Ppg3-related protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ppg3-related protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HD94_LEIBR

TriTrypDb:

LbrM.24.0380 , LBRM2903_240008800

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.481
CLV_NRD_NRD_1	401	403	PF00675	0.669
CLV_NRD_NRD_1	412	414	PF00675	0.581
CLV_NRD_NRD_1	458	460	PF00675	0.683
CLV_NRD_NRD_1	520	522	PF00675	0.745
CLV_NRD_NRD_1	675	677	PF00675	0.631
CLV_PCSK_KEX2_1	101	103	PF00082	0.481
CLV_PCSK_KEX2_1	384	386	PF00082	0.745
CLV_PCSK_KEX2_1	401	403	PF00082	0.616
CLV_PCSK_KEX2_1	412	414	PF00082	0.581
CLV_PCSK_KEX2_1	460	462	PF00082	0.772
CLV_PCSK_KEX2_1	520	522	PF00082	0.684
CLV_PCSK_KEX2_1	675	677	PF00082	0.680
CLV_PCSK_KEX2_1	68	70	PF00082	0.506
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.591
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.803
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.465
CLV_PCSK_PC7_1	380	386	PF00082	0.581
CLV_PCSK_PC7_1	408	414	PF00082	0.743
CLV_PCSK_PC7_1	64	70	PF00082	0.445
CLV_PCSK_SKI1_1	161	165	PF00082	0.681
CLV_PCSK_SKI1_1	287	291	PF00082	0.678
CLV_PCSK_SKI1_1	3	7	PF00082	0.818
CLV_PCSK_SKI1_1	552	556	PF00082	0.678
CLV_PCSK_SKI1_1	578	582	PF00082	0.751
CLV_PCSK_SKI1_1	80	84	PF00082	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.573
DEG_SPOP_SBC_1	386	390	PF00917	0.764
DEG_SPOP_SBC_1	596	600	PF00917	0.570
DEG_SPOP_SBC_1	692	696	PF00917	0.687
DOC_CYCLIN_RxL_1	158	167	PF00134	0.680
DOC_MAPK_MEF2A_6	56	63	PF00069	0.685
DOC_MAPK_NFAT4_5	56	64	PF00069	0.420
DOC_PP2B_LxvP_1	719	722	PF13499	0.828
DOC_USP7_MATH_1	133	137	PF00917	0.677
DOC_USP7_MATH_1	235	239	PF00917	0.712
DOC_USP7_MATH_1	386	390	PF00917	0.799
DOC_USP7_MATH_1	429	433	PF00917	0.718
DOC_USP7_MATH_1	480	484	PF00917	0.687
DOC_USP7_MATH_1	486	490	PF00917	0.722
DOC_USP7_MATH_1	571	575	PF00917	0.585
DOC_USP7_MATH_1	590	594	PF00917	0.648
DOC_USP7_MATH_1	596	600	PF00917	0.683
DOC_USP7_MATH_1	647	651	PF00917	0.575
DOC_USP7_UBL2_3	114	118	PF12436	0.657
DOC_USP7_UBL2_3	318	322	PF12436	0.653
DOC_USP7_UBL2_3	625	629	PF12436	0.599
DOC_WW_Pin1_4	245	250	PF00397	0.570
DOC_WW_Pin1_4	427	432	PF00397	0.747
DOC_WW_Pin1_4	437	442	PF00397	0.765
DOC_WW_Pin1_4	504	509	PF00397	0.613
DOC_WW_Pin1_4	657	662	PF00397	0.801
DOC_WW_Pin1_4	707	712	PF00397	0.615
