LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HD44_LEIBR
TriTrypDb:
LbrM.23.1840 , LBRM2903_050011800 *
Length:
905

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7

Expansion

Sequence features

A4HD44
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD44

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 410 414 PF00656 0.547
CLV_C14_Caspase3-7 575 579 PF00656 0.637
CLV_NRD_NRD_1 52 54 PF00675 0.470
CLV_NRD_NRD_1 540 542 PF00675 0.678
CLV_NRD_NRD_1 576 578 PF00675 0.511
CLV_NRD_NRD_1 599 601 PF00675 0.652
CLV_NRD_NRD_1 798 800 PF00675 0.644
CLV_NRD_NRD_1 827 829 PF00675 0.819
CLV_PCSK_FUR_1 159 163 PF00082 0.305
CLV_PCSK_KEX2_1 161 163 PF00082 0.318
CLV_PCSK_KEX2_1 52 54 PF00082 0.470
CLV_PCSK_KEX2_1 540 542 PF00082 0.682
CLV_PCSK_KEX2_1 576 578 PF00082 0.511
CLV_PCSK_KEX2_1 598 600 PF00082 0.652
CLV_PCSK_KEX2_1 797 799 PF00082 0.714
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.318
CLV_PCSK_PC7_1 48 54 PF00082 0.485
CLV_PCSK_SKI1_1 264 268 PF00082 0.440
CLV_PCSK_SKI1_1 360 364 PF00082 0.546
CLV_PCSK_SKI1_1 650 654 PF00082 0.519
CLV_PCSK_SKI1_1 809 813 PF00082 0.627
DEG_APCC_DBOX_1 263 271 PF00400 0.440
DEG_APCC_DBOX_1 597 605 PF00400 0.659
DEG_SPOP_SBC_1 856 860 PF00917 0.544
DOC_CDC14_PxL_1 185 193 PF14671 0.382
DOC_CKS1_1 34 39 PF01111 0.517
DOC_CKS1_1 581 586 PF01111 0.582
DOC_CKS1_1 681 686 PF01111 0.566
DOC_CYCLIN_yClb3_PxF_3 147 153 PF00134 0.344
DOC_CYCLIN_yCln2_LP_2 142 148 PF00134 0.350
DOC_CYCLIN_yCln2_LP_2 652 658 PF00134 0.533
DOC_CYCLIN_yCln2_LP_2 766 772 PF00134 0.524
DOC_MAPK_DCC_7 598 606 PF00069 0.598
DOC_MAPK_gen_1 159 168 PF00069 0.445
DOC_MAPK_gen_1 598 606 PF00069 0.663
DOC_MAPK_gen_1 738 747 PF00069 0.685
DOC_MAPK_gen_1 797 806 PF00069 0.661
DOC_MAPK_MEF2A_6 161 170 PF00069 0.448
DOC_MAPK_MEF2A_6 186 194 PF00069 0.447
DOC_MAPK_MEF2A_6 292 300 PF00069 0.481
DOC_MAPK_MEF2A_6 68 75 PF00069 0.496
DOC_MAPK_MEF2A_6 738 747 PF00069 0.685
DOC_MAPK_MEF2A_6 797 806 PF00069 0.521
DOC_MAPK_NFAT4_5 740 748 PF00069 0.701
DOC_PP1_RVXF_1 834 841 PF00149 0.671
DOC_PP2B_LxvP_1 652 655 PF13499 0.525
DOC_PP2B_LxvP_1 745 748 PF13499 0.651
DOC_PP4_FxxP_1 35 38 PF00568 0.518
DOC_PP4_FxxP_1 581 584 PF00568 0.584
DOC_USP7_MATH_1 116 120 PF00917 0.476
DOC_USP7_MATH_1 220 224 PF00917 0.374
DOC_USP7_MATH_1 288 292 PF00917 0.504
DOC_USP7_MATH_1 502 506 PF00917 0.667
DOC_USP7_MATH_1 523 527 PF00917 0.561
DOC_USP7_MATH_1 614 618 PF00917 0.691
