Dynein intermediate-chain-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynein intermediate chain 1, axonemal

Species:

Leishmania braziliensis

UniProt:

A4HD84_LEIBR

TriTrypDb:

LbrM.24.0280 , LBRM2903_240007700

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036157	outer dynein arm	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HD84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD84

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033058	directional locomotion	2	1
GO:0036158	outer dynein arm assembly	7	1
GO:0040011	locomotion	1	1
GO:0043056	forward locomotion	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0060294	cilium movement involved in cell motility	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	564	568	PF00656	0.358
CLV_NRD_NRD_1	118	120	PF00675	0.419
CLV_NRD_NRD_1	206	208	PF00675	0.583
CLV_NRD_NRD_1	26	28	PF00675	0.591
CLV_NRD_NRD_1	301	303	PF00675	0.492
CLV_NRD_NRD_1	645	647	PF00675	0.471
CLV_PCSK_FUR_1	116	120	PF00082	0.415
CLV_PCSK_KEX2_1	118	120	PF00082	0.419
CLV_PCSK_KEX2_1	206	208	PF00082	0.568
CLV_PCSK_SKI1_1	143	147	PF00082	0.515
CLV_PCSK_SKI1_1	240	244	PF00082	0.499
CLV_PCSK_SKI1_1	304	308	PF00082	0.286
CLV_PCSK_SKI1_1	455	459	PF00082	0.483
CLV_PCSK_SKI1_1	460	464	PF00082	0.484
CLV_PCSK_SKI1_1	57	61	PF00082	0.452
CLV_PCSK_SKI1_1	611	615	PF00082	0.363
CLV_PCSK_SKI1_1	681	685	PF00082	0.436
DEG_SPOP_SBC_1	576	580	PF00917	0.289
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.353
DOC_MAPK_DCC_7	554	562	PF00069	0.402
DOC_MAPK_gen_1	116	125	PF00069	0.562
DOC_MAPK_gen_1	302	311	PF00069	0.321
DOC_MAPK_gen_1	611	620	PF00069	0.311
DOC_MAPK_MEF2A_6	633	641	PF00069	0.295
DOC_MAPK_MEF2A_6	669	678	PF00069	0.332
DOC_PP4_FxxP_1	328	331	PF00568	0.503
DOC_USP7_MATH_1	221	225	PF00917	0.616
DOC_USP7_MATH_1	227	231	PF00917	0.624
DOC_USP7_MATH_1	250	254	PF00917	0.289
DOC_USP7_MATH_1	346	350	PF00917	0.566
DOC_USP7_MATH_1	576	580	PF00917	0.289
DOC_USP7_MATH_1	7	11	PF00917	0.683
DOC_USP7_MATH_1	84	88	PF00917	0.326
DOC_USP7_UBL2_3	300	304	PF12436	0.487
DOC_USP7_UBL2_3	550	554	PF12436	0.422
DOC_WW_Pin1_4	103	108	PF00397	0.567
DOC_WW_Pin1_4	245	250	PF00397	0.503
DOC_WW_Pin1_4	3	8	PF00397	0.691
DOC_WW_Pin1_4	487	492	PF00397	0.492
DOC_WW_Pin1_4	530	535	PF00397	0.514
DOC_WW_Pin1_4	553	558	PF00397	0.500
DOC_WW_Pin1_4	639	644	PF00397	0.306
LIG_14-3-3_CanoR_1	154	160	PF00244	0.451
LIG_14-3-3_CanoR_1	166	172	PF00244	0.510
LIG_14-3-3_CanoR_1	179	188	PF00244	0.318
LIG_14-3-3_CanoR_1	395	401	PF00244	0.528
LIG_14-3-3_CanoR_1	8	12	PF00244	0.624
LIG_14-3-3_CanoR_1	89	95	PF00244	0.490
LIG_Actin_WH2_2	632	648	PF00022	0.409
LIG_APCC_ABBA_1	69	74	PF00400	0.443
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BIR_III_4	567	571	PF00653	0.369
LIG_BRCT_BRCA1_1	174	178	PF00533	0.410
LIG_BRCT_BRCA1_1	247	251	PF00533	0.516
