GPI ethanolamine phosphate transferase 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI ethanolamine phosphate transferase 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HD90_LEIBR

TriTrypDb:

LbrM.24.0340 , LBRM2903_240008400 , LBRM2903_240008500

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	8
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	8
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HD90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD90

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	9
GO:0006505	GPI anchor metabolic process	6	9
GO:0006506	GPI anchor biosynthetic process	6	9
GO:0006629	lipid metabolic process	3	9
GO:0006643	membrane lipid metabolic process	4	9
GO:0006644	phospholipid metabolic process	4	9
GO:0006650	glycerophospholipid metabolic process	5	9
GO:0006661	phosphatidylinositol biosynthetic process	6	9
GO:0006664	glycolipid metabolic process	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008610	lipid biosynthetic process	4	9
GO:0008654	phospholipid biosynthetic process	5	9
GO:0009058	biosynthetic process	2	9
GO:0009247	glycolipid biosynthetic process	5	9
GO:0009987	cellular process	1	9
GO:0019538	protein metabolic process	3	9
GO:0019637	organophosphate metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044255	cellular lipid metabolic process	3	9
GO:0045017	glycerolipid biosynthetic process	4	9
GO:0046467	membrane lipid biosynthetic process	4	9
GO:0046474	glycerophospholipid biosynthetic process	5	9
GO:0046486	glycerolipid metabolic process	4	9
GO:0046488	phosphatidylinositol metabolic process	6	9
GO:0071704	organic substance metabolic process	2	9
GO:0090407	organophosphate biosynthetic process	4	9
GO:1901135	carbohydrate derivative metabolic process	3	9
GO:1901137	carbohydrate derivative biosynthetic process	4	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901576	organic substance biosynthetic process	3	9
GO:1903509	liposaccharide metabolic process	4	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	8
GO:0051377	mannose-ethanolamine phosphotransferase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.337
CLV_NRD_NRD_1	195	197	PF00675	0.565
CLV_NRD_NRD_1	366	368	PF00675	0.524
CLV_NRD_NRD_1	409	411	PF00675	0.437
CLV_NRD_NRD_1	482	484	PF00675	0.538
CLV_NRD_NRD_1	686	688	PF00675	0.262
CLV_NRD_NRD_1	733	735	PF00675	0.421
CLV_NRD_NRD_1	892	894	PF00675	0.541
CLV_PCSK_KEX2_1	195	197	PF00082	0.551
CLV_PCSK_KEX2_1	366	368	PF00082	0.529
CLV_PCSK_KEX2_1	482	484	PF00082	0.582
CLV_PCSK_KEX2_1	686	688	PF00082	0.424
CLV_PCSK_KEX2_1	733	735	PF00082	0.421