DOC_USP7_MATH_1 736 740 PF00917 0.766
DOC_USP7_MATH_1 817 821 PF00917 0.682
DOC_USP7_MATH_1 824 828 PF00917 0.619
DOC_USP7_MATH_1 873 877 PF00917 0.503
DOC_USP7_MATH_1 9 13 PF00917 0.586
DOC_USP7_MATH_1 90 94 PF00917 0.592
DOC_USP7_UBL2_3 812 816 PF12436 0.675
DOC_WW_Pin1_4 141 146 PF00397 0.482
DOC_WW_Pin1_4 171 176 PF00397 0.393
DOC_WW_Pin1_4 28 33 PF00397 0.514
DOC_WW_Pin1_4 327 332 PF00397 0.497
DOC_WW_Pin1_4 345 350 PF00397 0.576
DOC_WW_Pin1_4 391 396 PF00397 0.535
DOC_WW_Pin1_4 498 503 PF00397 0.708
DOC_WW_Pin1_4 505 510 PF00397 0.688
DOC_WW_Pin1_4 569 574 PF00397 0.530
DOC_WW_Pin1_4 580 585 PF00397 0.637
DOC_WW_Pin1_4 680 685 PF00397 0.559
DOC_WW_Pin1_4 717 722 PF00397 0.701
LIG_14-3-3_CanoR_1 162 166 PF00244 0.306
LIG_14-3-3_CanoR_1 274 279 PF00244 0.472
LIG_14-3-3_CanoR_1 305 310 PF00244 0.357
LIG_14-3-3_CanoR_1 336 342 PF00244 0.560
LIG_14-3-3_CanoR_1 48 54 PF00244 0.592
LIG_14-3-3_CanoR_1 530 535 PF00244 0.632
LIG_14-3-3_CanoR_1 541 550 PF00244 0.613
LIG_14-3-3_CanoR_1 555 563 PF00244 0.519
LIG_14-3-3_CanoR_1 624 631 PF00244 0.548
LIG_14-3-3_CanoR_1 632 636 PF00244 0.499
LIG_14-3-3_CanoR_1 685 694 PF00244 0.618
LIG_14-3-3_CanoR_1 801 807 PF00244 0.674
LIG_14-3-3_CanoR_1 866 871 PF00244 0.628
LIG_Actin_WH2_2 181 197 PF00022 0.370
LIG_APCC_ABBA_1 124 129 PF00400 0.513
LIG_APCC_ABBAyCdc20_2 560 566 PF00400 0.537
LIG_CtBP_PxDLS_1 862 866 PF00389 0.515
LIG_eIF4E_1 444 450 PF01652 0.515
LIG_FHA_1 141 147 PF00498 0.433
LIG_FHA_1 172 178 PF00498 0.378
LIG_FHA_1 2 8 PF00498 0.569
LIG_FHA_1 219 225 PF00498 0.514
LIG_FHA_1 278 284 PF00498 0.406
LIG_FHA_1 359 365 PF00498 0.612
LIG_FHA_1 368 374 PF00498 0.545
LIG_FHA_1 450 456 PF00498 0.490
LIG_FHA_1 475 481 PF00498 0.541
LIG_FHA_1 543 549 PF00498 0.726
LIG_FHA_1 777 783 PF00498 0.623
LIG_FHA_2 482 488 PF00498 0.598
LIG_FHA_2 570 576 PF00498 0.567
LIG_FHA_2 841 847 PF00498 0.651
LIG_FHA_2 899 905 PF00498 0.627
LIG_GBD_Chelix_1 192 200 PF00786 0.303
LIG_Integrin_isoDGR_2 495 497 PF01839 0.581
LIG_Integrin_RGD_1 205 207 PF01839 0.474
LIG_IRF3_LxIS_1 24 31 PF10401 0.520
LIG_LIR_Apic_2 33 38 PF02991 0.514
LIG_LIR_Apic_2 578 584 PF02991 0.647
LIG_LIR_Gen_1 152 157 PF02991 0.458
LIG_LIR_Gen_1 167 178 PF02991 0.298
LIG_LIR_Gen_1 697 708 PF02991 0.513
LIG_LIR_LC3C_4 152 157 PF02991 0.295
LIG_LIR_Nem_3 152 156 PF02991 0.461
LIG_LIR_Nem_3 167 173 PF02991 0.306
LIG_LIR_Nem_3 697 703 PF02991 0.517