LIG_BRCT_BRCA1_1	324	328	PF00533	0.312
LIG_BRCT_BRCA1_1	578	582	PF00533	0.272
LIG_BRCT_BRCA1_1	91	95	PF00533	0.569
LIG_BRCT_BRCA1_2	324	330	PF00533	0.418
LIG_Clathr_ClatBox_1	94	98	PF01394	0.493
LIG_CSL_BTD_1	531	534	PF09270	0.353
LIG_deltaCOP1_diTrp_1	422	429	PF00928	0.300
LIG_deltaCOP1_diTrp_1	546	552	PF00928	0.411
LIG_FHA_1	140	146	PF00498	0.422
LIG_FHA_1	431	437	PF00498	0.398
LIG_FHA_1	546	552	PF00498	0.418
LIG_FHA_1	599	605	PF00498	0.427
LIG_FHA_1	614	620	PF00498	0.336
LIG_FHA_1	636	642	PF00498	0.434
LIG_FHA_1	86	92	PF00498	0.557
LIG_FHA_2	129	135	PF00498	0.592
LIG_FHA_2	456	462	PF00498	0.481
LIG_FHA_2	675	681	PF00498	0.367
LIG_Integrin_isoDGR_2	312	314	PF01839	0.379
LIG_LIR_Apic_2	325	331	PF02991	0.482
LIG_LIR_Apic_2	404	409	PF02991	0.343
LIG_LIR_Gen_1	325	331	PF02991	0.415
LIG_LIR_Gen_1	422	430	PF02991	0.443
LIG_LIR_Gen_1	579	587	PF02991	0.426
LIG_LIR_Nem_3	175	181	PF02991	0.543
LIG_LIR_Nem_3	183	188	PF02991	0.389
LIG_LIR_Nem_3	325	329	PF02991	0.407
LIG_LIR_Nem_3	435	441	PF02991	0.338
LIG_LIR_Nem_3	529	535	PF02991	0.444
LIG_LIR_Nem_3	571	577	PF02991	0.287
LIG_LIR_Nem_3	579	585	PF02991	0.300
LIG_REV1ctd_RIR_1	294	304	PF16727	0.359
LIG_SH2_CRK	326	330	PF00017	0.420
LIG_SH2_CRK	406	410	PF00017	0.319
LIG_SH2_STAP1	315	319	PF00017	0.435
LIG_SH2_STAP1	528	532	PF00017	0.411
LIG_SH2_STAP1	577	581	PF00017	0.282
LIG_SH2_STAT5	528	531	PF00017	0.417
LIG_SH3_3	156	162	PF00018	0.370
LIG_SH3_3	351	357	PF00018	0.396
LIG_SH3_3	531	537	PF00018	0.436
LIG_SH3_3	645	651	PF00018	0.434
LIG_SH3_3	78	84	PF00018	0.361
LIG_SUMO_SIM_anti_2	624	632	PF11976	0.233
LIG_SUMO_SIM_par_1	431	437	PF11976	0.349
LIG_SUMO_SIM_par_1	558	564	PF11976	0.386
LIG_SUMO_SIM_par_1	624	632	PF11976	0.233
LIG_SUMO_SIM_par_1	672	677	PF11976	0.358
LIG_TRAF2_1	190	193	PF00917	0.280
LIG_TYR_ITAM	312	329	PF00017	0.353
LIG_WRPW_2	82	85	PF00400	0.314
MOD_CDK_SPK_2	3	8	PF00069	0.683
MOD_CDK_SPxxK_3	639	646	PF00069	0.311
MOD_CK1_1	220	226	PF00069	0.413
MOD_CK1_1	437	443	PF00069	0.283
MOD_CK1_1	6	12	PF00069	0.693
MOD_CK2_1	429	435	PF00069	0.407
MOD_CK2_1	450	456	PF00069	0.480
MOD_CK2_1	46	52	PF00069	0.557
MOD_GlcNHglycan	1	4	PF01048	0.468
MOD_GlcNHglycan	174	177	PF01048	0.511
MOD_GlcNHglycan	18	21	PF01048	0.671
MOD_GlcNHglycan	217	222	PF01048	0.615
MOD_GlcNHglycan	223	226	PF01048	0.590
MOD_GlcNHglycan	252	255	PF01048	0.511
MOD_GlcNHglycan	348	351	PF01048	0.541
MOD_GlcNHglycan	48	51	PF01048	0.532
MOD_GlcNHglycan	543	546	PF01048	0.224
MOD_GSK3_1	149	156	PF00069	0.530
MOD_GSK3_1	217	224	PF00069	0.536
MOD_GSK3_1	3	10	PF00069	0.661
MOD_GSK3_1	430	437	PF00069	0.460
MOD_GSK3_1	464	471	PF00069	0.502
MOD_GSK3_1	483	490	PF00069	0.411
MOD_GSK3_1	526	533	PF00069	0.480
MOD_GSK3_1	541	548	PF00069	0.362
MOD_GSK3_1	635	642	PF00069	0.386
MOD_GSK3_1	85	92	PF00069	0.417
