Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyruvate dehydrogenase (lipoamide) kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD59_LEIBR

TriTrypDb:

LbrM.24.0010 , LBRM2903_240005000

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	12
GO:0031974	membrane-enclosed lumen	2	12
GO:0043233	organelle lumen	3	12
GO:0070013	intracellular organelle lumen	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HD59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD59

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0006109	regulation of carbohydrate metabolic process	5	1
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	1
GO:0010906	regulation of glucose metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.444
CLV_C14_Caspase3-7	22	26	PF00656	0.587
CLV_NRD_NRD_1	125	127	PF00675	0.227
CLV_NRD_NRD_1	177	179	PF00675	0.219
CLV_NRD_NRD_1	3	5	PF00675	0.509
CLV_NRD_NRD_1	37	39	PF00675	0.668
CLV_PCSK_KEX2_1	125	127	PF00082	0.302
CLV_PCSK_KEX2_1	177	179	PF00082	0.219
CLV_PCSK_KEX2_1	199	201	PF00082	0.147
CLV_PCSK_KEX2_1	3	5	PF00082	0.525
CLV_PCSK_KEX2_1	362	364	PF00082	0.466
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.147
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.466
CLV_PCSK_SKI1_1	177	181	PF00082	0.255
CLV_PCSK_SKI1_1	363	367	PF00082	0.433
CLV_PCSK_SKI1_1	61	65	PF00082	0.644
DEG_APCC_DBOX_1	116	124	PF00400	0.407
DEG_APCC_DBOX_1	227	235	PF00400	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.455
DEG_SCF_FBW7_1	157	164	PF00400	0.427
DEG_SPOP_SBC_1	41	45	PF00917	0.566
DOC_CKS1_1	102	107	PF01111	0.343
DOC_CKS1_1	73	78	PF01111	0.550
DOC_CYCLIN_yClb5_NLxxxL_5	67	74	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.568
DOC_MAPK_DCC_7	306	315	PF00069	0.220
DOC_MAPK_gen_1	171	181	PF00069	0.543
DOC_MAPK_gen_1	199	206	PF00069	0.471
DOC_MAPK_gen_1	280	287	PF00069	0.403
DOC_MAPK_gen_1	343	353	PF00069	0.465
DOC_MAPK_gen_1	362	368	PF00069	0.286
DOC_MAPK_gen_1	61	70	PF00069	0.543
DOC_MAPK_gen_1	88	96	PF00069	0.454
DOC_MAPK_HePTP_8	303	315	PF00069	0.336
DOC_MAPK_MEF2A_6	306	315	PF00069	0.341
DOC_MAPK_MEF2A_6	346	355	PF00069	0.447
DOC_PP1_RVXF_1	228	234	PF00149	0.398
DOC_PP1_RVXF_1	90	97	PF00149	0.345
DOC_PP2B_LxvP_1	261	264	PF13499	0.427
DOC_PP2B_LxvP_1	439	442	PF13499	0.305
DOC_SPAK_OSR1_1	232	236	PF12202	0.407
DOC_USP7_MATH_1	40	44	PF00917	0.459
DOC_USP7_MATH_1	447	451	PF00917	0.461
DOC_USP7_UBL2_3	289	293	PF12436	0.416
DOC_USP7_UBL2_3	346	350	PF12436	0.465
DOC_USP7_UBL2_3	35	39	PF12436	0.463
DOC_USP7_UBL2_3	88	92	PF12436	0.471
DOC_WW_Pin1_4	101	106	PF00397	0.457
DOC_WW_Pin1_4	157	162	PF00397	0.504
DOC_WW_Pin1_4	404	409	PF00397	0.345
DOC_WW_Pin1_4	42	47	PF00397	0.446
