Guanine nucleotide-binding protein beta subunit-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD40/YVTN repeat-like-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HD70_LEIBR

TriTrypDb:

LbrM.24.0120 , LBRM2903_240006000

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.378
CLV_C14_Caspase3-7	267	271	PF00656	0.393
CLV_C14_Caspase3-7	71	75	PF00656	0.533
CLV_NRD_NRD_1	130	132	PF00675	0.420
CLV_NRD_NRD_1	150	152	PF00675	0.213
CLV_NRD_NRD_1	239	241	PF00675	0.508
CLV_NRD_NRD_1	328	330	PF00675	0.652
CLV_NRD_NRD_1	64	66	PF00675	0.286
CLV_PCSK_KEX2_1	130	132	PF00082	0.434
CLV_PCSK_KEX2_1	239	241	PF00082	0.508
CLV_PCSK_KEX2_1	452	454	PF00082	0.400
CLV_PCSK_KEX2_1	64	66	PF00082	0.392
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.512
CLV_PCSK_SKI1_1	152	156	PF00082	0.520
CLV_PCSK_SKI1_1	233	237	PF00082	0.651
CLV_PCSK_SKI1_1	351	355	PF00082	0.464
CLV_Separin_Metazoa	61	65	PF03568	0.279
DEG_APCC_DBOX_1	150	158	PF00400	0.555
DEG_Nend_UBRbox_1	1	4	PF02207	0.513
DEG_SPOP_SBC_1	264	268	PF00917	0.382
DOC_CDC14_PxL_1	14	22	PF14671	0.366
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.478
DOC_MAPK_DCC_7	312	322	PF00069	0.480
DOC_MAPK_gen_1	151	157	PF00069	0.526
DOC_MAPK_MEF2A_6	2	9	PF00069	0.491
DOC_PP2B_LxvP_1	395	398	PF13499	0.283
DOC_PP2B_LxvP_1	543	546	PF13499	0.530
DOC_USP7_MATH_1	506	510	PF00917	0.636
DOC_USP7_MATH_1	57	61	PF00917	0.513
DOC_USP7_UBL2_3	47	51	PF12436	0.565
DOC_WW_Pin1_4	227	232	PF00397	0.548
DOC_WW_Pin1_4	461	466	PF00397	0.634
LIG_14-3-3_CanoR_1	239	249	PF00244	0.565
LIG_14-3-3_CanoR_1	290	298	PF00244	0.373
LIG_14-3-3_CanoR_1	301	306	PF00244	0.390
LIG_14-3-3_CanoR_1	34	42	PF00244	0.523
LIG_14-3-3_CanoR_1	64	69	PF00244	0.524
LIG_APCC_ABBA_1	96	101	PF00400	0.504
LIG_Clathr_ClatBox_1	373	377	PF01394	0.534
LIG_FHA_1	195	201	PF00498	0.465
LIG_FHA_1	2	8	PF00498	0.608
LIG_FHA_1	302	308	PF00498	0.464
LIG_FHA_1	37	43	PF00498	0.481
LIG_FHA_1	387	393	PF00498	0.487
LIG_FHA_1	430	436	PF00498	0.480
LIG_FHA_1	445	451	PF00498	0.265
LIG_FHA_1	538	544	PF00498	0.418
LIG_FHA_2	148	154	PF00498	0.412
LIG_FHA_2	21	27	PF00498	0.577
LIG_FHA_2	337	343	PF00498	0.512
LIG_GBD_Chelix_1	58	66	PF00786	0.495
LIG_LIR_Apic_2	12	18	PF02991	0.364
LIG_LIR_Gen_1	186	196	PF02991	0.563
LIG_LIR_Gen_1	518	528	PF02991	0.421
LIG_LIR_Gen_1	52	63	PF02991	0.449
LIG_LIR_Nem_3	186	192	PF02991	0.554
LIG_LIR_Nem_3	246	250	PF02991	0.527
LIG_LIR_Nem_3	275	279	PF02991	0.459
LIG_LIR_Nem_3	457	462	PF02991	0.596
LIG_LIR_Nem_3	518	523	PF02991	0.421
LIG_LIR_Nem_3	52	58	PF02991	0.405
LIG_LYPXL_yS_3	247	250	PF13949	0.330
LIG_PDZ_Class_2	550	555	PF00595	0.549
LIG_SH2_CRK	15	19	PF00017	0.370
LIG_SH2_CRK	313	317	PF00017	0.504
LIG_SH2_CRK	520	524	PF00017	0.376
LIG_SH2_CRK	55	59	PF00017	0.517
LIG_SH2_NCK_1	313	317	PF00017	0.327
LIG_SH2_STAP1	142	146	PF00017	0.369
LIG_SH2_STAP1	218	222	PF00017	0.431
LIG_SH2_STAP1	292	296	PF00017	0.367
LIG_SH2_STAP1	55	59	PF00017	0.536
LIG_SH2_STAT5	222	225	PF00017	0.416
LIG_SH2_STAT5	254	257	PF00017	0.501
LIG_SH2_STAT5	361	364	PF00017	0.360
LIG_SH2_STAT5	385	388	PF00017	0.457
LIG_SH2_STAT5	495	498	PF00017	0.519
