Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD61_LEIBR

TriTrypDb:

LbrM.24.0030

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.414
CLV_NRD_NRD_1	129	131	PF00675	0.562
CLV_NRD_NRD_1	135	137	PF00675	0.611
CLV_NRD_NRD_1	164	166	PF00675	0.723
CLV_NRD_NRD_1	46	48	PF00675	0.624
CLV_PCSK_KEX2_1	137	139	PF00082	0.565
CLV_PCSK_KEX2_1	46	48	PF00082	0.624
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.562
CLV_PCSK_SKI1_1	58	62	PF00082	0.486
DEG_APCC_KENBOX_2	107	111	PF00400	0.423
DEG_Nend_UBRbox_1	1	4	PF02207	0.509
DOC_MAPK_gen_1	107	114	PF00069	0.445
DOC_PP1_RVXF_1	56	63	PF00149	0.357
DOC_PP4_FxxP_1	62	65	PF00568	0.300
DOC_USP7_MATH_1	95	99	PF00917	0.502
DOC_USP7_UBL2_3	133	137	PF12436	0.507
DOC_WW_Pin1_4	154	159	PF00397	0.543
LIG_14-3-3_CanoR_1	152	157	PF00244	0.643
LIG_14-3-3_CanoR_1	2	7	PF00244	0.480
LIG_14-3-3_CanoR_1	58	63	PF00244	0.463
LIG_BRCT_BRCA1_1	100	104	PF00533	0.431
LIG_DLG_GKlike_1	2	9	PF00625	0.412
LIG_Integrin_RGD_1	160	162	PF01839	0.480
LIG_LIR_Apic_2	61	65	PF02991	0.300
LIG_LIR_Nem_3	101	106	PF02991	0.398
LIG_LIR_Nem_3	155	159	PF02991	0.468
LIG_LIR_Nem_3	5	9	PF02991	0.479
LIG_MLH1_MIPbox_1	100	104	PF16413	0.406
LIG_REV1ctd_RIR_1	101	112	PF16727	0.403
LIG_SH2_CRK	90	94	PF00017	0.470
LIG_SH2_STAT3	21	24	PF00017	0.602
LIG_SH3_1	47	53	PF00018	0.522
LIG_SH3_3	47	53	PF00018	0.411
LIG_TYR_ITIM	88	93	PF00017	0.489
LIG_WRC_WIRS_1	59	64	PF05994	0.406
MOD_CDC14_SPxK_1	157	160	PF00782	0.498
MOD_CDK_SPxK_1	154	160	PF00069	0.496
MOD_CK1_1	5	11	PF00069	0.530
MOD_CK1_1	98	104	PF00069	0.450
MOD_DYRK1A_RPxSP_1	154	158	PF00069	0.553
MOD_GlcNHglycan	117	120	PF01048	0.488
MOD_GlcNHglycan	97	100	PF01048	0.534
MOD_GSK3_1	115	122	PF00069	0.342
MOD_GSK3_1	33	40	PF00069	0.494
MOD_NEK2_1	83	88	PF00069	0.290
MOD_PKA_2	33	39	PF00069	0.469
MOD_PKA_2	83	89	PF00069	0.297
MOD_Plk_4	83	89	PF00069	0.297
MOD_ProDKin_1	154	160	PF00069	0.546
MOD_SUMO_rev_2	132	139	PF00179	0.580
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.460
TRG_ENDOCYTIC_2	90	93	PF00928	0.474
TRG_ER_diArg_1	151	154	PF00400	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NIP0	Trypanosomatidae	43%	98%
A0A3S7WXZ3	Leishmania donovani	80%	100%
A0A422P424	Trypanosoma rangeli	39%	100%
A4I0M6	Leishmania infantum	80%	100%
D0A6X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	95%
E9AWJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QAX7	Leishmania major	80%	100%