Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD63_LEIBR

TriTrypDb:

LbrM.24.0050 , LBRM2903_240005300

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.528
CLV_PCSK_KEX2_1	216	218	PF00082	0.354
CLV_PCSK_KEX2_1	32	34	PF00082	0.518
CLV_PCSK_KEX2_1	398	400	PF00082	0.310
CLV_PCSK_KEX2_1	405	407	PF00082	0.314
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.423
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.518
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.310
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.314
CLV_PCSK_SKI1_1	155	159	PF00082	0.577
CLV_PCSK_SKI1_1	170	174	PF00082	0.350
CLV_PCSK_SKI1_1	19	23	PF00082	0.583
CLV_PCSK_SKI1_1	216	220	PF00082	0.368
CLV_PCSK_SKI1_1	263	267	PF00082	0.357
CLV_PCSK_SKI1_1	283	287	PF00082	0.194
CLV_PCSK_SKI1_1	398	402	PF00082	0.288
CLV_PCSK_SKI1_1	419	423	PF00082	0.373
DEG_APCC_DBOX_1	23	31	PF00400	0.496
DEG_MDM2_SWIB_1	189	196	PF02201	0.330
DEG_Nend_Nbox_1	1	3	PF02207	0.508
DEG_SCF_FBW7_1	199	206	PF00400	0.314
DOC_CKS1_1	209	214	PF01111	0.335
DOC_CKS1_1	37	42	PF01111	0.488
DOC_CYCLIN_RxL_1	260	269	PF00134	0.388
DOC_MAPK_DCC_7	225	235	PF00069	0.441
DOC_MAPK_gen_1	216	223	PF00069	0.441
DOC_MAPK_MEF2A_6	292	300	PF00069	0.430
DOC_MAPK_MEF2A_6	419	428	PF00069	0.285
DOC_MAPK_MEF2A_6	42	51	PF00069	0.490
DOC_PP1_RVXF_1	156	162	PF00149	0.391
DOC_PP1_RVXF_1	188	195	PF00149	0.241
DOC_PP2B_LxvP_1	461	464	PF13499	0.361
DOC_USP7_MATH_1	157	161	PF00917	0.342
DOC_USP7_MATH_1	166	170	PF00917	0.357
DOC_USP7_UBL2_3	32	36	PF12436	0.409
DOC_USP7_UBL2_3	62	66	PF12436	0.490
DOC_WW_Pin1_4	138	143	PF00397	0.416
DOC_WW_Pin1_4	199	204	PF00397	0.410
DOC_WW_Pin1_4	208	213	PF00397	0.444
DOC_WW_Pin1_4	36	41	PF00397	0.470
DOC_WW_Pin1_4	96	101	PF00397	0.533
LIG_14-3-3_CanoR_1	113	119	PF00244	0.443
LIG_14-3-3_CanoR_1	140	149	PF00244	0.499
LIG_14-3-3_CanoR_1	24	30	PF00244	0.375
LIG_14-3-3_CanoR_1	263	273	PF00244	0.305
LIG_14-3-3_CanoR_1	283	288	PF00244	0.460
LIG_14-3-3_CanoR_1	434	438	PF00244	0.445
LIG_14-3-3_CanoR_1	9	14	PF00244	0.458
LIG_BRCT_BRCA1_1	185	189	PF00533	0.543
LIG_Clathr_ClatBox_1	146	150	PF01394	0.296
LIG_Clathr_ClatBox_1	232	236	PF01394	0.249
LIG_DCNL_PONY_1	1	4	PF03556	0.416
LIG_EH1_1	223	231	PF00400	0.238
LIG_FHA_1	122	128	PF00498	0.520
LIG_FHA_1	200	206	PF00498	0.574
LIG_FHA_1	276	282	PF00498	0.343
LIG_FHA_1	415	421	PF00498	0.294
LIG_FHA_1	447	453	PF00498	0.282
LIG_FHA_1	63	69	PF00498	0.691
LIG_FHA_2	312	318	PF00498	0.502
LIG_FHA_2	346	352	PF00498	0.395
LIG_FHA_2	363	369	PF00498	0.360
LIG_FHA_2	74	80	PF00498	0.442
LIG_GBD_Chelix_1	424	432	PF00786	0.417
LIG_GBD_Chelix_1	82	90	PF00786	0.556
LIG_LIR_Apic_2	249	254	PF02991	0.352
LIG_LIR_Gen_1	252	261	PF02991	0.456
LIG_LIR_Gen_1	351	361	PF02991	0.285
LIG_LIR_LC3C_4	150	153	PF02991	0.236
LIG_LIR_Nem_3	186	192	PF02991	0.423
LIG_LIR_Nem_3	252	258	PF02991	0.370
LIG_LIR_Nem_3	272	276	PF02991	0.225
LIG_LIR_Nem_3	351	357	PF02991	0.280
LIG_LIR_Nem_3	368	373	PF02991	0.280
LIG_NRBOX	194	200	PF00104	0.439
LIG_NRBOX	3	9	PF00104	0.399
LIG_OCRL_FandH_1	288	300	PF00620	0.432
LIG_Pex14_2	189	193	PF04695	0.335
LIG_Pex14_2	354	358	PF04695	0.380
