Conserved oligomeric Golgi complex subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG4 transport protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HD49_LEIBR

TriTrypDb:

LbrM.23.1890 , LBRM2903_050011300

Length:

894

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HD49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD49

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.472
CLV_C14_Caspase3-7	429	433	PF00656	0.421
CLV_MEL_PAP_1	804	810	PF00089	0.543
CLV_NRD_NRD_1	26	28	PF00675	0.486
CLV_NRD_NRD_1	314	316	PF00675	0.415
CLV_NRD_NRD_1	366	368	PF00675	0.328
CLV_NRD_NRD_1	390	392	PF00675	0.475
CLV_NRD_NRD_1	641	643	PF00675	0.741
CLV_NRD_NRD_1	793	795	PF00675	0.422
CLV_NRD_NRD_1	804	806	PF00675	0.409
CLV_NRD_NRD_1	88	90	PF00675	0.539
CLV_NRD_NRD_1	885	887	PF00675	0.497
CLV_PCSK_FUR_1	86	90	PF00082	0.634
CLV_PCSK_KEX2_1	25	27	PF00082	0.480
CLV_PCSK_KEX2_1	314	316	PF00082	0.328
CLV_PCSK_KEX2_1	366	368	PF00082	0.328
CLV_PCSK_KEX2_1	398	400	PF00082	0.437
CLV_PCSK_KEX2_1	641	643	PF00082	0.741
CLV_PCSK_KEX2_1	793	795	PF00082	0.412
CLV_PCSK_KEX2_1	806	808	PF00082	0.399
CLV_PCSK_KEX2_1	85	87	PF00082	0.502
CLV_PCSK_KEX2_1	88	90	PF00082	0.497
CLV_PCSK_KEX2_1	885	887	PF00082	0.412
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.437
CLV_PCSK_PC1ET2_1	806	808	PF00082	0.491
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.626
CLV_PCSK_PC7_1	21	27	PF00082	0.552
CLV_PCSK_PC7_1	881	887	PF00082	0.392
CLV_PCSK_SKI1_1	188	192	PF00082	0.353
CLV_PCSK_SKI1_1	316	320	PF00082	0.358
CLV_PCSK_SKI1_1	398	402	PF00082	0.483
CLV_PCSK_SKI1_1	477	481	PF00082	0.223
CLV_PCSK_SKI1_1	65	69	PF00082	0.438
CLV_PCSK_SKI1_1	666	670	PF00082	0.521
CLV_PCSK_SKI1_1	794	798	PF00082	0.475
CLV_PCSK_SKI1_1	801	805	PF00082	0.451
CLV_PCSK_SKI1_1	824	828	PF00082	0.393
CLV_PCSK_SKI1_1	839	843	PF00082	0.395
CLV_PCSK_SKI1_1	875	879	PF00082	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SPOP_SBC_1	156	160	PF00917	0.615
DEG_SPOP_SBC_1	414	418	PF00917	0.223
DOC_CKS1_1	652	657	PF01111	0.578
DOC_CYCLIN_RxL_1	873	883	PF00134	0.515
DOC_MAPK_gen_1	885	892	PF00069	0.527
DOC_MAPK_HePTP_8	882	894	PF00069	0.546
DOC_MAPK_MEF2A_6	885	894	PF00069	0.548
DOC_PP1_RVXF_1	879	885	PF00149	0.442
DOC_PP4_FxxP_1	452	455	PF00568	0.358
DOC_PP4_FxxP_1	652	655	PF00568	0.518
DOC_USP7_MATH_1	115	119	PF00917	0.586
DOC_USP7_MATH_1	156	160	PF00917	0.667
DOC_USP7_MATH_1	166	170	PF00917	0.558
DOC_USP7_MATH_1	260	264	PF00917	0.399
DOC_USP7_MATH_1	408	412	PF00917	0.468
DOC_USP7_MATH_1	530	534	PF00917	0.397
DOC_USP7_MATH_1	550	554	PF00917	0.475
DOC_USP7_MATH_1	597	601	PF00917	0.359
DOC_USP7_MATH_1	739	743	PF00917	0.477
DOC_USP7_MATH_1	75	79	PF00917	0.496
DOC_USP7_MATH_1	80	84	PF00917	0.461
DOC_USP7_MATH_1	822	826	PF00917	0.524
DOC_WW_Pin1_4	144	149	PF00397	0.634
DOC_WW_Pin1_4	343	348	PF00397	0.307
DOC_WW_Pin1_4	651	656	PF00397	0.578
DOC_WW_Pin1_4	686	691	PF00397	0.587
