	0.500
MOD_Plk_1	103	109	PF00069	0.351
MOD_Plk_1	145	151	PF00069	0.365
MOD_Plk_1	230	236	PF00069	0.481
MOD_Plk_1	251	257	PF00069	0.435
MOD_Plk_1	385	391	PF00069	0.507
MOD_Plk_1	531	537	PF00069	0.429
MOD_Plk_2-3	311	317	PF00069	0.520
MOD_Plk_4	10	16	PF00069	0.322
MOD_Plk_4	103	109	PF00069	0.399
MOD_Plk_4	113	119	PF00069	0.397
MOD_Plk_4	140	146	PF00069	0.307
MOD_Plk_4	165	171	PF00069	0.413
MOD_Plk_4	257	263	PF00069	0.565
MOD_Plk_4	385	391	PF00069	0.427
MOD_Plk_4	418	424	PF00069	0.373
MOD_Plk_4	541	547	PF00069	0.530
MOD_ProDKin_1	106	112	PF00069	0.416
MOD_ProDKin_1	294	300	PF00069	0.525
MOD_ProDKin_1	394	400	PF00069	0.453
MOD_ProDKin_1	68	74	PF00069	0.489
MOD_SUMO_for_1	514	517	PF00179	0.588
TRG_DiLeu_BaEn_2	523	529	PF01217	0.380
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.351
TRG_ENDOCYTIC_2	129	132	PF00928	0.373
TRG_ENDOCYTIC_2	191	194	PF00928	0.375
TRG_ER_diArg_1	154	156	PF00400	0.307
TRG_ER_diArg_1	268	270	PF00400	0.483
TRG_ER_diArg_1	300	303	PF00400	0.476
TRG_ER_diArg_1	496	499	PF00400	0.563
TRG_ER_diArg_1	551	553	PF00400	0.434
TRG_ER_diArg_1	6	9	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L4	Leptomonas seymouri	45%	93%
A0A3Q8IMJ3	Leishmania donovani	77%	95%
E9AH50	Leishmania infantum	77%	95%
E9AWM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	77%
Q4QAU2	Leishmania major	77%	100%