SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module, putative

Species:

Leishmania braziliensis

UniProt:

A4HD48_LEIBR

TriTrypDb:

LbrM.23.1880 , LBRM2903_050011400

Length:

991

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD48

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.629
CLV_C14_Caspase3-7	401	405	PF00656	0.602
CLV_C14_Caspase3-7	526	530	PF00656	0.620
CLV_C14_Caspase3-7	590	594	PF00656	0.432
CLV_NRD_NRD_1	302	304	PF00675	0.523
CLV_NRD_NRD_1	364	366	PF00675	0.632
CLV_NRD_NRD_1	370	372	PF00675	0.655
CLV_NRD_NRD_1	373	375	PF00675	0.672
CLV_NRD_NRD_1	434	436	PF00675	0.682
CLV_NRD_NRD_1	541	543	PF00675	0.498
CLV_NRD_NRD_1	729	731	PF00675	0.677
CLV_NRD_NRD_1	736	738	PF00675	0.612
CLV_PCSK_FUR_1	371	375	PF00082	0.653
CLV_PCSK_FUR_1	726	730	PF00082	0.672
CLV_PCSK_KEX2_1	2	4	PF00082	0.543
CLV_PCSK_KEX2_1	250	252	PF00082	0.303
CLV_PCSK_KEX2_1	302	304	PF00082	0.523
CLV_PCSK_KEX2_1	363	365	PF00082	0.638
CLV_PCSK_KEX2_1	369	371	PF00082	0.657
CLV_PCSK_KEX2_1	373	375	PF00082	0.672
CLV_PCSK_KEX2_1	385	387	PF00082	0.780
CLV_PCSK_KEX2_1	434	436	PF00082	0.571
CLV_PCSK_KEX2_1	541	543	PF00082	0.498
CLV_PCSK_KEX2_1	728	730	PF00082	0.680
CLV_PCSK_KEX2_1	736	738	PF00082	0.616
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.534
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.282
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.724
CLV_PCSK_PC7_1	359	365	PF00082	0.594
CLV_PCSK_PC7_1	369	375	PF00082	0.598
CLV_PCSK_PC7_1	732	738	PF00082	0.707
CLV_PCSK_SKI1_1	24	28	PF00082	0.541
CLV_PCSK_SKI1_1	3	7	PF00082	0.529
CLV_PCSK_SKI1_1	434	438	PF00082	0.646
CLV_PCSK_SKI1_1	498	502	PF00082	0.501
CLV_PCSK_SKI1_1	548	552	PF00082	0.488
CLV_PCSK_SKI1_1	785	789	PF00082	0.742
CLV_PCSK_SKI1_1	895	899	PF00082	0.532
DEG_APCC_DBOX_1	275	283	PF00400	0.482
DEG_MDM2_SWIB_1	897	904	PF02201	0.354
DEG_Nend_UBRbox_1	1	4	PF02207	0.545
DEG_SCF_TRCP1_1	529	534	PF00400	0.399
DEG_SPOP_SBC_1	619	623	PF00917	0.515
DEG_SPOP_SBC_1	847	851	PF00917	0.545
DEG_SPOP_SBC_1	877	881	PF00917	0.694
DOC_CKS1_1	7	12	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	142	145	PF00134	0.721
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	515	521	PF00134	0.513
DOC_MAPK_gen_1	215	224	PF00069	0.468
DOC_MAPK_gen_1	302	308	PF00069	0.479
DOC_MAPK_MEF2A_6	895	902	PF00069	0.409
DOC_PP2B_LxvP_1	134	137	PF13499	0.607
DOC_PP2B_LxvP_1	142	145	PF13499	0.667
DOC_PP2B_LxvP_1	207	210	PF13499	0.552