DOC_WW_Pin1_4	833	838	PF00397	0.550
LIG_14-3-3_CanoR_1	141	147	PF00244	0.547
LIG_14-3-3_CanoR_1	182	186	PF00244	0.396
LIG_14-3-3_CanoR_1	188	193	PF00244	0.358
LIG_14-3-3_CanoR_1	253	262	PF00244	0.223
LIG_14-3-3_CanoR_1	299	307	PF00244	0.376
LIG_14-3-3_CanoR_1	391	400	PF00244	0.475
LIG_14-3-3_CanoR_1	436	443	PF00244	0.475
LIG_14-3-3_CanoR_1	65	70	PF00244	0.466
LIG_14-3-3_CanoR_1	666	671	PF00244	0.491
LIG_14-3-3_CanoR_1	805	811	PF00244	0.472
LIG_14-3-3_CanoR_1	821	827	PF00244	0.312
LIG_APCC_ABBA_1	731	736	PF00400	0.506
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.593
LIG_BH_BH3_1	663	679	PF00452	0.513
LIG_Clathr_ClatBox_1	764	768	PF01394	0.419
LIG_deltaCOP1_diTrp_1	717	722	PF00928	0.431
LIG_EH1_1	841	849	PF00400	0.490
LIG_FHA_1	127	133	PF00498	0.371
LIG_FHA_1	207	213	PF00498	0.335
LIG_FHA_1	797	803	PF00498	0.442
LIG_FHA_1	848	854	PF00498	0.368
LIG_FHA_1	856	862	PF00498	0.425
LIG_FHA_1	98	104	PF00498	0.544
LIG_FHA_2	148	154	PF00498	0.726
LIG_FHA_2	189	195	PF00498	0.317
LIG_FHA_2	392	398	PF00498	0.435
LIG_FHA_2	419	425	PF00498	0.431
LIG_FHA_2	567	573	PF00498	0.344
LIG_FHA_2	652	658	PF00498	0.571
LIG_FHA_2	707	713	PF00498	0.517
LIG_FHA_2	719	725	PF00498	0.401
LIG_FHA_2	868	874	PF00498	0.434
LIG_FHA_2	878	884	PF00498	0.384
LIG_GBD_Chelix_1	237	245	PF00786	0.449
LIG_LIR_Gen_1	10	20	PF02991	0.358
LIG_LIR_Gen_1	380	389	PF02991	0.315
LIG_LIR_Gen_1	720	730	PF02991	0.454
LIG_LIR_Gen_1	736	745	PF02991	0.432
LIG_LIR_Gen_1	781	792	PF02991	0.293
LIG_LIR_Gen_1	840	849	PF02991	0.406
LIG_LIR_Nem_3	10	16	PF02991	0.357
LIG_LIR_Nem_3	380	386	PF02991	0.269
LIG_LIR_Nem_3	459	463	PF02991	0.392
LIG_LIR_Nem_3	572	578	PF02991	0.263
LIG_LIR_Nem_3	694	699	PF02991	0.586
LIG_LIR_Nem_3	720	725	PF02991	0.450
LIG_LIR_Nem_3	736	741	PF02991	0.434
LIG_LIR_Nem_3	747	753	PF02991	0.392
LIG_LIR_Nem_3	781	787	PF02991	0.306
LIG_LIR_Nem_3	809	814	PF02991	0.389
LIG_LIR_Nem_3	840	845	PF02991	0.395
LIG_NRBOX	89	95	PF00104	0.477
LIG_PCNA_PIPBox_1	446	455	PF02747	0.390
LIG_PCNA_PIPBox_1	520	529	PF02747	0.344
LIG_PCNA_yPIPBox_3	179	193	PF02747	0.482
LIG_PDZ_Class_2	889	894	PF00595	0.420
LIG_Pex14_1	718	722	PF04695	0.423
LIG_PTB_Apo_2	455	462	PF02174	0.223
LIG_PTB_Apo_2	50	57	PF02174	0.610
LIG_PTB_Phospho_1	50	56	PF10480	0.608
LIG_REV1ctd_RIR_1	573	583	PF16727	0.363
LIG_SH2_NCK_1	136	140	PF00017	0.454
LIG_SH2_NCK_1	527	531	PF00017	0.346
LIG_SH2_PTP2	383	386	PF00017	0.309
LIG_SH2_PTP2	453	456	PF00017	0.449
LIG_SH2_SRC	136	139	PF00017	0.311
LIG_SH2_STAP1	225	229	PF00017	0.413
LIG_SH2_STAP1	396	400	PF00017	0.449
LIG_SH2_STAP1	465	469	PF00017	0.475
LIG_SH2_STAP1	527	531	PF00017	0.264
LIG_SH2_STAT3	773	776	PF00017	0.529
LIG_SH2_STAT5	383	386	PF00017	0.386
LIG_SH2_STAT5	453	456	PF00017	0.336
LIG_SH2_STAT5	460	463	PF00017	0.293
LIG_SH2_STAT5	561	564	PF00017	0.432
LIG_SH2_STAT5	62	65	PF00017	0.582
LIG_SH2_STAT5	670	673	PF00017	0.461
LIG_SH2_STAT5	773	776	PF00017	0.471