LIG_MAD2 650 658 PF02301 0.532
LIG_MYND_1 744 748 PF01753 0.646
LIG_PCNA_PIPBox_1 437 446 PF02747 0.535
LIG_Rb_pABgroove_1 847 855 PF01858 0.521
LIG_SH2_CRK 664 668 PF00017 0.504
LIG_SH2_CRK 700 704 PF00017 0.529
LIG_SH2_CRK 853 857 PF00017 0.530
LIG_SH2_CRK 883 887 PF00017 0.558
LIG_SH2_GRB2like 401 404 PF00017 0.652
LIG_SH2_GRB2like 664 667 PF00017 0.510
LIG_SH2_NCK_1 883 887 PF00017 0.558
LIG_SH2_SRC 883 886 PF00017 0.484
LIG_SH2_STAP1 853 857 PF00017 0.530
LIG_SH2_STAT5 407 410 PF00017 0.607
LIG_SH2_STAT5 773 776 PF00017 0.572
LIG_SH3_2 733 738 PF14604 0.538
LIG_SH3_3 142 148 PF00018 0.456
LIG_SH3_3 174 180 PF00018 0.441
LIG_SH3_3 26 32 PF00018 0.547
LIG_SH3_3 414 420 PF00018 0.593
LIG_SH3_3 652 658 PF00018 0.485
LIG_SH3_3 673 679 PF00018 0.572
LIG_SH3_3 727 733 PF00018 0.688
LIG_SH3_3 745 751 PF00018 0.553
LIG_SH3_CIN85_PxpxPR_1 434 439 PF14604 0.537
LIG_SUMO_SIM_anti_2 152 158 PF11976 0.411
LIG_SUMO_SIM_anti_2 477 484 PF11976 0.545
LIG_SUMO_SIM_par_1 152 158 PF11976 0.397
LIG_SUMO_SIM_par_1 164 169 PF11976 0.368
LIG_SUMO_SIM_par_1 220 227 PF11976 0.478
LIG_SUMO_SIM_par_1 372 377 PF11976 0.632
LIG_SUMO_SIM_par_1 477 484 PF11976 0.545
LIG_SUMO_SIM_par_1 69 74 PF11976 0.342
LIG_SxIP_EBH_1 336 348 PF03271 0.504
LIG_TRAF2_1 126 129 PF00917 0.498
LIG_TRAF2_1 572 575 PF00917 0.572
LIG_TRAF2_1 789 792 PF00917 0.598
LIG_TYR_ITIM 698 703 PF00017 0.525
LIG_TYR_ITIM 881 886 PF00017 0.565
LIG_UBA3_1 190 195 PF00899 0.438
LIG_UBA3_1 479 486 PF00899 0.544
LIG_WRC_WIRS_1 150 155 PF05994 0.450
MOD_CDK_SPK_2 680 685 PF00069 0.624
MOD_CDK_SPxK_1 580 586 PF00069 0.706
MOD_CDK_SPxxK_3 569 576 PF00069 0.497
MOD_CK1_1 33 39 PF00069 0.515
MOD_CK1_1 337 343 PF00069 0.568
MOD_CK1_1 345 351 PF00069 0.615
MOD_CK1_1 358 364 PF00069 0.585
MOD_CK1_1 367 373 PF00069 0.542
MOD_CK1_1 505 511 PF00069 0.580
MOD_CK1_1 542 548 PF00069 0.675
MOD_CK1_1 688 694 PF00069 0.612
MOD_CK1_1 8 14 PF00069 0.553
MOD_CK1_1 827 833 PF00069 0.615
MOD_CK1_1 887 893 PF00069 0.604
MOD_CK1_1 895 901 PF00069 0.519
MOD_CK2_1 166 172 PF00069 0.318
MOD_CK2_1 220 226 PF00069 0.473
MOD_CK2_1 40 46 PF00069 0.528
MOD_CK2_1 481 487 PF00069 0.566
MOD_CK2_1 569 575 PF00069 0.581
MOD_CK2_1 722 728 PF00069 0.567
MOD_CK2_1 898 904 PF00069 0.624
MOD_GlcNHglycan 106 109 PF01048 0.596
MOD_GlcNHglycan 11 14 PF01048 0.570
MOD_GlcNHglycan 117 121 PF01048 0.452
MOD_GlcNHglycan 132 135 PF01048 0.421
MOD_GlcNHglycan 17 20 PF01048 0.521
