Ankyrin/TPR repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ankyrin/TPR repeat protein

Species:

Leishmania braziliensis

UniProt:

A4HD71_LEIBR

TriTrypDb:

LbrM.24.0130 , LBRM2903_240008700

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.507
CLV_NRD_NRD_1	349	351	PF00675	0.421
CLV_PCSK_KEX2_1	272	274	PF00082	0.488
CLV_PCSK_KEX2_1	359	361	PF00082	0.482
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.507
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.482
CLV_PCSK_SKI1_1	28	32	PF00082	0.546
CLV_PCSK_SKI1_1	295	299	PF00082	0.427
CLV_PCSK_SKI1_1	336	340	PF00082	0.431
CLV_PCSK_SKI1_1	351	355	PF00082	0.395
CLV_PCSK_SKI1_1	390	394	PF00082	0.535
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DOC_MAPK_gen_1	188	195	PF00069	0.402
DOC_MAPK_gen_1	295	304	PF00069	0.418
DOC_MAPK_gen_1	350	358	PF00069	0.533
DOC_MAPK_gen_1	86	95	PF00069	0.410
DOC_MAPK_HePTP_8	85	97	PF00069	0.255
DOC_MAPK_MEF2A_6	298	306	PF00069	0.420
DOC_MAPK_MEF2A_6	88	97	PF00069	0.377
DOC_PP4_FxxP_1	166	169	PF00568	0.411
DOC_USP7_MATH_1	150	154	PF00917	0.402
DOC_USP7_MATH_1	17	21	PF00917	0.560
DOC_USP7_MATH_1	235	239	PF00917	0.453
DOC_USP7_MATH_1	24	28	PF00917	0.570
DOC_USP7_UBL2_3	261	265	PF12436	0.497
DOC_WW_Pin1_4	210	215	PF00397	0.363
DOC_WW_Pin1_4	243	248	PF00397	0.363
DOC_WW_Pin1_4	76	81	PF00397	0.363
LIG_14-3-3_CanoR_1	228	234	PF00244	0.255
LIG_14-3-3_CanoR_1	350	358	PF00244	0.487
LIG_14-3-3_CanoR_1	6	14	PF00244	0.526
LIG_APCC_ABBA_1	302	307	PF00400	0.434
LIG_CtBP_PxDLS_1	247	251	PF00389	0.474
LIG_FHA_1	200	206	PF00498	0.389
LIG_FHA_1	255	261	PF00498	0.401
LIG_FHA_1	264	270	PF00498	0.406
LIG_FHA_1	299	305	PF00498	0.412
LIG_FHA_1	307	313	PF00498	0.422
LIG_FHA_1	77	83	PF00498	0.325
LIG_FHA_2	137	143	PF00498	0.374
LIG_FHA_2	244	250	PF00498	0.486
LIG_FHA_2	375	381	PF00498	0.533
LIG_FHA_2	68	74	PF00498	0.255
LIG_LIR_Apic_2	165	169	PF02991	0.434
LIG_LIR_Gen_1	179	190	PF02991	0.409
LIG_LIR_Nem_3	179	185	PF02991	0.391
LIG_LIR_Nem_3	386	392	PF02991	0.574
LIG_Pex14_1	344	348	PF04695	0.420
LIG_Pex14_2	182	186	PF04695	0.404
LIG_SH2_CRK	45	49	PF00017	0.504
LIG_SH2_GRB2like	314	317	PF00017	0.419
LIG_SH2_GRB2like	321	324	PF00017	0.387
LIG_SH2_NCK_1	327	331	PF00017	0.298
LIG_SH2_NCK_1	361	365	PF00017	0.337
LIG_SH2_STAP1	116	120	PF00017	0.474
LIG_SH2_STAP1	164	168	PF00017	0.427
LIG_SH2_STAP1	300	304	PF00017	0.410
LIG_SH2_STAP1	314	318	PF00017	0.390
LIG_SH2_STAP1	327	331	PF00017	0.517
LIG_SH2_STAT3	321	324	PF00017	0.418
LIG_SH2_STAT5	122	125	PF00017	0.363
LIG_SH2_STAT5	138	141	PF00017	0.574
LIG_SH2_STAT5	300	303	PF00017	0.414
LIG_SH2_STAT5	321	324	PF00017	0.425
LIG_SH2_STAT5	327	330	PF00017	0.423
LIG_SH2_STAT5	348	351	PF00017	0.382
