Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HD54_LEIBR

TriTrypDb:

LbrM.23.1940 , LBRM2903_230030600

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	380	384	PF00656	0.368
CLV_C14_Caspase3-7	394	398	PF00656	0.421
CLV_C14_Caspase3-7	399	403	PF00656	0.596
CLV_NRD_NRD_1	145	147	PF00675	0.528
CLV_NRD_NRD_1	487	489	PF00675	0.509
CLV_NRD_NRD_1	506	508	PF00675	0.326
CLV_NRD_NRD_1	68	70	PF00675	0.631
CLV_PCSK_KEX2_1	145	147	PF00082	0.528
CLV_PCSK_KEX2_1	506	508	PF00082	0.588
CLV_PCSK_KEX2_1	68	70	PF00082	0.581
CLV_PCSK_SKI1_1	254	258	PF00082	0.436
CLV_PCSK_SKI1_1	354	358	PF00082	0.378
CLV_PCSK_SKI1_1	389	393	PF00082	0.573
CLV_PCSK_SKI1_1	73	77	PF00082	0.538
DEG_APCC_DBOX_1	26	34	PF00400	0.562
DEG_APCC_DBOX_1	505	513	PF00400	0.593
DEG_SPOP_SBC_1	78	82	PF00917	0.608
DOC_MAPK_DCC_7	127	136	PF00069	0.455
DOC_MAPK_gen_1	127	136	PF00069	0.402
DOC_MAPK_gen_1	248	257	PF00069	0.348
DOC_MAPK_gen_1	372	378	PF00069	0.258
DOC_MAPK_MEF2A_6	127	136	PF00069	0.427
DOC_MAPK_MEF2A_6	251	259	PF00069	0.498
DOC_MAPK_RevD_3	132	146	PF00069	0.504
DOC_PP4_FxxP_1	13	16	PF00568	0.543
DOC_PP4_FxxP_1	165	168	PF00568	0.464
DOC_USP7_MATH_1	114	118	PF00917	0.715
DOC_USP7_MATH_1	125	129	PF00917	0.342
DOC_USP7_MATH_1	232	236	PF00917	0.561
DOC_USP7_MATH_1	341	345	PF00917	0.669
DOC_USP7_MATH_1	396	400	PF00917	0.632
DOC_USP7_MATH_1	430	434	PF00917	0.326
DOC_USP7_MATH_1	439	443	PF00917	0.411
DOC_USP7_MATH_1	6	10	PF00917	0.552
DOC_USP7_UBL2_3	368	372	PF12436	0.289
DOC_WW_Pin1_4	31	36	PF00397	0.348
DOC_WW_Pin1_4	339	344	PF00397	0.641
DOC_WW_Pin1_4	403	408	PF00397	0.662
DOC_WW_Pin1_4	79	84	PF00397	0.645
LIG_14-3-3_CanoR_1	212	220	PF00244	0.410
LIG_14-3-3_CanoR_1	243	252	PF00244	0.491
LIG_14-3-3_CanoR_1	27	31	PF00244	0.601
LIG_14-3-3_CanoR_1	298	302	PF00244	0.398
LIG_14-3-3_CanoR_1	480	485	PF00244	0.405
LIG_14-3-3_CanoR_1	506	510	PF00244	0.571
LIG_Actin_WH2_2	283	300	PF00022	0.460
LIG_APCC_ABBA_1	375	380	PF00400	0.421
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BIR_III_4	155	159	PF00653	0.484
LIG_BRCT_BRCA1_1	363	367	PF00533	0.403
LIG_BRCT_BRCA1_1	470	474	PF00533	0.421
LIG_deltaCOP1_diTrp_1	280	287	PF00928	0.490
LIG_FHA_1	137	143	PF00498	0.490
LIG_FHA_1	244	250	PF00498	0.491
LIG_FHA_1	298	304	PF00498	0.327
LIG_FHA_1	99	105	PF00498	0.747
LIG_FHA_2	392	398	PF00498	0.400
LIG_FHA_2	453	459	PF00498	0.452
LIG_LIR_Apic_2	163	168	PF02991	0.433
LIG_LIR_Gen_1	361	371	PF02991	0.430
LIG_LIR_Nem_3	172	177	PF02991	0.505
LIG_LIR_Nem_3	361	366	PF02991	0.400
LIG_MYND_3	509	513	PF01753	0.609
LIG_NRBOX	199	205	PF00104	0.358
LIG_NRBOX	494	500	PF00104	0.498
LIG_PCNA_yPIPBox_3	197	209	PF02747	0.405
LIG_Pex14_1	283	287	PF04695	0.487
LIG_Pex14_2	363	367	PF04695	0.491
LIG_RPA_C_Fungi	141	153	PF08784	0.472
LIG_SH2_CRK	74	78	PF00017	0.617
LIG_SH2_NCK_1	460	464	PF00017	0.517
LIG_SH2_NCK_1	74	78	PF00017	0.617
LIG_SH2_PTP2	133	136	PF00017	0.489
LIG_SH2_STAP1	19	23	PF00017	0.643
LIG_SH2_STAT5	133	136	PF00017	0.377
LIG_SH2_STAT5	189	192	PF00017	0.406
LIG_SH2_STAT5	412	415	PF00017	0.372
LIG_SH2_STAT5	434	437	PF00017	0.492
LIG_SH2_STAT5	440	443	PF00017	0.568
