Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HD56_LEIBR

TriTrypDb:

LbrM.23.1960 , LBRM2903_230030900

Length:

721

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.596
CLV_C14_Caspase3-7	207	211	PF00656	0.573
CLV_MEL_PAP_1	503	509	PF00089	0.706
CLV_NRD_NRD_1	21	23	PF00675	0.487
CLV_NRD_NRD_1	253	255	PF00675	0.512
CLV_NRD_NRD_1	285	287	PF00675	0.477
CLV_NRD_NRD_1	313	315	PF00675	0.436
CLV_NRD_NRD_1	451	453	PF00675	0.670
CLV_NRD_NRD_1	626	628	PF00675	0.808
CLV_NRD_NRD_1	630	632	PF00675	0.705
CLV_NRD_NRD_1	650	652	PF00675	0.489
CLV_NRD_NRD_1	96	98	PF00675	0.617
CLV_PCSK_KEX2_1	253	255	PF00082	0.458
CLV_PCSK_KEX2_1	285	287	PF00082	0.598
CLV_PCSK_KEX2_1	400	402	PF00082	0.739
CLV_PCSK_KEX2_1	451	453	PF00082	0.670
CLV_PCSK_KEX2_1	611	613	PF00082	0.738
CLV_PCSK_KEX2_1	626	628	PF00082	0.759
CLV_PCSK_KEX2_1	95	97	PF00082	0.718
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.739
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.731
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.560
CLV_PCSK_SKI1_1	232	236	PF00082	0.635
CLV_PCSK_SKI1_1	278	282	PF00082	0.518
CLV_PCSK_SKI1_1	336	340	PF00082	0.544
CLV_PCSK_SKI1_1	348	352	PF00082	0.381
CLV_PCSK_SKI1_1	41	45	PF00082	0.751
DEG_SPOP_SBC_1	287	291	PF00917	0.562
DEG_SPOP_SBC_1	381	385	PF00917	0.624
DEG_SPOP_SBC_1	679	683	PF00917	0.782
DOC_CKS1_1	558	563	PF01111	0.588
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	558	564	PF00134	0.528
DOC_MAPK_gen_1	10	20	PF00069	0.540
DOC_MAPK_gen_1	285	295	PF00069	0.529
DOC_MAPK_gen_1	336	345	PF00069	0.607
DOC_MAPK_gen_1	431	441	PF00069	0.552
DOC_MAPK_gen_1	578	587	PF00069	0.672
DOC_MAPK_MEF2A_6	434	443	PF00069	0.497
DOC_USP7_MATH_1	14	18	PF00917	0.539
DOC_USP7_MATH_1	287	291	PF00917	0.514
DOC_USP7_MATH_1	304	308	PF00917	0.496
DOC_USP7_MATH_1	395	399	PF00917	0.784
DOC_USP7_MATH_1	43	47	PF00917	0.695
DOC_USP7_MATH_1	489	493	PF00917	0.641
DOC_USP7_MATH_1	536	540	PF00917	0.592
DOC_USP7_MATH_1	619	623	PF00917	0.831
DOC_USP7_MATH_1	657	661	PF00917	0.695
DOC_USP7_MATH_1	680	684	PF00917	0.774
DOC_WW_Pin1_4	288	293	PF00397	0.546
DOC_WW_Pin1_4	53	58	PF00397	0.724
DOC_WW_Pin1_4	557	562	PF00397	0.571
DOC_WW_Pin1_4	672	677	PF00397	0.751
LIG_14-3-3_CanoR_1	106	112	PF00244	0.635
LIG_14-3-3_CanoR_1	22	31	PF00244	0.420
LIG_14-3-3_CanoR_1	232	240	PF00244	0.663
LIG_14-3-3_CanoR_1	253	258	PF00244	0.398
LIG_14-3-3_CanoR_1	285	295	PF00244	0.458