LIG_SH3_1	339	345	PF00018	0.326
LIG_SH3_3	339	345	PF00018	0.481
LIG_UBA3_1	128	135	PF00899	0.474
LIG_UBA3_1	181	189	PF00899	0.433
LIG_UBA3_1	59	67	PF00899	0.293
MOD_CK1_1	109	115	PF00069	0.448
MOD_CK1_1	362	368	PF00069	0.333
MOD_CK2_1	136	142	PF00069	0.369
MOD_CK2_1	67	73	PF00069	0.255
MOD_GlcNHglycan	108	111	PF01048	0.455
MOD_GlcNHglycan	152	155	PF01048	0.413
MOD_GlcNHglycan	236	240	PF01048	0.397
MOD_GlcNHglycan	45	48	PF01048	0.294
MOD_GSK3_1	104	111	PF00069	0.468
MOD_GSK3_1	138	145	PF00069	0.546
MOD_GSK3_1	176	183	PF00069	0.396
MOD_GSK3_1	359	366	PF00069	0.567
MOD_N-GLC_1	254	259	PF02516	0.585
MOD_NEK2_1	229	234	PF00069	0.384
MOD_NEK2_1	263	268	PF00069	0.604
MOD_NEK2_2	133	138	PF00069	0.397
MOD_PIKK_1	263	269	PF00454	0.406
MOD_PIKK_1	366	372	PF00454	0.556
MOD_PKA_1	359	365	PF00069	0.565
MOD_PKA_2	359	365	PF00069	0.345
MOD_PKA_2	5	11	PF00069	0.549
MOD_Plk_1	24	30	PF00069	0.521
MOD_Plk_1	263	269	PF00069	0.460
MOD_Plk_4	133	139	PF00069	0.436
MOD_Plk_4	142	148	PF00069	0.417
MOD_ProDKin_1	210	216	PF00069	0.363
MOD_ProDKin_1	243	249	PF00069	0.363
MOD_ProDKin_1	76	82	PF00069	0.363
MOD_SUMO_for_1	384	387	PF00179	0.570
MOD_SUMO_rev_2	238	247	PF00179	0.512
TRG_DiLeu_BaEn_1	142	147	PF01217	0.474
TRG_DiLeu_BaEn_1	225	230	PF01217	0.363
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.263
TRG_DiLeu_LyEn_5	225	230	PF01217	0.474
TRG_ENDOCYTIC_2	45	48	PF00928	0.507
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I340	Leptomonas seymouri	82%	100%
A0A0S4J2H9	Bodo saltans	26%	69%
A0A1X0NIN0	Trypanosomatidae	65%	100%
A0A3Q8ICQ2	Leishmania donovani	87%	100%
A0A3R7N419	Trypanosoma rangeli	63%	100%
A6NHY2	Homo sapiens	23%	75%
C9ZRD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	95%
D0A6Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D3J162	Medicago truncatula	27%	73%
E5RJM6	Homo sapiens	29%	99%
E9AH25	Leishmania infantum	87%	100%
E9AWK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q337A0	Oryza sativa subsp. japonica	32%	76%
Q3V096	Mus musculus	27%	75%
Q495B1	Homo sapiens	27%	75%
Q4FE45	Arabidopsis thaliana	28%	77%
Q4QAW7	Leishmania major	86%	100%
Q5UPG5	Acanthamoeba polyphaga mimivirus	28%	94%
Q6AWW5	Arabidopsis thaliana	28%	75%
Q6KAE5	Oryza sativa subsp. japonica	32%	79%
Q7EZ44	Oryza sativa subsp. japonica	30%	80%
Q8N9B4	Homo sapiens	27%	100%
Q8Q0U0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	29%	100%
Q9H560	Homo sapiens	24%	100%
Q9J4Z5	Fowlpox virus (strain NVSL)	28%	90%
Q9J516	Fowlpox virus (strain NVSL)	26%	91%
Q9J5A7	Fowlpox virus (strain NVSL)	26%	73%
Q9J5G9	Fowlpox virus (strain NVSL)	23%	95%
Q9J5H9	Fowlpox virus (strain NVSL)	25%	68%
Q9SAR5	Arabidopsis thaliana	28%	100%
V5BW01	Trypanosoma cruzi	65%	100%