Putative transcription elongation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HD78_LEIBR

TriTrypDb:

LbrM.24.0200 , LBRM2903_240006700

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD78

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003746	translation elongation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0045182	translation regulator activity	1	11
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.388
CLV_NRD_NRD_1	120	122	PF00675	0.601
CLV_NRD_NRD_1	124	126	PF00675	0.595
CLV_NRD_NRD_1	231	233	PF00675	0.318
CLV_NRD_NRD_1	257	259	PF00675	0.254
CLV_NRD_NRD_1	277	279	PF00675	0.514
CLV_NRD_NRD_1	326	328	PF00675	0.292
CLV_PCSK_KEX2_1	165	167	PF00082	0.475
CLV_PCSK_KEX2_1	231	233	PF00082	0.318
CLV_PCSK_KEX2_1	48	50	PF00082	0.569
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.475
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.569
CLV_PCSK_SKI1_1	165	169	PF00082	0.537
CLV_PCSK_SKI1_1	243	247	PF00082	0.293
DEG_SCF_FBW7_1	124	131	PF00400	0.662
DOC_ANK_TNKS_1	231	238	PF00023	0.480
DOC_CKS1_1	136	141	PF01111	0.592
DOC_CKS1_1	59	64	PF01111	0.601
DOC_PP4_FxxP_1	4	7	PF00568	0.484
DOC_PP4_FxxP_1	59	62	PF00568	0.598
DOC_USP7_MATH_1	132	136	PF00917	0.605
DOC_USP7_MATH_1	25	29	PF00917	0.625
DOC_USP7_MATH_1	296	300	PF00917	0.360
DOC_USP7_MATH_1	41	45	PF00917	0.550
DOC_USP7_MATH_1	50	54	PF00917	0.771
DOC_USP7_MATH_1	8	12	PF00917	0.602
DOC_USP7_MATH_1	84	88	PF00917	0.675
DOC_USP7_UBL2_3	122	126	PF12436	0.739
DOC_WW_Pin1_4	108	113	PF00397	0.470
DOC_WW_Pin1_4	124	129	PF00397	0.562
DOC_WW_Pin1_4	135	140	PF00397	0.561
DOC_WW_Pin1_4	14	19	PF00397	0.718
DOC_WW_Pin1_4	145	150	PF00397	0.548
DOC_WW_Pin1_4	156	161	PF00397	0.621
DOC_WW_Pin1_4	27	32	PF00397	0.628
DOC_WW_Pin1_4	58	63	PF00397	0.777
DOC_WW_Pin1_4	73	78	PF00397	0.492
DOC_WW_Pin1_4	96	101	PF00397	0.664
LIG_14-3-3_CanoR_1	166	170	PF00244	0.431
LIG_14-3-3_CanoR_1	185	193	PF00244	0.364
LIG_14-3-3_CanoR_1	243	248	PF00244	0.562
LIG_14-3-3_CanoR_1	49	55	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BRCT_BRCA1_1	285	289	PF00533	0.396
LIG_Clathr_ClatBox_1	244	248	PF01394	0.535
LIG_FHA_1	125	131	PF00498	0.539
LIG_FHA_1	136	142	PF00498	0.586
LIG_FHA_1	206	212	PF00498	0.402
LIG_FHA_1	312	318	PF00498	0.392
LIG_FHA_1	55	61	PF00498	0.672
LIG_FHA_1	77	83	PF00498	0.633
LIG_FHA_2	244	250	PF00498	0.531
LIG_LIR_Apic_2	2	7	PF02991	0.489
LIG_LIR_Apic_2	57	62	PF02991	0.598
LIG_LIR_Gen_1	114	124	PF02991	0.669
LIG_LIR_Gen_1	213	222	PF02991	0.532
LIG_LIR_Nem_3	114	119	PF02991	0.669
LIG_LIR_Nem_3	213	218	PF02991	0.448
LIG_LIR_Nem_3	323	329	PF02991	0.264
LIG_SH2_CRK	116	120	PF00017	0.654
LIG_SH2_GRB2like	116	119	PF00017	0.645
LIG_SH3_2	15	20	PF14604	0.474
LIG_SH3_3	109	115	PF00018	0.582
LIG_SH3_3	12	18	PF00018	0.545
LIG_SH3_3	133	139	PF00018	0.613
LIG_SH3_3	146	152	PF00018	0.550
LIG_SH3_3	19	25	PF00018	0.509
LIG_SH3_3	2	8	PF00018	0.577
LIG_SH3_3	49	55	PF00018	0.638
LIG_SUMO_SIM_par_1	313	318	PF11976	0.382
LIG_UBA3_1	218	226	PF00899	0.435
LIG_WW_3	17	21	PF00397	0.479
MOD_CDC14_SPxK_1	17	20	PF00782	0.477