LIG_14-3-3_CanoR_1	154	163	PF00244	0.542
LIG_14-3-3_CanoR_1	299	308	PF00244	0.659
LIG_14-3-3_CanoR_1	374	383	PF00244	0.809
LIG_14-3-3_CanoR_1	385	394	PF00244	0.682
LIG_14-3-3_CanoR_1	515	519	PF00244	0.581
LIG_14-3-3_CanoR_1	520	525	PF00244	0.558
LIG_14-3-3_CanoR_1	675	683	PF00244	0.848
LIG_14-3-3_CanoR_1	80	86	PF00244	0.688
LIG_Actin_WH2_2	103	120	PF00022	0.665
LIG_Actin_WH2_2	321	338	PF00022	0.655
LIG_BRCT_BRCA1_1	538	542	PF00533	0.574
LIG_BRCT_BRCA1_1	700	704	PF00533	0.566
LIG_BRCT_BRCA1_1	83	87	PF00533	0.668
LIG_BRCT_BRCA1_2	700	706	PF00533	0.569
LIG_FHA_1	12	18	PF00498	0.543
LIG_FHA_1	227	233	PF00498	0.536
LIG_FHA_1	443	449	PF00498	0.592
LIG_FHA_1	488	494	PF00498	0.539
LIG_FHA_1	563	569	PF00498	0.571
LIG_FHA_1	590	596	PF00498	0.559
LIG_FHA_1	684	690	PF00498	0.598
LIG_FHA_2	94	100	PF00498	0.687
LIG_LIR_Apic_2	188	193	PF02991	0.523
LIG_LIR_Apic_2	362	367	PF02991	0.796
LIG_LIR_Gen_1	167	175	PF02991	0.550
LIG_LIR_Gen_1	309	314	PF02991	0.540
LIG_LIR_Gen_1	84	94	PF02991	0.636
LIG_LIR_Nem_3	167	171	PF02991	0.664
LIG_LIR_Nem_3	309	313	PF02991	0.551
LIG_LIR_Nem_3	358	364	PF02991	0.799
LIG_LIR_Nem_3	420	425	PF02991	0.768
LIG_LYPXL_yS_3	422	425	PF13949	0.551
LIG_NRBOX	217	223	PF00104	0.726
LIG_PCNA_yPIPBox_3	211	225	PF02747	0.663
LIG_Pex14_1	310	314	PF04695	0.693
LIG_Rb_LxCxE_1	274	296	PF01857	0.630
LIG_SH2_CRK	168	172	PF00017	0.680
LIG_SH2_CRK	190	194	PF00017	0.528
LIG_SH2_CRK	364	368	PF00017	0.799
LIG_SH2_NCK_1	190	194	PF00017	0.528
LIG_SH2_NCK_1	364	368	PF00017	0.799
LIG_SH2_SRC	368	371	PF00017	0.804
LIG_SH2_SRC	48	51	PF00017	0.428
LIG_SH2_STAP1	115	119	PF00017	0.655
LIG_SH2_STAP1	168	172	PF00017	0.556
LIG_SH2_STAP1	361	365	PF00017	0.800
LIG_SH2_STAP1	94	98	PF00017	0.413
LIG_SH2_STAT3	94	97	PF00017	0.409
LIG_SH2_STAT5	190	193	PF00017	0.534
LIG_SH2_STAT5	27	30	PF00017	0.508
LIG_SH2_STAT5	280	283	PF00017	0.664
LIG_SH2_STAT5	368	371	PF00017	0.681
LIG_SH2_STAT5	48	51	PF00017	0.428
LIG_SH2_STAT5	94	97	PF00017	0.409
LIG_SH3_1	364	370	PF00018	0.798
LIG_SH3_3	237	243	PF00018	0.688
LIG_SH3_3	244	250	PF00018	0.685
LIG_SH3_3	344	350	PF00018	0.506
LIG_SH3_3	364	370	PF00018	0.798
LIG_SH3_3	423	429	PF00018	0.555
LIG_SH3_3	471	477	PF00018	0.553
LIG_SH3_3	525	531	PF00018	0.684
LIG_SUMO_SIM_par_1	250	255	PF11976	0.527
LIG_SUMO_SIM_par_1	472	478	PF11976	0.806
