Nucleoside 2-deoxyribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoside 2-deoxyribosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD42_LEIBR

TriTrypDb:

LbrM.23.1820 , LBRM2903_230029100

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD42

PDB structure(s): 6qai_A , 6qai_B

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009123	nucleoside monophosphate metabolic process	5	1
GO:0009125	nucleoside monophosphate catabolic process	6	1
GO:0009159	deoxyribonucleoside monophosphate catabolic process	7	1
GO:0009162	deoxyribonucleoside monophosphate metabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	1
GO:0070694	deoxyribonucleoside 5'-monophosphate N-glycosidase activity	5	1
GO:0016740	transferase activity	2	5
GO:0016757	glycosyltransferase activity	3	1
GO:0016763	pentosyltransferase activity	4	1
GO:0050144	nucleoside deoxyribosyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.394
CLV_PCSK_SKI1_1	28	32	PF00082	0.264
CLV_PCSK_SKI1_1	94	98	PF00082	0.260
DOC_CYCLIN_RxL_1	25	33	PF00134	0.477
DOC_CYCLIN_RxL_1	91	101	PF00134	0.516
DOC_MAPK_DCC_7	32	42	PF00069	0.547
DOC_MAPK_gen_1	32	39	PF00069	0.516
DOC_MAPK_MEF2A_6	34	42	PF00069	0.549
DOC_PP4_FxxP_1	123	126	PF00568	0.473
DOC_USP7_MATH_1	72	76	PF00917	0.460
DOC_WW_Pin1_4	68	73	PF00397	0.449
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_Clathr_ClatBox_1	39	43	PF01394	0.452
LIG_FHA_2	80	86	PF00498	0.449
LIG_LIR_Apic_2	121	126	PF02991	0.473
LIG_LIR_Gen_1	135	145	PF02991	0.415
LIG_LIR_Gen_1	21	31	PF02991	0.517
LIG_LIR_Nem_3	135	141	PF02991	0.383
LIG_LIR_Nem_3	142	148	PF02991	0.350
LIG_LIR_Nem_3	21	27	PF02991	0.517
LIG_Pex14_2	123	127	PF04695	0.473
LIG_Pex14_2	141	145	PF04695	0.360
LIG_SH2_CRK	24	28	PF00017	0.495
LIG_SH2_STAP1	88	92	PF00017	0.495
LIG_SH2_STAT3	110	113	PF00017	0.394
LIG_SH2_STAT5	24	27	PF00017	0.449
LIG_SH2_STAT5	8	11	PF00017	0.449
LIG_SH3_3	35	41	PF00018	0.449
LIG_WRC_WIRS_1	138	143	PF05994	0.376
LIG_WRC_WIRS_1	96	101	PF05994	0.516
MOD_CDC14_SPxK_1	71	74	PF00782	0.449
MOD_CDK_SPxK_1	68	74	PF00069	0.449
MOD_CK1_1	100	106	PF00069	0.535
MOD_CK2_1	102	108	PF00069	0.402
MOD_CK2_1	52	58	PF00069	0.394
MOD_CK2_1	79	85	PF00069	0.468
MOD_GlcNHglycan	46	49	PF01048	0.269
MOD_GSK3_1	68	75	PF00069	0.489
MOD_GSK3_1	98	105	PF00069	0.461
MOD_N-GLC_1	132	137	PF02516	0.274
MOD_PKA_2	52	58	PF00069	0.394
MOD_Plk_1	42	48	PF00069	0.394
MOD_Plk_2-3	102	108	PF00069	0.426
MOD_Plk_2-3	116	122	PF00069	0.543
MOD_ProDKin_1	68	74	PF00069	0.449
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.479
TRG_ENDOCYTIC_2	24	27	PF00928	0.449
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ26	Leptomonas seymouri	74%	100%
A0A1X0NWK1	Trypanosomatidae	64%	99%
A0A3R7L3D6	Trypanosoma rangeli	72%	100%
A0A3R7MAG4	Trypanosoma rangeli	66%	79%
A0A3S7WY56	Leishmania donovani	81%	100%
A0A422N0V5	Trypanosoma rangeli	69%	100%
C9ZNS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AH20	Leishmania infantum	82%	100%
E9AWJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QAY0	Leishmania major	82%	100%
Q9Y7P9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	73%