Putative ATPase domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase domain protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HD75_LEIBR

TriTrypDb:

LbrM.24.0170 , LBRM2903_240006400

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD75

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0051301	cell division	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.490
CLV_NRD_NRD_1	269	271	PF00675	0.678
CLV_NRD_NRD_1	372	374	PF00675	0.330
CLV_NRD_NRD_1	417	419	PF00675	0.404
CLV_NRD_NRD_1	490	492	PF00675	0.456
CLV_NRD_NRD_1	513	515	PF00675	0.419
CLV_PCSK_KEX2_1	204	206	PF00082	0.490
CLV_PCSK_KEX2_1	269	271	PF00082	0.547
CLV_PCSK_KEX2_1	372	374	PF00082	0.390
CLV_PCSK_KEX2_1	417	419	PF00082	0.289
CLV_PCSK_KEX2_1	490	492	PF00082	0.464
CLV_PCSK_PC7_1	368	374	PF00082	0.281
CLV_PCSK_SKI1_1	196	200	PF00082	0.539
CLV_PCSK_SKI1_1	204	208	PF00082	0.481
CLV_PCSK_SKI1_1	232	236	PF00082	0.500
CLV_PCSK_SKI1_1	417	421	PF00082	0.289
CLV_PCSK_SKI1_1	514	518	PF00082	0.388
DEG_APCC_DBOX_1	203	211	PF00400	0.609
DEG_APCC_DBOX_1	416	424	PF00400	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.432
DEG_SPOP_SBC_1	112	116	PF00917	0.606
DEG_SPOP_SBC_1	162	166	PF00917	0.531
DOC_CDC14_PxL_1	461	469	PF14671	0.349
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.557
DOC_MAPK_DCC_7	18	28	PF00069	0.425
DOC_MAPK_gen_1	289	298	PF00069	0.565
DOC_MAPK_gen_1	375	384	PF00069	0.349
DOC_MAPK_gen_1	454	464	PF00069	0.292
DOC_MAPK_gen_1	490	497	PF00069	0.427
DOC_MAPK_MEF2A_6	375	383	PF00069	0.271
DOC_PP2B_LxvP_1	534	537	PF13499	0.440
DOC_PP2B_LxvP_1	89	92	PF13499	0.565
DOC_USP7_MATH_1	112	116	PF00917	0.522
DOC_USP7_MATH_1	162	166	PF00917	0.572
DOC_USP7_MATH_1	272	276	PF00917	0.561
DOC_USP7_MATH_1	300	304	PF00917	0.474
DOC_USP7_MATH_1	59	63	PF00917	0.484
DOC_USP7_MATH_1	64	68	PF00917	0.486
DOC_USP7_UBL2_3	57	61	PF12436	0.476
DOC_WW_Pin1_4	268	273	PF00397	0.561
DOC_WW_Pin1_4	301	306	PF00397	0.620
DOC_WW_Pin1_4	375	380	PF00397	0.303
DOC_WW_Pin1_4	93	98	PF00397	0.480
LIG_14-3-3_CanoR_1	14	22	PF00244	0.538
LIG_14-3-3_CanoR_1	205	211	PF00244	0.547
LIG_14-3-3_CanoR_1	289	299	PF00244	0.491
LIG_14-3-3_CanoR_1	310	316	PF00244	0.694
LIG_14-3-3_CanoR_1	336	346	PF00244	0.307
LIG_14-3-3_CanoR_1	7	13	PF00244	0.434
LIG_Actin_WH2_2	353	370	PF00022	0.289
LIG_Actin_WH2_2	509	525	PF00022	0.504
LIG_BRCT_BRCA1_1	343	347	PF00533	0.407
LIG_BRCT_BRCA1_1	47	51	PF00533	0.365
LIG_EH1_1	289	297	PF00400	0.420
LIG_FHA_1	121	127	PF00498	0.493
LIG_FHA_1	14	20	PF00498	0.685
LIG_FHA_1	317	323	PF00498	0.372
LIG_FHA_1	376	382	PF00498	0.363
LIG_FHA_1	436	442	PF00498	0.384
LIG_FHA_1	73	79	PF00498	0.539
LIG_LIR_Apic_2	460	466	PF02991	0.314
LIG_LIR_Gen_1	105	112	PF02991	0.477
LIG_LIR_Gen_1	48	59	PF02991	0.427
LIG_LIR_Nem_3	105	111	PF02991	0.508
LIG_LIR_Nem_3	20	25	PF02991	0.513
LIG_LIR_Nem_3	344	350	PF02991	0.372
LIG_LIR_Nem_3	353	359	PF02991	0.288
LIG_LIR_Nem_3	48	54	PF02991	0.408
LIG_MLH1_MIPbox_1	47	51	PF16413	0.365
LIG_MYND_1	190	194	PF01753	0.443
LIG_NRBOX	140	146	PF00104	0.412
LIG_NRBOX	154	160	PF00104	0.386
LIG_NRBOX	311	317	PF00104	0.397
LIG_NRBOX	419	425	PF00104	0.271
LIG_NRBOX	48	54	PF00104	0.250
LIG_PCNA_yPIPBox_3	454	462	PF02747	0.335
LIG_PCNA_yPIPBox_3	510	523	PF02747	0.417
LIG_Pex14_1	104	108	PF04695	0.437
LIG_Pex14_2	479	483	PF04695	0.378
LIG_REV1ctd_RIR_1	477	486	PF16727	0.412
LIG_SH2_CRK	108	112	PF00017	0.459
LIG_SH2_NCK_1	108	112	PF00017	0.436
LIG_SH2_PTP2	463	466	PF00017	0.289
LIG_SH2_SRC	463	466	PF00017	0.314
LIG_SH2_STAP1	108	112	PF00017	0.436
LIG_SH2_STAT5	22	25	PF00017	0.511
LIG_SH2_STAT5	359	362	PF00017	0.289