MOD_GlcNHglycan 196 199 PF01048 0.378
MOD_GlcNHglycan 202 205 PF01048 0.454
MOD_GlcNHglycan 267 270 PF01048 0.441
MOD_GlcNHglycan 292 295 PF01048 0.489
MOD_GlcNHglycan 336 339 PF01048 0.549
MOD_GlcNHglycan 344 347 PF01048 0.606
MOD_GlcNHglycan 354 360 PF01048 0.563
MOD_GlcNHglycan 365 369 PF01048 0.550
MOD_GlcNHglycan 54 57 PF01048 0.515
MOD_GlcNHglycan 541 544 PF01048 0.585
MOD_GlcNHglycan 545 548 PF01048 0.609
MOD_GlcNHglycan 557 560 PF01048 0.677
MOD_GlcNHglycan 620 623 PF01048 0.675
MOD_GlcNHglycan 624 627 PF01048 0.627
MOD_GlcNHglycan 687 690 PF01048 0.475
MOD_GlcNHglycan 7 10 PF01048 0.586
MOD_GlcNHglycan 724 727 PF01048 0.595
MOD_GlcNHglycan 784 787 PF01048 0.761
MOD_GlcNHglycan 809 812 PF01048 0.608
MOD_GlcNHglycan 819 822 PF01048 0.620
MOD_GlcNHglycan 824 827 PF01048 0.616
MOD_GlcNHglycan 889 892 PF01048 0.689
MOD_GlcNHglycan 92 95 PF01048 0.592
MOD_GSK3_1 1 8 PF00069 0.575
MOD_GSK3_1 273 280 PF00069 0.448
MOD_GSK3_1 360 367 PF00069 0.679
MOD_GSK3_1 461 468 PF00069 0.691
MOD_GSK3_1 498 505 PF00069 0.638
MOD_GSK3_1 530 537 PF00069 0.604
MOD_GSK3_1 539 546 PF00069 0.652
MOD_GSK3_1 555 562 PF00069 0.556
MOD_GSK3_1 614 621 PF00069 0.623
MOD_GSK3_1 622 629 PF00069 0.609
MOD_GSK3_1 642 649 PF00069 0.428
MOD_GSK3_1 680 687 PF00069 0.623
MOD_GSK3_1 717 724 PF00069 0.704
MOD_GSK3_1 760 767 PF00069 0.560
MOD_GSK3_1 852 859 PF00069 0.567
MOD_GSK3_1 869 876 PF00069 0.576
MOD_LATS_1 272 278 PF00433 0.487
MOD_N-GLC_1 208 213 PF02516 0.562
MOD_N-GLC_1 274 279 PF02516 0.472
MOD_N-GLC_1 305 310 PF02516 0.434
MOD_N-GLC_1 40 45 PF02516 0.530
MOD_N-GLC_1 553 558 PF02516 0.563
MOD_N-GLC_1 569 574 PF02516 0.471
MOD_N-GLC_1 736 741 PF02516 0.616
MOD_N-GLC_2 403 405 PF02516 0.598
MOD_NEK2_1 1 6 PF00069 0.572
MOD_NEK2_1 155 160 PF00069 0.394
MOD_NEK2_1 166 171 PF00069 0.378
MOD_NEK2_1 194 199 PF00069 0.460
MOD_NEK2_1 200 205 PF00069 0.622
MOD_NEK2_1 281 286 PF00069 0.478
MOD_NEK2_1 287 292 PF00069 0.454
MOD_NEK2_1 304 309 PF00069 0.457
MOD_NEK2_1 334 339 PF00069 0.467
MOD_NEK2_1 40 45 PF00069 0.530
MOD_NEK2_1 412 417 PF00069 0.561
MOD_NEK2_1 449 454 PF00069 0.492
MOD_NEK2_1 539 544 PF00069 0.562
MOD_NEK2_1 694 699 PF00069 0.451
MOD_NEK2_1 782 787 PF00069 0.591
MOD_NEK2_1 802 807 PF00069 0.472
MOD_NEK2_1 852 857 PF00069 0.596
MOD_NEK2_2 559 564 PF00069 0.636
MOD_PIKK_1 318 324 PF00454 0.599
MOD_PIKK_1 467 473 PF00454 0.612
MOD_PK_1 161 167 PF00069 0.309