CLV_PCSK_KEX2_1	877	879	PF00082	0.407
CLV_PCSK_KEX2_1	891	893	PF00082	0.473
CLV_PCSK_PC1ET2_1	877	879	PF00082	0.365
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.378
CLV_PCSK_PC7_1	362	368	PF00082	0.456
CLV_PCSK_SKI1_1	448	452	PF00082	0.590
CLV_PCSK_SKI1_1	654	658	PF00082	0.377
CLV_PCSK_SKI1_1	767	771	PF00082	0.241
CLV_PCSK_SKI1_1	951	955	PF00082	0.315
DEG_APCC_DBOX_1	439	447	PF00400	0.336
DEG_SPOP_SBC_1	133	137	PF00917	0.371
DOC_CKS1_1	190	195	PF01111	0.418
DOC_CKS1_1	463	468	PF01111	0.324
DOC_CYCLIN_RxL_1	948	955	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.309
DOC_CYCLIN_yCln2_LP_2	657	663	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	850	856	PF00134	0.342
DOC_MAPK_gen_1	195	204	PF00069	0.314
DOC_MAPK_gen_1	448	457	PF00069	0.362
DOC_MAPK_MEF2A_6	420	427	PF00069	0.331
DOC_MAPK_MEF2A_6	528	536	PF00069	0.374
DOC_MAPK_MEF2A_6	616	625	PF00069	0.517
DOC_MAPK_MEF2A_6	664	672	PF00069	0.524
DOC_MAPK_MEF2A_6	767	776	PF00069	0.491
DOC_MAPK_NFAT4_5	616	624	PF00069	0.537
DOC_PP1_RVXF_1	567	574	PF00149	0.285
DOC_PP1_RVXF_1	949	955	PF00149	0.271
DOC_PP2B_LxvP_1	455	458	PF13499	0.269
DOC_PP2B_LxvP_1	565	568	PF13499	0.276
DOC_PP2B_LxvP_1	630	633	PF13499	0.585
DOC_PP2B_LxvP_1	657	660	PF13499	0.578
DOC_PP2B_LxvP_1	850	853	PF13499	0.342
DOC_PP2B_PxIxI_1	465	471	PF00149	0.364
DOC_USP7_MATH_1	351	355	PF00917	0.426
DOC_USP7_MATH_1	429	433	PF00917	0.409
DOC_USP7_MATH_1	475	479	PF00917	0.328
DOC_USP7_MATH_1	595	599	PF00917	0.558
DOC_USP7_MATH_1	735	739	PF00917	0.581
DOC_USP7_MATH_1	743	747	PF00917	0.360
DOC_USP7_MATH_1	864	868	PF00917	0.606
DOC_USP7_MATH_1	896	900	PF00917	0.761
DOC_WW_Pin1_4	189	194	PF00397	0.412
DOC_WW_Pin1_4	228	233	PF00397	0.291
DOC_WW_Pin1_4	239	244	PF00397	0.328
DOC_WW_Pin1_4	462	467	PF00397	0.329
DOC_WW_Pin1_4	507	512	PF00397	0.465
DOC_WW_Pin1_4	723	728	PF00397	0.535
LIG_14-3-3_CanoR_1	118	125	PF00244	0.344
LIG_14-3-3_CanoR_1	237	243	PF00244	0.235
LIG_14-3-3_CanoR_1	269	277	PF00244	0.226
LIG_14-3-3_CanoR_1	298	303	PF00244	0.292
LIG_14-3-3_CanoR_1	392	398	PF00244	0.355
LIG_14-3-3_CanoR_1	44	50	PF00244	0.358
LIG_14-3-3_CanoR_1	528	533	PF00244	0.433
LIG_14-3-3_CanoR_1	733	742	PF00244	0.627
LIG_14-3-3_CanoR_1	767	776	PF00244	0.196
LIG_14-3-3_CanoR_1	88	96	PF00244	0.372
LIG_14-3-3_CanoR_1	908	917	PF00244	0.512
LIG_Actin_WH2_2	274	291	PF00022	0.271
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BIR_III_4	94	98	PF00653	0.448
LIG_BRCT_BRCA1_1	842	846	PF00533	0.346
LIG_Clathr_ClatBox_1	64	68	PF01394	0.280
LIG_CSL_BTD_1	508	511	PF09270	0.469
LIG_deltaCOP1_diTrp_1	182	189	PF00928	0.308
LIG_deltaCOP1_diTrp_1	821	826	PF00928	0.272
