HEAT repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD76_LEIBR

TriTrypDb:

LbrM.24.0180 , LBRM2903_240006500

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HD76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.383
CLV_NRD_NRD_1	334	336	PF00675	0.309
CLV_NRD_NRD_1	397	399	PF00675	0.436
CLV_NRD_NRD_1	654	656	PF00675	0.453
CLV_NRD_NRD_1	694	696	PF00675	0.535
CLV_NRD_NRD_1	704	706	PF00675	0.482
CLV_NRD_NRD_1	715	717	PF00675	0.377
CLV_NRD_NRD_1	735	737	PF00675	0.312
CLV_NRD_NRD_1	760	762	PF00675	0.584
CLV_NRD_NRD_1	776	778	PF00675	0.565
CLV_NRD_NRD_1	810	812	PF00675	0.720
CLV_PCSK_KEX2_1	334	336	PF00082	0.309
CLV_PCSK_KEX2_1	397	399	PF00082	0.436
CLV_PCSK_KEX2_1	693	695	PF00082	0.468
CLV_PCSK_KEX2_1	704	706	PF00082	0.463
CLV_PCSK_KEX2_1	715	717	PF00082	0.498
CLV_PCSK_KEX2_1	735	737	PF00082	0.291
CLV_PCSK_KEX2_1	776	778	PF00082	0.712
CLV_PCSK_KEX2_1	809	811	PF00082	0.703
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.436
CLV_PCSK_PC7_1	805	811	PF00082	0.513
CLV_PCSK_SKI1_1	186	190	PF00082	0.368
CLV_PCSK_SKI1_1	316	320	PF00082	0.299
CLV_PCSK_SKI1_1	413	417	PF00082	0.445
CLV_PCSK_SKI1_1	422	426	PF00082	0.425
CLV_PCSK_SKI1_1	460	464	PF00082	0.322
CLV_PCSK_SKI1_1	474	478	PF00082	0.265
CLV_PCSK_SKI1_1	539	543	PF00082	0.369
CLV_PCSK_SKI1_1	640	644	PF00082	0.346
CLV_PCSK_SKI1_1	735	739	PF00082	0.433
CLV_PCSK_SKI1_1	740	744	PF00082	0.394
DEG_APCC_DBOX_1	128	136	PF00400	0.470
DEG_APCC_DBOX_1	334	342	PF00400	0.302
DEG_APCC_DBOX_1	459	467	PF00400	0.357
DEG_APCC_DBOX_1	735	743	PF00400	0.391
DEG_Nend_UBRbox_2	1	3	PF02207	0.535
DEG_SPOP_SBC_1	804	808	PF00917	0.515
DOC_CDC14_PxL_1	297	305	PF14671	0.224
DOC_CKS1_1	450	455	PF01111	0.258
DOC_CYCLIN_RxL_1	260	271	PF00134	0.310
DOC_CYCLIN_RxL_1	419	428	PF00134	0.347
DOC_CYCLIN_RxL_1	640	653	PF00134	0.404
DOC_MAPK_FxFP_2	402	405	PF00069	0.424
DOC_MAPK_gen_1	744	754	PF00069	0.511
DOC_MAPK_MEF2A_6	186	193	PF00069	0.334
DOC_PP1_RVXF_1	195	201	PF00149	0.285
DOC_PP2B_LxvP_1	259	262	PF13499	0.415
DOC_PP2B_PxIxI_1	193	199	PF00149	0.368
DOC_PP4_FxxP_1	402	405	PF00568	0.424
DOC_PP4_FxxP_1	783	786	PF00568	0.481
DOC_USP7_MATH_1	114	118	PF00917	0.414
DOC_USP7_MATH_1	469	473	PF00917	0.361
DOC_USP7_MATH_1	510	514	PF00917	0.444
DOC_USP7_MATH_1	787	791	PF00917	0.552
DOC_USP7_MATH_1	803	807	PF00917	0.472
DOC_USP7_UBL2_3	138	142	PF12436	0.459
DOC_USP7_UBL2_3	28	32	PF12436	0.691
DOC_USP7_UBL2_3	728	732	PF12436	0.393
DOC_WW_Pin1_4	2	7	PF00397	0.547