LIG_SH3_3	283	289	PF00018	0.223
LIG_SH3_3	508	514	PF00018	0.378
LIG_SH3_3	565	571	PF00018	0.421
LIG_SH3_3	727	733	PF00018	0.456
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.455
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.363
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.349
LIG_SUMO_SIM_anti_2	843	850	PF11976	0.392
LIG_SUMO_SIM_par_1	129	135	PF11976	0.552
LIG_SUMO_SIM_par_1	288	294	PF11976	0.296
LIG_SUMO_SIM_par_1	614	622	PF11976	0.629
LIG_SUMO_SIM_par_1	763	768	PF11976	0.413
LIG_SUMO_SIM_par_1	849	855	PF11976	0.386
LIG_TRAF2_1	135	138	PF00917	0.446
LIG_TRAF2_1	445	448	PF00917	0.228
LIG_TRAF2_1	552	555	PF00917	0.437
LIG_TRAF2_1	654	657	PF00917	0.358
LIG_TRAF2_1	860	863	PF00917	0.568
LIG_TRAF2_1	870	873	PF00917	0.341
LIG_TRFH_1	56	60	PF08558	0.582
LIG_UBA3_1	810	818	PF00899	0.522
LIG_UBA3_1	847	856	PF00899	0.444
LIG_WRC_WIRS_1	385	390	PF05994	0.385
LIG_WRC_WIRS_1	719	724	PF05994	0.387
LIG_WRC_WIRS_1	823	828	PF05994	0.438
MOD_CDK_SPxK_1	833	839	PF00069	0.576
MOD_CK1_1	147	153	PF00069	0.673
MOD_CK1_1	298	304	PF00069	0.344
MOD_CK1_1	418	424	PF00069	0.320
MOD_CK1_1	515	521	PF00069	0.375
MOD_CK1_1	621	627	PF00069	0.496
MOD_CK1_1	629	635	PF00069	0.738
MOD_CK1_1	843	849	PF00069	0.323
MOD_CK2_1	132	138	PF00069	0.538
MOD_CK2_1	147	153	PF00069	0.564
MOD_CK2_1	188	194	PF00069	0.266
MOD_CK2_1	240	246	PF00069	0.223
MOD_CK2_1	384	390	PF00069	0.463
MOD_CK2_1	391	397	PF00069	0.393
MOD_CK2_1	418	424	PF00069	0.421
MOD_CK2_1	44	50	PF00069	0.575
MOD_CK2_1	442	448	PF00069	0.243
MOD_CK2_1	530	536	PF00069	0.392
MOD_CK2_1	651	657	PF00069	0.588
MOD_CK2_1	75	81	PF00069	0.503
MOD_CK2_1	867	873	PF00069	0.459
MOD_CK2_1	877	883	PF00069	0.411
MOD_Cter_Amidation	639	642	PF01082	0.785
MOD_GlcNHglycan	122	125	PF01048	0.528
MOD_GlcNHglycan	326	329	PF01048	0.366
MOD_GlcNHglycan	332	335	PF01048	0.326
MOD_GlcNHglycan	339	342	PF01048	0.256
MOD_GlcNHglycan	350	353	PF01048	0.320
MOD_GlcNHglycan	363	366	PF01048	0.437
MOD_GlcNHglycan	401	404	PF01048	0.397
MOD_GlcNHglycan	417	420	PF01048	0.382
MOD_GlcNHglycan	514	517	PF01048	0.335
MOD_GlcNHglycan	520	523	PF01048	0.309
MOD_GlcNHglycan	532	535	PF01048	0.259
MOD_GlcNHglycan	589	592	PF01048	0.346
MOD_GlcNHglycan	594	597	PF01048	0.310
MOD_GlcNHglycan	599	602	PF01048	0.303
MOD_GlcNHglycan	629	632	PF01048	0.754
MOD_GlcNHglycan	635	638	PF01048	0.762
MOD_GlcNHglycan	65	68	PF01048	0.460
MOD_GlcNHglycan	686	689	PF01048	0.527
MOD_GlcNHglycan	99	103	PF01048	0.602
MOD_GSK3_1	116	123	PF00069	0.588
MOD_GSK3_1	219	226	PF00069	0.435
MOD_GSK3_1	291	298	PF00069	0.264
MOD_GSK3_1	330	337	PF00069	0.362
MOD_GSK3_1	373	380	PF00069	0.342
MOD_GSK3_1	414	421	PF00069	0.367
MOD_GSK3_1	525	532	PF00069	0.329
MOD_GSK3_1	626	633	PF00069	0.595
MOD_GSK3_1	65	72	PF00069	0.385
MOD_GSK3_1	682	689	PF00069	0.545
MOD_GSK3_1	843	850	PF00069	0.421
MOD_GSK3_1	851	858	PF00069	0.446
MOD_N-GLC_1	633	638	PF02516	0.797