DOC_PP2B_LxvP_1	211	214	PF13499	0.545
DOC_PP2B_LxvP_1	216	219	PF13499	0.495
DOC_PP2B_LxvP_1	482	485	PF13499	0.550
DOC_PP4_FxxP_1	122	125	PF00568	0.693
DOC_PP4_FxxP_1	267	270	PF00568	0.482
DOC_USP7_MATH_1	11	15	PF00917	0.578
DOC_USP7_MATH_1	178	182	PF00917	0.789
DOC_USP7_MATH_1	30	34	PF00917	0.523
DOC_USP7_MATH_1	334	338	PF00917	0.782
DOC_USP7_MATH_1	467	471	PF00917	0.809
DOC_USP7_MATH_1	585	589	PF00917	0.649
DOC_USP7_MATH_1	619	623	PF00917	0.784
DOC_USP7_MATH_1	695	699	PF00917	0.674
DOC_USP7_MATH_1	817	821	PF00917	0.697
DOC_USP7_MATH_1	824	828	PF00917	0.597
DOC_USP7_MATH_1	847	851	PF00917	0.625
DOC_USP7_MATH_1	875	879	PF00917	0.592
DOC_USP7_UBL2_3	802	806	PF12436	0.724
DOC_WW_Pin1_4	182	187	PF00397	0.773
DOC_WW_Pin1_4	6	11	PF00397	0.574
DOC_WW_Pin1_4	697	702	PF00397	0.761
DOC_WW_Pin1_4	714	719	PF00397	0.720
DOC_WW_Pin1_4	81	86	PF00397	0.608
DOC_WW_Pin1_4	851	856	PF00397	0.748
DOC_WW_Pin1_4	873	878	PF00397	0.574
DOC_WW_Pin1_4	907	912	PF00397	0.640
LIG_14-3-3_CanoR_1	278	283	PF00244	0.482
LIG_14-3-3_CanoR_1	434	439	PF00244	0.643
LIG_14-3-3_CanoR_1	492	501	PF00244	0.606
LIG_14-3-3_CanoR_1	736	741	PF00244	0.520
LIG_14-3-3_CanoR_1	773	778	PF00244	0.454
LIG_14-3-3_CanoR_1	986	990	PF00244	0.465
LIG_BRCT_BRCA1_1	32	36	PF00533	0.556
LIG_BRCT_BRCA1_1	987	991	PF00533	0.467
LIG_Clathr_ClatBox_1	955	959	PF01394	0.656
LIG_CSL_BTD_1	306	309	PF09270	0.506
LIG_CSL_BTD_1	852	855	PF09270	0.561
LIG_deltaCOP1_diTrp_1	600	606	PF00928	0.360
LIG_FHA_1	202	208	PF00498	0.663
LIG_FHA_1	225	231	PF00498	0.519
LIG_FHA_1	233	239	PF00498	0.481
LIG_FHA_1	50	56	PF00498	0.717
LIG_FHA_1	511	517	PF00498	0.425
LIG_FHA_1	584	590	PF00498	0.623
LIG_FHA_1	820	826	PF00498	0.706
LIG_FHA_1	894	900	PF00498	0.315
LIG_FHA_1	917	923	PF00498	0.535
LIG_FHA_1	943	949	PF00498	0.661
LIG_FHA_2	167	173	PF00498	0.702
LIG_FHA_2	186	192	PF00498	0.528
LIG_FHA_2	226	232	PF00498	0.321
LIG_FHA_2	241	247	PF00498	0.482
LIG_FHA_2	435	441	PF00498	0.631
LIG_FHA_2	461	467	PF00498	0.740
LIG_FHA_2	524	530	PF00498	0.601
LIG_FHA_2	532	538	PF00498	0.494
LIG_FHA_2	661	667	PF00498	0.602
LIG_FHA_2	679	685	PF00498	0.452
LIG_FHA_2	751	757	PF00498	0.405
LIG_FHA_2	808	814	PF00498	0.561
LIG_IBAR_NPY_1	517	519	PF08397	0.515
LIG_LIR_Apic_2	120	125	PF02991	0.699
LIG_LIR_Apic_2	126	132	PF02991	0.653
LIG_LIR_Apic_2	180	186	PF02991	0.621
LIG_LIR_Apic_2	265	270	PF02991	0.482
LIG_LIR_Gen_1	33	41	PF02991	0.658
LIG_LIR_Gen_1	680	691	PF02991	0.675
