Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD47_LEIBR

TriTrypDb:

LbrM.23.1870 , LBRM2903_050011500

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.567
CLV_C14_Caspase3-7	258	262	PF00656	0.582
CLV_MEL_PAP_1	328	334	PF00089	0.688
CLV_NRD_NRD_1	114	116	PF00675	0.711
CLV_NRD_NRD_1	140	142	PF00675	0.615
CLV_NRD_NRD_1	145	147	PF00675	0.594
CLV_NRD_NRD_1	18	20	PF00675	0.664
CLV_NRD_NRD_1	259	261	PF00675	0.724
CLV_NRD_NRD_1	524	526	PF00675	0.505
CLV_NRD_NRD_1	593	595	PF00675	0.511
CLV_NRD_NRD_1	616	618	PF00675	0.670
CLV_NRD_NRD_1	670	672	PF00675	0.705
CLV_NRD_NRD_1	721	723	PF00675	0.557
CLV_NRD_NRD_1	735	737	PF00675	0.536
CLV_NRD_NRD_1	820	822	PF00675	0.822
CLV_PCSK_FUR_1	719	723	PF00082	0.552
CLV_PCSK_KEX2_1	114	116	PF00082	0.711
CLV_PCSK_KEX2_1	140	142	PF00082	0.612
CLV_PCSK_KEX2_1	144	146	PF00082	0.601
CLV_PCSK_KEX2_1	155	157	PF00082	0.535
CLV_PCSK_KEX2_1	18	20	PF00082	0.650
CLV_PCSK_KEX2_1	259	261	PF00082	0.723
CLV_PCSK_KEX2_1	36	38	PF00082	0.505
CLV_PCSK_KEX2_1	524	526	PF00082	0.505
CLV_PCSK_KEX2_1	591	593	PF00082	0.523
CLV_PCSK_KEX2_1	616	618	PF00082	0.670
CLV_PCSK_KEX2_1	670	672	PF00082	0.705
CLV_PCSK_KEX2_1	721	723	PF00082	0.557
CLV_PCSK_KEX2_1	735	737	PF00082	0.536
CLV_PCSK_KEX2_1	820	822	PF00082	0.822
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.586
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.553
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.510
CLV_PCSK_PC7_1	140	146	PF00082	0.584
CLV_PCSK_SKI1_1	101	105	PF00082	0.647
CLV_PCSK_SKI1_1	49	53	PF00082	0.594
CLV_Separin_Metazoa	241	245	PF03568	0.587
CLV_Separin_Metazoa	457	461	PF03568	0.465
DEG_APCC_DBOX_1	593	601	PF00400	0.497
DEG_ODPH_VHL_1	79	91	PF01847	0.556
DEG_SPOP_SBC_1	44	48	PF00917	0.631
DOC_ANK_TNKS_1	330	337	PF00023	0.702
DOC_CYCLIN_RxL_1	716	729	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	865	871	PF00134	0.571
DOC_MAPK_gen_1	36	44	PF00069	0.552
DOC_MAPK_gen_1	591	599	PF00069	0.507
DOC_MAPK_gen_1	670	677	PF00069	0.705
DOC_PP1_RVXF_1	846	853	PF00149	0.635
DOC_PP2B_LxvP_1	103	106	PF13499	0.529
DOC_PP2B_LxvP_1	196	199	PF13499	0.634
DOC_PP2B_LxvP_1	289	292	PF13499	0.696
DOC_PP2B_LxvP_1	723	726	PF13499	0.581
DOC_PP2B_LxvP_1	814	817	PF13499	0.625
DOC_PP4_FxxP_1	332	335	PF00568	0.578
DOC_PP4_FxxP_1	649	652	PF00568	0.537
DOC_SPAK_OSR1_1	331	335	PF12202	0.566
DOC_USP7_MATH_1	28	32	PF00917	0.563
DOC_USP7_MATH_1	341	345	PF00917	0.719
DOC_USP7_MATH_1	365	369	PF00917	0.523
DOC_USP7_MATH_1	386	390	PF00917	0.684
DOC_USP7_MATH_1	40	44	PF00917	0.584
DOC_USP7_MATH_1	411	415	PF00917	0.655
DOC_USP7_MATH_1	421	425	PF00917	0.606