DOC_WW_Pin1_4	40	45	PF00397	0.532
DOC_WW_Pin1_4	449	454	PF00397	0.449
DOC_WW_Pin1_4	753	758	PF00397	0.650
DOC_WW_Pin1_4	799	804	PF00397	0.799
LIG_14-3-3_CanoR_1	121	125	PF00244	0.440
LIG_14-3-3_CanoR_1	18	26	PF00244	0.706
LIG_14-3-3_CanoR_1	316	326	PF00244	0.291
LIG_14-3-3_CanoR_1	436	443	PF00244	0.418
LIG_14-3-3_CanoR_1	539	547	PF00244	0.368
LIG_14-3-3_CanoR_1	601	605	PF00244	0.389
LIG_14-3-3_CanoR_1	613	618	PF00244	0.302
LIG_14-3-3_CanoR_1	805	812	PF00244	0.552
LIG_Actin_WH2_2	477	495	PF00022	0.368
LIG_Actin_WH2_2	603	620	PF00022	0.225
LIG_APCC_ABBA_1	533	538	PF00400	0.316
LIG_BRCT_BRCA1_1	350	354	PF00533	0.245
LIG_BRCT_BRCA1_1	54	58	PF00533	0.602
LIG_BRCT_BRCA1_1	608	612	PF00533	0.329
LIG_BRCT_BRCA1_1	779	783	PF00533	0.489
LIG_eIF4E_1	333	339	PF01652	0.430
LIG_FHA_1	368	374	PF00498	0.385
LIG_FHA_1	540	546	PF00498	0.359
LIG_FHA_1	665	671	PF00498	0.459
LIG_FHA_1	67	73	PF00498	0.533
LIG_FHA_1	698	704	PF00498	0.650
LIG_FHA_2	144	150	PF00498	0.385
LIG_FHA_2	175	181	PF00498	0.324
LIG_FHA_2	306	312	PF00498	0.241
LIG_FHA_2	388	394	PF00498	0.425
LIG_FHA_2	538	544	PF00498	0.352
LIG_GBD_Chelix_1	477	485	PF00786	0.421
LIG_LIR_Apic_2	2	6	PF02991	0.575
LIG_LIR_Apic_2	780	786	PF02991	0.483
LIG_LIR_Gen_1	123	133	PF02991	0.288
LIG_LIR_Gen_1	302	311	PF02991	0.308
LIG_LIR_Gen_1	379	389	PF02991	0.210
LIG_LIR_Gen_1	459	469	PF02991	0.428
LIG_LIR_Gen_1	499	509	PF02991	0.359
LIG_LIR_Gen_1	530	536	PF02991	0.257
LIG_LIR_Gen_1	603	612	PF02991	0.325
LIG_LIR_Gen_1	663	673	PF02991	0.331
LIG_LIR_Nem_3	123	128	PF02991	0.337
LIG_LIR_Nem_3	209	213	PF02991	0.345
LIG_LIR_Nem_3	302	307	PF02991	0.291
LIG_LIR_Nem_3	327	332	PF02991	0.358
LIG_LIR_Nem_3	336	342	PF02991	0.261
LIG_LIR_Nem_3	351	357	PF02991	0.314
LIG_LIR_Nem_3	360	364	PF02991	0.284
LIG_LIR_Nem_3	379	384	PF02991	0.287
LIG_LIR_Nem_3	459	465	PF02991	0.425
LIG_LIR_Nem_3	499	504	PF02991	0.362
LIG_LIR_Nem_3	530	535	PF02991	0.235
LIG_LIR_Nem_3	55	61	PF02991	0.466
LIG_LIR_Nem_3	603	607	PF02991	0.323
LIG_LIR_Nem_3	609	615	PF02991	0.317
LIG_NRBOX	143	149	PF00104	0.471
LIG_NRBOX	168	174	PF00104	0.389
LIG_NRBOX	302	308	PF00104	0.301
LIG_NRBOX	504	510	PF00104	0.393
LIG_NRBOX	738	744	PF00104	0.414
LIG_PCNA_yPIPBox_3	489	501	PF02747	0.237
LIG_Pex14_2	381	385	PF04695	0.410
LIG_REV1ctd_RIR_1	612	622	PF16727	0.412
LIG_SH2_CRK	3	7	PF00017	0.531
LIG_SH2_PTP2	532	535	PF00017	0.366
LIG_SH2_SRC	210	213	PF00017	0.382
LIG_SH2_STAT3	599	602	PF00017	0.429
