Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HD53_LEIBR

TriTrypDb:

LbrM.23.1930 , LBRM2903_230030500

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.619
CLV_C14_Caspase3-7	124	128	PF00656	0.578
CLV_NRD_NRD_1	16	18	PF00675	0.649
CLV_NRD_NRD_1	181	183	PF00675	0.546
CLV_NRD_NRD_1	187	189	PF00675	0.545
CLV_NRD_NRD_1	249	251	PF00675	0.535
CLV_NRD_NRD_1	291	293	PF00675	0.536
CLV_NRD_NRD_1	312	314	PF00675	0.516
CLV_NRD_NRD_1	363	365	PF00675	0.559
CLV_NRD_NRD_1	368	370	PF00675	0.532
CLV_NRD_NRD_1	9	11	PF00675	0.729
CLV_NRD_NRD_1	92	94	PF00675	0.541
CLV_PCSK_FUR_1	246	250	PF00082	0.534
CLV_PCSK_FUR_1	366	370	PF00082	0.511
CLV_PCSK_KEX2_1	16	18	PF00082	0.649
CLV_PCSK_KEX2_1	181	183	PF00082	0.546
CLV_PCSK_KEX2_1	187	189	PF00082	0.545
CLV_PCSK_KEX2_1	248	250	PF00082	0.538
CLV_PCSK_KEX2_1	291	293	PF00082	0.536
CLV_PCSK_KEX2_1	365	367	PF00082	0.536
CLV_PCSK_KEX2_1	368	370	PF00082	0.504
CLV_PCSK_KEX2_1	9	11	PF00082	0.729
CLV_PCSK_KEX2_1	92	94	PF00082	0.541
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.536
CLV_PCSK_PC7_1	177	183	PF00082	0.410
CLV_PCSK_PC7_1	287	293	PF00082	0.463
CLV_PCSK_PC7_1	364	370	PF00082	0.407
CLV_PCSK_SKI1_1	166	170	PF00082	0.593
CLV_PCSK_SKI1_1	204	208	PF00082	0.583
CLV_PCSK_SKI1_1	372	376	PF00082	0.500
CLV_PCSK_SKI1_1	426	430	PF00082	0.623
DEG_APCC_DBOX_1	203	211	PF00400	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DEG_SPOP_SBC_1	46	50	PF00917	0.528
DOC_CKS1_1	139	144	PF01111	0.605
DOC_CKS1_1	347	352	PF01111	0.557
DOC_CYCLIN_RxL_1	366	379	PF00134	0.553
DOC_MAPK_gen_1	364	376	PF00069	0.564
DOC_MAPK_MEF2A_6	267	276	PF00069	0.521
DOC_MAPK_RevD_3	300	314	PF00069	0.342
DOC_PP1_RVXF_1	265	271	PF00149	0.360
DOC_PP1_RVXF_1	409	415	PF00149	0.515
DOC_PP2B_LxvP_1	71	74	PF13499	0.526
DOC_USP7_MATH_1	117	121	PF00917	0.545
DOC_USP7_MATH_1	133	137	PF00917	0.501
DOC_USP7_MATH_1	46	50	PF00917	0.553
DOC_USP7_MATH_1	74	78	PF00917	0.538
DOC_USP7_UBL2_3	470	474	PF12436	0.665
DOC_WW_Pin1_4	138	143	PF00397	0.621
DOC_WW_Pin1_4	346	351	PF00397	0.561
DOC_WW_Pin1_4	446	451	PF00397	0.600
DOC_WW_Pin1_4	93	98	PF00397	0.658
LIG_14-3-3_CanoR_1	166	176	PF00244	0.571
LIG_14-3-3_CanoR_1	181	190	PF00244	0.415
LIG_14-3-3_CanoR_1	231	240	PF00244	0.527
LIG_14-3-3_CanoR_1	366	376	PF00244	0.562
LIG_14-3-3_CanoR_1	426	432	PF00244	0.456
LIG_Actin_WH2_2	298	315	PF00022	0.342
LIG_APCC_ABBA_1	374	379	PF00400	0.534
LIG_BRCT_BRCA1_1	294	298	PF00533	0.366
LIG_BRCT_BRCA1_1	319	323	PF00533	0.519
LIG_BRCT_BRCA1_1	34	38	PF00533	0.639
LIG_BRCT_BRCA1_1	41	45	PF00533	0.669
LIG_FHA_1	100	106	PF00498	0.540
LIG_FHA_1	284	290	PF00498	0.483
LIG_FHA_1	368	374	PF00498	0.564
LIG_FHA_1	390	396	PF00498	0.552
LIG_FHA_1	68	74	PF00498	0.698
LIG_FHA_2	167	173	PF00498	0.568
LIG_FHA_2	222	228	PF00498	0.348
LIG_FHA_2	304	310	PF00498	0.337
LIG_GBD_Chelix_1	268	276	PF00786	0.359
LIG_LIR_Gen_1	141	151	PF02991	0.580
LIG_LIR_Gen_1	303	312	PF02991	0.503
LIG_LIR_LC3C_4	195	198	PF02991	0.397
LIG_LIR_Nem_3	141	147	PF02991	0.582
LIG_LIR_Nem_3	303	307	PF02991	0.503
LIG_Pex14_2	323	327	PF04695	0.522
LIG_SH2_CRK	144	148	PF00017	0.583
LIG_SH2_PTP2	421	424	PF00017	0.519
LIG_SH2_STAT5	184	187	PF00017	0.517
LIG_SH2_STAT5	421	424	PF00017	0.519
LIG_SH3_1	429	435	PF00018	0.611
LIG_SH3_2	4	9	PF14604	0.617
LIG_SH3_3	1	7	PF00018	0.616
LIG_SH3_3	136	142	PF00018	0.628
