FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD85_LEIBR

TriTrypDb:

LbrM.24.0290 , LBRM2903_240007800

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.241
CLV_NRD_NRD_1	115	117	PF00675	0.513
CLV_NRD_NRD_1	296	298	PF00675	0.328
CLV_PCSK_KEX2_1	114	116	PF00082	0.513
CLV_PCSK_KEX2_1	168	170	PF00082	0.341
CLV_PCSK_KEX2_1	295	297	PF00082	0.326
CLV_PCSK_KEX2_1	360	362	PF00082	0.450
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.513
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.293
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.478
CLV_PCSK_PC7_1	110	116	PF00082	0.513
CLV_PCSK_SKI1_1	115	119	PF00082	0.652
CLV_PCSK_SKI1_1	122	126	PF00082	0.650
CLV_PCSK_SKI1_1	153	157	PF00082	0.577
CLV_PCSK_SKI1_1	168	172	PF00082	0.202
CLV_PCSK_SKI1_1	206	210	PF00082	0.273
DEG_SPOP_SBC_1	109	113	PF00917	0.619
DEG_SPOP_SBC_1	129	133	PF00917	0.473
DOC_CDC14_PxL_1	353	361	PF14671	0.494
DOC_CYCLIN_RxL_1	110	123	PF00134	0.472
DOC_CYCLIN_RxL_1	150	159	PF00134	0.511
DOC_MAPK_gen_1	168	175	PF00069	0.380
DOC_MAPK_gen_1	206	215	PF00069	0.356
DOC_MAPK_gen_1	314	323	PF00069	0.412
DOC_MAPK_JIP1_4	195	201	PF00069	0.247
DOC_MAPK_MEF2A_6	168	177	PF00069	0.267
DOC_MAPK_MEF2A_6	206	215	PF00069	0.265
DOC_MAPK_NFAT4_5	168	176	PF00069	0.440
DOC_PP4_FxxP_1	151	154	PF00568	0.527
DOC_PP4_FxxP_1	249	252	PF00568	0.247
DOC_USP7_MATH_1	109	113	PF00917	0.559
DOC_USP7_MATH_1	129	133	PF00917	0.675
DOC_USP7_MATH_1	18	22	PF00917	0.643
DOC_USP7_MATH_1	282	286	PF00917	0.227
DOC_USP7_MATH_1	375	379	PF00917	0.496
DOC_USP7_MATH_1	72	76	PF00917	0.665
DOC_WW_Pin1_4	10	15	PF00397	0.675
DOC_WW_Pin1_4	125	130	PF00397	0.681
DOC_WW_Pin1_4	19	24	PF00397	0.661
DOC_WW_Pin1_4	222	227	PF00397	0.277
DOC_WW_Pin1_4	39	44	PF00397	0.391
DOC_WW_Pin1_4	56	61	PF00397	0.661
DOC_WW_Pin1_4	91	96	PF00397	0.616
LIG_14-3-3_CanoR_1	100	107	PF00244	0.581
LIG_14-3-3_CanoR_1	110	118	PF00244	0.484
LIG_14-3-3_CanoR_1	130	135	PF00244	0.637
LIG_14-3-3_CanoR_1	169	174	PF00244	0.326
LIG_14-3-3_CanoR_1	188	197	PF00244	0.369
LIG_14-3-3_CanoR_1	283	287	PF00244	0.244
LIG_14-3-3_CanoR_1	319	324	PF00244	0.351
LIG_14-3-3_CanoR_1	369	374	PF00244	0.417
LIG_14-3-3_CanoR_1	38	43	PF00244	0.668
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BIR_III_2	57	61	PF00653	0.488
LIG_EH1_1	306	314	PF00400	0.326
LIG_eIF4E_1	307	313	PF01652	0.326
LIG_eIF4E_1	342	348	PF01652	0.278
LIG_FHA_1	101	107	PF00498	0.642
LIG_FHA_1	170	176	PF00498	0.346
LIG_FHA_1	232	238	PF00498	0.342
LIG_FHA_1	248	254	PF00498	0.174
LIG_FHA_1	57	63	PF00498	0.537
LIG_FHA_2	46	52	PF00498	0.709
LIG_GBD_Chelix_1	173	181	PF00786	0.233
LIG_GBD_Chelix_1	308	316	PF00786	0.332
LIG_LIR_Nem_3	289	294	PF02991	0.314
LIG_LIR_Nem_3	346	351	PF02991	0.330
LIG_PTB_Apo_2	301	308	PF02174	0.247
LIG_PTB_Phospho_1	301	307	PF10480	0.247
LIG_RPA_C_Fungi	105	117	PF08784	0.469
LIG_SH2_NCK_1	342	346	PF00017	0.468
LIG_SH2_PTP2	350	353	PF00017	0.502
LIG_SH2_STAT5	197	200	PF00017	0.299
LIG_SH2_STAT5	307	310	PF00017	0.247
LIG_SH2_STAT5	350	353	PF00017	0.502
LIG_SH3_3	137	143	PF00018	0.668
LIG_SH3_3	151	157	PF00018	0.625