MOD_N-GLC_1	691	696	PF02516	0.408
MOD_N-GLC_1	75	80	PF02516	0.578
MOD_NEK2_1	157	162	PF00069	0.635
MOD_NEK2_1	206	211	PF00069	0.369
MOD_NEK2_1	350	355	PF00069	0.223
MOD_NEK2_1	44	49	PF00069	0.532
MOD_NEK2_1	442	447	PF00069	0.344
MOD_NEK2_1	456	461	PF00069	0.344
MOD_NEK2_1	537	542	PF00069	0.388
MOD_NEK2_1	681	686	PF00069	0.375
MOD_NEK2_1	69	74	PF00069	0.503
MOD_NEK2_1	706	711	PF00069	0.488
MOD_NEK2_1	778	783	PF00069	0.312
MOD_NEK2_1	847	852	PF00069	0.424
MOD_NEK2_2	491	496	PF00069	0.223
MOD_NEK2_2	822	827	PF00069	0.497
MOD_PIKK_1	260	266	PF00454	0.449
MOD_PKA_1	391	397	PF00069	0.449
MOD_PKA_1	806	812	PF00069	0.455
MOD_PKA_2	181	187	PF00069	0.376
MOD_PKA_2	298	304	PF00069	0.357
MOD_PKA_2	34	40	PF00069	0.590
MOD_PKA_2	435	441	PF00069	0.453
MOD_PKA_2	806	812	PF00069	0.458
MOD_PKA_2	81	87	PF00069	0.488
MOD_Plk_1	126	132	PF00069	0.406
MOD_Plk_1	230	236	PF00069	0.328
MOD_Plk_1	373	379	PF00069	0.329
MOD_Plk_1	682	688	PF00069	0.576
MOD_Plk_1	691	697	PF00069	0.549
MOD_Plk_1	75	81	PF00069	0.577
MOD_Plk_1	98	104	PF00069	0.554
MOD_Plk_4	116	122	PF00069	0.545
MOD_Plk_4	126	132	PF00069	0.511
MOD_Plk_4	188	194	PF00069	0.281
MOD_Plk_4	201	207	PF00069	0.184
MOD_Plk_4	384	390	PF00069	0.420
MOD_Plk_4	456	462	PF00069	0.350
MOD_Plk_4	515	521	PF00069	0.363
MOD_Plk_4	555	561	PF00069	0.475
MOD_Plk_4	666	672	PF00069	0.510
MOD_Plk_4	726	732	PF00069	0.490
MOD_Plk_4	843	849	PF00069	0.413
MOD_ProDKin_1	144	150	PF00069	0.640
MOD_ProDKin_1	343	349	PF00069	0.307
MOD_ProDKin_1	651	657	PF00069	0.573
MOD_ProDKin_1	686	692	PF00069	0.580
MOD_ProDKin_1	833	839	PF00069	0.551
MOD_SUMO_for_1	745	748	PF00179	0.521
MOD_SUMO_rev_2	387	394	PF00179	0.397
MOD_SUMO_rev_2	872	877	PF00179	0.504
TRG_DiLeu_BaEn_1	127	132	PF01217	0.516
TRG_DiLeu_BaEn_3	373	379	PF01217	0.475
TRG_DiLeu_BaEn_4	554	560	PF01217	0.223
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.449
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.228
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.449
TRG_ENDOCYTIC_2	383	386	PF00928	0.331
TRG_ENDOCYTIC_2	453	456	PF00928	0.385
TRG_ENDOCYTIC_2	460	463	PF00928	0.385
TRG_ENDOCYTIC_2	56	59	PF00928	0.584
TRG_ER_diArg_1	24	27	PF00400	0.476
TRG_ER_diArg_1	804	807	PF00400	0.477
TRG_ER_diArg_1	86	89	PF00400	0.511
TRG_ER_diArg_1	884	886	PF00400	0.371
TRG_NLS_Bipartite_1	793	809	PF00514	0.508
TRG_NLS_MonoExtC_3	84	89	PF00514	0.627
TRG_NLS_MonoExtN_4	82	89	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	608	612	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU85	Leptomonas seymouri	65%	96%
A0A0S4IPR3	Bodo saltans	29%	100%
A0A1X0NK43	Trypanosomatidae	37%	93%
A0A3R7LU72	Trypanosoma rangeli	38%	100%
A0A3S7WP44	Leishmania donovani	80%	99%
A4HSI2	Leishmania infantum	81%	99%
C9ZUC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	88%
E9AKG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4QJE2	Leishmania major	81%	99%
V5BAR5	Trypanosoma cruzi	37%	97%