MOD_CDK_SPK_2	108	113	PF00069	0.466
MOD_CDK_SPK_2	96	101	PF00069	0.800
MOD_CDK_SPxK_1	14	20	PF00069	0.474
MOD_CDK_SPxxK_3	158	165	PF00069	0.551
MOD_CK1_1	107	113	PF00069	0.589
MOD_CK1_1	114	120	PF00069	0.582
MOD_CK1_1	135	141	PF00069	0.589
MOD_CK1_1	148	154	PF00069	0.563
MOD_CK1_1	156	162	PF00069	0.660
MOD_CK1_1	187	193	PF00069	0.542
MOD_CK1_1	269	275	PF00069	0.594
MOD_CK1_1	284	290	PF00069	0.514
MOD_CK1_1	32	38	PF00069	0.565
MOD_CK1_1	42	48	PF00069	0.754
MOD_CK1_1	63	69	PF00069	0.711
MOD_CK1_1	71	77	PF00069	0.688
MOD_CK2_1	296	302	PF00069	0.330
MOD_CK2_1	305	311	PF00069	0.231
MOD_DYRK1A_RPxSP_1	14	18	PF00069	0.467
MOD_GlcNHglycan	155	158	PF01048	0.649
MOD_GlcNHglycan	27	30	PF01048	0.803
MOD_GlcNHglycan	307	310	PF01048	0.291
MOD_GlcNHglycan	41	44	PF01048	0.774
MOD_GlcNHglycan	65	68	PF01048	0.568
MOD_GlcNHglycan	86	89	PF01048	0.684
MOD_GlcNHglycan	96	99	PF01048	0.594
MOD_GSK3_1	104	111	PF00069	0.626
MOD_GSK3_1	124	131	PF00069	0.632
MOD_GSK3_1	156	163	PF00069	0.604
MOD_GSK3_1	214	221	PF00069	0.515
MOD_GSK3_1	25	32	PF00069	0.588
MOD_GSK3_1	280	287	PF00069	0.513
MOD_GSK3_1	311	318	PF00069	0.342
MOD_GSK3_1	50	57	PF00069	0.596
MOD_GSK3_1	66	73	PF00069	0.679
MOD_GSK3_1	92	99	PF00069	0.753
MOD_N-GLC_1	272	277	PF02516	0.596
MOD_N-GLC_1	284	289	PF02516	0.527
MOD_N-GLC_1	39	44	PF02516	0.697
MOD_N-GLC_1	71	76	PF02516	0.536
MOD_N-GLC_2	320	322	PF02516	0.266
MOD_NEK2_1	218	223	PF00069	0.505
MOD_NEK2_1	281	286	PF00069	0.557
MOD_NEK2_1	68	73	PF00069	0.598
MOD_PIKK_1	184	190	PF00454	0.415
MOD_PIKK_1	32	38	PF00454	0.507
MOD_PIKK_1	321	327	PF00454	0.382
MOD_PK_1	104	110	PF00069	0.516
MOD_PKA_1	165	171	PF00069	0.435
MOD_PKA_2	165	171	PF00069	0.526
MOD_PKA_2	184	190	PF00069	0.506
MOD_PKA_2	281	287	PF00069	0.561
MOD_PKA_2	296	302	PF00069	0.392
MOD_PKA_2	303	309	PF00069	0.365
MOD_PKA_2	50	56	PF00069	0.488
MOD_Plk_1	284	290	PF00069	0.473
MOD_Plk_1	297	303	PF00069	0.215
MOD_Plk_1	71	77	PF00069	0.492
MOD_Plk_4	137	143	PF00069	0.675
MOD_Plk_4	214	220	PF00069	0.532
MOD_Plk_4	284	290	PF00069	0.421
MOD_Plk_4	311	317	PF00069	0.312
MOD_ProDKin_1	108	114	PF00069	0.460
MOD_ProDKin_1	124	130	PF00069	0.562
MOD_ProDKin_1	135	141	PF00069	0.561
MOD_ProDKin_1	14	20	PF00069	0.723
MOD_ProDKin_1	145	151	PF00069	0.548
MOD_ProDKin_1	156	162	PF00069	0.617
MOD_ProDKin_1	27	33	PF00069	0.623
MOD_ProDKin_1	58	64	PF00069	0.776
MOD_ProDKin_1	73	79	PF00069	0.494
MOD_ProDKin_1	96	102	PF00069	0.666
MOD_SUMO_rev_2	256	265	PF00179	0.468
TRG_DiLeu_BaEn_1	236	241	PF01217	0.518
TRG_ENDOCYTIC_2	116	119	PF00928	0.645
TRG_ER_diArg_1	230	232	PF00400	0.529
TRG_ER_diArg_1	49	52	PF00400	0.617
TRG_NLS_MonoCore_2	47	52	PF00514	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ1	Leptomonas seymouri	64%	95%
A0A1X0NIZ8	Trypanosomatidae	45%	100%
A0A3Q8IER0	Leishmania donovani	74%	99%
A0A422P430	Trypanosoma rangeli	42%	100%
E9AH32	Leishmania infantum	74%	99%
E9AWK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AWL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	98%
Q4QAW0	Leishmania major	74%	100%
V5DSP1	Trypanosoma cruzi	46%	100%