LIG_SH3_3	190	196	PF00018	0.296
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.380
LIG_SUMO_SIM_anti_2	266	272	PF11976	0.214
LIG_SUMO_SIM_par_1	171	176	PF11976	0.330
LIG_SUMO_SIM_par_1	266	272	PF11976	0.338
MOD_CDK_SPK_2	125	130	PF00069	0.654
MOD_CDK_SPK_2	39	44	PF00069	0.718
MOD_CDK_SPxxK_3	56	63	PF00069	0.593
MOD_CK1_1	128	134	PF00069	0.627
MOD_CK1_1	187	193	PF00069	0.317
MOD_CK1_1	21	27	PF00069	0.585
MOD_CK1_1	4	10	PF00069	0.721
MOD_CK2_1	216	222	PF00069	0.235
MOD_CK2_1	319	325	PF00069	0.340
MOD_CK2_1	45	51	PF00069	0.635
MOD_GlcNHglycan	190	193	PF01048	0.272
MOD_GlcNHglycan	75	78	PF01048	0.588
MOD_GlcNHglycan	84	87	PF01048	0.430
MOD_GSK3_1	125	132	PF00069	0.591
MOD_GSK3_1	180	187	PF00069	0.354
MOD_GSK3_1	21	28	PF00069	0.501
MOD_GSK3_1	216	223	PF00069	0.225
MOD_GSK3_1	317	324	PF00069	0.455
MOD_GSK3_1	4	11	PF00069	0.619
MOD_GSK3_1	91	98	PF00069	0.615
MOD_N-GLC_1	375	380	PF02516	0.446
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	177	182	PF00069	0.302
MOD_NEK2_1	231	236	PF00069	0.295
MOD_NEK2_1	238	243	PF00069	0.265
MOD_NEK2_2	95	100	PF00069	0.678
MOD_PIKK_1	247	253	PF00454	0.370
MOD_PK_1	130	136	PF00069	0.646
MOD_PK_1	319	325	PF00069	0.400
MOD_PKA_2	101	107	PF00069	0.575
MOD_PKA_2	109	115	PF00069	0.546
MOD_PKA_2	129	135	PF00069	0.636
MOD_PKA_2	184	190	PF00069	0.311
MOD_PKA_2	282	288	PF00069	0.244
MOD_PKB_1	100	108	PF00069	0.629
MOD_PKB_1	317	325	PF00069	0.406
MOD_PKB_1	36	44	PF00069	0.631
MOD_PKB_1	6	14	PF00069	0.480
MOD_Plk_1	122	128	PF00069	0.468
MOD_Plk_1	177	183	PF00069	0.310
MOD_Plk_1	238	244	PF00069	0.350
MOD_Plk_1	271	277	PF00069	0.334
MOD_Plk_1	317	323	PF00069	0.458
MOD_Plk_1	375	381	PF00069	0.419
MOD_Plk_1	44	50	PF00069	0.701
MOD_Plk_2-3	45	51	PF00069	0.469
MOD_Plk_4	102	108	PF00069	0.737
MOD_Plk_4	130	136	PF00069	0.478
MOD_Plk_4	156	162	PF00069	0.473
MOD_Plk_4	169	175	PF00069	0.333
MOD_Plk_4	177	183	PF00069	0.282
MOD_Plk_4	238	244	PF00069	0.340
MOD_Plk_4	282	288	PF00069	0.334
MOD_Plk_4	375	381	PF00069	0.440
MOD_ProDKin_1	10	16	PF00069	0.678
MOD_ProDKin_1	125	131	PF00069	0.681
MOD_ProDKin_1	19	25	PF00069	0.659
MOD_ProDKin_1	222	228	PF00069	0.277
MOD_ProDKin_1	39	45	PF00069	0.395
MOD_ProDKin_1	56	62	PF00069	0.660
MOD_ProDKin_1	91	97	PF00069	0.616
MOD_SUMO_for_1	62	65	PF00179	0.492
MOD_SUMO_rev_2	163	170	PF00179	0.514
MOD_SUMO_rev_2	355	362	PF00179	0.346
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.488
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.265
TRG_ENDOCYTIC_2	306	309	PF00928	0.247
TRG_ENDOCYTIC_2	350	353	PF00928	0.502
TRG_ER_diArg_1	294	297	PF00400	0.277
TRG_ER_diArg_1	5	8	PF00400	0.631
TRG_ER_diArg_1	99	102	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.246

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L6	Leptomonas seymouri	68%	96%
A0A0N1PG96	Leptomonas seymouri	25%	100%
A0A1X0NKH2	Trypanosomatidae	46%	100%
A0A1X0PA23	Trypanosomatidae	30%	100%
A0A422P410	Trypanosoma rangeli	49%	100%
A4I1V3	Leishmania infantum	25%	100%
D0A6Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
V5BAV0	Trypanosoma cruzi	50%	100%