DOC_WW_Pin1_4	72	77	PF00397	0.556
LIG_14-3-3_CanoR_1	128	137	PF00244	0.360
LIG_14-3-3_CanoR_1	367	375	PF00244	0.298
LIG_14-3-3_CanoR_1	378	383	PF00244	0.363
LIG_APCC_ABBA_1	263	268	PF00400	0.462
LIG_BRCT_BRCA1_1	360	364	PF00533	0.319
LIG_deltaCOP1_diTrp_1	33	37	PF00928	0.467
LIG_EH1_1	183	191	PF00400	0.407
LIG_eIF4E_1	184	190	PF01652	0.424
LIG_FHA_1	16	22	PF00498	0.601
LIG_FHA_1	241	247	PF00498	0.412
LIG_FHA_1	260	266	PF00498	0.353
LIG_FHA_1	320	326	PF00498	0.306
LIG_FHA_1	63	69	PF00498	0.653
LIG_FHA_2	102	108	PF00498	0.317
LIG_FHA_2	14	20	PF00498	0.583
LIG_FHA_2	162	168	PF00498	0.557
LIG_FHA_2	211	217	PF00498	0.382
LIG_FHA_2	347	353	PF00498	0.470
LIG_FHA_2	73	79	PF00498	0.382
LIG_LIR_Gen_1	153	162	PF02991	0.422
LIG_LIR_Gen_1	16	24	PF02991	0.594
LIG_LIR_Gen_1	201	211	PF02991	0.491
LIG_LIR_Gen_1	213	221	PF02991	0.367
LIG_LIR_Gen_1	322	330	PF02991	0.389
LIG_LIR_Gen_1	77	87	PF02991	0.417
LIG_LIR_Gen_1	93	102	PF02991	0.347
LIG_LIR_Nem_3	113	119	PF02991	0.324
LIG_LIR_Nem_3	153	157	PF02991	0.401
LIG_LIR_Nem_3	16	20	PF02991	0.592
LIG_LIR_Nem_3	201	206	PF02991	0.452
LIG_LIR_Nem_3	213	217	PF02991	0.382
LIG_LIR_Nem_3	312	318	PF02991	0.343
LIG_LIR_Nem_3	322	326	PF02991	0.320
LIG_LIR_Nem_3	33	37	PF02991	0.632
LIG_LIR_Nem_3	385	390	PF02991	0.410
LIG_LIR_Nem_3	77	82	PF02991	0.404
LIG_LIR_Nem_3	93	99	PF02991	0.368
LIG_MYND_1	11	15	PF01753	0.496
LIG_PDZ_Class_2	446	451	PF00595	0.305
LIG_Pex14_2	220	224	PF04695	0.450
LIG_Pex14_2	27	31	PF04695	0.576
LIG_PTB_Apo_2	234	241	PF02174	0.437
LIG_PTB_Apo_2	95	102	PF02174	0.438
LIG_PTB_Phospho_1	234	240	PF10480	0.437
LIG_PTB_Phospho_1	95	101	PF10480	0.442
LIG_SH2_CRK	238	242	PF00017	0.437
LIG_SH2_CRK	323	327	PF00017	0.281
LIG_SH2_CRK	390	394	PF00017	0.388
LIG_SH2_GRB2like	101	104	PF00017	0.455
LIG_SH2_SRC	323	326	PF00017	0.399
LIG_SH2_SRC	440	443	PF00017	0.376
LIG_SH2_STAP1	299	303	PF00017	0.389
LIG_SH2_STAP1	413	417	PF00017	0.287
LIG_SH2_STAT3	86	89	PF00017	0.319
LIG_SH2_STAT5	101	104	PF00017	0.431
LIG_SH2_STAT5	119	122	PF00017	0.395
LIG_SH2_STAT5	240	243	PF00017	0.414
LIG_SH2_STAT5	440	443	PF00017	0.299
LIG_SH3_3	252	258	PF00018	0.491
LIG_SH3_3	313	319	PF00018	0.365
LIG_SH3_3	70	76	PF00018	0.533
LIG_SH3_4	346	353	PF00018	0.330
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.388
LIG_SUMO_SIM_par_1	283	288	PF11976	0.282
LIG_TRAF2_1	249	252	PF00917	0.507
LIG_TRAF2_1	75	78	PF00917	0.445
LIG_TYR_ITIM	321	326	PF00017	0.280
LIG_UBA3_1	284	289	PF00899	0.398
LIG_WRC_WIRS_1	24	29	PF05994	0.479
MOD_CDC14_SPxK_1	407	410	PF00782	0.302
MOD_CDK_SPK_2	42	47	PF00069	0.579
MOD_CDK_SPxK_1	404	410	PF00069	0.336
MOD_CK1_1	188	194	PF00069	0.502
MOD_CK1_1	385	391	PF00069	0.428