LIG_LIR_Gen_1	896	904	PF02991	0.416
LIG_LIR_Gen_1	985	991	PF02991	0.474
LIG_LIR_LC3C_4	896	900	PF02991	0.322
LIG_LIR_Nem_3	600	606	PF02991	0.360
LIG_LIR_Nem_3	680	686	PF02991	0.666
LIG_LIR_Nem_3	84	89	PF02991	0.607
LIG_LIR_Nem_3	896	900	PF02991	0.389
LIG_LIR_Nem_3	985	990	PF02991	0.469
LIG_MYND_1	132	136	PF01753	0.659
LIG_MYND_1	140	144	PF01753	0.700
LIG_NRBOX	228	234	PF00104	0.331
LIG_NRBOX	278	284	PF00104	0.482
LIG_NRBOX	562	568	PF00104	0.357
LIG_PDZ_Class_2	986	991	PF00595	0.471
LIG_Pex14_1	893	897	PF04695	0.467
LIG_Pex14_2	897	901	PF04695	0.484
LIG_PTAP_UEV_1	717	722	PF05743	0.557
LIG_Rb_pABgroove_1	677	685	PF01858	0.476
LIG_SH2_CRK	129	133	PF00017	0.732
LIG_SH2_CRK	280	284	PF00017	0.530
LIG_SH2_CRK	683	687	PF00017	0.481
LIG_SH2_CRK	987	991	PF00017	0.392
LIG_SH2_NCK_1	519	523	PF00017	0.544
LIG_SH2_PTP2	305	308	PF00017	0.430
LIG_SH2_SRC	519	522	PF00017	0.417
LIG_SH2_STAP1	987	991	PF00017	0.467
LIG_SH2_STAT5	147	150	PF00017	0.828
LIG_SH2_STAT5	183	186	PF00017	0.759
LIG_SH2_STAT5	305	308	PF00017	0.430
LIG_SH2_STAT5	575	578	PF00017	0.504
LIG_SH2_STAT5	597	600	PF00017	0.395
LIG_SH2_STAT5	604	607	PF00017	0.328
LIG_SH3_1	636	642	PF00018	0.556
LIG_SH3_2	309	314	PF14604	0.567
LIG_SH3_3	122	128	PF00018	0.590
LIG_SH3_3	133	139	PF00018	0.532
LIG_SH3_3	197	203	PF00018	0.523
LIG_SH3_3	303	309	PF00018	0.447
LIG_SH3_3	4	10	PF00018	0.588
LIG_SH3_3	454	460	PF00018	0.592
LIG_SH3_3	477	483	PF00018	0.608
LIG_SH3_3	636	642	PF00018	0.625
LIG_SH3_3	712	718	PF00018	0.650
LIG_SH3_3	786	792	PF00018	0.740
LIG_SH3_3	852	858	PF00018	0.625
LIG_SH3_3	901	907	PF00018	0.641
LIG_SH3_3	919	925	PF00018	0.689
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.411
LIG_SUMO_SIM_par_1	49	59	PF11976	0.553
LIG_TRAF2_1	243	246	PF00917	0.502
LIG_TRAF2_1	665	668	PF00917	0.580
LIG_TYR_ITIM	602	607	PF00017	0.392
LIG_UBA3_1	890	895	PF00899	0.388
LIG_WRC_WIRS_1	894	899	PF05994	0.307
LIG_WW_1	144	147	PF00397	0.812
MOD_CK1_1	117	123	PF00069	0.598
MOD_CK1_1	149	155	PF00069	0.531
MOD_CK1_1	18	24	PF00069	0.734
MOD_CK1_1	185	191	PF00069	0.690
MOD_CK1_1	290	296	PF00069	0.557
MOD_CK1_1	384	390	PF00069	0.572
MOD_CK1_1	403	409	PF00069	0.663
MOD_CK1_1	410	416	PF00069	0.645
MOD_CK1_1	417	423	PF00069	0.691
MOD_CK1_1	622	628	PF00069	0.820
MOD_CK1_1	655	661	PF00069	0.683
MOD_CK1_1	71	77	PF00069	0.704
MOD_CK1_1	716	722	PF00069	0.679
MOD_CK1_1	78	84	PF00069	0.714
MOD_CK1_1	819	825	PF00069	0.670
MOD_CK1_1	848	854	PF00069	0.688