LIG_EH_1	273	277	PF12763	0.314
LIG_eIF4E_1	25	31	PF01652	0.343
LIG_eIF4E_1	835	841	PF01652	0.291
LIG_FHA_1	302	308	PF00498	0.242
LIG_FHA_1	32	38	PF00498	0.353
LIG_FHA_1	394	400	PF00498	0.339
LIG_FHA_1	463	469	PF00498	0.342
LIG_FHA_1	496	502	PF00498	0.315
LIG_FHA_1	521	527	PF00498	0.546
LIG_FHA_1	529	535	PF00498	0.301
LIG_FHA_1	605	611	PF00498	0.568
LIG_FHA_1	616	622	PF00498	0.597
LIG_FHA_1	641	647	PF00498	0.639
LIG_FHA_1	768	774	PF00498	0.399
LIG_FHA_1	793	799	PF00498	0.343
LIG_FHA_2	212	218	PF00498	0.218
LIG_FHA_2	292	298	PF00498	0.291
LIG_FHA_2	338	344	PF00498	0.328
LIG_FHA_2	482	488	PF00498	0.402
LIG_FHA_2	88	94	PF00498	0.421
LIG_FHA_2	884	890	PF00498	0.597
LIG_GBD_Chelix_1	62	70	PF00786	0.423
LIG_GBD_Chelix_1	768	776	PF00786	0.196
LIG_Integrin_isoDGR_2	765	767	PF01839	0.449
LIG_LIR_Apic_2	460	466	PF02991	0.392
LIG_LIR_Apic_2	723	727	PF02991	0.489
LIG_LIR_Gen_1	182	193	PF02991	0.321
LIG_LIR_Gen_1	222	232	PF02991	0.317
LIG_LIR_Gen_1	373	384	PF02991	0.389
LIG_LIR_Gen_1	843	854	PF02991	0.301
LIG_LIR_Gen_1	918	926	PF02991	0.343
LIG_LIR_Nem_3	182	188	PF02991	0.273
LIG_LIR_Nem_3	222	227	PF02991	0.317
LIG_LIR_Nem_3	330	336	PF02991	0.308
LIG_LIR_Nem_3	373	379	PF02991	0.407
LIG_LIR_Nem_3	617	623	PF02991	0.637
LIG_LIR_Nem_3	843	849	PF02991	0.301
LIG_LIR_Nem_3	918	923	PF02991	0.370
LIG_LIR_Nem_3	931	936	PF02991	0.227
LIG_NRBOX	531	537	PF00104	0.403
LIG_NRBOX	557	563	PF00104	0.393
LIG_NRBOX	620	626	PF00104	0.457
LIG_Pex14_1	185	189	PF04695	0.311
LIG_Pex14_1	677	681	PF04695	0.557
LIG_Pex14_1	822	826	PF04695	0.274
LIG_Pex14_2	333	337	PF04695	0.352
LIG_Pex14_2	542	546	PF04695	0.457
LIG_Pex14_2	805	809	PF04695	0.374
LIG_SH2_CRK	224	228	PF00017	0.291
LIG_SH2_CRK	415	419	PF00017	0.227
LIG_SH2_CRK	701	705	PF00017	0.540
LIG_SH2_CRK	751	755	PF00017	0.319
LIG_SH2_CRK	920	924	PF00017	0.343
LIG_SH2_GRB2like	415	418	PF00017	0.317
LIG_SH2_PTP2	922	925	PF00017	0.297
LIG_SH2_SRC	920	923	PF00017	0.247
LIG_SH2_STAP1	224	228	PF00017	0.251
LIG_SH2_STAP1	751	755	PF00017	0.343
LIG_SH2_STAP1	832	836	PF00017	0.294
LIG_SH2_STAP1	920	924	PF00017	0.343
LIG_SH2_STAT5	112	115	PF00017	0.258
LIG_SH2_STAT5	12	15	PF00017	0.596
LIG_SH2_STAT5	336	339	PF00017	0.348
LIG_SH2_STAT5	449	452	PF00017	0.368
LIG_SH2_STAT5	753	756	PF00017	0.356
LIG_SH2_STAT5	922	925	PF00017	0.294
LIG_SH2_STAT5	936	939	PF00017	0.307
LIG_SH3_1	187	193	PF00018	0.399
LIG_SH3_2	190	195	PF14604	0.418
LIG_SH3_3	127	133	PF00018	0.291
LIG_SH3_3	187	193	PF00018	0.424
LIG_SH3_3	199	205	PF00018	0.320
LIG_SH3_3	824	830	PF00018	0.325
LIG_Sin3_3	848	855	PF02671	0.286
LIG_SUMO_SIM_anti_2	304	311	PF11976	0.240
