Protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD79_LEIBR

TriTrypDb:

LbrM.24.0220 , LBRM2903_240007000

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD79

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0033554	cellular response to stress	3	1
GO:0035556	intracellular signal transduction	3	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.332
CLV_C14_Caspase3-7	425	429	PF00656	0.190
CLV_C14_Caspase3-7	518	522	PF00656	0.407
CLV_NRD_NRD_1	143	145	PF00675	0.472
CLV_NRD_NRD_1	228	230	PF00675	0.190
CLV_NRD_NRD_1	333	335	PF00675	0.295
CLV_PCSK_KEX2_1	143	145	PF00082	0.373
CLV_PCSK_KEX2_1	18	20	PF00082	0.634
CLV_PCSK_KEX2_1	333	335	PF00082	0.324
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.634
CLV_PCSK_SKI1_1	171	175	PF00082	0.261
CLV_PCSK_SKI1_1	299	303	PF00082	0.267
CLV_PCSK_SKI1_1	485	489	PF00082	0.372
CLV_PCSK_SKI1_1	517	521	PF00082	0.555
CLV_Separin_Metazoa	330	334	PF03568	0.190
DEG_APCC_DBOX_1	155	163	PF00400	0.332
DEG_APCC_DBOX_1	194	202	PF00400	0.326
DEG_APCC_DBOX_1	493	501	PF00400	0.267
DEG_Nend_UBRbox_2	1	3	PF02207	0.626
DEG_SPOP_SBC_1	407	411	PF00917	0.332
DEG_SPOP_SBC_1	44	48	PF00917	0.614
DOC_ANK_TNKS_1	423	430	PF00023	0.190
DOC_ANK_TNKS_1	89	96	PF00023	0.482
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.190
DOC_MAPK_MEF2A_6	323	331	PF00069	0.326
DOC_PP1_RVXF_1	156	162	PF00149	0.292
DOC_PP2B_LxvP_1	107	110	PF13499	0.332
DOC_PP4_FxxP_1	161	164	PF00568	0.408
DOC_PP4_FxxP_1	9	12	PF00568	0.481
DOC_SPAK_OSR1_1	90	94	PF12202	0.507
DOC_USP7_MATH_1	237	241	PF00917	0.326
DOC_USP7_MATH_1	345	349	PF00917	0.190
DOC_USP7_MATH_1	44	48	PF00917	0.683
DOC_USP7_MATH_1	464	468	PF00917	0.288
DOC_USP7_MATH_1	515	519	PF00917	0.486
DOC_USP7_MATH_1	537	541	PF00917	0.449
DOC_USP7_MATH_1	82	86	PF00917	0.382
DOC_WW_Pin1_4	28	33	PF00397	0.580
DOC_WW_Pin1_4	378	383	PF00397	0.326
DOC_WW_Pin1_4	530	535	PF00397	0.569
DOC_WW_Pin1_4	73	78	PF00397	0.499
LIG_14-3-3_CanoR_1	147	153	PF00244	0.360
LIG_14-3-3_CanoR_1	43	50	PF00244	0.486
LIG_14-3-3_CanoR_1	485	495	PF00244	0.255
LIG_Actin_WH2_2	479	496	PF00022	0.190
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.258
LIG_BRCT_BRCA1_1	183	187	PF00533	0.642
LIG_BRCT_BRCA1_1	532	536	PF00533	0.594
LIG_BRCT_BRCA1_1	539	543	PF00533	0.526
LIG_EH_1	290	294	PF12763	0.267
LIG_FHA_1	434	440	PF00498	0.296
LIG_FHA_2	163	169	PF00498	0.438
LIG_FHA_2	186	192	PF00498	0.501
LIG_FHA_2	292	298	PF00498	0.314
LIG_FHA_2	348	354	PF00498	0.339
LIG_FHA_2	359	365	PF00498	0.314
LIG_Integrin_isoDGR_2	141	143	PF01839	0.332
LIG_LIR_Apic_2	160	164	PF02991	0.403
LIG_LIR_Apic_2	414	420	PF02991	0.267
LIG_LIR_Apic_2	6	12	PF02991	0.482
LIG_LIR_Gen_1	184	193	PF02991	0.468
LIG_LIR_Gen_1	280	286	PF02991	0.310
LIG_LIR_Nem_3	175	179	PF02991	0.367
LIG_LIR_Nem_3	184	190	PF02991	0.483
LIG_LIR_Nem_3	280	285	PF02991	0.310
LIG_NRBOX	443	449	PF00104	0.326
LIG_Pex14_2	135	139	PF04695	0.326
LIG_Pex14_2	9	13	PF04695	0.581
LIG_PTB_Apo_2	123	130	PF02174	0.190
LIG_SH2_NCK_1	417	421	PF00017	0.374
LIG_SH2_STAP1	383	387	PF00017	0.326