MOD_CK1_1	856	862	PF00069	0.780
MOD_CK1_1	878	884	PF00069	0.548
MOD_CK2_1	166	172	PF00069	0.703
MOD_CK2_1	185	191	PF00069	0.598
MOD_CK2_1	240	246	PF00069	0.482
MOD_CK2_1	39	45	PF00069	0.537
MOD_CK2_1	417	423	PF00069	0.788
MOD_CK2_1	434	440	PF00069	0.590
MOD_CK2_1	460	466	PF00069	0.735
MOD_CK2_1	531	537	PF00069	0.397
MOD_CK2_1	662	668	PF00069	0.565
MOD_CK2_1	735	741	PF00069	0.552
MOD_CK2_1	750	756	PF00069	0.407
MOD_CK2_1	807	813	PF00069	0.642
MOD_Cter_Amidation	432	435	PF01082	0.574
MOD_GlcNHglycan	116	119	PF01048	0.794
MOD_GlcNHglycan	148	151	PF01048	0.820
MOD_GlcNHglycan	17	20	PF01048	0.754
MOD_GlcNHglycan	174	177	PF01048	0.682
MOD_GlcNHglycan	180	183	PF01048	0.635
MOD_GlcNHglycan	336	339	PF01048	0.758
MOD_GlcNHglycan	404	408	PF01048	0.846
MOD_GlcNHglycan	409	412	PF01048	0.762
MOD_GlcNHglycan	485	488	PF01048	0.503
MOD_GlcNHglycan	529	532	PF01048	0.474
MOD_GlcNHglycan	624	627	PF01048	0.713
MOD_GlcNHglycan	654	657	PF01048	0.697
MOD_GlcNHglycan	658	661	PF01048	0.667
MOD_GlcNHglycan	70	73	PF01048	0.737
MOD_GlcNHglycan	718	721	PF01048	0.682
MOD_GlcNHglycan	819	822	PF01048	0.566
MOD_GlcNHglycan	826	829	PF01048	0.521
MOD_GlcNHglycan	858	861	PF01048	0.692
MOD_GlcNHglycan	883	886	PF01048	0.452
MOD_GlcNHglycan	911	914	PF01048	0.734
MOD_GlcNHglycan	975	978	PF01048	0.481
MOD_GSK3_1	11	18	PF00069	0.725
MOD_GSK3_1	178	185	PF00069	0.737
MOD_GSK3_1	187	194	PF00069	0.641
MOD_GSK3_1	20	27	PF00069	0.688
MOD_GSK3_1	332	339	PF00069	0.622
MOD_GSK3_1	396	403	PF00069	0.681
MOD_GSK3_1	405	412	PF00069	0.653
MOD_GSK3_1	413	420	PF00069	0.727
MOD_GSK3_1	488	495	PF00069	0.623
MOD_GSK3_1	523	530	PF00069	0.463
MOD_GSK3_1	56	63	PF00069	0.612
MOD_GSK3_1	618	625	PF00069	0.714
MOD_GSK3_1	652	659	PF00069	0.717
MOD_GSK3_1	695	702	PF00069	0.612
MOD_GSK3_1	71	78	PF00069	0.792
MOD_GSK3_1	710	717	PF00069	0.638
MOD_GSK3_1	771	778	PF00069	0.500
MOD_GSK3_1	807	814	PF00069	0.653
MOD_GSK3_1	815	822	PF00069	0.639
MOD_GSK3_1	842	849	PF00069	0.686
MOD_GSK3_1	871	878	PF00069	0.815
MOD_N-GLC_1	613	618	PF02516	0.474
MOD_N-GLC_1	807	812	PF02516	0.572
MOD_NEK2_1	100	105	PF00069	0.525
MOD_NEK2_1	224	229	PF00069	0.451
MOD_NEK2_1	232	237	PF00069	0.482
MOD_NEK2_1	39	44	PF00069	0.706
MOD_NEK2_1	414	419	PF00069	0.666
MOD_NEK2_1	48	53	PF00069	0.636
MOD_NEK2_1	55	60	PF00069	0.606
MOD_NEK2_1	613	618	PF00069	0.504
MOD_NEK2_1	777	782	PF00069	0.524
MOD_NEK2_2	678	683	PF00069	0.461
MOD_NEK2_2	721	726	PF00069	0.579
MOD_NEK2_2	829	834	PF00069	0.606