DOC_USP7_MATH_1	531	535	PF00917	0.502
DOC_USP7_MATH_1	603	607	PF00917	0.764
DOC_USP7_MATH_1	643	647	PF00917	0.598
DOC_USP7_MATH_1	696	700	PF00917	0.634
DOC_USP7_MATH_1	824	828	PF00917	0.571
DOC_USP7_MATH_1	833	837	PF00917	0.584
DOC_USP7_MATH_1	843	847	PF00917	0.624
DOC_WW_Pin1_4	101	106	PF00397	0.535
DOC_WW_Pin1_4	160	165	PF00397	0.725
DOC_WW_Pin1_4	252	257	PF00397	0.708
DOC_WW_Pin1_4	292	297	PF00397	0.759
DOC_WW_Pin1_4	304	309	PF00397	0.697
DOC_WW_Pin1_4	347	352	PF00397	0.734
DOC_WW_Pin1_4	367	372	PF00397	0.467
DOC_WW_Pin1_4	399	404	PF00397	0.694
DOC_WW_Pin1_4	4	9	PF00397	0.551
DOC_WW_Pin1_4	405	410	PF00397	0.638
DOC_WW_Pin1_4	471	476	PF00397	0.556
DOC_WW_Pin1_4	49	54	PF00397	0.569
DOC_WW_Pin1_4	620	625	PF00397	0.695
DOC_WW_Pin1_4	627	632	PF00397	0.607
DOC_WW_Pin1_4	64	69	PF00397	0.605
DOC_WW_Pin1_4	664	669	PF00397	0.596
DOC_WW_Pin1_4	698	703	PF00397	0.556
DOC_WW_Pin1_4	74	79	PF00397	0.608
DOC_WW_Pin1_4	859	864	PF00397	0.710
LIG_14-3-3_CanoR_1	18	27	PF00244	0.596
LIG_14-3-3_CanoR_1	184	188	PF00244	0.575
LIG_14-3-3_CanoR_1	398	403	PF00244	0.600
LIG_14-3-3_CanoR_1	489	495	PF00244	0.580
LIG_14-3-3_CanoR_1	645	652	PF00244	0.603
LIG_14-3-3_CanoR_1	654	662	PF00244	0.580
LIG_14-3-3_CanoR_1	820	826	PF00244	0.666
LIG_14-3-3_CanoR_1	870	877	PF00244	0.663
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_BIR_III_4	878	882	PF00653	0.631
LIG_BRCT_BRCA1_1	23	27	PF00533	0.544
LIG_BRCT_BRCA1_1	261	265	PF00533	0.583
LIG_BRCT_BRCA1_1	328	332	PF00533	0.566
LIG_BRCT_BRCA1_1	645	649	PF00533	0.537
LIG_BRCT_BRCA1_1	895	899	PF00533	0.562
LIG_deltaCOP1_diTrp_1	890	899	PF00928	0.532
LIG_EVH1_1	814	818	PF00568	0.659
LIG_FHA_1	184	190	PF00498	0.581
LIG_FHA_1	20	26	PF00498	0.650
LIG_FHA_1	224	230	PF00498	0.581
LIG_FHA_1	367	373	PF00498	0.655
LIG_FHA_1	388	394	PF00498	0.666
LIG_FHA_1	39	45	PF00498	0.504
LIG_FHA_1	50	56	PF00498	0.570
LIG_FHA_1	616	622	PF00498	0.785
LIG_FHA_1	68	74	PF00498	0.627
LIG_FHA_1	707	713	PF00498	0.671
LIG_FHA_2	261	267	PF00498	0.580
LIG_FHA_2	343	349	PF00498	0.581
LIG_FHA_2	417	423	PF00498	0.580
LIG_FHA_2	428	434	PF00498	0.510
LIG_FHA_2	489	495	PF00498	0.653
LIG_FHA_2	512	518	PF00498	0.629
LIG_FHA_2	871	877	PF00498	0.575
LIG_GSK3_LRP6_1	409	414	PF00069	0.565
LIG_HCF-1_HBM_1	209	212	PF13415	0.580
LIG_LIR_Apic_2	329	335	PF02991	0.565
LIG_LIR_Apic_2	646	652	PF02991	0.534
LIG_LIR_Gen_1	534	542	PF02991	0.531
LIG_LIR_Gen_1	638	643	PF02991	0.524
LIG_LIR_Gen_1	779	786	PF02991	0.548
LIG_LIR_Gen_1	841	850	PF02991	0.554
LIG_LIR_LC3C_4	286	291	PF02991	0.559
LIG_LIR_Nem_3	361	366	PF02991	0.535
LIG_LIR_Nem_3	379	384	PF02991	0.546