LIG_SUMO_SIM_anti_2	424	429	PF11976	0.299
LIG_SUMO_SIM_anti_2	530	536	PF11976	0.343
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.263
LIG_SUMO_SIM_anti_2	726	732	PF11976	0.494
LIG_SUMO_SIM_par_1	304	311	PF11976	0.313
LIG_SUMO_SIM_par_1	62	68	PF11976	0.257
LIG_SUMO_SIM_par_1	838	843	PF11976	0.225
LIG_SUMO_SIM_par_1	955	962	PF11976	0.374
LIG_TRAF2_1	324	327	PF00917	0.342
LIG_TRAF2_1	886	889	PF00917	0.769
LIG_TRFH_1	564	568	PF08558	0.196
LIG_TRFH_1	849	853	PF08558	0.315
LIG_TYR_ITIM	413	418	PF00017	0.254
LIG_TYR_ITSM	916	923	PF00017	0.286
LIG_UBA3_1	943	951	PF00899	0.289
LIG_WRC_WIRS_1	204	209	PF05994	0.374
MOD_CDK_SPxK_1	189	195	PF00069	0.509
MOD_CDK_SPxxK_3	189	196	PF00069	0.508
MOD_CDK_SPxxK_3	507	514	PF00069	0.461
MOD_CK1_1	116	122	PF00069	0.455
MOD_CK1_1	3	9	PF00069	0.514
MOD_CK1_1	301	307	PF00069	0.303
MOD_CK1_1	35	41	PF00069	0.388
MOD_CK1_1	352	358	PF00069	0.426
MOD_CK1_1	462	468	PF00069	0.343
MOD_CK1_1	503	509	PF00069	0.350
MOD_CK1_1	520	526	PF00069	0.287
MOD_CK1_1	726	732	PF00069	0.414
MOD_CK1_1	738	744	PF00069	0.479
MOD_CK1_1	780	786	PF00069	0.286
MOD_CK1_1	928	934	PF00069	0.403
MOD_CK2_1	239	245	PF00069	0.286
MOD_CK2_1	291	297	PF00069	0.343
MOD_CK2_1	321	327	PF00069	0.307
MOD_CK2_1	87	93	PF00069	0.506
MOD_CK2_1	883	889	PF00069	0.656
MOD_GlcNHglycan	121	124	PF01048	0.461
MOD_GlcNHglycan	175	178	PF01048	0.430
MOD_GlcNHglycan	224	227	PF01048	0.407
MOD_GlcNHglycan	316	319	PF01048	0.315
MOD_GlcNHglycan	323	326	PF01048	0.442
MOD_GlcNHglycan	351	354	PF01048	0.611
MOD_GlcNHglycan	431	434	PF01048	0.440
MOD_GlcNHglycan	502	505	PF01048	0.196
MOD_GlcNHglycan	584	587	PF01048	0.596
MOD_GlcNHglycan	677	680	PF01048	0.488
MOD_GlcNHglycan	737	740	PF01048	0.514
MOD_GlcNHglycan	745	748	PF01048	0.289
MOD_GlcNHglycan	911	914	PF01048	0.472
MOD_GlcNHglycan	927	930	PF01048	0.245
MOD_GlcNHglycan	933	936	PF01048	0.420
MOD_GSK3_1	113	120	PF00069	0.454
MOD_GSK3_1	154	161	PF00069	0.554
MOD_GSK3_1	297	304	PF00069	0.272
MOD_GSK3_1	31	38	PF00069	0.363
MOD_GSK3_1	321	328	PF00069	0.410
MOD_GSK3_1	462	469	PF00069	0.472
MOD_GSK3_1	503	510	PF00069	0.359
MOD_GSK3_1	587	594	PF00069	0.713
MOD_GSK3_1	600	607	PF00069	0.442
MOD_GSK3_1	734	741	PF00069	0.633
MOD_GSK3_1	776	783	PF00069	0.393
MOD_GSK3_1	860	867	PF00069	0.514
MOD_GSK3_1	896	903	PF00069	0.675
MOD_GSK3_1	911	918	PF00069	0.275
MOD_N-GLC_1	173	178	PF02516	0.444
MOD_N-GLC_1	289	294	PF02516	0.290
MOD_N-GLC_1	429	434	PF02516	0.462
MOD_N-GLC_1	822	827	PF02516	0.303
MOD_NEK2_1	173	178	PF00069	0.311
MOD_NEK2_1	30	35	PF00069	0.294
MOD_NEK2_1	36	41	PF00069	0.403
MOD_NEK2_1	393	398	PF00069	0.385
MOD_NEK2_1	486	491	PF00069	0.331