LIG_SH2_STAT5	111	114	PF00017	0.337
LIG_SH2_STAT5	124	127	PF00017	0.245
LIG_SH2_STAT5	210	213	PF00017	0.322
LIG_SH2_STAT5	487	490	PF00017	0.432
LIG_SH2_STAT5	532	535	PF00017	0.346
LIG_SH2_STAT5	604	607	PF00017	0.285
LIG_SH2_STAT5	97	100	PF00017	0.411
LIG_SH3_3	130	136	PF00018	0.409
LIG_SH3_3	188	194	PF00018	0.383
LIG_SH3_3	509	515	PF00018	0.457
LIG_SH3_3	62	68	PF00018	0.602
LIG_SH3_3	749	755	PF00018	0.525
LIG_SH3_3	760	766	PF00018	0.628
LIG_SH3_3	788	794	PF00018	0.719
LIG_SUMO_SIM_anti_2	218	224	PF11976	0.427
LIG_SUMO_SIM_par_1	130	137	PF11976	0.469
LIG_SUMO_SIM_par_1	218	224	PF11976	0.222
LIG_SUMO_SIM_par_1	320	327	PF11976	0.290
LIG_SUMO_SIM_par_1	423	428	PF11976	0.404
LIG_SUMO_SIM_par_1	750	756	PF11976	0.441
LIG_TRAF2_1	104	107	PF00917	0.391
LIG_TRAF2_1	308	311	PF00917	0.467
LIG_TRFH_1	783	787	PF08558	0.476
LIG_TYR_ITIM	208	213	PF00017	0.382
LIG_UBA3_1	220	227	PF00899	0.432
LIG_UBA3_1	338	343	PF00899	0.430
LIG_WRC_WIRS_1	497	502	PF05994	0.215
MOD_CDC14_SPxK_1	756	759	PF00782	0.679
MOD_CDK_SPxK_1	753	759	PF00069	0.653
MOD_CDK_SPxK_1	799	805	PF00069	0.655
MOD_CK1_1	150	156	PF00069	0.376
MOD_CK1_1	428	434	PF00069	0.466
MOD_CK1_1	438	444	PF00069	0.347
MOD_CK1_1	499	505	PF00069	0.322
MOD_CK2_1	101	107	PF00069	0.408
MOD_CK2_1	174	180	PF00069	0.330
MOD_CK2_1	2	8	PF00069	0.490
MOD_CK2_1	305	311	PF00069	0.451
MOD_CK2_1	387	393	PF00069	0.454
MOD_CK2_1	537	543	PF00069	0.336
MOD_CK2_1	742	748	PF00069	0.428
MOD_Cter_Amidation	713	716	PF01082	0.376
MOD_Cter_Amidation	759	762	PF01082	0.595
MOD_GlcNHglycan	106	110	PF01048	0.474
MOD_GlcNHglycan	427	430	PF01048	0.441
MOD_GlcNHglycan	440	443	PF01048	0.367
MOD_GlcNHglycan	49	52	PF01048	0.597
MOD_GlcNHglycan	501	504	PF01048	0.412
MOD_GlcNHglycan	54	58	PF01048	0.632
MOD_GSK3_1	101	108	PF00069	0.402
MOD_GSK3_1	134	141	PF00069	0.424
MOD_GSK3_1	143	150	PF00069	0.303
MOD_GSK3_1	172	179	PF00069	0.300
MOD_GSK3_1	211	218	PF00069	0.351
MOD_GSK3_1	221	228	PF00069	0.263
MOD_GSK3_1	344	351	PF00069	0.478
MOD_GSK3_1	367	374	PF00069	0.407
MOD_GSK3_1	40	47	PF00069	0.545
MOD_GSK3_1	407	414	PF00069	0.352
MOD_GSK3_1	492	499	PF00069	0.469
MOD_GSK3_1	583	590	PF00069	0.404
MOD_GSK3_1	650	657	PF00069	0.455
MOD_GSK3_1	799	806	PF00069	0.751
MOD_N-GLC_1	114	119	PF02516	0.356
MOD_N-GLC_1	225	230	PF02516	0.391
MOD_NEK2_1	147	152	PF00069	0.473
MOD_NEK2_1	328	333	PF00069	0.221
MOD_NEK2_1	384	389	PF00069	0.317
MOD_NEK2_1	643	648	PF00069	0.381
MOD_NEK2_1	650	655	PF00069	0.413