LIG_UBA3_1	297	304	PF00899	0.421
LIG_UBA3_1	49	56	PF00899	0.555
MOD_CK1_1	127	133	PF00069	0.720
MOD_CK1_1	387	393	PF00069	0.809
MOD_CK1_1	432	438	PF00069	0.853
MOD_CK1_1	439	445	PF00069	0.721
MOD_CK1_1	503	509	PF00069	0.798
MOD_CK1_1	510	516	PF00069	0.742
MOD_CK1_1	556	562	PF00069	0.698
MOD_CK1_1	563	569	PF00069	0.655
MOD_CK1_1	597	603	PF00069	0.799
MOD_CK1_1	605	611	PF00069	0.671
MOD_CK1_1	621	627	PF00069	0.566
MOD_CK1_1	650	656	PF00069	0.851
MOD_CK1_1	691	697	PF00069	0.811
MOD_CK1_1	86	92	PF00069	0.473
MOD_CK2_1	633	639	PF00069	0.639
MOD_CK2_1	93	99	PF00069	0.602
MOD_GlcNHglycan	110	113	PF01048	0.497
MOD_GlcNHglycan	129	132	PF01048	0.544
MOD_GlcNHglycan	156	159	PF01048	0.568
MOD_GlcNHglycan	237	240	PF01048	0.704
MOD_GlcNHglycan	254	257	PF01048	0.480
MOD_GlcNHglycan	3	6	PF01048	0.755
MOD_GlcNHglycan	301	304	PF01048	0.685
MOD_GlcNHglycan	347	350	PF01048	0.657
MOD_GlcNHglycan	370	373	PF01048	0.576
MOD_GlcNHglycan	435	438	PF01048	0.772
MOD_GlcNHglycan	509	512	PF01048	0.699
MOD_GlcNHglycan	52	55	PF01048	0.681
MOD_GlcNHglycan	599	602	PF01048	0.841
MOD_GlcNHglycan	620	623	PF01048	0.600
MOD_GlcNHglycan	683	686	PF01048	0.839
MOD_GlcNHglycan	690	693	PF01048	0.717
MOD_GlcNHglycan	698	701	PF01048	0.579
MOD_GSK3_1	129	136	PF00069	0.681
MOD_GSK3_1	152	159	PF00069	0.685
MOD_GSK3_1	173	180	PF00069	0.686
MOD_GSK3_1	188	195	PF00069	0.551
MOD_GSK3_1	217	224	PF00069	0.657
MOD_GSK3_1	241	248	PF00069	0.652
MOD_GSK3_1	351	358	PF00069	0.626
MOD_GSK3_1	427	434	PF00069	0.829
MOD_GSK3_1	435	442	PF00069	0.714
MOD_GSK3_1	500	507	PF00069	0.628
MOD_GSK3_1	510	517	PF00069	0.670
MOD_GSK3_1	520	527	PF00069	0.548
MOD_GSK3_1	532	539	PF00069	0.702
MOD_GSK3_1	542	549	PF00069	0.571
MOD_GSK3_1	553	560	PF00069	0.687
MOD_GSK3_1	590	597	PF00069	0.801
MOD_GSK3_1	599	606	PF00069	0.665
MOD_GSK3_1	617	624	PF00069	0.566
MOD_GSK3_1	649	656	PF00069	0.829
MOD_GSK3_1	670	677	PF00069	0.853
MOD_GSK3_1	688	695	PF00069	0.535
MOD_GSK3_1	710	717	PF00069	0.580
MOD_GSK3_1	93	100	PF00069	0.581
MOD_N-GLC_1	1	6	PF02516	0.560
MOD_N-GLC_1	355	360	PF02516	0.530
MOD_N-GLC_1	376	381	PF02516	0.562
MOD_N-GLC_1	487	492	PF02516	0.542
MOD_N-GLC_1	647	652	PF02516	0.663
MOD_N-GLC_1	74	79	PF02516	0.455
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	124	129	PF00069	0.626
MOD_NEK2_1	152	157	PF00069	0.681
