Neutral sphingomyelinase activation associated factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

neutral sphingomyelinase activation associated factor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HD41_LEIBR

TriTrypDb:

LbrM.23.1810 , LBRM2903_230029000

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD41

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004620	phospholipase activity	5	5
GO:0004767	sphingomyelin phosphodiesterase activity	6	5
GO:0008081	phosphoric diester hydrolase activity	5	5
GO:0016298	lipase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0042578	phosphoric ester hydrolase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	587	591	PF00656	0.650
CLV_C14_Caspase3-7	904	908	PF00656	0.409
CLV_NRD_NRD_1	147	149	PF00675	0.578
CLV_NRD_NRD_1	164	166	PF00675	0.476
CLV_NRD_NRD_1	3	5	PF00675	0.612
CLV_NRD_NRD_1	835	837	PF00675	0.467
CLV_PCSK_KEX2_1	147	149	PF00082	0.578
CLV_PCSK_KEX2_1	164	166	PF00082	0.468
CLV_PCSK_KEX2_1	2	4	PF00082	0.627
CLV_PCSK_KEX2_1	835	837	PF00082	0.467
CLV_PCSK_SKI1_1	133	137	PF00082	0.516
CLV_PCSK_SKI1_1	173	177	PF00082	0.407
CLV_PCSK_SKI1_1	33	37	PF00082	0.641
CLV_PCSK_SKI1_1	401	405	PF00082	0.225
CLV_PCSK_SKI1_1	463	467	PF00082	0.312
CLV_PCSK_SKI1_1	623	627	PF00082	0.441
CLV_PCSK_SKI1_1	87	91	PF00082	0.436
CLV_PCSK_SKI1_1	92	96	PF00082	0.450
DEG_APCC_DBOX_1	32	40	PF00400	0.615
DEG_APCC_DBOX_1	6	14	PF00400	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DEG_SCF_FBW7_1	227	234	PF00400	0.448
DOC_AGCK_PIF_1	499	504	PF00069	0.312
DOC_CDC14_PxL_1	393	401	PF14671	0.312
DOC_CYCLIN_RxL_1	884	893	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	95	98	PF00134	0.455
DOC_MAPK_DCC_7	509	518	PF00069	0.316
DOC_MAPK_FxFP_2	296	299	PF00069	0.312
DOC_MAPK_FxFP_2	502	505	PF00069	0.388
DOC_MAPK_gen_1	170	178	PF00069	0.380
DOC_MAPK_gen_1	2	10	PF00069	0.600
DOC_MAPK_gen_1	241	249	PF00069	0.317
DOC_MAPK_gen_1	542	551	PF00069	0.434
DOC_MAPK_gen_1	570	580	PF00069	0.557
DOC_MAPK_gen_1	812	820	PF00069	0.492
DOC_MAPK_MEF2A_6	509	518	PF00069	0.312
DOC_MAPK_MEF2A_6	525	534	PF00069	0.312
DOC_MAPK_MEF2A_6	650	657	PF00069	0.343
DOC_MAPK_MEF2A_6	909	916	PF00069	0.397
DOC_MAPK_NFAT4_5	650	658	PF00069	0.349
DOC_MAPK_NFAT4_5	909	917	PF00069	0.370
DOC_PP1_RVXF_1	208	215	PF00149	0.359
DOC_PP2B_LxvP_1	254	257	PF13499	0.338
DOC_PP2B_LxvP_1	386	389	PF13499	0.388
DOC_PP2B_LxvP_1	511	514	PF13499	0.388
DOC_PP2B_LxvP_1	95	98	PF13499	0.552