MOD_LATS_1	373	379	PF00433	0.508
MOD_N-GLC_1	149	154	PF02516	0.489
MOD_N-GLC_1	46	51	PF02516	0.552
MOD_N-GLC_1	598	603	PF02516	0.494
MOD_N-GLC_2	265	267	PF02516	0.369
MOD_NEK2_1	394	399	PF00069	0.524
MOD_NEK2_1	434	439	PF00069	0.255
MOD_NEK2_1	463	468	PF00069	0.317
MOD_NEK2_1	506	511	PF00069	0.337
MOD_NEK2_2	227	232	PF00069	0.568
MOD_NEK2_2	332	337	PF00069	0.423
MOD_NEK2_2	357	362	PF00069	0.308
MOD_NEK2_2	545	550	PF00069	0.429
MOD_NEK2_2	577	582	PF00069	0.279
MOD_NEK2_2	7	12	PF00069	0.457
MOD_PIKK_1	153	159	PF00454	0.489
MOD_PIKK_1	497	503	PF00454	0.315
MOD_PKA_1	27	33	PF00069	0.601
MOD_PKA_1	646	652	PF00069	0.462
MOD_PKA_2	153	159	PF00069	0.515
MOD_PKA_2	394	400	PF00069	0.546
MOD_PKA_2	43	49	PF00069	0.596
MOD_PKA_2	632	638	PF00069	0.309
MOD_PKA_2	7	13	PF00069	0.655
MOD_Plk_1	217	223	PF00069	0.582
MOD_Plk_1	357	363	PF00069	0.264
MOD_Plk_1	375	381	PF00069	0.430
MOD_Plk_1	430	436	PF00069	0.456
MOD_Plk_1	545	551	PF00069	0.422
MOD_Plk_1	674	680	PF00069	0.347
MOD_Plk_4	286	292	PF00069	0.464
MOD_Plk_4	375	381	PF00069	0.471
MOD_Plk_4	434	440	PF00069	0.449
MOD_Plk_4	527	533	PF00069	0.353
MOD_Plk_4	577	583	PF00069	0.304
MOD_Plk_4	605	611	PF00069	0.347
MOD_Plk_4	632	638	PF00069	0.307
MOD_Plk_4	90	96	PF00069	0.537
MOD_ProDKin_1	103	109	PF00069	0.561
MOD_ProDKin_1	245	251	PF00069	0.497
MOD_ProDKin_1	3	9	PF00069	0.691
MOD_ProDKin_1	487	493	PF00069	0.495
MOD_ProDKin_1	530	536	PF00069	0.514
MOD_ProDKin_1	553	559	PF00069	0.497
MOD_ProDKin_1	639	645	PF00069	0.307
TRG_DiLeu_BaEn_1	286	291	PF01217	0.372
TRG_DiLeu_BaEn_1	502	507	PF01217	0.445
TRG_ENDOCYTIC_2	315	318	PF00928	0.309
TRG_ENDOCYTIC_2	326	329	PF00928	0.418
TRG_ENDOCYTIC_2	528	531	PF00928	0.487
TRG_ENDOCYTIC_2	82	85	PF00928	0.403
TRG_ER_diArg_1	116	119	PF00400	0.418
TRG_LysEnd_GGAAcLL_1	680	686	PF00790	0.493
TRG_NES_CRM1_1	668	680	PF08389	0.480
TRG_NLS_MonoExtN_4	300	306	PF00514	0.421
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I862	Leptomonas seymouri	81%	100%
A0A0S4INJ7	Bodo saltans	58%	100%
A0A1X0NJ43	Trypanosomatidae	61%	100%
A0A3Q8ICR4	Leishmania donovani	90%	100%
A0A422P471	Trypanosoma rangeli	61%	100%
A4HK88	Leishmania braziliensis	26%	100%
C9ZJC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
D0A6Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AH39	Leishmania infantum	89%	100%
E9AWL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
F1QHZ6	Danio rerio	28%	88%
Q16959	Heliocidaris crassispina	41%	98%
Q32KS2	Bos taurus	36%	98%
Q39578	Chlamydomonas reinhardtii	38%	100%
Q4QAV3	Leishmania major	89%	100%
Q4V8G4	Rattus norvegicus	26%	85%
Q5U4F6	Mus musculus	27%	100%
Q5VTH9	Homo sapiens	26%	81%
Q5XIL8	Rattus norvegicus	36%	97%
Q6GPB9	Xenopus laevis	27%	92%
Q8C0M8	Mus musculus	38%	98%
Q9UI46	Homo sapiens	37%	98%
V5BJK6	Trypanosoma cruzi	29%	83%
V5DSN6	Trypanosoma cruzi	61%	100%