LIG_14-3-3_CanoR_1	348	353	PF00244	0.343
LIG_14-3-3_CanoR_1	410	416	PF00244	0.695
LIG_14-3-3_CanoR_1	431	437	PF00244	0.608
LIG_14-3-3_CanoR_1	451	457	PF00244	0.461
LIG_14-3-3_CanoR_1	551	561	PF00244	0.700
LIG_14-3-3_CanoR_1	567	575	PF00244	0.582
LIG_14-3-3_CanoR_1	670	678	PF00244	0.708
LIG_14-3-3_CanoR_1	711	719	PF00244	0.576
LIG_14-3-3_CanoR_1	80	90	PF00244	0.551
LIG_APCC_ABBA_1	158	163	PF00400	0.440
LIG_APCC_ABBA_1	298	303	PF00400	0.383
LIG_APCC_ABBA_1	316	321	PF00400	0.548
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.615
LIG_BRCT_BRCA1_1	23	27	PF00533	0.609
LIG_eIF4E_1	488	494	PF01652	0.638
LIG_FHA_1	436	442	PF00498	0.486
LIG_FHA_1	468	474	PF00498	0.549
LIG_FHA_1	661	667	PF00498	0.579
LIG_FHA_1	67	73	PF00498	0.709
LIG_FHA_2	174	180	PF00498	0.634
LIG_FHA_2	205	211	PF00498	0.408
LIG_FHA_2	320	326	PF00498	0.520
LIG_FHA_2	375	381	PF00498	0.697
LIG_FHA_2	389	395	PF00498	0.541
LIG_FHA_2	586	592	PF00498	0.664
LIG_FHA_2	84	90	PF00498	0.803
LIG_LIR_Apic_2	169	173	PF02991	0.330
LIG_LIR_Gen_1	24	34	PF02991	0.616
LIG_LIR_Gen_1	321	332	PF02991	0.454
LIG_LIR_Gen_1	435	444	PF02991	0.641
LIG_LIR_Nem_3	24	30	PF02991	0.603
LIG_LIR_Nem_3	321	327	PF02991	0.453
LIG_LIR_Nem_3	435	439	PF02991	0.581
LIG_PDZ_Class_2	716	721	PF00595	0.570
LIG_PTB_Apo_2	495	502	PF02174	0.652
LIG_PTB_Phospho_1	495	501	PF10480	0.656
LIG_RPA_C_Fungi	646	658	PF08784	0.572
LIG_SH2_CRK	102	106	PF00017	0.715
LIG_SH2_GRB2like	496	499	PF00017	0.696
LIG_SH2_NCK_1	488	492	PF00017	0.714
LIG_SH2_PTP2	170	173	PF00017	0.398
LIG_SH2_SRC	488	491	PF00017	0.679
LIG_SH2_SRC	496	499	PF00017	0.634
LIG_SH2_STAP1	162	166	PF00017	0.597
LIG_SH2_STAT5	170	173	PF00017	0.464
LIG_SH2_STAT5	201	204	PF00017	0.628
LIG_SH2_STAT5	425	428	PF00017	0.598
LIG_SH2_STAT5	514	517	PF00017	0.551
LIG_SH2_STAT5	606	609	PF00017	0.615
LIG_SH2_STAT5	68	71	PF00017	0.562
LIG_SH3_3	125	131	PF00018	0.681
LIG_SH3_3	281	287	PF00018	0.498
LIG_SH3_3	326	332	PF00018	0.569
LIG_SH3_3	530	536	PF00018	0.706
LIG_SH3_3	576	582	PF00018	0.653
LIG_SH3_3	673	679	PF00018	0.647
LIG_SH3_3	8	14	PF00018	0.559
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.385
LIG_SUMO_SIM_par_1	116	123	PF11976	0.597
LIG_SUMO_SIM_par_1	188	196	PF11976	0.632
LIG_SUMO_SIM_par_1	325	331	PF11976	0.308
LIG_SUMO_SIM_par_1	437	442	PF11976	0.486
LIG_SxIP_EBH_1	658	672	PF03271	0.681
LIG_TRAF2_1	221	224	PF00917	0.510
LIG_TRAF2_1	61	64	PF00917	0.791
LIG_TYR_ITIM	160	165	PF00017	0.523