LIG_LIR_Nem_3	638	642	PF02991	0.531
LIG_LIR_Nem_3	779	784	PF02991	0.547
LIG_LIR_Nem_3	841	847	PF02991	0.552
LIG_MYND_1	292	296	PF01753	0.693
LIG_PDZ_Class_2	908	913	PF00595	0.508
LIG_Pex14_2	495	499	PF04695	0.473
LIG_SH2_CRK	781	785	PF00017	0.583
LIG_SH2_CRK	844	848	PF00017	0.677
LIG_SH2_GRB2like	212	215	PF00017	0.591
LIG_SH2_GRB2like	781	784	PF00017	0.552
LIG_SH2_SRC	384	387	PF00017	0.566
LIG_SH2_SRC	455	458	PF00017	0.461
LIG_SH2_STAP1	212	216	PF00017	0.591
LIG_SH2_STAP1	455	459	PF00017	0.595
LIG_SH2_STAT5	376	379	PF00017	0.672
LIG_SH2_STAT5	384	387	PF00017	0.585
LIG_SH2_STAT5	490	493	PF00017	0.649
LIG_SH2_STAT5	724	727	PF00017	0.756
LIG_SH2_STAT5	97	100	PF00017	0.759
LIG_SH3_2	665	670	PF14604	0.564
LIG_SH3_2	798	803	PF14604	0.608
LIG_SH3_2	815	820	PF14604	0.663
LIG_SH3_3	173	179	PF00018	0.639
LIG_SH3_3	240	246	PF00018	0.645
LIG_SH3_3	407	413	PF00018	0.606
LIG_SH3_3	597	603	PF00018	0.627
LIG_SH3_3	618	624	PF00018	0.617
LIG_SH3_3	659	665	PF00018	0.680
LIG_SH3_3	666	672	PF00018	0.542
LIG_SH3_3	75	81	PF00018	0.700
LIG_SH3_3	760	766	PF00018	0.663
LIG_SH3_3	795	801	PF00018	0.613
LIG_SH3_3	812	818	PF00018	0.607
LIG_SH3_3	851	857	PF00018	0.619
LIG_SUMO_SIM_anti_2	435	442	PF11976	0.662
LIG_SUMO_SIM_par_1	38	48	PF11976	0.559
LIG_SUMO_SIM_par_1	511	517	PF11976	0.469
LIG_TRAF2_1	188	191	PF00917	0.569
LIG_TRAF2_1	491	494	PF00917	0.511
LIG_WW_1	94	97	PF00397	0.633
LIG_WW_3	249	253	PF00397	0.615
LIG_WW_3	667	671	PF00397	0.658
LIG_WW_3	93	97	PF00397	0.632
MOD_CDC14_SPxK_1	623	626	PF00782	0.698
MOD_CDC14_SPxK_1	667	670	PF00782	0.568
MOD_CDK_SPxK_1	620	626	PF00069	0.697
MOD_CDK_SPxK_1	664	670	PF00069	0.571
MOD_CDK_SPxxK_3	252	259	PF00069	0.709
MOD_CDK_SPxxK_3	367	374	PF00069	0.658
MOD_CDK_SPxxK_3	49	56	PF00069	0.561
MOD_CDK_SPxxK_3	64	71	PF00069	0.609
MOD_CDK_SPxxK_3	664	671	PF00069	0.700
MOD_CK1_1	13	19	PF00069	0.639
MOD_CK1_1	147	153	PF00069	0.762
MOD_CK1_1	192	198	PF00069	0.686
MOD_CK1_1	2	8	PF00069	0.595
MOD_CK1_1	21	27	PF00069	0.571
MOD_CK1_1	255	261	PF00069	0.671
MOD_CK1_1	307	313	PF00069	0.589
MOD_CK1_1	380	386	PF00069	0.795
MOD_CK1_1	424	430	PF00069	0.573
MOD_CK1_1	43	49	PF00069	0.607
MOD_CK1_1	441	447	PF00069	0.593
MOD_CK1_1	471	477	PF00069	0.559
MOD_CK1_1	605	611	PF00069	0.645
MOD_CK1_1	67	73	PF00069	0.655
MOD_CK1_1	680	686	PF00069	0.810
MOD_CK1_1	776	782	PF00069	0.542
MOD_CK1_1	832	838	PF00069	0.582
MOD_CK1_1	846	852	PF00069	0.637
MOD_CK1_1	892	898	PF00069	0.672
MOD_CK1_1	900	906	PF00069	0.572
MOD_CK2_1	260	266	PF00069	0.582
MOD_CK2_1	342	348	PF00069	0.584
MOD_CK2_1	416	422	PF00069	0.583
MOD_CK2_1	427	433	PF00069	0.545