MOD_NEK2_1	494	499	PF00069	0.315
MOD_NEK2_1	500	505	PF00069	0.315
MOD_NEK2_1	542	547	PF00069	0.337
MOD_NEK2_1	557	562	PF00069	0.281
MOD_NEK2_1	604	609	PF00069	0.536
MOD_NEK2_1	720	725	PF00069	0.362
MOD_NEK2_1	74	79	PF00069	0.351
MOD_NEK2_1	758	763	PF00069	0.309
MOD_NEK2_1	776	781	PF00069	0.286
MOD_NEK2_1	840	845	PF00069	0.353
MOD_NEK2_2	595	600	PF00069	0.423
MOD_NEK2_2	830	835	PF00069	0.362
MOD_PIKK_1	337	343	PF00454	0.346
MOD_PIKK_1	792	798	PF00454	0.315
MOD_PKA_2	117	123	PF00069	0.419
MOD_PKA_2	268	274	PF00069	0.196
MOD_PKA_2	297	303	PF00069	0.282
MOD_PKA_2	481	487	PF00069	0.399
MOD_PKA_2	527	533	PF00069	0.377
MOD_PKA_2	615	621	PF00069	0.445
MOD_PKA_2	735	741	PF00069	0.579
MOD_PKA_2	87	93	PF00069	0.454
MOD_PKB_1	296	304	PF00069	0.343
MOD_Plk_1	113	119	PF00069	0.422
MOD_Plk_1	181	187	PF00069	0.382
MOD_Plk_1	459	465	PF00069	0.444
MOD_Plk_1	648	654	PF00069	0.426
MOD_Plk_1	822	828	PF00069	0.349
MOD_Plk_4	165	171	PF00069	0.404
MOD_Plk_4	25	31	PF00069	0.326
MOD_Plk_4	301	307	PF00069	0.363
MOD_Plk_4	32	38	PF00069	0.328
MOD_Plk_4	327	333	PF00069	0.343
MOD_Plk_4	503	509	PF00069	0.331
MOD_Plk_4	530	536	PF00069	0.345
MOD_Plk_4	542	548	PF00069	0.402
MOD_Plk_4	557	563	PF00069	0.406
MOD_Plk_4	595	601	PF00069	0.562
MOD_Plk_4	615	621	PF00069	0.454
MOD_Plk_4	631	637	PF00069	0.264
MOD_Plk_4	726	732	PF00069	0.579
MOD_Plk_4	753	759	PF00069	0.460
MOD_Plk_4	822	828	PF00069	0.437
MOD_Plk_4	830	836	PF00069	0.481
MOD_Plk_4	911	917	PF00069	0.398
MOD_ProDKin_1	189	195	PF00069	0.509
MOD_ProDKin_1	228	234	PF00069	0.343
MOD_ProDKin_1	239	245	PF00069	0.395
MOD_ProDKin_1	462	468	PF00069	0.389
MOD_ProDKin_1	507	513	PF00069	0.458
MOD_ProDKin_1	723	729	PF00069	0.405
TRG_DiLeu_BaEn_1	553	558	PF01217	0.388
TRG_DiLeu_BaEn_2	326	332	PF01217	0.349
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.283
TRG_DiLeu_BaLyEn_6	708	713	PF01217	0.471
TRG_ENDOCYTIC_2	224	227	PF00928	0.374
TRG_ENDOCYTIC_2	415	418	PF00928	0.411
TRG_ENDOCYTIC_2	751	754	PF00928	0.333
TRG_ENDOCYTIC_2	920	923	PF00928	0.287
TRG_ER_diArg_1	366	368	PF00400	0.322
TRG_ER_diArg_1	482	485	PF00400	0.529
TRG_ER_diArg_1	685	687	PF00400	0.277
TRG_ER_diArg_1	733	736	PF00400	0.518
TRG_NLS_Bipartite_1	876	895	PF00514	0.475
TRG_NLS_MonoExtC_3	890	895	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	654	658	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEK1	Leptomonas seymouri	60%	100%
A0A1X0NIL0	Trypanosomatidae	39%	100%
A0A3Q8IBS9	Leishmania donovani	79%	100%
A0A3R7MBN8	Trypanosoma rangeli	32%	100%
E9AH45	Leishmania infantum	78%	100%
E9AWM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAU7	Leishmania major	78%	100%