MOD_CK1_1	400	406	PF00069	0.537
MOD_CK2_1	13	19	PF00069	0.595
MOD_CK2_1	210	216	PF00069	0.419
MOD_CK2_1	246	252	PF00069	0.507
MOD_CK2_1	346	352	PF00069	0.455
MOD_CK2_1	56	62	PF00069	0.503
MOD_CK2_1	72	78	PF00069	0.397
MOD_CMANNOS	149	152	PF00535	0.237
MOD_GlcNHglycan	251	255	PF01048	0.147
MOD_GSK3_1	157	164	PF00069	0.553
MOD_GSK3_1	184	191	PF00069	0.445
MOD_GSK3_1	246	253	PF00069	0.426
MOD_GSK3_1	378	385	PF00069	0.346
MOD_GSK3_1	399	406	PF00069	0.454
MOD_GSK3_1	42	49	PF00069	0.471
MOD_N-GLC_1	184	189	PF02516	0.207
MOD_N-GLC_1	423	428	PF02516	0.325
MOD_NEK2_1	239	244	PF00069	0.457
MOD_NEK2_1	285	290	PF00069	0.460
MOD_NEK2_1	382	387	PF00069	0.313
MOD_NEK2_1	56	61	PF00069	0.389
MOD_NEK2_2	150	155	PF00069	0.407
MOD_NEK2_2	373	378	PF00069	0.473
MOD_PIKK_1	135	141	PF00454	0.407
MOD_PKA_1	280	286	PF00069	0.351
MOD_PKA_2	366	372	PF00069	0.329
MOD_PKB_1	126	134	PF00069	0.367
MOD_Plk_1	184	190	PF00069	0.419
MOD_Plk_1	250	256	PF00069	0.449
MOD_Plk_1	351	357	PF00069	0.449
MOD_Plk_1	423	429	PF00069	0.314
MOD_Plk_4	111	117	PF00069	0.513
MOD_Plk_4	185	191	PF00069	0.524
MOD_Plk_4	280	286	PF00069	0.314
MOD_ProDKin_1	101	107	PF00069	0.454
MOD_ProDKin_1	157	163	PF00069	0.504
MOD_ProDKin_1	404	410	PF00069	0.336
MOD_ProDKin_1	42	48	PF00069	0.447
MOD_ProDKin_1	72	78	PF00069	0.553
MOD_SUMO_for_1	198	201	PF00179	0.452
MOD_SUMO_rev_2	28	37	PF00179	0.482
MOD_SUMO_rev_2	300	308	PF00179	0.392
MOD_SUMO_rev_2	58	66	PF00179	0.533
TRG_DiLeu_BaEn_4	77	83	PF01217	0.412
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.516
TRG_ENDOCYTIC_2	214	217	PF00928	0.469
TRG_ENDOCYTIC_2	238	241	PF00928	0.433
TRG_ENDOCYTIC_2	323	326	PF00928	0.319
TRG_ENDOCYTIC_2	390	393	PF00928	0.431
TRG_ER_diArg_1	125	128	PF00400	0.427
TRG_ER_diArg_1	176	178	PF00400	0.419
TRG_ER_diArg_1	2	4	PF00400	0.527
TRG_ER_diArg_1	228	231	PF00400	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAJ6	Leptomonas seymouri	67%	100%
A0A0S4JGW0	Bodo saltans	37%	98%
A0A1X0NJE4	Trypanosomatidae	55%	100%
A0A3S7WY35	Leishmania donovani	91%	93%
A0A422MQ68	Trypanosoma rangeli	49%	100%
A4I0M4	Leishmania infantum	91%	93%
D0A6X1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AWJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O02623	Ascaris suum	24%	100%
O54937	Rattus norvegicus	23%	100%
O88345	Ictidomys tridecemlineatus	21%	100%
Q02332	Caenorhabditis elegans	23%	100%
Q15118	Homo sapiens	23%	100%
Q15120	Homo sapiens	24%	100%
Q16654	Homo sapiens	22%	100%
Q4QAX9	Leishmania major	91%	100%
Q63065	Rattus norvegicus	23%	100%
Q64536	Rattus norvegicus	22%	100%
Q922H2	Mus musculus	23%	100%
Q9JK42	Mus musculus	22%	100%
Q9SBJ1	Arabidopsis thaliana	25%	100%
V5C0T8	Trypanosoma cruzi	49%	100%