MOD_CK2_1	442	448	PF00069	0.699
MOD_CK2_1	488	494	PF00069	0.520
MOD_CK2_1	511	517	PF00069	0.469
MOD_Cter_Amidation	112	115	PF01082	0.712
MOD_Cter_Amidation	589	592	PF01082	0.522
MOD_DYRK1A_RPxSP_1	252	256	PF00069	0.664
MOD_DYRK1A_RPxSP_1	4	8	PF00069	0.544
MOD_GlcNHglycan	191	194	PF01048	0.598
MOD_GlcNHglycan	309	312	PF01048	0.619
MOD_GlcNHglycan	328	331	PF01048	0.605
MOD_GlcNHglycan	351	354	PF01048	0.640
MOD_GlcNHglycan	4	7	PF01048	0.614
MOD_GlcNHglycan	422	426	PF01048	0.752
MOD_GlcNHglycan	470	473	PF01048	0.680
MOD_GlcNHglycan	580	583	PF01048	0.604
MOD_GlcNHglycan	607	610	PF01048	0.637
MOD_GlcNHglycan	646	649	PF01048	0.561
MOD_GlcNHglycan	656	659	PF01048	0.593
MOD_GlcNHglycan	687	690	PF01048	0.716
MOD_GlcNHglycan	693	696	PF01048	0.600
MOD_GlcNHglycan	698	701	PF01048	0.608
MOD_GlcNHglycan	740	743	PF01048	0.677
MOD_GlcNHglycan	775	778	PF01048	0.561
MOD_GlcNHglycan	821	824	PF01048	0.557
MOD_GlcNHglycan	826	829	PF01048	0.549
MOD_GlcNHglycan	831	834	PF01048	0.524
MOD_GlcNHglycan	840	843	PF01048	0.481
MOD_GlcNHglycan	902	905	PF01048	0.630
MOD_GSK3_1	14	21	PF00069	0.703
MOD_GSK3_1	147	154	PF00069	0.673
MOD_GSK3_1	160	167	PF00069	0.652
MOD_GSK3_1	23	30	PF00069	0.628
MOD_GSK3_1	255	262	PF00069	0.812
MOD_GSK3_1	300	307	PF00069	0.660
MOD_GSK3_1	337	344	PF00069	0.655
MOD_GSK3_1	38	45	PF00069	0.536
MOD_GSK3_1	4	11	PF00069	0.624
MOD_GSK3_1	405	412	PF00069	0.648
MOD_GSK3_1	421	428	PF00069	0.537
MOD_GSK3_1	438	445	PF00069	0.640
MOD_GSK3_1	464	471	PF00069	0.627
MOD_GSK3_1	47	54	PF00069	0.539
MOD_GSK3_1	637	644	PF00069	0.618
MOD_GSK3_1	650	657	PF00069	0.676
MOD_GSK3_1	677	684	PF00069	0.795
MOD_GSK3_1	687	694	PF00069	0.644
MOD_GSK3_1	711	718	PF00069	0.545
MOD_GSK3_1	772	779	PF00069	0.551
MOD_GSK3_1	824	831	PF00069	0.636
MOD_GSK3_1	848	855	PF00069	0.705
MOD_GSK3_1	859	866	PF00069	0.638
MOD_GSK3_1	889	896	PF00069	0.798
MOD_LATS_1	133	139	PF00433	0.568
MOD_LATS_1	396	402	PF00433	0.587
MOD_N-GLC_1	174	179	PF02516	0.586
MOD_N-GLC_1	337	342	PF02516	0.578
MOD_N-GLC_1	833	838	PF02516	0.539
MOD_N-GLC_2	468	470	PF02516	0.615
MOD_NEK2_1	189	194	PF00069	0.683
MOD_NEK2_1	223	228	PF00069	0.585
MOD_NEK2_1	27	32	PF00069	0.640
MOD_NEK2_1	302	307	PF00069	0.629
MOD_NEK2_1	366	371	PF00069	0.631
MOD_NEK2_1	677	682	PF00069	0.693
MOD_NEK2_1	773	778	PF00069	0.550
MOD_NEK2_1	897	902	PF00069	0.654
MOD_NEK2_2	843	848	PF00069	0.635
MOD_PIKK_1	147	153	PF00454	0.584
MOD_PIKK_1	164	170	PF00454	0.632
MOD_PIKK_1	174	180	PF00454	0.654
MOD_PIKK_1	224	230	PF00454	0.693
MOD_PIKK_1	317	323	PF00454	0.578
MOD_PIKK_1	411	417	PF00454	0.687
MOD_PKA_1	114	120	PF00069	0.571
MOD_PKA_1	144	150	PF00069	0.588