MOD_NEK2_1	185	190	PF00069	0.752
MOD_NEK2_1	217	222	PF00069	0.777
MOD_NEK2_1	252	257	PF00069	0.556
MOD_NEK2_1	375	380	PF00069	0.831
MOD_NEK2_1	433	438	PF00069	0.796
MOD_NEK2_1	444	449	PF00069	0.614
MOD_NEK2_1	555	560	PF00069	0.721
MOD_NEK2_1	595	600	PF00069	0.736
MOD_NEK2_1	688	693	PF00069	0.567
MOD_NEK2_1	83	88	PF00069	0.532
MOD_NEK2_1	93	98	PF00069	0.634
MOD_NEK2_2	670	675	PF00069	0.584
MOD_PIKK_1	105	111	PF00454	0.474
MOD_PIKK_1	124	130	PF00454	0.385
MOD_PIKK_1	133	139	PF00454	0.569
MOD_PIKK_1	355	361	PF00454	0.600
MOD_PIKK_1	387	393	PF00454	0.610
MOD_PIKK_1	442	448	PF00454	0.593
MOD_PIKK_1	536	542	PF00454	0.737
MOD_PIKK_1	571	577	PF00454	0.566
MOD_PIKK_1	678	684	PF00454	0.604
MOD_PIKK_1	93	99	PF00454	0.686
MOD_PK_1	393	399	PF00069	0.557
MOD_PKA_1	384	390	PF00069	0.715
MOD_PKA_1	520	526	PF00069	0.579
MOD_PKA_1	675	681	PF00069	0.583
MOD_PKA_2	339	345	PF00069	0.451
MOD_PKA_2	373	379	PF00069	0.794
MOD_PKA_2	384	390	PF00069	0.695
MOD_PKA_2	514	520	PF00069	0.641
MOD_PKA_2	674	680	PF00069	0.851
MOD_Plk_1	1	7	PF00069	0.557
MOD_Plk_1	487	493	PF00069	0.541
MOD_Plk_1	546	552	PF00069	0.578
MOD_Plk_2-3	57	63	PF00069	0.458
MOD_Plk_4	217	223	PF00069	0.751
MOD_Plk_4	34	40	PF00069	0.595
MOD_Plk_4	393	399	PF00069	0.557
MOD_Plk_4	83	89	PF00069	0.476
MOD_ProDKin_1	245	251	PF00069	0.566
MOD_ProDKin_1	427	433	PF00069	0.748
MOD_ProDKin_1	437	443	PF00069	0.766
MOD_ProDKin_1	504	510	PF00069	0.614
MOD_ProDKin_1	657	663	PF00069	0.801
MOD_ProDKin_1	707	713	PF00069	0.613
MOD_SUMO_for_1	113	116	PF00179	0.658
MOD_SUMO_rev_2	111	120	PF00179	0.654
MOD_SUMO_rev_2	316	324	PF00179	0.657
TRG_DiLeu_BaEn_1	34	39	PF01217	0.665
TRG_DiLeu_BaEn_4	409	415	PF01217	0.745
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.461
TRG_DiLeu_BaLyEn_6	684	689	PF01217	0.573
TRG_ENDOCYTIC_2	168	171	PF00928	0.680
TRG_ENDOCYTIC_2	422	425	PF00928	0.818
TRG_ENDOCYTIC_2	85	88	PF00928	0.540
TRG_ER_diArg_1	400	402	PF00400	0.678
TRG_ER_diArg_1	412	414	PF00400	0.569
TRG_ER_diArg_1	674	676	PF00400	0.641
TRG_NES_CRM1_1	109	121	PF08389	0.656
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	495	500	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBZ7	Leishmania donovani	57%	71%
E9AH49	Leishmania infantum	57%	71%
E9AWM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	73%
Q4QAU3	Leishmania major	56%	100%