Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD64_LEIBR

TriTrypDb:

LbrM.24.0060 , LBRM2903_240005400

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HD64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.335
CLV_C14_Caspase3-7	55	59	PF00656	0.330
CLV_MEL_PAP_1	298	304	PF00089	0.297
CLV_PCSK_KEX2_1	305	307	PF00082	0.488
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.507
CLV_PCSK_PC7_1	301	307	PF00082	0.474
CLV_PCSK_SKI1_1	177	181	PF00082	0.525
CLV_PCSK_SKI1_1	222	226	PF00082	0.579
CLV_PCSK_SKI1_1	295	299	PF00082	0.466
CLV_PCSK_SKI1_1	34	38	PF00082	0.547
DEG_APCC_DBOX_1	203	211	PF00400	0.270
DEG_SPOP_SBC_1	43	47	PF00917	0.284
DOC_CYCLIN_RxL_1	153	164	PF00134	0.431
DOC_CYCLIN_yClb5_NLxxxL_5	198	207	PF00134	0.280
DOC_MAPK_FxFP_2	371	374	PF00069	0.606
DOC_MAPK_gen_1	313	321	PF00069	0.697
DOC_PP4_FxxP_1	371	374	PF00568	0.785
LIG_14-3-3_CanoR_1	156	161	PF00244	0.454
LIG_14-3-3_CanoR_1	175	184	PF00244	0.407
LIG_14-3-3_CanoR_1	204	214	PF00244	0.346
LIG_Actin_WH2_2	163	179	PF00022	0.257
LIG_BIR_III_4	113	117	PF00653	0.264
LIG_BRCT_BRCA1_1	137	141	PF00533	0.518
LIG_BRCT_BRCA1_1	158	162	PF00533	0.396
LIG_BRCT_BRCA1_1	23	27	PF00533	0.418
LIG_EVH1_2	367	371	PF00568	0.601
LIG_FHA_1	162	168	PF00498	0.292
LIG_FHA_1	207	213	PF00498	0.386
LIG_FHA_1	243	249	PF00498	0.306
LIG_FHA_1	38	44	PF00498	0.441
LIG_FHA_1	51	57	PF00498	0.397
LIG_FHA_1	84	90	PF00498	0.340
LIG_FHA_2	184	190	PF00498	0.422
LIG_FHA_2	53	59	PF00498	0.325
LIG_FHA_2	86	92	PF00498	0.426
LIG_LIR_Apic_2	140	145	PF02991	0.365
LIG_LIR_Apic_2	370	374	PF02991	0.748
LIG_LIR_Gen_1	119	126	PF02991	0.320
LIG_LIR_Gen_1	45	56	PF02991	0.406
LIG_LIR_Nem_3	192	196	PF02991	0.400
LIG_LIR_Nem_3	231	235	PF02991	0.412
LIG_LIR_Nem_3	323	329	PF02991	0.633
LIG_LIR_Nem_3	45	51	PF02991	0.431
LIG_NRBOX	76	82	PF00104	0.263
LIG_PDZ_Class_2	394	399	PF00595	0.764
LIG_Pex14_1	277	281	PF04695	0.363
LIG_Pex14_2	255	259	PF04695	0.270
LIG_Pex14_2	371	375	PF04695	0.605
LIG_PTB_Apo_2	79	86	PF02174	0.270
LIG_PTB_Phospho_1	79	85	PF10480	0.263
LIG_REV1ctd_RIR_1	253	259	PF16727	0.296
LIG_SH2_CRK	235	239	PF00017	0.429
LIG_SH2_GRB2like	135	138	PF00017	0.451
LIG_SH2_STAP1	163	167	PF00017	0.255
LIG_SH2_STAP1	232	236	PF00017	0.392
LIG_SH2_STAT3	337	340	PF00017	0.690
LIG_SH2_STAT3	373	376	PF00017	0.794
LIG_SH2_STAT3	387	390	PF00017	0.797
LIG_SH2_STAT3	392	395	PF00017	0.678
LIG_SH2_STAT5	135	138	PF00017	0.437
LIG_SH2_STAT5	163	166	PF00017	0.396
LIG_SH2_STAT5	246	249	PF00017	0.368
LIG_SH2_STAT5	278	281	PF00017	0.324
LIG_SH2_STAT5	85	88	PF00017	0.463
LIG_SH3_3	142	148	PF00018	0.363
LIG_SH3_3	59	65	PF00018	0.467
LIG_SUMO_SIM_anti_2	4	11	PF11976	0.403
LIG_SUMO_SIM_anti_2	45	55	PF11976	0.259