MOD_PKA_1	18	24	PF00069	0.636
MOD_PKA_1	259	265	PF00069	0.710
MOD_PKA_2	114	120	PF00069	0.571
MOD_PKA_2	134	140	PF00069	0.687
MOD_PKA_2	144	150	PF00069	0.639
MOD_PKA_2	18	24	PF00069	0.547
MOD_PKA_2	183	189	PF00069	0.577
MOD_PKA_2	224	230	PF00069	0.695
MOD_PKA_2	259	265	PF00069	0.596
MOD_PKA_2	488	494	PF00069	0.588
MOD_PKA_2	523	529	PF00069	0.497
MOD_PKA_2	615	621	PF00069	0.688
MOD_PKA_2	644	650	PF00069	0.561
MOD_PKA_2	819	825	PF00069	0.594
MOD_PKA_2	869	875	PF00069	0.689
MOD_Plk_1	260	266	PF00069	0.582
MOD_Plk_1	38	44	PF00069	0.555
MOD_Plk_1	387	393	PF00069	0.686
MOD_Plk_1	637	643	PF00069	0.593
MOD_Plk_1	889	895	PF00069	0.673
MOD_Plk_2-3	538	544	PF00069	0.485
MOD_Plk_4	260	266	PF00069	0.663
MOD_Plk_4	30	36	PF00069	0.570
MOD_Plk_4	380	386	PF00069	0.637
MOD_Plk_4	387	393	PF00069	0.643
MOD_Plk_4	508	514	PF00069	0.480
MOD_Plk_4	531	537	PF00069	0.493
MOD_Plk_4	681	687	PF00069	0.578
MOD_Plk_4	889	895	PF00069	0.673
MOD_ProDKin_1	101	107	PF00069	0.542
MOD_ProDKin_1	160	166	PF00069	0.728
MOD_ProDKin_1	252	258	PF00069	0.708
MOD_ProDKin_1	292	298	PF00069	0.761
MOD_ProDKin_1	304	310	PF00069	0.699
MOD_ProDKin_1	347	353	PF00069	0.733
MOD_ProDKin_1	367	373	PF00069	0.467
MOD_ProDKin_1	399	405	PF00069	0.691
MOD_ProDKin_1	4	10	PF00069	0.551
MOD_ProDKin_1	409	415	PF00069	0.597
MOD_ProDKin_1	471	477	PF00069	0.559
MOD_ProDKin_1	49	55	PF00069	0.562
MOD_ProDKin_1	620	626	PF00069	0.697
MOD_ProDKin_1	627	633	PF00069	0.605
MOD_ProDKin_1	64	70	PF00069	0.604
MOD_ProDKin_1	664	670	PF00069	0.597
MOD_ProDKin_1	698	704	PF00069	0.553
MOD_ProDKin_1	74	80	PF00069	0.606
MOD_ProDKin_1	859	865	PF00069	0.711
MOD_SUMO_for_1	518	521	PF00179	0.595
TRG_DiLeu_BaEn_1	285	290	PF01217	0.562
TRG_DiLeu_BaEn_1	388	393	PF01217	0.664
TRG_DiLeu_BaLyEn_6	795	800	PF01217	0.571
TRG_DiLeu_BaLyEn_6	860	865	PF01217	0.563
TRG_ENDOCYTIC_2	455	458	PF00928	0.622
TRG_ENDOCYTIC_2	537	540	PF00928	0.620
TRG_ENDOCYTIC_2	781	784	PF00928	0.584
TRG_ENDOCYTIC_2	844	847	PF00928	0.785
TRG_ER_diArg_1	144	146	PF00400	0.611
TRG_ER_diArg_1	18	20	PF00400	0.555
TRG_ER_diArg_1	251	254	PF00400	0.635
TRG_ER_diArg_1	592	594	PF00400	0.520
TRG_ER_diArg_1	616	619	PF00400	0.668
TRG_ER_diArg_1	669	671	PF00400	0.600
TRG_ER_diArg_1	719	722	PF00400	0.619
TRG_ER_diArg_1	734	736	PF00400	0.552
TRG_ER_diArg_1	819	821	PF00400	0.811
TRG_ER_diArg_1	98	101	PF00400	0.631
TRG_NES_CRM1_1	715	729	PF08389	0.601
TRG_NLS_MonoCore_2	590	595	PF00514	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5I7	Leishmania donovani	50%	100%
E9AKG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4QJE0	Leishmania major	50%	97%