LIG_SH2_CRK	273	277	PF00017	0.441
LIG_SH2_CRK	435	439	PF00017	0.412
LIG_SH2_NCK_1	251	255	PF00017	0.341
LIG_SH2_STAT5	242	245	PF00017	0.345
LIG_SH2_STAT5	273	276	PF00017	0.339
LIG_SH2_STAT5	435	438	PF00017	0.407
LIG_SH2_STAT5	88	91	PF00017	0.390
LIG_Sin3_3	418	425	PF02671	0.319
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.539
LIG_SUMO_SIM_anti_2	143	150	PF11976	0.242
LIG_SUMO_SIM_anti_2	449	456	PF11976	0.345
LIG_SUMO_SIM_par_1	194	200	PF11976	0.325
LIG_SUMO_SIM_par_1	231	237	PF11976	0.255
LIG_TRAF2_1	314	317	PF00917	0.360
LIG_TYR_ITIM	240	245	PF00017	0.410
LIG_UBA3_1	392	398	PF00899	0.309
LIG_UBA3_1	56	62	PF00899	0.604
LIG_UBA3_1	71	78	PF00899	0.554
LIG_Vh1_VBS_1	287	305	PF01044	0.233
MOD_CDK_SPxK_1	36	42	PF00069	0.530
MOD_CDK_SPxxK_3	96	103	PF00069	0.461
MOD_CK1_1	141	147	PF00069	0.286
MOD_CK1_1	197	203	PF00069	0.393
MOD_CK1_1	208	214	PF00069	0.445
MOD_CK1_1	308	314	PF00069	0.360
MOD_CK1_1	333	339	PF00069	0.381
MOD_CK2_1	243	249	PF00069	0.285
MOD_CK2_1	311	317	PF00069	0.426
MOD_CK2_1	73	79	PF00069	0.455
MOD_Cter_Amidation	214	217	PF01082	0.467
MOD_GlcNHglycan	143	146	PF01048	0.512
MOD_GlcNHglycan	199	202	PF01048	0.359
MOD_GlcNHglycan	212	215	PF01048	0.432
MOD_GlcNHglycan	332	335	PF01048	0.418
MOD_GlcNHglycan	381	384	PF01048	0.472
MOD_GlcNHglycan	52	55	PF01048	0.482
MOD_GSK3_1	119	126	PF00069	0.379
MOD_GSK3_1	199	206	PF00069	0.325
MOD_GSK3_1	271	278	PF00069	0.382
MOD_GSK3_1	433	440	PF00069	0.545
MOD_LATS_1	138	144	PF00433	0.307
MOD_N-GLC_1	379	384	PF02516	0.452
MOD_NEK2_1	151	156	PF00069	0.361
MOD_NEK2_1	172	177	PF00069	0.415
MOD_NEK2_1	194	199	PF00069	0.529
MOD_NEK2_1	205	210	PF00069	0.375
MOD_NEK2_1	243	248	PF00069	0.237
MOD_NEK2_1	264	269	PF00069	0.497
MOD_NEK2_1	50	55	PF00069	0.446
MOD_NEK2_1	60	65	PF00069	0.464
MOD_OFUCOSY	120	125	PF10250	0.293
MOD_PIKK_1	205	211	PF00454	0.444
MOD_PIKK_1	311	317	PF00454	0.515
MOD_PKA_2	308	314	PF00069	0.581
MOD_PKA_2	433	439	PF00069	0.448
MOD_Plk_1	108	114	PF00069	0.351
MOD_Plk_1	183	189	PF00069	0.520
MOD_Plk_1	78	84	PF00069	0.454
MOD_Plk_4	194	200	PF00069	0.430
MOD_Plk_4	25	31	PF00069	0.568
MOD_Plk_4	427	433	PF00069	0.427
MOD_Plk_4	84	90	PF00069	0.382
MOD_ProDKin_1	138	144	PF00069	0.410
MOD_ProDKin_1	199	205	PF00069	0.411
MOD_ProDKin_1	208	214	PF00069	0.430
MOD_ProDKin_1	36	42	PF00069	0.472
MOD_ProDKin_1	96	102	PF00069	0.535
TRG_DiLeu_BaEn_1	260	265	PF01217	0.287
TRG_DiLeu_BaEn_1	416	421	PF01217	0.510
TRG_DiLeu_BaEn_1	450	455	PF01217	0.342
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.280
TRG_DiLeu_LyEn_5	260	265	PF01217	0.271
TRG_ENDOCYTIC_2	242	245	PF00928	0.410
TRG_ENDOCYTIC_2	273	276	PF00928	0.440
TRG_ENDOCYTIC_2	435	438	PF00928	0.407
TRG_NLS_MonoExtN_4	395	401	PF00514	0.291
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX3	Leptomonas seymouri	53%	100%
A0A1X0NIQ1	Trypanosomatidae	28%	100%
A0A3R7MWR0	Trypanosoma rangeli	29%	98%
A0A3S7WY18	Leishmania donovani	80%	100%
A4I0M8	Leishmania infantum	80%	100%
D0A6X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
E9AWJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAX5	Leishmania major	80%	100%
V5BRC9	Trypanosoma cruzi	29%	99%