RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HD66_LEIBR

TriTrypDb:

LbrM.24.0080 , LBRM2903_240005600

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD66

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.298
CLV_C14_Caspase3-7	429	433	PF00656	0.329
CLV_NRD_NRD_1	59	61	PF00675	0.387
CLV_PCSK_KEX2_1	162	164	PF00082	0.375
CLV_PCSK_KEX2_1	59	61	PF00082	0.387
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.375
CLV_PCSK_SKI1_1	143	147	PF00082	0.474
CLV_PCSK_SKI1_1	346	350	PF00082	0.373
DEG_Kelch_Keap1_1	62	67	PF01344	0.327
DEG_SCF_TRCP1_1	249	255	PF00400	0.201
DOC_MAPK_gen_1	162	168	PF00069	0.285
DOC_PP1_RVXF_1	192	198	PF00149	0.261
DOC_USP7_MATH_1	234	238	PF00917	0.584
DOC_USP7_MATH_1	315	319	PF00917	0.288
DOC_WW_Pin1_4	219	224	PF00397	0.457
DOC_WW_Pin1_4	363	368	PF00397	0.520
LIG_14-3-3_CanoR_1	194	204	PF00244	0.448
LIG_14-3-3_CanoR_1	408	415	PF00244	0.411
LIG_BIR_III_4	472	476	PF00653	0.440
LIG_deltaCOP1_diTrp_1	268	277	PF00928	0.468
LIG_FHA_1	240	246	PF00498	0.474
LIG_FHA_1	285	291	PF00498	0.331
LIG_FHA_2	196	202	PF00498	0.516
LIG_FHA_2	233	239	PF00498	0.509
LIG_FHA_2	329	335	PF00498	0.392
LIG_FHA_2	450	456	PF00498	0.527
LIG_FHA_2	97	103	PF00498	0.223
LIG_LIR_Gen_1	311	322	PF02991	0.425
LIG_LIR_Gen_1	460	471	PF02991	0.471
LIG_LIR_Nem_3	311	317	PF02991	0.407
LIG_LIR_Nem_3	460	466	PF02991	0.494
LIG_LIR_Nem_3	99	104	PF02991	0.360
LIG_MYND_1	423	427	PF01753	0.494
LIG_PCNA_yPIPBox_3	135	149	PF02747	0.399
LIG_Pex14_2	137	141	PF04695	0.380
LIG_Pex14_2	405	409	PF04695	0.532
LIG_REV1ctd_RIR_1	80	89	PF16727	0.437
LIG_SH2_CRK	101	105	PF00017	0.471
LIG_SH2_CRK	115	119	PF00017	0.496
LIG_SH2_CRK	350	354	PF00017	0.256
LIG_SH2_NCK_1	314	318	PF00017	0.553
LIG_SH2_SRC	314	317	PF00017	0.280
LIG_SH2_STAP1	164	168	PF00017	0.405
LIG_SH2_STAT5	261	264	PF00017	0.356
LIG_SH2_STAT5	340	343	PF00017	0.327
LIG_SH2_STAT5	395	398	PF00017	0.326
LIG_SH2_STAT5	49	52	PF00017	0.321
LIG_SH3_3	13	19	PF00018	0.537
LIG_SH3_3	187	193	PF00018	0.501
LIG_SH3_3	296	302	PF00018	0.468
LIG_SH3_3	361	367	PF00018	0.362
LIG_SH3_3	438	444	PF00018	0.340
LIG_SH3_3	97	103	PF00018	0.315
LIG_Sin3_3	165	172	PF02671	0.253
LIG_SUMO_SIM_par_1	184	189	PF11976	0.510
LIG_SxIP_EBH_1	29	38	PF03271	0.375
LIG_TYR_ITIM	113	118	PF00017	0.399
MOD_CK1_1	214	220	PF00069	0.591
MOD_CK1_1	232	238	PF00069	0.405
MOD_CK1_1	38	44	PF00069	0.423
MOD_CK1_1	404	410	PF00069	0.450
MOD_CK1_1	53	59	PF00069	0.389
MOD_CK2_1	181	187	PF00069	0.464
MOD_CK2_1	232	238	PF00069	0.508
MOD_CK2_1	328	334	PF00069	0.405
MOD_GlcNHglycan	216	219	PF01048	0.549
MOD_GlcNHglycan	249	252	PF01048	0.425
MOD_GlcNHglycan	37	40	PF01048	0.312
MOD_GlcNHglycan	428	431	PF01048	0.511
MOD_GlcNHglycan	52	55	PF01048	0.353
MOD_GlcNHglycan	64	67	PF01048	0.483
MOD_GlcNHglycan	9	12	PF01048	0.377
MOD_GSK3_1	177	184	PF00069	0.408
MOD_GSK3_1	212	219	PF00069	0.482
MOD_GSK3_1	228	235	PF00069	0.459
MOD_GSK3_1	304	311	PF00069	0.537
MOD_GSK3_1	49	56	PF00069	0.385
MOD_N-GLC_1	149	154	PF02516	0.361
MOD_NEK2_1	149	154	PF00069	0.435
MOD_NEK2_1	188	193	PF00069	0.366
MOD_NEK2_1	227	232	PF00069	0.477
MOD_NEK2_1	275	280	PF00069	0.280
MOD_PIKK_1	229	235	PF00454	0.532
MOD_PIKK_1	398	404	PF00454	0.467
MOD_PKA_2	195	201	PF00069	0.315
MOD_PKA_2	407	413	PF00069	0.385
MOD_PKB_1	194	202	PF00069	0.276
MOD_Plk_1	188	194	PF00069	0.283
MOD_Plk_1	27	33	PF00069	0.325
MOD_Plk_2-3	181	187	PF00069	0.505
MOD_Plk_2-3	252	258	PF00069	0.407
MOD_Plk_4	181	187	PF00069	0.414
MOD_Plk_4	27	33	PF00069	0.400
MOD_Plk_4	53	59	PF00069	0.492
MOD_Plk_4	96	102	PF00069	0.391
MOD_ProDKin_1	219	225	PF00069	0.458
MOD_ProDKin_1	363	369	PF00069	0.523
MOD_SUMO_for_1	279	282	PF00179	0.442
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.288
TRG_ENDOCYTIC_2	101	104	PF00928	0.470
TRG_ENDOCYTIC_2	115	118	PF00928	0.501
TRG_ENDOCYTIC_2	314	317	PF00928	0.442
TRG_ENDOCYTIC_2	350	353	PF00928	0.406
TRG_ER_diArg_1	193	196	PF00400	0.278
TRG_ER_diArg_1	58	60	PF00400	0.299
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Y9	Leptomonas seymouri	58%	100%
A0A1X0NKC7	Trypanosomatidae	34%	100%
A0A3Q8ICQ4	Leishmania donovani	78%	89%
A0A3R7LDY0	Trypanosoma rangeli	36%	100%
A4I0N1	Leishmania infantum	78%	88%
D0A6X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AWJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	93%
Q4QAX2	Leishmania major	77%	100%
V5DSQ1	Trypanosoma cruzi	35%	100%