MOD_NEK2_2	469	474	PF00069	0.253
MOD_PIKK_1	150	156	PF00454	0.320
MOD_PIKK_1	230	236	PF00454	0.261
MOD_PIKK_1	44	50	PF00454	0.460
MOD_PIKK_1	648	654	PF00454	0.392
MOD_PKA_2	120	126	PF00069	0.445
MOD_PKA_2	435	441	PF00069	0.301
MOD_PKA_2	593	599	PF00069	0.408
MOD_PKA_2	600	606	PF00069	0.341
MOD_PKA_2	632	638	PF00069	0.446
MOD_PKA_2	654	660	PF00069	0.474
MOD_PKA_2	804	810	PF00069	0.513
MOD_Plk_1	376	382	PF00069	0.241
MOD_Plk_1	469	475	PF00069	0.397
MOD_Plk_1	537	543	PF00069	0.329
MOD_Plk_1	664	670	PF00069	0.342
MOD_Plk_2-3	101	107	PF00069	0.498
MOD_Plk_2-3	305	311	PF00069	0.451
MOD_Plk_2-3	371	377	PF00069	0.446
MOD_Plk_2-3	537	543	PF00069	0.376
MOD_Plk_4	143	149	PF00069	0.385
MOD_Plk_4	184	190	PF00069	0.323
MOD_Plk_4	211	217	PF00069	0.461
MOD_Plk_4	328	334	PF00069	0.416
MOD_Plk_4	376	382	PF00069	0.245
MOD_Plk_4	496	502	PF00069	0.416
MOD_Plk_4	504	510	PF00069	0.412
MOD_Plk_4	555	561	PF00069	0.436
MOD_Plk_4	563	569	PF00069	0.401
MOD_Plk_4	600	606	PF00069	0.419
MOD_ProDKin_1	2	8	PF00069	0.543
MOD_ProDKin_1	40	46	PF00069	0.530
MOD_ProDKin_1	449	455	PF00069	0.439
MOD_ProDKin_1	753	759	PF00069	0.653
MOD_ProDKin_1	799	805	PF00069	0.800
MOD_SUMO_for_1	743	746	PF00179	0.402
MOD_SUMO_rev_2	486	495	PF00179	0.382
TRG_DiLeu_BaEn_1	352	357	PF01217	0.305
TRG_DiLeu_BaEn_2	359	365	PF01217	0.288
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.396
TRG_DiLeu_BaLyEn_6	645	650	PF01217	0.390
TRG_DiLeu_LyEn_5	445	450	PF01217	0.449
TRG_ENDOCYTIC_2	210	213	PF00928	0.382
TRG_ENDOCYTIC_2	532	535	PF00928	0.215
TRG_ENDOCYTIC_2	604	607	PF00928	0.289
TRG_ER_diArg_1	275	278	PF00400	0.371
TRG_ER_diArg_1	333	335	PF00400	0.339
TRG_ER_diArg_1	703	705	PF00400	0.484
TRG_ER_diArg_1	809	811	PF00400	0.654
TRG_ER_FFAT_2	495	506	PF00635	0.332
TRG_NES_CRM1_1	202	217	PF08389	0.360
TRG_NES_CRM1_1	281	293	PF08389	0.333
TRG_NLS_MonoExtC_3	692	698	PF00514	0.364
TRG_NLS_MonoExtN_4	25	31	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	749	753	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P426	Leptomonas seymouri	68%	99%
A0A1X0NKB5	Trypanosomatidae	49%	100%
A0A3Q8IBR9	Leishmania donovani	86%	100%
A0A3S5ISP0	Trypanosoma rangeli	46%	100%
D0A6Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AH30	Leishmania infantum	86%	100%
E9AWK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAW2	Leishmania major	86%	100%
Q6NUP7	Homo sapiens	24%	93%
Q8C0Y0	Mus musculus	23%	93%
V5C0S3	Trypanosoma cruzi	47%	100%