MOD_PKA_1 161 167 PF00069 0.309
MOD_PKA_1 52 58 PF00069 0.450
MOD_PKA_2 161 167 PF00069 0.390
MOD_PKA_2 273 279 PF00069 0.482
MOD_PKA_2 304 310 PF00069 0.355
MOD_PKA_2 47 53 PF00069 0.602
MOD_PKA_2 539 545 PF00069 0.578
MOD_PKA_2 554 560 PF00069 0.520
MOD_PKA_2 631 637 PF00069 0.510
MOD_PKA_2 684 690 PF00069 0.630
MOD_PKA_2 802 808 PF00069 0.656
MOD_PKA_2 827 833 PF00069 0.606
MOD_PKA_2 90 96 PF00069 0.522
MOD_Plk_1 166 172 PF00069 0.369
MOD_Plk_1 274 280 PF00069 0.409
MOD_Plk_1 305 311 PF00069 0.436
MOD_Plk_1 40 46 PF00069 0.528
MOD_Plk_1 898 904 PF00069 0.486
MOD_Plk_4 149 155 PF00069 0.525
MOD_Plk_4 161 167 PF00069 0.313
MOD_Plk_4 40 46 PF00069 0.528
MOD_Plk_4 631 637 PF00069 0.542
MOD_Plk_4 726 732 PF00069 0.568
MOD_Plk_4 852 858 PF00069 0.635
MOD_ProDKin_1 141 147 PF00069 0.487
MOD_ProDKin_1 171 177 PF00069 0.385
MOD_ProDKin_1 28 34 PF00069 0.513
MOD_ProDKin_1 327 333 PF00069 0.501
MOD_ProDKin_1 345 351 PF00069 0.577
MOD_ProDKin_1 391 397 PF00069 0.535
MOD_ProDKin_1 498 504 PF00069 0.709
MOD_ProDKin_1 505 511 PF00069 0.688
MOD_ProDKin_1 569 575 PF00069 0.527
MOD_ProDKin_1 580 586 PF00069 0.636
MOD_ProDKin_1 680 686 PF00069 0.563
MOD_ProDKin_1 717 723 PF00069 0.702
TRG_DiLeu_BaEn_1 118 123 PF01217 0.592
TRG_DiLeu_BaEn_1 478 483 PF01217 0.542
TRG_DiLeu_BaEn_1 65 70 PF01217 0.429
TRG_DiLeu_BaLyEn_6 177 182 PF01217 0.353
TRG_DiLeu_BaLyEn_6 186 191 PF01217 0.389
TRG_DiLeu_BaLyEn_6 417 422 PF01217 0.590
TRG_DiLeu_BaLyEn_6 741 746 PF01217 0.703
TRG_ENDOCYTIC_2 664 667 PF00928 0.510
TRG_ENDOCYTIC_2 700 703 PF00928 0.521
TRG_ENDOCYTIC_2 853 856 PF00928 0.532
TRG_ENDOCYTIC_2 883 886 PF00928 0.561
TRG_ER_diArg_1 404 407 PF00400 0.543
TRG_ER_diArg_1 52 54 PF00400 0.470
TRG_ER_diArg_1 529 532 PF00400 0.708
TRG_ER_diArg_1 539 541 PF00400 0.606
TRG_ER_diArg_1 597 600 PF00400 0.647
TRG_ER_diArg_1 797 799 PF00400 0.650
TRG_ER_diArg_1 801 804 PF00400 0.610
TRG_ER_diArg_1 834 837 PF00400 0.570
TRG_NES_CRM1_1 61 74 PF08389 0.408
TRG_Pf-PMV_PEXEL_1 406 410 PF00026 0.583
TRG_Pf-PMV_PEXEL_1 42 46 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 52 57 PF00026 0.452

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE62 Leptomonas seymouri 35% 100%
A0A3S5H5I9 Leishmania donovani 69% 100%
A4HSI7 Leishmania infantum 69% 100%
E9AKH1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 100%
Q4QJD7 Leishmania major 68% 99%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS