Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD73_LEIBR

TriTrypDb:

LbrM.24.0150 , LBRM2903_240006100 , LBRM2903_240006200

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.451
CLV_NRD_NRD_1	36	38	PF00675	0.636
CLV_NRD_NRD_1	61	63	PF00675	0.515
CLV_PCSK_KEX2_1	256	258	PF00082	0.750
CLV_PCSK_KEX2_1	278	280	PF00082	0.735
CLV_PCSK_KEX2_1	60	62	PF00082	0.742
CLV_PCSK_KEX2_1	82	84	PF00082	0.503
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.750
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.735
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.742
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.503
CLV_PCSK_SKI1_1	128	132	PF00082	0.643
CLV_PCSK_SKI1_1	169	173	PF00082	0.532
CLV_PCSK_SKI1_1	38	42	PF00082	0.589
CLV_PCSK_SKI1_1	92	96	PF00082	0.525
DOC_MAPK_gen_1	34	42	PF00069	0.652
DOC_PP2B_LxvP_1	204	207	PF13499	0.405
DOC_PP4_FxxP_1	245	248	PF00568	0.610
DOC_USP7_MATH_1	240	244	PF00917	0.664
DOC_USP7_MATH_1	66	70	PF00917	0.658
DOC_USP7_MATH_1	97	101	PF00917	0.486
DOC_USP7_UBL2_3	14	18	PF12436	0.640
LIG_14-3-3_CanoR_1	116	121	PF00244	0.589
LIG_14-3-3_CanoR_1	239	249	PF00244	0.744
LIG_14-3-3_CanoR_1	257	262	PF00244	0.483
LIG_14-3-3_CanoR_1	37	43	PF00244	0.539
LIG_14-3-3_CanoR_1	92	99	PF00244	0.674
LIG_AP2alpha_2	120	122	PF02296	0.663
LIG_BIR_III_2	96	100	PF00653	0.454
LIG_BRCT_BRCA1_1	107	111	PF00533	0.614
LIG_BRCT_BRCA1_1	118	122	PF00533	0.587
LIG_FHA_2	1	7	PF00498	0.447
LIG_FHA_2	115	121	PF00498	0.529
LIG_FHA_2	179	185	PF00498	0.547
LIG_FHA_2	39	45	PF00498	0.634
LIG_FHA_2	68	74	PF00498	0.627
LIG_FHA_2	79	85	PF00498	0.453
LIG_FHA_2	91	97	PF00498	0.575
LIG_Integrin_isoDGR_2	198	200	PF01839	0.419
LIG_LIR_Apic_2	117	121	PF02991	0.709
LIG_LIR_Apic_2	243	248	PF02991	0.607
LIG_LIR_Apic_2	30	36	PF02991	0.393
LIG_LIR_Nem_3	170	175	PF02991	0.485
LIG_Pex14_1	118	122	PF04695	0.704
LIG_SH2_SRC	142	145	PF00017	0.465
LIG_SH2_SRC	267	270	PF00017	0.574
LIG_SH2_STAP1	142	146	PF00017	0.493
LIG_SH2_STAT5	103	106	PF00017	0.595
LIG_SH2_STAT5	78	81	PF00017	0.547
LIG_SH3_3	37	43	PF00018	0.614
LIG_SH3_3	48	54	PF00018	0.678
LIG_TRAF2_1	3	6	PF00917	0.499
MOD_CK1_1	49	55	PF00069	0.713
MOD_CK1_1	69	75	PF00069	0.383
MOD_CK2_1	146	152	PF00069	0.577
MOD_CK2_1	178	184	PF00069	0.572
MOD_CK2_1	67	73	PF00069	0.465
MOD_CK2_1	78	84	PF00069	0.399
MOD_GlcNHglycan	112	115	PF01048	0.718
MOD_GlcNHglycan	131	134	PF01048	0.622
MOD_GlcNHglycan	148	151	PF01048	0.661
MOD_GlcNHglycan	216	219	PF01048	0.713
MOD_GlcNHglycan	48	51	PF01048	0.680
MOD_GlcNHglycan	99	102	PF01048	0.718
MOD_GSK3_1	110	117	PF00069	0.670
MOD_GSK3_1	158	165	PF00069	0.543
MOD_GSK3_1	214	221	PF00069	0.650
MOD_GSK3_1	248	255	PF00069	0.638
MOD_GSK3_1	256	263	PF00069	0.617
MOD_GSK3_1	281	288	PF00069	0.699
MOD_GSK3_1	72	79	PF00069	0.561
MOD_GSK3_1	88	95	PF00069	0.521
MOD_N-GLC_1	158	163	PF02516	0.408
MOD_N-GLC_1	263	268	PF02516	0.649
MOD_NEK2_1	122	127	PF00069	0.637
MOD_NEK2_1	146	151	PF00069	0.510
MOD_NEK2_1	76	81	PF00069	0.628
MOD_NEK2_1	8	13	PF00069	0.581
MOD_NEK2_1	88	93	PF00069	0.499
MOD_PKA_1	256	262	PF00069	0.738
MOD_PKA_2	256	262	PF00069	0.738
MOD_PKA_2	76	82	PF00069	0.657
MOD_Plk_1	158	164	PF00069	0.634
MOD_Plk_1	55	61	PF00069	0.669
MOD_Plk_1	72	78	PF00069	0.479
MOD_Plk_4	281	287	PF00069	0.741
MOD_Plk_4	99	105	PF00069	0.573
TRG_DiLeu_BaEn_1	187	192	PF01217	0.679
TRG_DiLeu_LyEn_5	187	192	PF01217	0.411
TRG_NLS_MonoExtC_3	59	64	PF00514	0.498
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA94	Leptomonas seymouri	57%	100%
A0A1X0NIP3	Trypanosomatidae	43%	100%
A0A3S7WY29	Leishmania donovani	81%	100%
A0A422P481	Trypanosoma rangeli	44%	100%
D0A6Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AH27	Leishmania infantum	81%	100%
E9AWK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QAW5	Leishmania major	81%	100%
V5DSP6	Trypanosoma cruzi	43%	100%