LIG_SH2_STAT5	275	278	PF00017	0.288
LIG_SH2_STAT5	284	287	PF00017	0.242
LIG_SH2_STAT5	311	314	PF00017	0.336
LIG_SH2_STAT5	449	452	PF00017	0.371
LIG_SH3_3	149	155	PF00018	0.328
LIG_SH3_3	29	35	PF00018	0.640
LIG_SH3_3	454	460	PF00018	0.266
LIG_SH3_3	531	537	PF00018	0.612
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.216
LIG_TRAF2_1	165	168	PF00917	0.460
LIG_TRFH_1	196	200	PF08558	0.326
LIG_TRFH_1	73	77	PF08558	0.446
MOD_CK1_1	180	186	PF00069	0.597
MOD_CK1_1	24	30	PF00069	0.642
MOD_CK1_1	240	246	PF00069	0.287
MOD_CK1_1	31	37	PF00069	0.625
MOD_CK1_1	411	417	PF00069	0.292
MOD_CK1_1	48	54	PF00069	0.525
MOD_CK1_1	81	87	PF00069	0.380
MOD_CK2_1	162	168	PF00069	0.444
MOD_CK2_1	185	191	PF00069	0.518
MOD_CK2_1	291	297	PF00069	0.326
MOD_CK2_1	493	499	PF00069	0.275
MOD_Cter_Amidation	141	144	PF01082	0.326
MOD_GlcNHglycan	184	187	PF01048	0.547
MOD_GlcNHglycan	20	24	PF01048	0.654
MOD_GlcNHglycan	206	209	PF01048	0.190
MOD_GlcNHglycan	345	348	PF01048	0.360
MOD_GlcNHglycan	393	396	PF01048	0.332
MOD_GlcNHglycan	410	413	PF01048	0.190
MOD_GlcNHglycan	452	455	PF01048	0.315
MOD_GlcNHglycan	475	478	PF01048	0.185
MOD_GlcNHglycan	50	53	PF01048	0.679
MOD_GlcNHglycan	516	520	PF01048	0.528
MOD_GlcNHglycan	526	529	PF01048	0.481
MOD_GlcNHglycan	80	83	PF01048	0.401
MOD_GSK3_1	131	138	PF00069	0.274
MOD_GSK3_1	177	184	PF00069	0.551
MOD_GSK3_1	24	31	PF00069	0.621
MOD_GSK3_1	243	250	PF00069	0.281
MOD_GSK3_1	339	346	PF00069	0.385
MOD_GSK3_1	354	361	PF00069	0.179
MOD_GSK3_1	407	414	PF00069	0.326
MOD_GSK3_1	44	51	PF00069	0.522
MOD_GSK3_1	464	471	PF00069	0.247
MOD_GSK3_1	485	492	PF00069	0.410
MOD_GSK3_1	526	533	PF00069	0.553
MOD_GSK3_1	78	85	PF00069	0.427
MOD_N-GLC_1	135	140	PF02516	0.267
MOD_N-GLC_1	468	473	PF02516	0.332
MOD_N-GLC_1	82	87	PF02516	0.345
MOD_NEK2_1	135	140	PF00069	0.326
MOD_NEK2_1	182	187	PF00069	0.393
MOD_NEK2_1	422	427	PF00069	0.222
MOD_NEK2_1	468	473	PF00069	0.382
MOD_NEK2_1	526	531	PF00069	0.563
MOD_NEK2_1	78	83	PF00069	0.458
MOD_NEK2_2	237	242	PF00069	0.326
MOD_PK_1	313	319	PF00069	0.190
MOD_PKA_2	148	154	PF00069	0.326
MOD_PKA_2	215	221	PF00069	0.304
MOD_PKA_2	42	48	PF00069	0.497
MOD_PKA_2	493	499	PF00069	0.326
MOD_PKB_1	19	27	PF00069	0.640
MOD_PKB_1	41	49	PF00069	0.520
MOD_Plk_1	131	137	PF00069	0.326
MOD_Plk_1	243	249	PF00069	0.255
MOD_Plk_1	468	474	PF00069	0.332
MOD_Plk_1	489	495	PF00069	0.438
MOD_Plk_1	515	521	PF00069	0.486
MOD_Plk_1	82	88	PF00069	0.442
MOD_Plk_4	119	125	PF00069	0.314
MOD_Plk_4	135	141	PF00069	0.199
MOD_Plk_4	148	154	PF00069	0.267
MOD_Plk_4	157	163	PF00069	0.258
MOD_Plk_4	354	360	PF00069	0.372
MOD_Plk_4	365	371	PF00069	0.309
MOD_Plk_4	411	417	PF00069	0.263
MOD_ProDKin_1	28	34	PF00069	0.575
MOD_ProDKin_1	378	384	PF00069	0.326
MOD_ProDKin_1	530	536	PF00069	0.567
MOD_ProDKin_1	73	79	PF00069	0.506
MOD_SUMO_for_1	17	20	PF00179	0.625
MOD_SUMO_for_1	322	325	PF00179	0.267
MOD_SUMO_rev_2	316	324	PF00179	0.326
MOD_SUMO_rev_2	371	380	PF00179	0.328
MOD_SUMO_rev_2	516	525	PF00179	0.412
TRG_ER_diArg_1	143	145	PF00400	0.472