LIG_SH2_STAT5	482	485	PF00017	0.413
LIG_SH3_3	187	193	PF00018	0.516
LIG_SUMO_SIM_par_1	354	359	PF11976	0.410
LIG_SUMO_SIM_par_1	50	57	PF11976	0.456
LIG_TRAF2_1	95	98	PF00917	0.677
LIG_TYR_ITIM	131	136	PF00017	0.382
LIG_TYR_ITIM	72	77	PF00017	0.394
LIG_UBA3_1	87	93	PF00899	0.509
MOD_CK1_1	215	221	PF00069	0.528
MOD_CK1_1	235	241	PF00069	0.551
MOD_CK1_1	335	341	PF00069	0.537
MOD_CK1_1	406	412	PF00069	0.754
MOD_CK1_1	433	439	PF00069	0.395
MOD_CK1_1	508	514	PF00069	0.527
MOD_CK1_1	92	98	PF00069	0.708
MOD_CK2_1	411	417	PF00069	0.531
MOD_CK2_1	452	458	PF00069	0.522
MOD_CK2_1	79	85	PF00069	0.676
MOD_CK2_1	92	98	PF00069	0.662
MOD_GlcNHglycan	127	130	PF01048	0.484
MOD_GlcNHglycan	21	24	PF01048	0.558
MOD_GlcNHglycan	214	217	PF01048	0.541
MOD_GlcNHglycan	234	237	PF01048	0.483
MOD_GlcNHglycan	334	337	PF01048	0.442
MOD_GlcNHglycan	363	366	PF01048	0.426
MOD_GlcNHglycan	397	401	PF01048	0.720
MOD_GlcNHglycan	484	487	PF01048	0.585
MOD_GlcNHglycan	8	11	PF01048	0.522
MOD_GSK3_1	114	121	PF00069	0.713
MOD_GSK3_1	212	219	PF00069	0.369
MOD_GSK3_1	332	339	PF00069	0.564
MOD_GSK3_1	341	348	PF00069	0.561
MOD_GSK3_1	402	409	PF00069	0.656
MOD_GSK3_1	441	448	PF00069	0.530
MOD_GSK3_1	449	456	PF00069	0.410
MOD_GSK3_1	73	80	PF00069	0.625
MOD_GSK3_1	88	95	PF00069	0.787
MOD_LATS_1	210	216	PF00433	0.316
MOD_N-GLC_1	216	221	PF02516	0.386
MOD_N-GLC_1	232	237	PF02516	0.324
MOD_N-GLC_1	31	36	PF02516	0.518
MOD_N-GLC_1	332	337	PF02516	0.508
MOD_N-GLC_1	47	52	PF02516	0.424
MOD_N-GLC_2	351	353	PF02516	0.416
MOD_NEK2_1	18	23	PF00069	0.494
MOD_NEK2_1	241	246	PF00069	0.486
MOD_NEK2_1	297	302	PF00069	0.262
MOD_NEK2_1	42	47	PF00069	0.517
MOD_NEK2_1	449	454	PF00069	0.459
MOD_NEK2_1	474	479	PF00069	0.428
MOD_NEK2_1	88	93	PF00069	0.536
MOD_NEK2_1	99	104	PF00069	0.494
MOD_OFUCOSY	353	360	PF10250	0.406
MOD_PIKK_1	243	249	PF00454	0.377
MOD_PIKK_1	99	105	PF00454	0.589
MOD_PKA_2	170	176	PF00069	0.507
MOD_PKA_2	26	32	PF00069	0.603
MOD_PKA_2	297	303	PF00069	0.259
MOD_PKA_2	505	511	PF00069	0.544
MOD_Plk_1	216	222	PF00069	0.394
MOD_Plk_4	445	451	PF00069	0.317
MOD_Plk_4	474	480	PF00069	0.517
MOD_Plk_4	83	89	PF00069	0.485
MOD_ProDKin_1	31	37	PF00069	0.348
MOD_ProDKin_1	339	345	PF00069	0.634
MOD_ProDKin_1	403	409	PF00069	0.661
MOD_ProDKin_1	79	85	PF00069	0.650
MOD_SUMO_for_1	367	370	PF00179	0.290
MOD_SUMO_for_1	461	464	PF00179	0.524
MOD_SUMO_rev_2	364	374	PF00179	0.343
MOD_SUMO_rev_2	485	490	PF00179	0.522
TRG_DiLeu_BaEn_1	85	90	PF01217	0.498
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.560
TRG_ENDOCYTIC_2	133	136	PF00928	0.377
TRG_ENDOCYTIC_2	201	204	PF00928	0.368
TRG_ENDOCYTIC_2	74	77	PF00928	0.602
TRG_ER_diArg_1	144	146	PF00400	0.524
TRG_NES_CRM1_1	292	305	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU4	Leptomonas seymouri	55%	99%
A0A1X0P8W2	Trypanosomatidae	33%	100%
A0A3S7X019	Leishmania donovani	81%	100%
A0A422N4R1	Trypanosoma rangeli	32%	100%
A4I2A7	Leishmania infantum	81%	100%
C9ZXD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AYF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q918	Leishmania major	80%	100%
V5BF90	Trypanosoma cruzi	29%	100%