DUF3592 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD67_LEIBR

TriTrypDb:

LbrM.24.0090 , LBRM2903_240005700

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HD67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.488
CLV_NRD_NRD_1	182	184	PF00675	0.453
CLV_NRD_NRD_1	67	69	PF00675	0.535
CLV_PCSK_KEX2_1	91	93	PF00082	0.548
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.548
CLV_PCSK_SKI1_1	8	12	PF00082	0.425
DOC_CDC14_PxL_1	122	130	PF14671	0.282
DOC_MAPK_gen_1	190	196	PF00069	0.709
DOC_PP1_RVXF_1	191	197	PF00149	0.682
DOC_USP7_MATH_1	47	51	PF00917	0.236
DOC_USP7_UBL2_3	140	144	PF12436	0.297
DOC_WW_Pin1_4	215	220	PF00397	0.614
DOC_WW_Pin1_4	99	104	PF00397	0.282
LIG_14-3-3_CanoR_1	133	137	PF00244	0.296
LIG_14-3-3_CanoR_1	213	220	PF00244	0.618
LIG_14-3-3_CanoR_1	56	65	PF00244	0.346
LIG_14-3-3_CanoR_1	73	78	PF00244	0.190
LIG_Actin_WH2_2	168	185	PF00022	0.543
LIG_APCC_ABBAyCdc20_2	133	139	PF00400	0.296
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_FHA_2	113	119	PF00498	0.278
LIG_LIR_Nem_3	157	163	PF02991	0.401
LIG_Pex14_2	156	160	PF04695	0.323
LIG_Pex14_2	163	167	PF04695	0.306
LIG_SH2_CRK	45	49	PF00017	0.273
LIG_SH2_CRK	7	11	PF00017	0.676
LIG_SH2_GRB2like	38	41	PF00017	0.335
LIG_SH2_SRC	199	202	PF00017	0.741
LIG_SH2_STAP1	112	116	PF00017	0.194
LIG_SH2_STAP1	80	84	PF00017	0.273
LIG_SH2_STAT5	121	124	PF00017	0.275
LIG_SH2_STAT5	38	41	PF00017	0.329
LIG_SH2_STAT5	93	96	PF00017	0.274
LIG_SH3_1	199	205	PF00018	0.716
LIG_SH3_2	205	210	PF14604	0.749
LIG_SH3_3	191	197	PF00018	0.622
LIG_SH3_3	199	205	PF00018	0.675
LIG_SH3_3	206	212	PF00018	0.685
LIG_SH3_3	23	29	PF00018	0.447
LIG_TYR_ITIM	70	75	PF00017	0.282
LIG_UBA3_1	64	69	PF00899	0.296
MOD_CDC14_SPxK_1	102	105	PF00782	0.282
MOD_CDC14_SPxK_1	218	221	PF00782	0.613
MOD_CDK_SPxK_1	215	221	PF00069	0.615
MOD_CDK_SPxK_1	99	105	PF00069	0.282
MOD_CK2_1	112	118	PF00069	0.284
MOD_Cter_Amidation	89	92	PF01082	0.491
MOD_GlcNHglycan	146	149	PF01048	0.482
MOD_GlcNHglycan	2	5	PF01048	0.438
MOD_GSK3_1	152	159	PF00069	0.282
MOD_GSK3_1	215	222	PF00069	0.616
MOD_GSK3_1	92	99	PF00069	0.286
MOD_NEK2_1	156	161	PF00069	0.282
MOD_PIKK_1	213	219	PF00454	0.718
MOD_PIKK_1	57	63	PF00454	0.362
MOD_PK_1	73	79	PF00069	0.193
MOD_PKA_2	132	138	PF00069	0.285
MOD_PKA_2	96	102	PF00069	0.275
MOD_Plk_1	112	118	PF00069	0.215
MOD_Plk_1	156	162	PF00069	0.282
MOD_Plk_2-3	114	120	PF00069	0.313
MOD_Plk_2-3	152	158	PF00069	0.282
MOD_Plk_4	132	138	PF00069	0.282
MOD_ProDKin_1	215	221	PF00069	0.615
MOD_ProDKin_1	99	105	PF00069	0.282
MOD_SUMO_for_1	82	85	PF00179	0.334
MOD_SUMO_rev_2	135	143	PF00179	0.348
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.378
TRG_ENDOCYTIC_2	45	48	PF00928	0.259
TRG_ENDOCYTIC_2	7	10	PF00928	0.623
TRG_ENDOCYTIC_2	72	75	PF00928	0.282
TRG_ER_diArg_1	192	195	PF00400	0.649
TRG_NLS_MonoExtN_4	188	194	PF00514	0.687
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P429	Leptomonas seymouri	87%	100%
A0A0S4J094	Bodo saltans	67%	100%
A0A1X0NJD4	Trypanosomatidae	77%	100%
A0A3R7KS59	Trypanosoma rangeli	69%	100%
A0A3S7WXZ8	Leishmania donovani	91%	97%
D0A6Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AH21	Leishmania infantum	90%	97%
E9AWJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	90%
Q4QAX1	Leishmania major	91%	100%