J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD65_LEIBR

TriTrypDb:

LbrM.24.0070 , LBRM2903_240005500

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HD65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.476
CLV_C14_Caspase3-7	232	236	PF00656	0.428
CLV_C14_Caspase3-7	249	253	PF00656	0.575
CLV_C14_Caspase3-7	396	400	PF00656	0.658
CLV_C14_Caspase3-7	76	80	PF00656	0.441
CLV_NRD_NRD_1	227	229	PF00675	0.774
CLV_NRD_NRD_1	31	33	PF00675	0.634
CLV_NRD_NRD_1	384	386	PF00675	0.414
CLV_NRD_NRD_1	392	394	PF00675	0.435
CLV_NRD_NRD_1	74	76	PF00675	0.561
CLV_PCSK_KEX2_1	227	229	PF00082	0.781
CLV_PCSK_KEX2_1	377	379	PF00082	0.400
CLV_PCSK_KEX2_1	392	394	PF00082	0.438
CLV_PCSK_KEX2_1	74	76	PF00082	0.572
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.400
CLV_PCSK_PC7_1	388	394	PF00082	0.427
CLV_PCSK_SKI1_1	188	192	PF00082	0.720
CLV_PCSK_SKI1_1	300	304	PF00082	0.602
CLV_PCSK_SKI1_1	313	317	PF00082	0.548
CLV_PCSK_SKI1_1	377	381	PF00082	0.401
CLV_PCSK_SKI1_1	38	42	PF00082	0.672
CLV_PCSK_SKI1_1	417	421	PF00082	0.437
CLV_PCSK_SKI1_1	68	72	PF00082	0.544
DEG_Nend_UBRbox_1	1	4	PF02207	0.521
DOC_MAPK_MEF2A_6	411	418	PF00069	0.595
DOC_MAPK_NFAT4_5	411	419	PF00069	0.609
DOC_MAPK_RevD_3	60	75	PF00069	0.373
DOC_USP7_MATH_1	165	169	PF00917	0.420
DOC_USP7_MATH_1	248	252	PF00917	0.585
DOC_USP7_MATH_1	261	265	PF00917	0.520
DOC_USP7_MATH_1	387	391	PF00917	0.616
DOC_USP7_MATH_1	402	406	PF00917	0.636
DOC_USP7_UBL2_3	23	27	PF12436	0.442
LIG_14-3-3_CanoR_1	130	139	PF00244	0.485
LIG_14-3-3_CanoR_1	227	234	PF00244	0.542
LIG_14-3-3_CanoR_1	392	398	PF00244	0.658
LIG_14-3-3_CanoR_1	74	78	PF00244	0.389
LIG_14-3-3_CanoR_1	89	93	PF00244	0.364
LIG_Actin_WH2_2	174	190	PF00022	0.448
LIG_APCC_ABBA_1	333	338	PF00400	0.378
LIG_BH_BH3_1	4	20	PF00452	0.364
LIG_BIR_III_4	79	83	PF00653	0.456
LIG_EH1_1	324	332	PF00400	0.349
LIG_EVH1_2	254	258	PF00568	0.432
LIG_FHA_1	187	193	PF00498	0.458
LIG_FHA_1	307	313	PF00498	0.434
LIG_FHA_2	139	145	PF00498	0.428
LIG_FHA_2	247	253	PF00498	0.539
LIG_FHA_2	285	291	PF00498	0.473
LIG_FHA_2	299	305	PF00498	0.374
LIG_FHA_2	394	400	PF00498	0.649
LIG_FHA_2	408	414	PF00498	0.575
LIG_FHA_2	74	80	PF00498	0.400
LIG_LIR_Gen_1	24	30	PF02991	0.441
LIG_LIR_Gen_1	320	331	PF02991	0.378
LIG_LIR_Gen_1	85	94	PF02991	0.358
LIG_LIR_Nem_3	134	139	PF02991	0.458
LIG_LIR_Nem_3	24	28	PF02991	0.412
LIG_LIR_Nem_3	320	326	PF02991	0.378
LIG_LIR_Nem_3	43	47	PF02991	0.254
LIG_LIR_Nem_3	85	90	PF02991	0.372
LIG_LIR_Nem_3	91	97	PF02991	0.333
LIG_NRBOX	66	72	PF00104	0.355
LIG_Pex14_2	380	384	PF04695	0.603
LIG_SH2_PTP2	136	139	PF00017	0.495
LIG_SH2_PTP2	323	326	PF00017	0.344
LIG_SH2_SRC	126	129	PF00017	0.426
LIG_SH2_SRC	136	139	PF00017	0.443
LIG_SH2_SRC	94	97	PF00017	0.352
LIG_SH2_STAP1	372	376	PF00017	0.591
