Glycosomal membrane like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane like protein

Species:

Leishmania braziliensis

UniProt:

A4HD72_LEIBR

TriTrypDb:

LbrM.24.0140

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HD72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD72

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	14
GO:0009987	cellular process	1	14
GO:0016043	cellular component organization	3	14
GO:0016559	peroxisome fission	6	14
GO:0048285	organelle fission	5	14
GO:0071840	cellular component organization or biogenesis	2	14

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	93	97	PF00656	0.399
CLV_PCSK_KEX2_1	146	148	PF00082	0.376
CLV_PCSK_KEX2_1	72	74	PF00082	0.329
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.410
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.329
CLV_PCSK_SKI1_1	19	23	PF00082	0.297
CLV_PCSK_SKI1_1	78	82	PF00082	0.259
CLV_PCSK_SKI1_1	85	89	PF00082	0.314
DEG_APCC_DBOX_1	77	85	PF00400	0.529
DOC_CYCLIN_RxL_1	82	89	PF00134	0.399
DOC_MAPK_gen_1	146	154	PF00069	0.551
DOC_PP1_RVXF_1	53	60	PF00149	0.489
DOC_PP1_RVXF_1	76	83	PF00149	0.487
DOC_USP7_MATH_1	113	117	PF00917	0.239
DOC_USP7_MATH_1	13	17	PF00917	0.553
DOC_USP7_MATH_1	198	202	PF00917	0.613
DOC_USP7_MATH_1	45	49	PF00917	0.532
DOC_WW_Pin1_4	106	111	PF00397	0.329
DOC_WW_Pin1_4	206	211	PF00397	0.544
LIG_14-3-3_CanoR_1	120	124	PF00244	0.380
LIG_14-3-3_CanoR_1	156	162	PF00244	0.434
LIG_14-3-3_CanoR_1	55	60	PF00244	0.463
LIG_Actin_WH2_2	63	80	PF00022	0.369
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_EH1_1	126	134	PF00400	0.175
LIG_GBD_Chelix_1	3	11	PF00786	0.238
LIG_Integrin_RGD_1	147	149	PF01839	0.324
LIG_LIR_Gen_1	134	144	PF02991	0.235
LIG_LIR_Gen_1	89	100	PF02991	0.379
LIG_LIR_Nem_3	122	127	PF02991	0.362
LIG_LIR_Nem_3	134	139	PF02991	0.350
LIG_LIR_Nem_3	89	95	PF02991	0.347
LIG_Pex14_2	100	104	PF04695	0.236
LIG_Pex14_2	88	92	PF04695	0.361
LIG_PTB_Apo_2	94	101	PF02174	0.352
LIG_Rb_pABgroove_1	82	90	PF01858	0.399
LIG_REV1ctd_RIR_1	25	33	PF16727	0.553
LIG_SH2_CRK	136	140	PF00017	0.330
LIG_SH2_STAP1	127	131	PF00017	0.437
LIG_SH3_2	142	147	PF14604	0.616
LIG_SH3_3	136	142	PF00018	0.438
LIG_SUMO_SIM_par_1	131	137	PF11976	0.331
LIG_UBA3_1	56	65	PF00899	0.489
MOD_CDC14_SPxK_1	209	212	PF00782	0.552
MOD_CDK_SPxK_1	206	212	PF00069	0.545
MOD_CK1_1	116	122	PF00069	0.360
MOD_CK1_1	201	207	PF00069	0.606
MOD_GlcNHglycan	162	165	PF01048	0.360
MOD_GlcNHglycan	184	187	PF01048	0.303
MOD_GlcNHglycan	200	203	PF01048	0.350
MOD_N-GLC_1	106	111	PF02516	0.430
MOD_N-GLC_2	157	159	PF02516	0.313
MOD_N-GLC_2	167	169	PF02516	0.341
MOD_NEK2_1	152	157	PF00069	0.549
MOD_NEK2_1	40	45	PF00069	0.412
MOD_PKA_2	119	125	PF00069	0.275
MOD_PKA_2	155	161	PF00069	0.460
MOD_Plk_4	119	125	PF00069	0.333
MOD_Plk_4	55	61	PF00069	0.497
MOD_Plk_4	6	12	PF00069	0.529
MOD_ProDKin_1	106	112	PF00069	0.329
MOD_ProDKin_1	206	212	PF00069	0.545
TRG_ENDOCYTIC_2	136	139	PF00928	0.348
TRG_NES_CRM1_1	76	89	PF08389	0.491
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ6	Leptomonas seymouri	77%	100%
A0A0N1PCA1	Leptomonas seymouri	26%	99%
A0A0S4IU25	Bodo saltans	24%	100%
A0A1X0NJI5	Trypanosomatidae	32%	100%
A0A1X0NR15	Trypanosomatidae	28%	100%
A0A3Q8IB71	Leishmania donovani	86%	100%
A0A422P470	Trypanosoma rangeli	28%	100%
A4HGT0	Leishmania braziliensis	24%	99%
A4I3V7	Leishmania infantum	25%	99%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AH26	Leishmania infantum	86%	100%
E9AWK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9B047	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
Q4QAW6	Leishmania major	84%	100%