DOC_PP2B_PxIxI_1	57	63	PF00149	0.335
DOC_PP4_FxxP_1	189	192	PF00568	0.411
DOC_PP4_FxxP_1	237	240	PF00568	0.398
DOC_PP4_FxxP_1	296	299	PF00568	0.312
DOC_PP4_FxxP_1	315	318	PF00568	0.312
DOC_PP4_FxxP_1	502	505	PF00568	0.388
DOC_PP4_FxxP_1	747	750	PF00568	0.507
DOC_SPAK_OSR1_1	815	819	PF12202	0.472
DOC_USP7_MATH_1	122	126	PF00917	0.503
DOC_USP7_MATH_1	452	456	PF00917	0.388
DOC_USP7_MATH_1	465	469	PF00917	0.242
DOC_USP7_MATH_1	553	557	PF00917	0.514
DOC_USP7_MATH_1	799	803	PF00917	0.536
DOC_USP7_MATH_1	885	889	PF00917	0.439
DOC_WW_Pin1_4	106	111	PF00397	0.462
DOC_WW_Pin1_4	223	228	PF00397	0.604
DOC_WW_Pin1_4	307	312	PF00397	0.231
DOC_WW_Pin1_4	329	334	PF00397	0.388
DOC_WW_Pin1_4	437	442	PF00397	0.388
DOC_WW_Pin1_4	54	59	PF00397	0.362
DOC_WW_Pin1_4	631	636	PF00397	0.521
DOC_WW_Pin1_4	707	712	PF00397	0.440
DOC_WW_Pin1_4	746	751	PF00397	0.397
DOC_WW_Pin1_4	837	842	PF00397	0.424
DOC_WW_Pin1_4	881	886	PF00397	0.422
LIG_14-3-3_CanoR_1	205	209	PF00244	0.504
LIG_14-3-3_CanoR_1	273	279	PF00244	0.253
LIG_14-3-3_CanoR_1	335	339	PF00244	0.273
LIG_14-3-3_CanoR_1	401	410	PF00244	0.240
LIG_14-3-3_CanoR_1	460	470	PF00244	0.231
LIG_14-3-3_CanoR_1	509	514	PF00244	0.388
LIG_14-3-3_CanoR_1	542	547	PF00244	0.536
LIG_14-3-3_CanoR_1	623	628	PF00244	0.437
LIG_14-3-3_CanoR_1	662	667	PF00244	0.423
LIG_14-3-3_CanoR_1	7	11	PF00244	0.499
LIG_14-3-3_CanoR_1	741	746	PF00244	0.385
LIG_14-3-3_CanoR_1	835	841	PF00244	0.565
LIG_14-3-3_CanoR_1	918	925	PF00244	0.438
LIG_Actin_WH2_2	332	349	PF00022	0.410
LIG_Actin_WH2_2	822	837	PF00022	0.492
LIG_APCC_ABBA_1	371	376	PF00400	0.302
LIG_APCC_ABBA_1	433	438	PF00400	0.352
LIG_APCC_ABBA_1	532	537	PF00400	0.312
LIG_APCC_ABBA_1	683	688	PF00400	0.355
LIG_BIR_III_2	537	541	PF00653	0.231
LIG_BRCT_BRCA1_1	233	237	PF00533	0.373
LIG_BRCT_BRCA1_1	406	410	PF00533	0.388
LIG_BRCT_BRCA1_1	454	458	PF00533	0.388
LIG_BRCT_BRCA1_1	620	624	PF00533	0.553
LIG_BRCT_BRCA1_1	743	747	PF00533	0.356
LIG_deltaCOP1_diTrp_1	115	121	PF00928	0.438
LIG_EVH1_1	189	193	PF00568	0.390
LIG_FHA_1	228	234	PF00498	0.469
LIG_FHA_1	350	356	PF00498	0.364
LIG_FHA_1	383	389	PF00498	0.312
LIG_FHA_1	41	47	PF00498	0.486
LIG_FHA_1	583	589	PF00498	0.665
LIG_FHA_1	597	603	PF00498	0.595
LIG_FHA_1	612	618	PF00498	0.447
LIG_FHA_1	637	643	PF00498	0.528
LIG_FHA_1	704	710	PF00498	0.407
LIG_FHA_1	718	724	PF00498	0.438
LIG_FHA_1	740	746	PF00498	0.550
LIG_FHA_1	775	781	PF00498	0.449
LIG_FHA_1	901	907	PF00498	0.466
LIG_FHA_2	12	18	PF00498	0.579