MOD_CDC14_SPxK_1	56	59	PF00782	0.626
MOD_CDK_SPxK_1	53	59	PF00069	0.616
MOD_CK1_1	21	27	PF00069	0.592
MOD_CK1_1	307	313	PF00069	0.430
MOD_CK1_1	385	391	PF00069	0.653
MOD_CK1_1	411	417	PF00069	0.734
MOD_CK1_1	429	435	PF00069	0.686
MOD_CK1_1	527	533	PF00069	0.760
MOD_CK1_1	570	576	PF00069	0.537
MOD_CK1_1	660	666	PF00069	0.743
MOD_CK1_1	669	675	PF00069	0.752
MOD_CK1_1	695	701	PF00069	0.824
MOD_CK1_1	713	719	PF00069	0.529
MOD_CK2_1	206	212	PF00069	0.418
MOD_CK2_1	22	28	PF00069	0.549
MOD_CK2_1	319	325	PF00069	0.483
MOD_CK2_1	386	392	PF00069	0.738
MOD_CK2_1	43	49	PF00069	0.695
MOD_CK2_1	536	542	PF00069	0.792
MOD_CK2_1	58	64	PF00069	0.747
MOD_CK2_1	83	89	PF00069	0.755
MOD_Cter_Amidation	449	452	PF01082	0.663
MOD_Cter_Amidation	629	632	PF01082	0.631
MOD_DYRK1A_RPxSP_1	288	292	PF00069	0.552
MOD_GlcNHglycan	107	110	PF01048	0.646
MOD_GlcNHglycan	195	198	PF01048	0.480
MOD_GlcNHglycan	384	387	PF01048	0.823
MOD_GlcNHglycan	394	398	PF01048	0.621
MOD_GlcNHglycan	45	48	PF01048	0.699
MOD_GlcNHglycan	554	557	PF01048	0.768
MOD_GlcNHglycan	627	630	PF01048	0.805
MOD_GlcNHglycan	638	641	PF01048	0.739
MOD_GlcNHglycan	672	675	PF01048	0.824
MOD_GlcNHglycan	698	701	PF01048	0.753
MOD_GlcNHglycan	705	708	PF01048	0.833
MOD_GlcNHglycan	714	718	PF01048	0.705
MOD_GlcNHglycan	97	100	PF01048	0.737
MOD_GSK3_1	101	108	PF00069	0.616
MOD_GSK3_1	14	21	PF00069	0.616
MOD_GSK3_1	173	180	PF00069	0.542
MOD_GSK3_1	381	388	PF00069	0.700
MOD_GSK3_1	411	418	PF00069	0.812
MOD_GSK3_1	452	459	PF00069	0.659
MOD_GSK3_1	524	531	PF00069	0.579
MOD_GSK3_1	601	608	PF00069	0.745
MOD_GSK3_1	621	628	PF00069	0.752
MOD_GSK3_1	657	664	PF00069	0.768
MOD_GSK3_1	666	673	PF00069	0.769
MOD_GSK3_1	692	699	PF00069	0.641
MOD_GSK3_1	703	710	PF00069	0.658
MOD_LATS_1	694	700	PF00433	0.588
MOD_N-GLC_1	204	209	PF02516	0.557
MOD_N-GLC_1	230	235	PF02516	0.560
MOD_N-GLC_1	304	309	PF02516	0.319
MOD_N-GLC_1	429	434	PF02516	0.765
MOD_N-GLC_1	66	71	PF02516	0.564
MOD_N-GLC_1	707	712	PF02516	0.680
MOD_N-GLC_2	306	308	PF02516	0.366
MOD_NEK2_1	105	110	PF00069	0.774
MOD_NEK2_1	153	158	PF00069	0.445
MOD_NEK2_1	204	209	PF00069	0.581
MOD_NEK2_1	382	387	PF00069	0.759
MOD_NEK2_1	393	398	PF00069	0.672
MOD_NEK2_1	415	420	PF00069	0.770
MOD_NEK2_1	585	590	PF00069	0.614
MOD_NEK2_1	66	71	PF00069	0.715
MOD_NEK2_2	101	106	PF00069	0.557
MOD_PIKK_1	524	530	PF00454	0.661
MOD_PIKK_1	586	592	PF00454	0.545
MOD_PIKK_1	59	65	PF00454	0.820