LIG_SH3_3	228	234	PF00018	0.615
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.381
LIG_SxIP_EBH_1	498	510	PF03271	0.404
LIG_TYR_ITIM	187	192	PF00017	0.550
LIG_WRC_WIRS_1	550	555	PF05994	0.671
MOD_CDC14_SPxK_1	230	233	PF00782	0.668
MOD_CDK_SPxK_1	227	233	PF00069	0.630
MOD_CK1_1	266	272	PF00069	0.519
MOD_CK1_1	356	362	PF00069	0.474
MOD_CK1_1	426	432	PF00069	0.485
MOD_CK1_1	489	495	PF00069	0.343
MOD_CK1_1	500	506	PF00069	0.577
MOD_CK1_1	508	514	PF00069	0.624
MOD_CK1_1	92	98	PF00069	0.460
MOD_CK2_1	20	26	PF00069	0.517
MOD_CK2_1	240	246	PF00069	0.470
MOD_CK2_1	396	402	PF00069	0.582
MOD_GlcNHglycan	158	161	PF01048	0.462
MOD_GlcNHglycan	355	359	PF01048	0.530
MOD_GlcNHglycan	425	428	PF01048	0.482
MOD_GlcNHglycan	472	475	PF01048	0.415
MOD_GlcNHglycan	515	518	PF01048	0.626
MOD_GlcNHglycan	91	94	PF01048	0.577
MOD_GSK3_1	156	163	PF00069	0.524
MOD_GSK3_1	22	29	PF00069	0.438
MOD_GSK3_1	234	241	PF00069	0.527
MOD_GSK3_1	265	272	PF00069	0.390
MOD_GSK3_1	365	372	PF00069	0.532
MOD_GSK3_1	386	393	PF00069	0.474
MOD_GSK3_1	406	413	PF00069	0.207
MOD_GSK3_1	429	436	PF00069	0.426
MOD_GSK3_1	470	477	PF00069	0.426
MOD_GSK3_1	497	504	PF00069	0.592
MOD_GSK3_1	64	71	PF00069	0.522
MOD_N-GLC_1	212	217	PF02516	0.594
MOD_N-GLC_1	423	428	PF02516	0.493
MOD_N-GLC_1	497	502	PF02516	0.588
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	132	137	PF00069	0.424
MOD_NEK2_1	20	25	PF00069	0.580
MOD_NEK2_1	212	217	PF00069	0.490
MOD_NEK2_1	238	243	PF00069	0.507
MOD_NEK2_1	296	301	PF00069	0.462
MOD_NEK2_1	346	351	PF00069	0.422
MOD_NEK2_1	353	358	PF00069	0.437
MOD_NEK2_1	404	409	PF00069	0.497
MOD_NEK2_1	476	481	PF00069	0.396
MOD_NEK2_1	499	504	PF00069	0.542
MOD_NEK2_2	234	239	PF00069	0.588
MOD_PIKK_1	109	115	PF00454	0.392
MOD_PIKK_1	379	385	PF00454	0.432
MOD_PK_1	312	318	PF00069	0.377
MOD_PKA_1	239	245	PF00069	0.572
MOD_PKA_1	64	70	PF00069	0.307
MOD_PKA_2	238	244	PF00069	0.438
MOD_PKA_2	64	70	PF00069	0.526
MOD_Plk_1	212	218	PF00069	0.496
MOD_Plk_1	410	416	PF00069	0.416
MOD_Plk_2-3	537	543	PF00069	0.379
MOD_Plk_2-3	549	555	PF00069	0.516
MOD_Plk_4	160	166	PF00069	0.546
MOD_Plk_4	212	218	PF00069	0.482
MOD_Plk_4	301	307	PF00069	0.531
MOD_Plk_4	369	375	PF00069	0.406
MOD_Plk_4	411	417	PF00069	0.392
MOD_Plk_4	527	533	PF00069	0.540
MOD_ProDKin_1	227	233	PF00069	0.561
MOD_ProDKin_1	461	467	PF00069	0.630
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.456
TRG_ENDOCYTIC_2	189	192	PF00928	0.562
TRG_ENDOCYTIC_2	247	250	PF00928	0.330
TRG_ENDOCYTIC_2	313	316	PF00928	0.508
TRG_ENDOCYTIC_2	520	523	PF00928	0.376
TRG_ENDOCYTIC_2	55	58	PF00928	0.527
TRG_ER_diArg_1	129	131	PF00400	0.434
TRG_ER_diArg_1	238	240	PF00400	0.522
TRG_ER_diArg_1	63	65	PF00400	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S8	Leptomonas seymouri	73%	100%
A0A1X0NIQ5	Trypanosomatidae	47%	99%
A0A3R7NVJ1	Trypanosoma rangeli	48%	99%
A0A3S7WY01	Leishmania donovani	91%	100%
D0A6Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
E9AH24	Leishmania infantum	91%	100%
E9AWK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAW8	Leishmania major	90%	100%
V5C0S8	Trypanosoma cruzi	48%	99%