LIG_FHA_2	318	324	PF00498	0.307
LIG_FHA_2	36	42	PF00498	0.635
LIG_FHA_2	585	591	PF00498	0.647
LIG_FHA_2	628	634	PF00498	0.411
LIG_FHA_2	787	793	PF00498	0.444
LIG_FHA_2	902	908	PF00498	0.430
LIG_FXI_DFP_1	666	670	PF00024	0.443
LIG_LIR_Apic_2	234	240	PF02991	0.378
LIG_LIR_Apic_2	294	299	PF02991	0.312
LIG_LIR_Apic_2	307	311	PF02991	0.312
LIG_LIR_Apic_2	314	318	PF02991	0.183
LIG_LIR_Apic_2	734	739	PF02991	0.302
LIG_LIR_Apic_2	744	750	PF02991	0.331
LIG_LIR_Gen_1	276	284	PF02991	0.302
LIG_LIR_Gen_1	420	430	PF02991	0.305
LIG_LIR_Gen_1	621	629	PF02991	0.522
LIG_LIR_Gen_1	814	825	PF02991	0.487
LIG_LIR_LC3C_4	720	725	PF02991	0.444
LIG_LIR_Nem_3	182	188	PF02991	0.375
LIG_LIR_Nem_3	276	281	PF02991	0.302
LIG_LIR_Nem_3	29	35	PF02991	0.561
LIG_LIR_Nem_3	319	324	PF02991	0.312
LIG_LIR_Nem_3	407	413	PF02991	0.312
LIG_LIR_Nem_3	420	425	PF02991	0.305
LIG_LIR_Nem_3	496	502	PF02991	0.312
LIG_LIR_Nem_3	526	530	PF02991	0.312
LIG_LIR_Nem_3	621	627	PF02991	0.524
LIG_LIR_Nem_3	665	669	PF02991	0.520
LIG_LIR_Nem_3	814	820	PF02991	0.478
LIG_LIR_Nem_3	867	872	PF02991	0.611
LIG_MYND_1	428	432	PF01753	0.388
LIG_PDZ_Class_1	920	925	PF00595	0.447
LIG_Pex14_1	117	121	PF04695	0.502
LIG_Pex14_2	185	189	PF04695	0.375
LIG_Pex14_2	418	422	PF04695	0.312
LIG_Pex14_2	816	820	PF04695	0.387
LIG_PTB_Apo_2	416	423	PF02174	0.327
LIG_RPA_C_Fungi	913	925	PF08784	0.404
LIG_SH2_CRK	308	312	PF00017	0.231
LIG_SH2_NCK_1	308	312	PF00017	0.326
LIG_SH2_NCK_1	360	364	PF00017	0.312
LIG_SH2_SRC	354	357	PF00017	0.312
LIG_SH2_STAP1	278	282	PF00017	0.510
LIG_SH2_STAP1	356	360	PF00017	0.312
LIG_SH2_STAP1	523	527	PF00017	0.312
LIG_SH2_STAT5	177	180	PF00017	0.448
LIG_SH2_STAT5	222	225	PF00017	0.392
LIG_SH2_STAT5	280	283	PF00017	0.317
LIG_SH2_STAT5	308	311	PF00017	0.334
LIG_SH2_STAT5	354	357	PF00017	0.350
LIG_SH2_STAT5	369	372	PF00017	0.345
LIG_SH2_STAT5	629	632	PF00017	0.406
LIG_SH2_STAT5	693	696	PF00017	0.360
LIG_SH3_3	184	190	PF00018	0.523
LIG_SH3_3	296	302	PF00018	0.312
LIG_SH3_3	426	432	PF00018	0.391
LIG_SH3_3	443	449	PF00018	0.219
LIG_SH3_3	58	64	PF00018	0.487
LIG_SH3_3	91	97	PF00018	0.543
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.312
LIG_SUMO_SIM_anti_2	720	729	PF11976	0.434
LIG_SUMO_SIM_par_1	384	390	PF11976	0.313
LIG_SUMO_SIM_par_1	41	49	PF11976	0.514
LIG_SUMO_SIM_par_1	607	614	PF11976	0.446
LIG_SUMO_SIM_par_1	641	648	PF11976	0.429
LIG_SUMO_SIM_par_1	653	659	PF11976	0.436
LIG_SUMO_SIM_par_1	693	699	PF11976	0.386
LIG_SUMO_SIM_par_1	720	729	PF11976	0.434