MOD_PIKK_1	595	601	PF00454	0.576
MOD_PK_1	452	458	PF00069	0.601
MOD_PK_1	611	617	PF00069	0.731
MOD_PKA_1	22	28	PF00069	0.430
MOD_PKA_1	253	259	PF00069	0.390
MOD_PKA_1	400	406	PF00069	0.739
MOD_PKA_1	611	617	PF00069	0.735
MOD_PKA_1	95	101	PF00069	0.559
MOD_PKA_2	105	111	PF00069	0.760
MOD_PKA_2	174	180	PF00069	0.514
MOD_PKA_2	21	27	PF00069	0.378
MOD_PKA_2	253	259	PF00069	0.390
MOD_PKA_2	287	293	PF00069	0.546
MOD_PKA_2	400	406	PF00069	0.713
MOD_PKA_2	411	417	PF00069	0.475
MOD_PKA_2	444	450	PF00069	0.604
MOD_PKA_2	528	534	PF00069	0.735
MOD_PKA_2	552	558	PF00069	0.691
MOD_PKA_2	58	64	PF00069	0.636
MOD_PKA_2	601	607	PF00069	0.668
MOD_PKA_2	611	617	PF00069	0.768
MOD_PKA_2	620	626	PF00069	0.625
MOD_PKA_2	657	663	PF00069	0.714
MOD_PKA_2	669	675	PF00069	0.727
MOD_PKA_2	695	701	PF00069	0.702
MOD_PKA_2	710	716	PF00069	0.581
MOD_PKA_2	81	87	PF00069	0.546
MOD_PKA_2	95	101	PF00069	0.630
MOD_PKB_1	80	88	PF00069	0.549
MOD_Plk_1	223	229	PF00069	0.487
MOD_Plk_1	248	254	PF00069	0.318
MOD_Plk_1	304	310	PF00069	0.317
MOD_Plk_1	489	495	PF00069	0.608
MOD_Plk_2-3	325	331	PF00069	0.308
MOD_Plk_4	224	230	PF00069	0.564
MOD_Plk_4	263	269	PF00069	0.450
MOD_Plk_4	307	313	PF00069	0.546
MOD_Plk_4	319	325	PF00069	0.405
MOD_Plk_4	337	343	PF00069	0.534
MOD_Plk_4	435	441	PF00069	0.732
MOD_Plk_4	489	495	PF00069	0.564
MOD_Plk_4	601	607	PF00069	0.620
MOD_Plk_4	611	617	PF00069	0.616
MOD_ProDKin_1	288	294	PF00069	0.537
MOD_ProDKin_1	53	59	PF00069	0.726
MOD_ProDKin_1	557	563	PF00069	0.572
MOD_ProDKin_1	672	678	PF00069	0.741
MOD_SUMO_rev_2	331	341	PF00179	0.485
MOD_SUMO_rev_2	359	365	PF00179	0.607
TRG_DiLeu_BaEn_2	541	547	PF01217	0.533
TRG_DiLeu_BaEn_3	223	229	PF01217	0.487
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.490
TRG_ENDOCYTIC_2	102	105	PF00928	0.714
TRG_ENDOCYTIC_2	162	165	PF00928	0.516
TRG_ENDOCYTIC_2	201	204	PF00928	0.632
TRG_ER_diArg_1	252	254	PF00400	0.514
TRG_ER_diArg_1	284	286	PF00400	0.579
TRG_ER_diArg_1	32	35	PF00400	0.654
TRG_ER_diArg_1	550	553	PF00400	0.736
TRG_ER_diArg_1	80	83	PF00400	0.553
TRG_NLS_MonoExtC_3	650	655	PF00514	0.572
TRG_NLS_MonoExtN_4	649	656	PF00514	0.641
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM04	Leptomonas seymouri	52%	100%
A0A3Q8IDQ2	Leishmania donovani	74%	100%
A0A3R7RDL2	Trypanosoma rangeli	36%	100%
A4I2A4	Leishmania infantum	74%	100%
E9AYF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q921	Leishmania major	74%	100%