Putative aspartate aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartate aminotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD93_LEIBR

TriTrypDb:

LbrM.24.0370 , LBRM2903_340013800

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD93

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044281	small molecule metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	5	13
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0070279	vitamin B6 binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.212
CLV_NRD_NRD_1	36	38	PF00675	0.440
CLV_PCSK_KEX2_1	192	194	PF00082	0.213
CLV_PCSK_SKI1_1	366	370	PF00082	0.472
CLV_PCSK_SKI1_1	72	76	PF00082	0.506
CLV_Separin_Metazoa	288	292	PF03568	0.472
DOC_CKS1_1	290	295	PF01111	0.472
DOC_MAPK_DCC_7	192	202	PF00069	0.370
DOC_MAPK_gen_1	192	199	PF00069	0.222
DOC_MAPK_gen_1	354	361	PF00069	0.251
DOC_MAPK_HePTP_8	190	202	PF00069	0.358
DOC_MAPK_MEF2A_6	15	22	PF00069	0.358
DOC_MAPK_MEF2A_6	193	202	PF00069	0.339
DOC_PP1_RVXF_1	364	370	PF00149	0.472
DOC_PP1_RVXF_1	65	71	PF00149	0.373
DOC_PP4_FxxP_1	70	73	PF00568	0.491
DOC_USP7_MATH_1	116	120	PF00917	0.440
DOC_USP7_MATH_1	160	164	PF00917	0.386
DOC_USP7_MATH_1	323	327	PF00917	0.413
DOC_USP7_UBL2_3	300	304	PF12436	0.280
DOC_WW_Pin1_4	114	119	PF00397	0.442
DOC_WW_Pin1_4	177	182	PF00397	0.467
DOC_WW_Pin1_4	289	294	PF00397	0.392
DOC_WW_Pin1_4	9	14	PF00397	0.437
LIG_14-3-3_CanoR_1	272	276	PF00244	0.331
LIG_14-3-3_CanoR_1	354	360	PF00244	0.207
LIG_14-3-3_CanoR_1	81	88	PF00244	0.338
LIG_APCC_ABBA_1	196	201	PF00400	0.392
LIG_APCC_ABBA_1	20	25	PF00400	0.358
LIG_FHA_1	110	116	PF00498	0.477
LIG_FHA_1	207	213	PF00498	0.423
LIG_FHA_1	227	233	PF00498	0.441
LIG_FHA_1	245	251	PF00498	0.382
LIG_FHA_1	290	296	PF00498	0.463
LIG_FHA_1	89	95	PF00498	0.362
LIG_FHA_2	173	179	PF00498	0.344
LIG_FHA_2	254	260	PF00498	0.472
LIG_FHA_2	46	52	PF00498	0.393
LIG_Integrin_isoDGR_2	364	366	PF01839	0.358
LIG_Integrin_RGD_1	193	195	PF01839	0.338
LIG_LIR_Apic_2	274	278	PF02991	0.394
LIG_LIR_Gen_1	182	191	PF02991	0.370
LIG_LIR_Gen_1	327	337	PF02991	0.348
LIG_LIR_Nem_3	133	139	PF02991	0.370
LIG_LIR_Nem_3	182	187	PF02991	0.358
LIG_LIR_Nem_3	201	207	PF02991	0.239
LIG_LIR_Nem_3	239	243	PF02991	0.398
LIG_LIR_Nem_3	327	333	PF02991	0.348
LIG_LIR_Nem_3	51	55	PF02991	0.349
LIG_MAD2	220	228	PF02301	0.207
LIG_RPA_C_Fungi	241	253	PF08784	0.472
LIG_SH2_CRK	275	279	PF00017	0.364
LIG_SH2_CRK	52	56	PF00017	0.344
LIG_SH2_GRB2like	139	142	PF00017	0.459
LIG_SH2_GRB2like	275	278	PF00017	0.344
LIG_SH2_NCK_1	275	279	PF00017	0.344
LIG_SH2_NCK_1	52	56	PF00017	0.344
LIG_SH2_SRC	52	55	PF00017	0.358
LIG_SH2_STAP1	357	361	PF00017	0.491
LIG_SH2_STAT3	140	143	PF00017	0.483
LIG_SH2_STAT3	155	158	PF00017	0.468
LIG_SH2_STAT3	379	382	PF00017	0.440
LIG_SH2_STAT5	155	158	PF00017	0.458
LIG_SH2_STAT5	217	220	PF00017	0.472
LIG_SH2_STAT5	230	233	PF00017	0.472
LIG_SH2_STAT5	332	335	PF00017	0.491
LIG_SH2_STAT5	360	363	PF00017	0.453
LIG_SH2_STAT5	379	382	PF00017	0.184
LIG_SH3_3	110	116	PF00018	0.405
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.358
LIG_TRAF2_1	180	183	PF00917	0.416
LIG_WRC_WIRS_1	58	63	PF05994	0.413
MOD_CDC14_SPxK_1	12	15	PF00782	0.294
MOD_CDK_SPxK_1	9	15	PF00069	0.298
MOD_CDK_SPxxK_3	289	296	PF00069	0.472
MOD_CK1_1	105	111	PF00069	0.491
MOD_CK1_1	370	376	PF00069	0.491
MOD_CK2_1	177	183	PF00069	0.413
MOD_CK2_1	253	259	PF00069	0.413
MOD_GlcNHglycan	104	107	PF01048	0.502
MOD_GlcNHglycan	369	372	PF01048	0.344
MOD_GlcNHglycan	83	86	PF01048	0.413
MOD_GlcNHglycan	88	91	PF01048	0.385
MOD_GSK3_1	101	108	PF00069	0.452
MOD_GSK3_1	232	239	PF00069	0.452
MOD_GSK3_1	262	269	PF00069	0.427
MOD_GSK3_1	355	362	PF00069	0.428
MOD_GSK3_1	57	64	PF00069	0.435
MOD_LATS_1	251	257	PF00433	0.472
MOD_N-GLC_2	17	19	PF02516	0.472
MOD_NEK2_1	101	106	PF00069	0.163
MOD_NEK2_1	236	241	PF00069	0.434
MOD_NEK2_1	61	66	PF00069	0.440
MOD_NEK2_1	88	93	PF00069	0.364
MOD_PIKK_1	253	259	PF00454	0.386
