Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD87_LEIBR

TriTrypDb:

LbrM.24.0310 , LBRM2903_240008100

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.461
CLV_NRD_NRD_1	18	20	PF00675	0.629
CLV_NRD_NRD_1	198	200	PF00675	0.375
CLV_NRD_NRD_1	236	238	PF00675	0.615
CLV_NRD_NRD_1	59	61	PF00675	0.600
CLV_NRD_NRD_1	84	86	PF00675	0.646
CLV_PCSK_KEX2_1	18	20	PF00082	0.625
CLV_PCSK_KEX2_1	197	199	PF00082	0.497
CLV_PCSK_KEX2_1	236	238	PF00082	0.615
CLV_PCSK_KEX2_1	59	61	PF00082	0.565
CLV_PCSK_KEX2_1	84	86	PF00082	0.646
CLV_PCSK_SKI1_1	10	14	PF00082	0.582
CLV_PCSK_SKI1_1	102	106	PF00082	0.679
CLV_PCSK_SKI1_1	23	27	PF00082	0.511
CLV_PCSK_SKI1_1	236	240	PF00082	0.579
CLV_PCSK_SKI1_1	60	64	PF00082	0.780
DEG_APCC_DBOX_1	244	252	PF00400	0.448
DEG_SPOP_SBC_1	216	220	PF00917	0.662
DOC_CKS1_1	163	168	PF01111	0.584
DOC_CYCLIN_RxL_1	233	242	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.713
DOC_MAPK_gen_1	233	241	PF00069	0.503
DOC_MAPK_gen_1	243	251	PF00069	0.516
DOC_MAPK_RevD_3	3	19	PF00069	0.614
DOC_PP2B_LxvP_1	34	37	PF13499	0.495
DOC_USP7_MATH_1	137	141	PF00917	0.735
DOC_USP7_MATH_1	281	285	PF00917	0.657
DOC_USP7_MATH_1	89	93	PF00917	0.681
DOC_USP7_UBL2_3	139	143	PF12436	0.470
DOC_WW_Pin1_4	162	167	PF00397	0.573
DOC_WW_Pin1_4	217	222	PF00397	0.624
DOC_WW_Pin1_4	223	228	PF00397	0.486
DOC_WW_Pin1_4	91	96	PF00397	0.642
LIG_14-3-3_CanoR_1	155	163	PF00244	0.688
LIG_14-3-3_CanoR_1	18	22	PF00244	0.676
LIG_14-3-3_CanoR_1	236	242	PF00244	0.567
LIG_14-3-3_CanoR_1	84	89	PF00244	0.734
LIG_BIR_III_4	103	107	PF00653	0.621
LIG_CSL_BTD_1	5	8	PF09270	0.476
LIG_CtBP_PxDLS_1	255	259	PF00389	0.535
LIG_FHA_1	233	239	PF00498	0.526
LIG_FHA_1	29	35	PF00498	0.609
LIG_FHA_1	307	313	PF00498	0.392
LIG_LIR_Apic_2	117	123	PF02991	0.549
LIG_LIR_Gen_1	203	213	PF02991	0.451
LIG_LIR_Nem_3	203	208	PF02991	0.442
LIG_NRBOX	260	266	PF00104	0.551
LIG_Pex14_2	21	25	PF04695	0.699
LIG_Pex14_2	301	305	PF04695	0.402
LIG_SH2_PTP2	205	208	PF00017	0.440
LIG_SH2_PTP2	4	7	PF00017	0.692
LIG_SH2_STAP1	176	180	PF00017	0.637
LIG_SH2_STAT3	180	183	PF00017	0.462
LIG_SH2_STAT5	176	179	PF00017	0.569
LIG_SH2_STAT5	205	208	PF00017	0.440
LIG_SH2_STAT5	4	7	PF00017	0.692
LIG_SH3_3	164	170	PF00018	0.650
LIG_SH3_3	2	8	PF00018	0.497
LIG_SH3_3	34	40	PF00018	0.699
LIG_SH3_3	83	89	PF00018	0.616
LIG_SUMO_SIM_par_1	237	242	PF11976	0.441
LIG_SUMO_SIM_par_1	246	252	PF11976	0.417
LIG_SUMO_SIM_par_1	254	260	PF11976	0.441
LIG_SUMO_SIM_par_1	52	57	PF11976	0.522
LIG_TRAF2_1	181	184	PF00917	0.427
MOD_CDK_SPxxK_3	162	169	PF00069	0.586
MOD_CK1_1	171	177	PF00069	0.686
MOD_CK1_1	72	78	PF00069	0.621
MOD_CK2_1	156	162	PF00069	0.593
MOD_CK2_1	178	184	PF00069	0.460
MOD_CK2_1	226	232	PF00069	0.587
MOD_CK2_1	266	272	PF00069	0.607
MOD_Cter_Amidation	57	60	PF01082	0.544
MOD_DYRK1A_RPxSP_1	91	95	PF00069	0.721
MOD_GlcNHglycan	139	142	PF01048	0.658
MOD_GlcNHglycan	15	18	PF01048	0.693
MOD_GlcNHglycan	158	161	PF01048	0.618
MOD_GlcNHglycan	179	183	PF01048	0.370
MOD_GlcNHglycan	47	50	PF01048	0.662
MOD_GSK3_1	13	20	PF00069	0.648
MOD_GSK3_1	174	181	PF00069	0.613
MOD_GSK3_1	281	288	PF00069	0.625
MOD_LATS_1	100	106	PF00433	0.473
MOD_LATS_1	68	74	PF00433	0.753
MOD_N-GLC_1	114	119	PF02516	0.652
MOD_N-GLC_1	307	312	PF02516	0.614
MOD_NEK2_1	151	156	PF00069	0.646
MOD_PIKK_1	39	45	PF00454	0.657
MOD_PKA_1	84	90	PF00069	0.768
MOD_PKA_2	17	23	PF00069	0.653
MOD_PKA_2	209	215	PF00069	0.605
MOD_PKA_2	84	90	PF00069	0.768
MOD_Plk_4	171	177	PF00069	0.701
MOD_ProDKin_1	162	168	PF00069	0.569
MOD_ProDKin_1	217	223	PF00069	0.624
MOD_ProDKin_1	91	97	PF00069	0.642
MOD_SUMO_rev_2	229	235	PF00179	0.419
TRG_ENDOCYTIC_2	205	208	PF00928	0.440
TRG_ER_diArg_1	197	199	PF00400	0.412
TRG_ER_diArg_1	236	238	PF00400	0.617
TRG_ER_diArg_1	83	85	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G9	Leptomonas seymouri	61%	100%
A0A1X0NJB4	Trypanosomatidae	35%	100%
A0A3Q8IB82	Leishmania donovani	82%	100%
A0A3R7RTA5	Trypanosoma rangeli	38%	100%
D0A6Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AH42	Leishmania infantum	82%	100%
E9AWM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAV0	Leishmania major	81%	100%
V5C0R1	Trypanosoma cruzi	40%	100%