Phosducin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD74_LEIBR

TriTrypDb:

LbrM.24.0160 , LBRM2903_240006300

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD74

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.361
CLV_NRD_NRD_1	73	75	PF00675	0.511
CLV_NRD_NRD_1	98	100	PF00675	0.290
CLV_PCSK_FUR_1	96	100	PF00082	0.271
CLV_PCSK_KEX2_1	161	163	PF00082	0.349
CLV_PCSK_KEX2_1	96	98	PF00082	0.272
CLV_PCSK_SKI1_1	163	167	PF00082	0.265
CLV_PCSK_SKI1_1	193	197	PF00082	0.362
DEG_Nend_UBRbox_2	1	3	PF02207	0.734
DOC_MAPK_gen_1	161	170	PF00069	0.558
DOC_MAPK_gen_1	96	103	PF00069	0.562
DOC_MAPK_MEF2A_6	182	189	PF00069	0.452
DOC_SPAK_OSR1_1	111	115	PF12202	0.501
DOC_USP7_MATH_1	143	147	PF00917	0.490
DOC_USP7_UBL2_3	193	197	PF12436	0.549
DOC_USP7_UBL2_3	58	62	PF12436	0.706
LIG_14-3-3_CanoR_1	107	115	PF00244	0.507
LIG_14-3-3_CanoR_1	161	166	PF00244	0.530
LIG_14-3-3_CanoR_1	8	17	PF00244	0.565
LIG_APCC_ABBA_1	187	192	PF00400	0.558
LIG_APCC_Cbox_2	181	187	PF00515	0.434
LIG_eIF4E_1	183	189	PF01652	0.524
LIG_FHA_1	131	137	PF00498	0.488
LIG_FHA_1	171	177	PF00498	0.491
LIG_FHA_1	28	34	PF00498	0.614
LIG_FHA_1	77	83	PF00498	0.717
LIG_FHA_2	10	16	PF00498	0.567
LIG_FHA_2	231	237	PF00498	0.589
LIG_FHA_2	48	54	PF00498	0.708
LIG_LIR_Gen_1	11	21	PF02991	0.570
LIG_LIR_Gen_1	233	242	PF02991	0.475
LIG_LIR_Nem_3	109	115	PF02991	0.486
LIG_LIR_Nem_3	11	17	PF02991	0.564
LIG_LIR_Nem_3	230	235	PF02991	0.653
LIG_RPA_C_Fungi	92	104	PF08784	0.219
LIG_SH2_SRC	52	55	PF00017	0.521
LIG_SH2_STAT5	123	126	PF00017	0.382
LIG_SH2_STAT5	183	186	PF00017	0.481
LIG_SH2_STAT5	232	235	PF00017	0.476
LIG_SH3_2	177	182	PF14604	0.316
LIG_SH3_3	174	180	PF00018	0.473
LIG_SH3_3	48	54	PF00018	0.573
LIG_SH3_5	119	123	PF00018	0.450
LIG_SUMO_SIM_anti_2	88	96	PF11976	0.219
LIG_SUMO_SIM_par_1	166	174	PF11976	0.219
MOD_CK1_1	169	175	PF00069	0.233
MOD_CK2_1	143	149	PF00069	0.418
MOD_CK2_1	230	236	PF00069	0.586
MOD_CK2_1	82	88	PF00069	0.475
MOD_CK2_1	9	15	PF00069	0.579
MOD_Cter_Amidation	72	75	PF01082	0.514
MOD_GSK3_1	125	132	PF00069	0.372
MOD_GSK3_1	166	173	PF00069	0.285
MOD_N-GLC_2	46	48	PF02516	0.653
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_2	47	52	PF00069	0.499
MOD_PK_1	161	167	PF00069	0.421
MOD_PKA_1	161	167	PF00069	0.433
MOD_PKA_2	106	112	PF00069	0.219
MOD_PKA_2	161	167	PF00069	0.462
MOD_PKA_2	9	15	PF00069	0.581
MOD_Plk_1	230	236	PF00069	0.705
MOD_Plk_2-3	231	237	PF00069	0.477
MOD_Plk_4	166	172	PF00069	0.349
MOD_Plk_4	47	53	PF00069	0.496
MOD_SUMO_for_1	61	64	PF00179	0.743
MOD_SUMO_rev_2	57	63	PF00179	0.598
TRG_ENDOCYTIC_2	235	238	PF00928	0.566
TRG_ER_diArg_1	161	163	PF00400	0.433
TRG_ER_diArg_1	95	98	PF00400	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II20	Leptomonas seymouri	72%	100%
A0A0S4J2X1	Bodo saltans	48%	96%
A0A1X0NJ53	Trypanosomatidae	58%	99%
A0A3R7KUG1	Trypanosoma rangeli	29%	98%
A0A3R7KZ12	Trypanosoma rangeli	58%	92%
A0A3S7WY28	Leishmania donovani	81%	100%
D0A6Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	99%
E9AH28	Leishmania infantum	81%	100%
E9AWK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAW4	Leishmania major	82%	100%
V5BAV9	Trypanosoma cruzi	57%	100%