MOD_PIKK_1	262	268	PF00454	0.299
MOD_PIKK_1	45	51	PF00454	0.467
MOD_PKA_2	252	258	PF00069	0.472
MOD_PKA_2	271	277	PF00069	0.472
MOD_PKA_2	45	51	PF00069	0.448
MOD_Plk_4	160	166	PF00069	0.392
MOD_Plk_4	226	232	PF00069	0.472
MOD_Plk_4	266	272	PF00069	0.382
MOD_Plk_4	338	344	PF00069	0.482
MOD_Plk_4	355	361	PF00069	0.487
MOD_Plk_4	57	63	PF00069	0.469
MOD_ProDKin_1	114	120	PF00069	0.442
MOD_ProDKin_1	177	183	PF00069	0.467
MOD_ProDKin_1	289	295	PF00069	0.392
MOD_ProDKin_1	9	15	PF00069	0.434
MOD_SUMO_rev_2	297	306	PF00179	0.358
TRG_DiLeu_BaEn_3	182	188	PF01217	0.491
TRG_ENDOCYTIC_2	139	142	PF00928	0.437
TRG_ENDOCYTIC_2	204	207	PF00928	0.344
TRG_ENDOCYTIC_2	52	55	PF00928	0.348
TRG_ER_diArg_1	191	193	PF00400	0.338
TRG_ER_diArg_1	313	316	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.207
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0F7CUE9	Hapsidospora irregularis	32%	100%
A0A0N0P7Z5	Leptomonas seymouri	76%	88%
A0A0N1PAS7	Leptomonas seymouri	30%	100%
A0A0S4IPP7	Bodo saltans	48%	95%
A0A0S4JFW4	Bodo saltans	37%	94%
A0A1X0NIT8	Trypanosomatidae	35%	96%
A0A1X0NJG0	Trypanosomatidae	49%	93%
A0A1X0NJN9	Trypanosomatidae	36%	96%
A0A1X0NKG0	Trypanosomatidae	49%	93%
A0A3Q8IG20	Leishmania donovani	35%	94%
A0A3R7MWM6	Trypanosoma rangeli	51%	93%
A0A3S7WY33	Leishmania donovani	92%	90%
A0A422NI78	Trypanosoma rangeli	36%	93%
A4HMB3	Leishmania braziliensis	35%	95%
A5A6K8	Pan troglodytes	38%	94%
D0A277	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
D0A706	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	93%
E9AH48	Leishmania infantum	92%	90%
E9AWM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	90%
E9B5W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	94%
O42652	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	95%
O85746	Klebsiella pneumoniae	35%	98%
O94320	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	89%
P00503	Sus scrofa	38%	94%
P00504	Gallus gallus	37%	94%
P00505	Homo sapiens	40%	90%
P00506	Sus scrofa	40%	90%
P00507	Rattus norvegicus	40%	90%
P00508	Gallus gallus	40%	92%
P00509	Escherichia coli (strain K12)	38%	98%
P04693	Escherichia coli (strain K12)	36%	98%
P05201	Mus musculus	38%	94%
P05202	Mus musculus	40%	90%
P08906	Equus caballus	38%	94%
P08907	Equus caballus	39%	97%
P12344	Bos taurus	40%	90%
P12345	Oryctolagus cuniculus	41%	90%
P13221	Rattus norvegicus	38%	94%
P17174	Homo sapiens	38%	94%
P23542	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	93%
P26563	Lupinus angustifolius	39%	86%
P28011	Medicago sativa	40%	93%
P28734	Daucus carota	41%	96%
P33097	Bos taurus	38%	94%
P37833	Oryza sativa subsp. japonica	39%	96%
P43336	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	36%	97%
P44425	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	34%	98%
P46248	Arabidopsis thaliana	39%	86%
P46643	Arabidopsis thaliana	40%	90%
P46644	Arabidopsis thaliana	40%	87%
P46645	Arabidopsis thaliana	37%	96%
P46646	Arabidopsis thaliana	38%	97%
P58661	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	38%	98%
P72173	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	37%	98%
P74861	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	38%	98%
P95468	Paracoccus denitrificans	30%	99%
Q01802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	86%
Q02636	Rhizobium meliloti (strain 1021)	34%	100%
Q22067	Caenorhabditis elegans	37%	95%
Q28F67	Xenopus tropicalis	40%	91%
Q2PD92	Leishmania infantum	35%	94%
Q2T9S8	Bos taurus	28%	96%
Q4FX34	Leishmania major	35%	100%
Q4QAU4	Leishmania major	92%	100%
Q4R559	Macaca fascicularis	40%	90%
Q4R5L1	Macaca fascicularis	38%	94%
Q54SF7	Dictyostelium discoideum	42%	89%
Q55F21	Dictyostelium discoideum	41%	91%
Q56114	Salmonella typhi	38%	98%
Q5R691	Pongo abelii	38%	94%
Q5REB0	Pongo abelii	40%	90%
Q7SYK7	Danio rerio	40%	91%
Q7TSV6	Mus musculus	29%	96%
Q8NHS2	Homo sapiens	28%	92%
V5BSS0	Trypanosoma cruzi	36%	96%
V5BVY2	Trypanosoma cruzi	49%	93%