WD repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

WD repeat protein

Gene product:

WD repeat protein

Species:

Leishmania braziliensis

UniProt:

A4HD80_LEIBR

TriTrypDb:

LbrM.24.0230 , LBRM2903_240007100

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD80

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.260
CLV_NRD_NRD_1	142	144	PF00675	0.348
CLV_NRD_NRD_1	232	234	PF00675	0.555
CLV_NRD_NRD_1	44	46	PF00675	0.226
CLV_PCSK_KEX2_1	142	144	PF00082	0.348
CLV_PCSK_KEX2_1	215	217	PF00082	0.436
CLV_PCSK_KEX2_1	232	234	PF00082	0.471
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.465
CLV_PCSK_SKI1_1	142	146	PF00082	0.341
CLV_PCSK_SKI1_1	291	295	PF00082	0.409
CLV_PCSK_SKI1_1	398	402	PF00082	0.318
CLV_PCSK_SKI1_1	419	423	PF00082	0.312
CLV_PCSK_SKI1_1	460	464	PF00082	0.336
DEG_Nend_UBRbox_2	1	3	PF02207	0.619
DEG_SPOP_SBC_1	164	168	PF00917	0.449
DEG_SPOP_SBC_1	317	321	PF00917	0.443
DOC_ANK_TNKS_1	231	238	PF00023	0.595
DOC_CYCLIN_RxL_1	395	403	PF00134	0.322
DOC_MAPK_gen_1	215	222	PF00069	0.547
DOC_USP7_MATH_1	164	168	PF00917	0.339
DOC_USP7_MATH_1	317	321	PF00917	0.435
DOC_USP7_MATH_1	343	347	PF00917	0.382
DOC_USP7_MATH_2	198	204	PF00917	0.558
DOC_USP7_UBL2_3	419	423	PF12436	0.463
DOC_WW_Pin1_4	308	313	PF00397	0.421
DOC_WW_Pin1_4	347	352	PF00397	0.294
DOC_WW_Pin1_4	61	66	PF00397	0.416
LIG_14-3-3_CanoR_1	179	183	PF00244	0.345
LIG_14-3-3_CanoR_1	330	340	PF00244	0.485
LIG_14-3-3_CanoR_1	372	380	PF00244	0.411
LIG_14-3-3_CanoR_1	40	45	PF00244	0.312
LIG_14-3-3_CanoR_1	417	422	PF00244	0.333
LIG_Actin_WH2_2	356	374	PF00022	0.450
LIG_BIR_III_4	361	365	PF00653	0.343
LIG_BRCT_BRCA1_1	289	293	PF00533	0.385
LIG_Clathr_ClatBox_1	55	59	PF01394	0.440
LIG_deltaCOP1_diTrp_1	433	438	PF00928	0.297
LIG_FHA_1	107	113	PF00498	0.543
LIG_FHA_1	121	127	PF00498	0.469
LIG_FHA_1	266	272	PF00498	0.372
LIG_FHA_1	3	9	PF00498	0.513
LIG_FHA_1	319	325	PF00498	0.346
LIG_FHA_1	332	338	PF00498	0.332
LIG_FHA_1	426	432	PF00498	0.318
LIG_FHA_1	79	85	PF00498	0.444
LIG_FHA_2	204	210	PF00498	0.439
LIG_FHA_2	223	229	PF00498	0.435
LIG_FHA_2	255	261	PF00498	0.424
LIG_FHA_2	308	314	PF00498	0.479
LIG_FHA_2	387	393	PF00498	0.320
LIG_LIR_Apic_2	308	312	PF02991	0.354
LIG_LIR_Apic_2	59	65	PF02991	0.416
LIG_LIR_Gen_1	176	185	PF02991	0.441
LIG_LIR_Gen_1	50	60	PF02991	0.359
LIG_LIR_Gen_1	94	105	PF02991	0.416
LIG_LIR_Nem_3	176	180	PF02991	0.387
LIG_LIR_Nem_3	50	55	PF02991	0.366
LIG_LIR_Nem_3	94	100	PF02991	0.439
LIG_PDZ_Class_2	461	466	PF00595	0.449
LIG_PTB_Apo_2	362	369	PF02174	0.206
LIG_REV1ctd_RIR_1	366	376	PF16727	0.402