TRG_ER_diArg_1	312	315	PF00400	0.332
TRG_ER_diArg_1	332	334	PF00400	0.212
TRG_ER_diArg_1	39	42	PF00400	0.556
TRG_ER_diArg_1	424	427	PF00400	0.318
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P787	Leptomonas seymouri	22%	100%
A0A0N1HTF0	Leptomonas seymouri	24%	86%
A0A0N1HZY0	Leptomonas seymouri	56%	90%
A0A0S4IUF2	Bodo saltans	22%	99%
A0A0S4IZ14	Bodo saltans	39%	91%
A0A0S4J1U0	Bodo saltans	25%	74%
A0A0S4JC94	Bodo saltans	25%	77%
A0A0S4JI27	Bodo saltans	25%	75%
A0A1X0P795	Trypanosomatidae	24%	80%
A0A3Q8INQ4	Leishmania donovani	24%	100%
A0A3S5H5G0	Leishmania donovani	26%	100%
A0A3S5IR34	Trypanosoma rangeli	27%	84%
A0A3S7WTN9	Leishmania donovani	23%	100%
A0A3S7WVR6	Leishmania donovani	26%	87%
A0A3S7WY10	Leishmania donovani	80%	100%
A0A3S7X2F1	Leishmania donovani	27%	93%
A0A3S7X8Z8	Leishmania donovani	28%	100%
A0A422P4L8	Trypanosoma rangeli	25%	100%
A4H459	Leishmania braziliensis	26%	100%
A4H8C4	Leishmania braziliensis	23%	100%
A4HA97	Leishmania braziliensis	25%	96%
A4HEA1	Leishmania braziliensis	26%	96%
A4HHE4	Leishmania braziliensis	28%	92%
A4HSE2	Leishmania infantum	26%	100%
A4HWP5	Leishmania infantum	23%	100%
A4HYH7	Leishmania infantum	26%	87%
A4I1T4	Leishmania infantum	24%	100%
A4IB02	Leishmania infantum	28%	100%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZMG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	84%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZWL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	85%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9ACY7	Leishmania major	23%	82%
E9AET0	Leishmania major	29%	100%
E9AH34	Leishmania infantum	80%	100%
E9AHI7	Leishmania infantum	27%	93%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ASA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	87%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	94%
O43293	Homo sapiens	28%	100%
O61267	Drosophila melanogaster	27%	100%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	94%
O96017	Homo sapiens	29%	100%
P22216	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	66%
P34101	Dictyostelium discoideum	28%	91%
P39009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P50526	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	83%
Q06850	Arabidopsis thaliana	28%	89%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q10292	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q2QQR2	Oryza sativa subsp. japonica	27%	89%
Q38870	Arabidopsis thaliana	28%	84%
Q4Q204	Leishmania major	27%	100%
Q4QAV8	Leishmania major	80%	99%
Q4QD63	Leishmania major	25%	87%
Q4QF23	Leishmania major	24%	100%
Q4QJJ0	Leishmania major	26%	100%
Q54BF0	Dictyostelium discoideum	26%	92%
Q54MH0	Dictyostelium discoideum	29%	72%
Q54VI1	Dictyostelium discoideum	28%	76%
Q5F3L1	Gallus gallus	25%	69%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%
Q6F3A6	Oryza sativa subsp. japonica	28%	91%
Q75GK4	Oryza sativa subsp. japonica	27%	100%
Q9SG12	Arabidopsis thaliana	25%	91%
Q9Z265	Mus musculus	28%	99%
Q9ZSA4	Arabidopsis thaliana	26%	100%