LIG_TRAF2_1	361	364	PF00917	0.623
LIG_TYR_ITIM	191	196	PF00017	0.434
LIG_UBA3_1	30	34	PF00899	0.252
LIG_WRC_WIRS_1	180	185	PF05994	0.430
LIG_WRC_WIRS_1	266	271	PF05994	0.321
MOD_CK1_1	150	156	PF00069	0.419
MOD_CK1_1	206	212	PF00069	0.404
MOD_CK2_1	146	152	PF00069	0.357
MOD_Cter_Amidation	303	306	PF01082	0.408
MOD_GlcNHglycan	113	117	PF01048	0.587
MOD_GlcNHglycan	149	152	PF01048	0.597
MOD_GlcNHglycan	177	180	PF01048	0.468
MOD_GlcNHglycan	302	305	PF01048	0.387
MOD_GlcNHglycan	343	346	PF01048	0.498
MOD_GSK3_1	112	119	PF00069	0.378
MOD_GSK3_1	133	140	PF00069	0.413
MOD_GSK3_1	146	153	PF00069	0.300
MOD_GSK3_1	161	168	PF00069	0.258
MOD_GSK3_1	175	182	PF00069	0.429
MOD_GSK3_1	261	268	PF00069	0.438
MOD_GSK3_1	300	307	PF00069	0.574
MOD_GSK3_1	65	72	PF00069	0.456
MOD_GSK3_1	83	90	PF00069	0.407
MOD_N-GLC_1	156	161	PF02516	0.543
MOD_N-GLC_1	242	247	PF02516	0.439
MOD_N-GLC_1	34	39	PF02516	0.588
MOD_N-GLC_1	99	104	PF02516	0.574
MOD_N-GLC_2	137	139	PF02516	0.677
MOD_NEK2_1	112	117	PF00069	0.396
MOD_NEK2_1	12	17	PF00069	0.561
MOD_NEK2_1	196	201	PF00069	0.409
MOD_NEK2_1	203	208	PF00069	0.418
MOD_NEK2_1	290	295	PF00069	0.539
MOD_NEK2_1	42	47	PF00069	0.410
MOD_NEK2_1	51	56	PF00069	0.368
MOD_NEK2_1	83	88	PF00069	0.401
MOD_PIKK_1	196	202	PF00454	0.429
MOD_PIKK_1	216	222	PF00454	0.217
MOD_PIKK_1	350	356	PF00454	0.687
MOD_PIKK_1	359	365	PF00454	0.644
MOD_PKA_2	203	209	PF00069	0.402
MOD_PKA_2	300	306	PF00069	0.669
MOD_PKB_1	173	181	PF00069	0.244
MOD_Plk_1	156	162	PF00069	0.320
MOD_Plk_1	21	27	PF00069	0.507
MOD_Plk_1	222	228	PF00069	0.389
MOD_Plk_1	242	248	PF00069	0.185
MOD_Plk_1	34	40	PF00069	0.337
MOD_Plk_2-3	189	195	PF00069	0.290
MOD_Plk_4	128	134	PF00069	0.415
MOD_Plk_4	137	143	PF00069	0.469
MOD_Plk_4	156	162	PF00069	0.339
MOD_Plk_4	179	185	PF00069	0.389
MOD_Plk_4	2	8	PF00069	0.633
MOD_Plk_4	225	231	PF00069	0.377
MOD_Plk_4	234	240	PF00069	0.339
MOD_Plk_4	44	50	PF00069	0.327
MOD_Plk_4	65	71	PF00069	0.399
MOD_Plk_4	99	105	PF00069	0.327
MOD_SUMO_for_1	309	312	PF00179	0.525
TRG_ENDOCYTIC_2	120	123	PF00928	0.444
TRG_ENDOCYTIC_2	193	196	PF00928	0.441
TRG_ENDOCYTIC_2	235	238	PF00928	0.405
TRG_ENDOCYTIC_2	278	281	PF00928	0.327
TRG_ER_diArg_1	172	175	PF00400	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L6	Leptomonas seymouri	47%	94%
A0A0S4IYQ4	Bodo saltans	26%	100%
A0A1X0NJ62	Trypanosomatidae	27%	100%
A0A3R7P473	Trypanosoma rangeli	26%	100%
A0A3S7WY17	Leishmania donovani	62%	100%
A4I0M9	Leishmania infantum	61%	100%
D0A6X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AWJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	98%
Q4QAX4	Leishmania major	61%	100%
V5C0T3	Trypanosoma cruzi	27%	100%