LIG_SH2_GRB2like	325	328	PF00017	0.388
LIG_SH2_NCK_1	119	123	PF00017	0.557
LIG_SH2_PTP2	97	100	PF00017	0.483
LIG_SH2_STAT5	173	176	PF00017	0.301
LIG_SH2_STAT5	325	328	PF00017	0.388
LIG_SH2_STAT5	72	75	PF00017	0.480
LIG_SH2_STAT5	97	100	PF00017	0.416
LIG_SH3_1	154	160	PF00018	0.481
LIG_SH3_2	186	191	PF14604	0.493
LIG_SH3_3	154	160	PF00018	0.481
LIG_SH3_3	17	23	PF00018	0.612
LIG_SH3_3	183	189	PF00018	0.520
LIG_SH3_3	192	198	PF00018	0.497
LIG_SH3_3	8	14	PF00018	0.692
LIG_SUMO_SIM_par_1	159	168	PF11976	0.322
LIG_TRAF2_1	205	208	PF00917	0.440
LIG_TRAF2_1	34	37	PF00917	0.402
LIG_UBA3_1	367	376	PF00899	0.348
MOD_CK1_1	120	126	PF00069	0.582
MOD_CK1_1	165	171	PF00069	0.352
MOD_CK1_1	178	184	PF00069	0.486
MOD_CK1_1	203	209	PF00069	0.544
MOD_CK1_1	21	27	PF00069	0.592
MOD_CK1_1	265	271	PF00069	0.436
MOD_CK1_1	308	314	PF00069	0.404
MOD_CK1_1	448	454	PF00069	0.360
MOD_CK1_1	77	83	PF00069	0.470
MOD_CK2_1	203	209	PF00069	0.451
MOD_CK2_1	254	260	PF00069	0.518
MOD_CK2_1	31	37	PF00069	0.551
MOD_CK2_1	386	392	PF00069	0.316
MOD_GlcNHglycan	101	104	PF01048	0.356
MOD_GlcNHglycan	113	117	PF01048	0.633
MOD_GlcNHglycan	202	205	PF01048	0.535
MOD_GlcNHglycan	264	267	PF01048	0.311
MOD_GlcNHglycan	353	357	PF01048	0.245
MOD_GlcNHglycan	384	387	PF01048	0.352
MOD_GlcNHglycan	402	405	PF01048	0.276
MOD_GlcNHglycan	76	79	PF01048	0.303
MOD_GlcNHglycan	85	88	PF01048	0.300
MOD_GSK3_1	18	25	PF00069	0.619
MOD_GSK3_1	199	206	PF00069	0.480
MOD_GSK3_1	277	284	PF00069	0.466
MOD_GSK3_1	31	38	PF00069	0.490
MOD_GSK3_1	343	350	PF00069	0.219
MOD_GSK3_1	382	389	PF00069	0.378
MOD_GSK3_1	413	420	PF00069	0.464
MOD_GSK3_1	74	81	PF00069	0.549
MOD_GSK3_1	83	90	PF00069	0.505
MOD_N-GLC_1	277	282	PF02516	0.428
MOD_N-GLC_1	305	310	PF02516	0.490
MOD_N-GLC_1	413	418	PF02516	0.355
MOD_NEK2_1	101	106	PF00069	0.373
MOD_NEK2_1	112	117	PF00069	0.493
MOD_NEK2_1	162	167	PF00069	0.350
MOD_NEK2_1	175	180	PF00069	0.292
MOD_NEK2_1	253	258	PF00069	0.426
MOD_NEK2_1	307	312	PF00069	0.440
MOD_NEK2_1	352	357	PF00069	0.266
MOD_NEK2_1	371	376	PF00069	0.482
MOD_NEK2_1	400	405	PF00069	0.281
MOD_NEK2_1	85	90	PF00069	0.432
MOD_PIKK_1	106	112	PF00454	0.570
MOD_PKA_2	178	184	PF00069	0.359
MOD_PKA_2	231	237	PF00069	0.589
MOD_PKA_2	371	377	PF00069	0.375
MOD_Plk_1	175	181	PF00069	0.364
MOD_Plk_1	298	304	PF00069	0.364
MOD_Plk_1	305	311	PF00069	0.344
MOD_Plk_1	386	392	PF00069	0.393
MOD_Plk_1	93	99	PF00069	0.471
MOD_Plk_2-3	31	37	PF00069	0.634
MOD_Plk_2-3	387	393	PF00069	0.333
MOD_Plk_4	417	423	PF00069	0.505
MOD_Plk_4	80	86	PF00069	0.422
MOD_Plk_4	93	99	PF00069	0.401