LIG_TRAF2_1	566	569	PF00917	0.471
LIG_TRFH_1	189	193	PF08558	0.412
LIG_TYR_ITIM	366	371	PF00017	0.312
LIG_UBA3_1	281	286	PF00899	0.388
LIG_WW_3	539	543	PF00397	0.388
MOD_CDC14_SPxK_1	332	335	PF00782	0.388
MOD_CDC14_SPxK_1	884	887	PF00782	0.433
MOD_CDK_SPxK_1	329	335	PF00069	0.388
MOD_CDK_SPxK_1	881	887	PF00069	0.427
MOD_CK1_1	131	137	PF00069	0.510
MOD_CK1_1	157	163	PF00069	0.420
MOD_CK1_1	274	280	PF00069	0.335
MOD_CK1_1	316	322	PF00069	0.312
MOD_CK1_1	334	340	PF00069	0.243
MOD_CK1_1	34	40	PF00069	0.548
MOD_CK1_1	402	408	PF00069	0.312
MOD_CK1_1	45	51	PF00069	0.528
MOD_CK1_1	6	12	PF00069	0.503
MOD_CK1_1	613	619	PF00069	0.538
MOD_CK1_1	696	702	PF00069	0.411
MOD_CK1_1	749	755	PF00069	0.480
MOD_CK1_1	843	849	PF00069	0.579
MOD_CK1_1	893	899	PF00069	0.375
MOD_CK1_1	908	914	PF00069	0.353
MOD_CK2_1	11	17	PF00069	0.570
MOD_CK2_1	143	149	PF00069	0.470
MOD_CK2_1	273	279	PF00069	0.337
MOD_CK2_1	35	41	PF00069	0.636
MOD_CK2_1	461	467	PF00069	0.231
MOD_CK2_1	516	522	PF00069	0.312
MOD_CK2_1	786	792	PF00069	0.481
MOD_GlcNHglycan	156	159	PF01048	0.492
MOD_GlcNHglycan	29	32	PF01048	0.507
MOD_GlcNHglycan	361	364	PF01048	0.312
MOD_GlcNHglycan	463	466	PF01048	0.325
MOD_GlcNHglycan	471	474	PF01048	0.437
MOD_GlcNHglycan	620	623	PF01048	0.486
MOD_GlcNHglycan	733	736	PF01048	0.417
MOD_GlcNHglycan	766	769	PF01048	0.464
MOD_GlcNHglycan	862	865	PF01048	0.495
MOD_GlcNHglycan	892	895	PF01048	0.416
MOD_GlcNHglycan	98	101	PF01048	0.457
MOD_GSK3_1	153	160	PF00069	0.502
MOD_GSK3_1	223	230	PF00069	0.592
MOD_GSK3_1	27	34	PF00069	0.580
MOD_GSK3_1	313	320	PF00069	0.310
MOD_GSK3_1	354	361	PF00069	0.328
MOD_GSK3_1	401	408	PF00069	0.312
MOD_GSK3_1	461	468	PF00069	0.317
MOD_GSK3_1	549	556	PF00069	0.557
MOD_GSK3_1	584	591	PF00069	0.743
MOD_GSK3_1	607	614	PF00069	0.520
MOD_GSK3_1	623	630	PF00069	0.378
MOD_GSK3_1	684	691	PF00069	0.441
MOD_GSK3_1	703	710	PF00069	0.284
MOD_GSK3_1	751	758	PF00069	0.373
MOD_GSK3_1	836	843	PF00069	0.576
MOD_GSK3_1	881	888	PF00069	0.581
MOD_GSK3_1	889	896	PF00069	0.465
MOD_GSK3_1	901	908	PF00069	0.348
MOD_GSK3_1	96	103	PF00069	0.474
MOD_N-GLC_1	153	158	PF02516	0.403
MOD_N-GLC_1	405	410	PF02516	0.312
MOD_NEK2_1	313	318	PF00069	0.319
MOD_NEK2_1	35	40	PF00069	0.628
MOD_NEK2_1	355	360	PF00069	0.334
MOD_NEK2_1	377	382	PF00069	0.439
MOD_NEK2_1	399	404	PF00069	0.314
MOD_NEK2_1	516	521	PF00069	0.505
MOD_NEK2_1	686	691	PF00069	0.355
MOD_NEK2_1	695	700	PF00069	0.377
MOD_NEK2_1	726	731	PF00069	0.438