LIG_SH2_STAT3	372	375	PF00017	0.595
LIG_SH2_STAT5	126	129	PF00017	0.421
LIG_SH2_STAT5	136	139	PF00017	0.424
LIG_SH2_STAT5	323	326	PF00017	0.338
LIG_SH2_STAT5	334	337	PF00017	0.307
LIG_SH2_STAT5	69	72	PF00017	0.347
LIG_SH3_3	55	61	PF00018	0.372
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.454
LIG_SUMO_SIM_par_1	204	210	PF11976	0.521
LIG_SUMO_SIM_par_1	60	65	PF11976	0.390
LIG_TRAF2_1	219	222	PF00917	0.599
LIG_TYR_ITIM	321	326	PF00017	0.344
LIG_TYR_ITIM	49	54	PF00017	0.356
LIG_TYR_ITIM	92	97	PF00017	0.355
MOD_CK1_1	129	135	PF00069	0.486
MOD_CK2_1	137	143	PF00069	0.465
MOD_CK2_1	274	280	PF00069	0.500
MOD_CK2_1	298	304	PF00069	0.415
MOD_CK2_1	402	408	PF00069	0.631
MOD_GlcNHglycan	229	232	PF01048	0.746
MOD_GSK3_1	182	189	PF00069	0.499
MOD_GSK3_1	242	249	PF00069	0.511
MOD_GSK3_1	346	353	PF00069	0.698
MOD_N-GLC_1	306	311	PF02516	0.636
MOD_NEK2_1	1	6	PF00069	0.475
MOD_NEK2_1	182	187	PF00069	0.520
MOD_NEK2_1	317	322	PF00069	0.374
MOD_NEK2_1	325	330	PF00069	0.370
MOD_NEK2_1	62	67	PF00069	0.362
MOD_NEK2_1	8	13	PF00069	0.428
MOD_NEK2_1	88	93	PF00069	0.371
MOD_NEK2_2	186	191	PF00069	0.467
MOD_PIKK_1	120	126	PF00454	0.361
MOD_PIKK_1	371	377	PF00454	0.607
MOD_PKA_1	227	233	PF00069	0.423
MOD_PKA_2	1	7	PF00069	0.543
MOD_PKA_2	129	135	PF00069	0.488
MOD_PKA_2	227	233	PF00069	0.477
MOD_PKA_2	242	248	PF00069	0.586
MOD_PKA_2	387	393	PF00069	0.623
MOD_PKA_2	402	408	PF00069	0.630
MOD_PKA_2	73	79	PF00069	0.377
MOD_PKA_2	88	94	PF00069	0.365
MOD_Plk_1	317	323	PF00069	0.296
MOD_Plk_2-3	409	415	PF00069	0.516
MOD_Plk_4	132	138	PF00069	0.445
MOD_Plk_4	317	323	PF00069	0.291
MOD_Plk_4	358	364	PF00069	0.641
MOD_Plk_4	83	89	PF00069	0.449
MOD_SUMO_for_1	315	318	PF00179	0.455
MOD_SUMO_for_1	40	43	PF00179	0.499
MOD_SUMO_rev_2	104	111	PF00179	0.427
MOD_SUMO_rev_2	196	200	PF00179	0.495
MOD_SUMO_rev_2	29	35	PF00179	0.393
MOD_SUMO_rev_2	310	315	PF00179	0.429
MOD_SUMO_rev_2	404	412	PF00179	0.669
MOD_SUMO_rev_2	413	419	PF00179	0.648
TRG_DiLeu_BaEn_1	170	175	PF01217	0.427
TRG_DiLeu_BaEn_1	213	218	PF01217	0.457
TRG_DiLeu_LyEn_5	213	218	PF01217	0.396
TRG_ENDOCYTIC_2	136	139	PF00928	0.473
TRG_ENDOCYTIC_2	25	28	PF00928	0.417
TRG_ENDOCYTIC_2	323	326	PF00928	0.367
TRG_ENDOCYTIC_2	51	54	PF00928	0.358
TRG_ENDOCYTIC_2	94	97	PF00928	0.352
TRG_ER_diArg_1	214	217	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.694
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N9	Leptomonas seymouri	76%	99%
A0A0S4IV95	Bodo saltans	54%	100%
A0A1X0NKJ2	Trypanosomatidae	63%	99%
A0A3Q8ICV4	Leishmania donovani	81%	100%
A4I0N0	Leishmania infantum	82%	100%
D0A6X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
E9AWJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QAX3	Leishmania major	82%	100%
V5BW05	Trypanosoma cruzi	63%	94%