MOD_ProDKin_1	308	314	PF00069	0.414
MOD_ProDKin_1	347	353	PF00069	0.301
MOD_ProDKin_1	61	67	PF00069	0.416
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.380
TRG_ENDOCYTIC_2	52	55	PF00928	0.416
TRG_ENDOCYTIC_2	97	100	PF00928	0.416
TRG_ER_diArg_1	142	144	PF00400	0.348
TRG_ER_diArg_1	457	460	PF00400	0.284
TRG_NES_CRM1_1	361	373	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV6	Leptomonas seymouri	77%	100%
A0A0S4J9M2	Bodo saltans	49%	93%
A0A1X0NIM0	Trypanosomatidae	57%	100%
A0A3Q8IMH5	Leishmania donovani	90%	79%
A0A3R7LDW9	Trypanosoma rangeli	60%	100%
A4HI50	Leishmania braziliensis	23%	70%
D0A6Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AH35	Leishmania infantum	90%	100%
E9AWL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O14021	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O22466	Solanum lycopersicum	24%	100%
O22467	Arabidopsis thaliana	25%	100%
O22468	Arabidopsis thaliana	24%	100%
O22469	Arabidopsis thaliana	23%	100%
O22607	Arabidopsis thaliana	23%	92%
O93377	Xenopus laevis	25%	100%
P0CS36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	100%
P0CS37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	100%
P13712	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P90916	Caenorhabditis elegans	24%	100%
P90917	Caenorhabditis elegans	24%	100%
Q09028	Homo sapiens	25%	100%
Q10G81	Oryza sativa subsp. japonica	25%	100%
Q16576	Homo sapiens	24%	100%
Q24572	Drosophila melanogaster	25%	100%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q3MHL3	Bos taurus	25%	100%
Q3SWX8	Bos taurus	24%	100%
Q4I7L0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	24%	100%
Q4P553	Ustilago maydis (strain 521 / FGSC 9021)	26%	100%
Q4QAV7	Leishmania major	89%	100%
Q4R304	Macaca fascicularis	24%	100%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q54SD4	Dictyostelium discoideum	22%	100%
Q5M7K4	Xenopus tropicalis	25%	100%
Q5R654	Pongo abelii	25%	100%
Q5RF92	Pongo abelii	25%	100%
Q60972	Mus musculus	25%	100%
Q60973	Mus musculus	24%	100%
Q61Y48	Caenorhabditis briggsae	24%	100%
Q6C7Q4	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q6INH0	Xenopus laevis	25%	100%
Q6P315	Xenopus tropicalis	24%	100%
Q6P3H7	Danio rerio	25%	100%
Q71UF4	Rattus norvegicus	24%	100%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q7ZTY4	Danio rerio	24%	100%
Q8AVH1	Xenopus laevis	25%	100%
Q8SRK1	Encephalitozoon cuniculi (strain GB-M1)	24%	100%
Q9I8G9	Gallus gallus	24%	100%
Q9W7I5	Gallus gallus	25%	100%
Q9Y825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5BAV4	Trypanosoma cruzi	60%	89%