MOD_PIKK_1	127	133	PF00454	0.724
MOD_PIKK_1	290	296	PF00454	0.636
MOD_PIKK_1	771	777	PF00454	0.625
MOD_PIKK_1	959	965	PF00454	0.675
MOD_PKA_1	434	440	PF00069	0.615
MOD_PKA_1	736	742	PF00069	0.447
MOD_PKA_2	434	440	PF00069	0.561
MOD_PKA_2	735	741	PF00069	0.559
MOD_PKA_2	985	991	PF00069	0.474
MOD_PKB_1	276	284	PF00069	0.482
MOD_PKB_1	771	779	PF00069	0.446
MOD_Plk_1	107	113	PF00069	0.538
MOD_Plk_1	224	230	PF00069	0.441
MOD_Plk_1	48	54	PF00069	0.645
MOD_Plk_2-3	225	231	PF00069	0.429
MOD_Plk_2-3	523	529	PF00069	0.506
MOD_Plk_4	100	106	PF00069	0.614
MOD_Plk_4	117	123	PF00069	0.515
MOD_Plk_4	225	231	PF00069	0.429
MOD_Plk_4	278	284	PF00069	0.482
MOD_Plk_4	49	55	PF00069	0.586
MOD_Plk_4	561	567	PF00069	0.360
MOD_Plk_4	678	684	PF00069	0.508
MOD_Plk_4	750	756	PF00069	0.412
MOD_Plk_4	811	817	PF00069	0.559
MOD_Plk_4	893	899	PF00069	0.310
MOD_Plk_4	924	930	PF00069	0.672
MOD_Plk_4	951	957	PF00069	0.638
MOD_Plk_4	985	991	PF00069	0.474
MOD_ProDKin_1	182	188	PF00069	0.773
MOD_ProDKin_1	6	12	PF00069	0.578
MOD_ProDKin_1	697	703	PF00069	0.755
MOD_ProDKin_1	714	720	PF00069	0.721
MOD_ProDKin_1	81	87	PF00069	0.606
MOD_ProDKin_1	851	857	PF00069	0.749
MOD_ProDKin_1	873	879	PF00069	0.573
MOD_ProDKin_1	907	913	PF00069	0.642
MOD_SUMO_for_1	105	108	PF00179	0.519
MOD_SUMO_for_1	249	252	PF00179	0.482
MOD_SUMO_rev_2	377	384	PF00179	0.543
MOD_SUMO_rev_2	938	945	PF00179	0.564
TRG_DiLeu_BaEn_1	225	230	PF01217	0.433
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.706
TRG_DiLeu_BaLyEn_6	970	975	PF01217	0.525
TRG_ENDOCYTIC_2	280	283	PF00928	0.526
TRG_ENDOCYTIC_2	305	308	PF00928	0.430
TRG_ENDOCYTIC_2	604	607	PF00928	0.391
TRG_ENDOCYTIC_2	683	686	PF00928	0.657
TRG_ENDOCYTIC_2	987	990	PF00928	0.458
TRG_ER_diArg_1	214	217	PF00400	0.482
TRG_ER_diArg_1	363	365	PF00400	0.628
TRG_ER_diArg_1	369	371	PF00400	0.650
TRG_ER_diArg_1	373	376	PF00400	0.666
TRG_ER_diArg_1	479	482	PF00400	0.611
TRG_ER_diArg_1	540	542	PF00400	0.500
TRG_ER_diArg_1	725	728	PF00400	0.706
TRG_ER_diArg_1	729	732	PF00400	0.695
TRG_NLS_Bipartite_1	369	389	PF00514	0.622
TRG_NLS_MonoExtC_3	384	390	PF00514	0.650
TRG_NLS_MonoExtN_4	383	389	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	538	543	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE1	Leptomonas seymouri	40%	100%
A0A3S7WP43	Leishmania donovani	73%	100%
A4HSI3	Leishmania infantum	73%	100%
E9AKG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QJE1	Leishmania major	73%	97%