Cytochrome c oxidase subunit V

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase subunit V

Species:

Leishmania braziliensis

UniProt:

A4HD57_LEIBR

TriTrypDb:

LbrM.23.1970 , LBRM2903_230031000

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HD57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD57

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016491	oxidoreductase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.633
CLV_NRD_NRD_1	36	38	PF00675	0.438
CLV_NRD_NRD_1	62	64	PF00675	0.452
CLV_PCSK_KEX2_1	2	4	PF00082	0.557
CLV_PCSK_KEX2_1	62	64	PF00082	0.438
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.517
CLV_PCSK_SKI1_1	143	147	PF00082	0.342
CLV_PCSK_SKI1_1	16	20	PF00082	0.475
CLV_PCSK_SKI1_1	76	80	PF00082	0.460
CLV_PCSK_SKI1_1	88	92	PF00082	0.346
DEG_APCC_KENBOX_2	68	72	PF00400	0.407
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DOC_CDC14_PxL_1	95	103	PF14671	0.365
DOC_CKS1_1	176	181	PF01111	0.520
DOC_CYCLIN_RxL_1	140	148	PF00134	0.338
DOC_MAPK_DCC_7	129	137	PF00069	0.282
DOC_MAPK_gen_1	69	79	PF00069	0.497
DOC_MAPK_MEF2A_6	104	112	PF00069	0.409
DOC_MAPK_MEF2A_6	129	137	PF00069	0.282
DOC_MAPK_MEF2A_6	72	79	PF00069	0.499
DOC_PP4_FxxP_1	120	123	PF00568	0.373
DOC_PP4_FxxP_1	176	179	PF00568	0.518
DOC_PP4_FxxP_1	4	7	PF00568	0.565
DOC_PP4_FxxP_1	78	81	PF00568	0.416
DOC_SPAK_OSR1_1	3	7	PF12202	0.624
DOC_USP7_UBL2_3	189	193	PF12436	0.564
DOC_WW_Pin1_4	151	156	PF00397	0.384
DOC_WW_Pin1_4	175	180	PF00397	0.505
LIG_14-3-3_CanoR_1	156	162	PF00244	0.369
LIG_14-3-3_CanoR_1	44	53	PF00244	0.434
LIG_APCC_ABBA_1	131	136	PF00400	0.370
LIG_BRCT_BRCA1_1	10	14	PF00533	0.516
LIG_eIF4E_1	140	146	PF01652	0.439
LIG_FHA_1	176	182	PF00498	0.522
LIG_GBD_Chelix_1	137	145	PF00786	0.324
LIG_LIR_Apic_2	118	123	PF02991	0.372
LIG_LIR_Apic_2	173	179	PF02991	0.502
LIG_LIR_Gen_1	124	135	PF02991	0.395
LIG_LIR_Gen_1	29	39	PF02991	0.398
LIG_LIR_Gen_1	73	81	PF02991	0.433
LIG_LIR_Nem_3	124	130	PF02991	0.417
LIG_LIR_Nem_3	73	77	PF02991	0.446
LIG_LYPXL_yS_3	98	101	PF13949	0.370
LIG_Pex14_2	14	18	PF04695	0.515
LIG_Pex14_2	19	23	PF04695	0.439
LIG_Pex14_2	74	78	PF04695	0.479
LIG_REV1ctd_RIR_1	16	25	PF16727	0.463
LIG_SH2_CRK	127	131	PF00017	0.390
LIG_SH2_STAP1	127	131	PF00017	0.390
LIG_SH2_STAP1	32	36	PF00017	0.455
LIG_SH2_STAP1	49	53	PF00017	0.348
LIG_SH2_STAP1	93	97	PF00017	0.365
LIG_SH2_STAT5	140	143	PF00017	0.445
LIG_SH3_3	127	133	PF00018	0.385
LIG_SH3_3	74	80	PF00018	0.436
LIG_SH3_5	123	127	PF00018	0.433
LIG_UBA3_1	145	150	PF00899	0.371
LIG_WRC_WIRS_1	185	190	PF05994	0.461
MOD_CDK_SPK_2	151	156	PF00069	0.384
MOD_CK2_1	141	147	PF00069	0.331
MOD_CK2_1	157	163	PF00069	0.391
MOD_GSK3_1	10	17	PF00069	0.572
MOD_GSK3_1	141	148	PF00069	0.371
MOD_GSK3_1	157	164	PF00069	0.411
MOD_GSK3_1	27	34	PF00069	0.521
MOD_GSK3_1	44	51	PF00069	0.385
MOD_N-GLC_1	70	75	PF02516	0.428
MOD_NEK2_1	14	19	PF00069	0.619
MOD_NEK2_1	141	146	PF00069	0.334
MOD_NEK2_1	161	166	PF00069	0.392
MOD_NEK2_2	27	32	PF00069	0.419
MOD_PIKK_1	44	50	PF00454	0.430
MOD_Plk_1	70	76	PF00069	0.434
MOD_Plk_4	141	147	PF00069	0.331
MOD_Plk_4	157	163	PF00069	0.370
MOD_Plk_4	27	33	PF00069	0.411
MOD_Plk_4	70	76	PF00069	0.470
MOD_Plk_4	91	97	PF00069	0.356
MOD_ProDKin_1	151	157	PF00069	0.378
MOD_ProDKin_1	175	181	PF00069	0.510
MOD_SUMO_for_1	108	111	PF00179	0.430
MOD_SUMO_for_1	149	152	PF00179	0.399
MOD_SUMO_rev_2	66	74	PF00179	0.457
TRG_DiLeu_BaEn_2	69	75	PF01217	0.451
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.333
TRG_ENDOCYTIC_2	127	130	PF00928	0.399
TRG_ENDOCYTIC_2	32	35	PF00928	0.486
TRG_ENDOCYTIC_2	93	96	PF00928	0.344
TRG_ENDOCYTIC_2	98	101	PF00928	0.363
TRG_ER_diArg_1	61	63	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C4	Leptomonas seymouri	92%	100%
A0A1X0NHI2	Trypanosomatidae	88%	100%
A0A3Q8IDX4	Leishmania donovani	94%	100%
A0A3R7N5B2	Trypanosoma rangeli	89%	100%
A4I2A3	Leishmania infantum	94%	100%
C9ZXD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
E9AYF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q922	Leishmania major	94%	100%