LIG_SH3_3	429	435	PF00018	0.611
LIG_SH3_3	462	468	PF00018	0.562
LIG_SH3_3	55	61	PF00018	0.695
LIG_SH3_3	70	76	PF00018	0.528
LIG_SH3_3	91	97	PF00018	0.705
LIG_TRAF2_1	189	192	PF00917	0.391
LIG_TRAF2_1	306	309	PF00917	0.332
MOD_CDK_SPxxK_3	446	453	PF00069	0.538
MOD_CK1_1	103	109	PF00069	0.553
MOD_CK1_1	121	127	PF00069	0.546
MOD_CK1_1	19	25	PF00069	0.732
MOD_CK1_1	28	34	PF00069	0.604
MOD_CK1_1	44	50	PF00069	0.519
MOD_CK1_1	52	58	PF00069	0.545
MOD_CK1_1	67	73	PF00069	0.624
MOD_CK1_1	77	83	PF00069	0.612
MOD_CK2_1	166	172	PF00069	0.583
MOD_CK2_1	186	192	PF00069	0.350
MOD_CK2_1	221	227	PF00069	0.348
MOD_CK2_1	303	309	PF00069	0.338
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.542
MOD_GlcNHglycan	105	108	PF01048	0.543
MOD_GlcNHglycan	115	118	PF01048	0.558
MOD_GlcNHglycan	129	132	PF01048	0.528
MOD_GlcNHglycan	162	165	PF01048	0.591
MOD_GlcNHglycan	169	172	PF01048	0.495
MOD_GlcNHglycan	233	236	PF01048	0.530
MOD_GlcNHglycan	319	322	PF01048	0.519
MOD_GlcNHglycan	88	91	PF01048	0.548
MOD_GSK3_1	113	120	PF00069	0.528
MOD_GSK3_1	123	130	PF00069	0.634
MOD_GSK3_1	133	140	PF00069	0.621
MOD_GSK3_1	151	158	PF00069	0.478
MOD_GSK3_1	167	174	PF00069	0.502
MOD_GSK3_1	17	24	PF00069	0.720
MOD_GSK3_1	182	189	PF00069	0.417
MOD_GSK3_1	28	35	PF00069	0.594
MOD_GSK3_1	389	396	PF00069	0.555
MOD_GSK3_1	40	47	PF00069	0.552
MOD_GSK3_1	420	427	PF00069	0.541
MOD_GSK3_1	99	106	PF00069	0.600
MOD_N-GLC_2	386	388	PF02516	0.380
MOD_NEK2_1	101	106	PF00069	0.670
MOD_NEK2_1	137	142	PF00069	0.554
MOD_NEK2_1	151	156	PF00069	0.584
MOD_NEK2_1	276	281	PF00069	0.371
MOD_NEK2_1	323	328	PF00069	0.523
MOD_NEK2_1	38	43	PF00069	0.625
MOD_NEK2_1	45	50	PF00069	0.643
MOD_NEK2_2	133	138	PF00069	0.539
MOD_NEK2_2	393	398	PF00069	0.534
MOD_PIKK_1	19	25	PF00454	0.594
MOD_PIKK_1	28	34	PF00454	0.604
MOD_PK_1	461	467	PF00069	0.506
MOD_PKA_1	16	22	PF00069	0.729
MOD_PKA_2	155	161	PF00069	0.453
MOD_PKA_2	16	22	PF00069	0.580
MOD_PKA_2	180	186	PF00069	0.418
MOD_PKA_2	2	8	PF00069	0.704
MOD_PKA_2	32	38	PF00069	0.528
MOD_PKA_2	367	373	PF00069	0.405
MOD_PKB_1	229	237	PF00069	0.532
MOD_Plk_1	171	177	PF00069	0.553
MOD_Plk_1	424	430	PF00069	0.580
MOD_Plk_1	67	73	PF00069	0.539
MOD_Plk_4	171	177	PF00069	0.390
MOD_Plk_4	300	306	PF00069	0.503
MOD_Plk_4	393	399	PF00069	0.537
MOD_Plk_4	461	467	PF00069	0.506
MOD_ProDKin_1	138	144	PF00069	0.622
MOD_ProDKin_1	346	352	PF00069	0.560
MOD_ProDKin_1	446	452	PF00069	0.599
MOD_ProDKin_1	93	99	PF00069	0.660
MOD_SUMO_rev_2	189	196	PF00179	0.523
MOD_SUMO_rev_2	330	336	PF00179	0.531
MOD_SUMO_rev_2	360	367	PF00179	0.415
TRG_DiLeu_BaEn_1	192	197	PF01217	0.551
TRG_DiLeu_BaEn_1	202	207	PF01217	0.432
TRG_DiLeu_BaEn_1	339	344	PF01217	0.527
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.399
TRG_ENDOCYTIC_2	144	147	PF00928	0.582
TRG_ENDOCYTIC_2	421	424	PF00928	0.519
TRG_ER_diArg_1	246	249	PF00400	0.510
TRG_ER_diArg_1	366	369	PF00400	0.559
TRG_ER_diArg_1	409	412	PF00400	0.520
TRG_ER_diArg_1	8	10	PF00400	0.730
TRG_ER_diArg_1	91	93	PF00400	0.544
TRG_ER_diLys_1	470	474	PF00400	0.665
TRG_NLS_MonoExtC_3	364	369	PF00514	0.412
TRG_NLS_MonoExtN_4	362	369	PF00514	0.415
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC93	Leishmania donovani	71%	100%
A4I2A8	Leishmania infantum	72%	100%
E9AYF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4Q917	Leishmania major	71%	100%