MOD_NEK2_1	764	769	PF00069	0.345
MOD_NEK2_1	871	876	PF00069	0.532
MOD_NEK2_1	889	894	PF00069	0.471
MOD_NEK2_1	900	905	PF00069	0.417
MOD_NEK2_1	912	917	PF00069	0.368
MOD_NEK2_2	259	264	PF00069	0.317
MOD_OFUCOSY	785	790	PF10250	0.469
MOD_PIKK_1	313	319	PF00454	0.388
MOD_PIKK_1	627	633	PF00454	0.419
MOD_PIKK_1	718	724	PF00454	0.454
MOD_PIKK_1	849	855	PF00454	0.458
MOD_PK_1	271	277	PF00069	0.303
MOD_PK_1	509	515	PF00069	0.388
MOD_PKA_1	3	9	PF00069	0.571
MOD_PKA_1	835	841	PF00069	0.469
MOD_PKA_2	122	128	PF00069	0.459
MOD_PKA_2	204	210	PF00069	0.422
MOD_PKA_2	259	265	PF00069	0.419
MOD_PKA_2	26	32	PF00069	0.470
MOD_PKA_2	3	9	PF00069	0.519
MOD_PKA_2	334	340	PF00069	0.297
MOD_PKA_2	740	746	PF00069	0.542
MOD_PKA_2	835	841	PF00069	0.469
MOD_PKA_2	917	923	PF00069	0.413
MOD_PKB_1	271	279	PF00069	0.231
MOD_Plk_1	349	355	PF00069	0.364
MOD_Plk_4	113	119	PF00069	0.528
MOD_Plk_4	231	237	PF00069	0.384
MOD_Plk_4	334	340	PF00069	0.273
MOD_Plk_4	584	590	PF00069	0.555
MOD_Plk_4	6	12	PF00069	0.555
MOD_Plk_4	607	613	PF00069	0.499
MOD_Plk_4	741	747	PF00069	0.373
MOD_Plk_4	800	806	PF00069	0.403
MOD_Plk_4	840	846	PF00069	0.499
MOD_Plk_4	893	899	PF00069	0.447
MOD_Plk_4	901	907	PF00069	0.605
MOD_Plk_4	908	914	PF00069	0.510
MOD_ProDKin_1	106	112	PF00069	0.462
MOD_ProDKin_1	223	229	PF00069	0.601
MOD_ProDKin_1	307	313	PF00069	0.231
MOD_ProDKin_1	329	335	PF00069	0.388
MOD_ProDKin_1	437	443	PF00069	0.388
MOD_ProDKin_1	54	60	PF00069	0.357
MOD_ProDKin_1	631	637	PF00069	0.513
MOD_ProDKin_1	707	713	PF00069	0.438
MOD_ProDKin_1	746	752	PF00069	0.394
MOD_ProDKin_1	837	843	PF00069	0.425
MOD_ProDKin_1	881	887	PF00069	0.427
TRG_DiLeu_BaEn_1	576	581	PF01217	0.494
TRG_DiLeu_BaEn_1	638	643	PF01217	0.369
TRG_DiLeu_BaEn_1	867	872	PF01217	0.611
TRG_DiLeu_BaEn_2	340	346	PF01217	0.312
TRG_DiLeu_BaEn_4	350	356	PF01217	0.388
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.388
TRG_ENDOCYTIC_2	278	281	PF00928	0.312
TRG_ENDOCYTIC_2	298	301	PF00928	0.303
TRG_ENDOCYTIC_2	368	371	PF00928	0.315
TRG_ENDOCYTIC_2	716	719	PF00928	0.295
TRG_ER_diArg_1	1	4	PF00400	0.633
TRG_ER_diArg_1	270	273	PF00400	0.231
TRG_ER_diArg_1	834	836	PF00400	0.460
TRG_NES_CRM1_1	569	583	PF08389	0.487
TRG_NES_CRM1_1	811	823	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P621	Leptomonas seymouri	53%	99%
A0A3Q8IMF5	Leishmania donovani	81%	100%
E9AH19	Leishmania infantum	82%	100%
E9AWI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAY1	Leishmania major	80%	100%