LIG_SH2_STAT5	463	466	PF00017	0.289
LIG_SH2_STAT5	511	514	PF00017	0.405
LIG_SH3_3	207	213	PF00018	0.541
LIG_SH3_3	340	346	PF00018	0.281
LIG_SH3_3	459	465	PF00018	0.404
LIG_SH3_3	553	559	PF00018	0.521
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.345
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.407
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.307
LIG_SUMO_SIM_par_1	132	138	PF11976	0.261
LIG_SUMO_SIM_par_1	380	386	PF11976	0.314
LIG_TYR_ITIM	106	111	PF00017	0.459
LIG_UBA3_1	49	57	PF00899	0.416
LIG_WRC_WIRS_1	65	70	PF05994	0.452
MOD_CK1_1	114	120	PF00069	0.562
MOD_CK1_1	173	179	PF00069	0.487
MOD_CK1_1	314	320	PF00069	0.495
MOD_CK1_1	530	536	PF00069	0.589
MOD_CK1_1	67	73	PF00069	0.503
MOD_CK2_1	214	220	PF00069	0.605
MOD_DYRK1A_RPxSP_1	375	379	PF00069	0.284
MOD_GlcNHglycan	172	175	PF01048	0.383
MOD_GlcNHglycan	222	225	PF01048	0.658
MOD_GlcNHglycan	326	329	PF01048	0.288
MOD_GlcNHglycan	433	436	PF01048	0.408
MOD_GlcNHglycan	518	522	PF01048	0.427
MOD_GlcNHglycan	527	530	PF01048	0.540
MOD_GlcNHglycan	69	72	PF01048	0.495
MOD_GSK3_1	120	127	PF00069	0.504
MOD_GSK3_1	220	227	PF00069	0.489
MOD_GSK3_1	268	275	PF00069	0.564
MOD_GSK3_1	290	297	PF00069	0.541
MOD_GSK3_1	311	318	PF00069	0.497
MOD_GSK3_1	337	344	PF00069	0.292
MOD_GSK3_1	350	357	PF00069	0.302
MOD_GSK3_1	399	406	PF00069	0.289
MOD_GSK3_1	431	438	PF00069	0.465
MOD_GSK3_1	60	67	PF00069	0.517
MOD_N-GLC_2	238	240	PF02516	0.494
MOD_NEK2_1	144	149	PF00069	0.427
MOD_NEK2_1	163	168	PF00069	0.407
MOD_NEK2_1	206	211	PF00069	0.563
MOD_NEK2_1	214	219	PF00069	0.660
MOD_NEK2_1	228	233	PF00069	0.617
MOD_NEK2_1	311	316	PF00069	0.526
MOD_NEK2_1	413	418	PF00069	0.330
MOD_NEK2_1	517	522	PF00069	0.428
MOD_NEK2_1	53	58	PF00069	0.484
MOD_NEK2_1	546	551	PF00069	0.437
MOD_NEK2_1	6	11	PF00069	0.436
MOD_NEK2_1	72	77	PF00069	0.350
MOD_NEK2_2	45	50	PF00069	0.448
MOD_OFUCOSY	3	10	PF10250	0.429
MOD_PIKK_1	173	179	PF00454	0.428
MOD_PIKK_1	272	278	PF00454	0.572
MOD_PK_1	129	135	PF00069	0.518
MOD_PKA_2	13	19	PF00069	0.521
MOD_PKA_2	290	296	PF00069	0.350
MOD_PKA_2	6	12	PF00069	0.435
MOD_PKB_1	289	297	PF00069	0.420
MOD_Plk_1	350	356	PF00069	0.335
MOD_Plk_1	45	51	PF00069	0.416
MOD_Plk_1	517	523	PF00069	0.477
MOD_Plk_1	99	105	PF00069	0.437
MOD_Plk_4	291	297	PF00069	0.389
MOD_Plk_4	311	317	PF00069	0.621
MOD_Plk_4	45	51	PF00069	0.513
MOD_Plk_4	457	463	PF00069	0.346
MOD_Plk_4	548	554	PF00069	0.430
MOD_Plk_4	64	70	PF00069	0.331
MOD_ProDKin_1	268	274	PF00069	0.560
MOD_ProDKin_1	301	307	PF00069	0.627
MOD_ProDKin_1	375	381	PF00069	0.303
MOD_ProDKin_1	93	99	PF00069	0.469
TRG_DiLeu_BaEn_2	260	266	PF01217	0.551
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.426
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.552
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.643
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.527
TRG_ENDOCYTIC_2	108	111	PF00928	0.460
TRG_ENDOCYTIC_2	22	25	PF00928	0.432
TRG_ER_diArg_1	203	205	PF00400	0.480
TRG_ER_diArg_1	289	292	PF00400	0.572
TRG_ER_diArg_1	371	373	PF00400	0.414
TRG_ER_diArg_1	417	419	PF00400	0.404
TRG_NES_CRM1_1	233	244	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.193
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKH8	Trypanosomatidae	35%	100%
A0A1X0NXH5	Trypanosomatidae	26%	79%
A0A3Q8IG04	Leishmania donovani	84%	100%
A0A3R7MBQ6	Trypanosoma rangeli	38%	100%
D0A6Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AH29	Leishmania infantum	84%	100%
E9AWK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QAW3	Leishmania major	83%	100%
V5BRB9	Trypanosoma cruzi	40%	100%