Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD40_LEIBR

TriTrypDb:

LbrM.23.1800 , LBRM2903_230028900

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	316	318	PF00675	0.433
CLV_NRD_NRD_1	320	322	PF00675	0.437
CLV_NRD_NRD_1	74	76	PF00675	0.455
CLV_PCSK_FUR_1	314	318	PF00082	0.350
CLV_PCSK_KEX2_1	263	265	PF00082	0.487
CLV_PCSK_KEX2_1	313	315	PF00082	0.343
CLV_PCSK_KEX2_1	316	318	PF00082	0.341
CLV_PCSK_KEX2_1	320	322	PF00082	0.333
CLV_PCSK_KEX2_1	76	78	PF00082	0.462
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.534
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.350
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.558
CLV_PCSK_PC7_1	316	322	PF00082	0.482
CLV_PCSK_SKI1_1	167	171	PF00082	0.682
CLV_PCSK_SKI1_1	172	176	PF00082	0.592
CLV_PCSK_SKI1_1	247	251	PF00082	0.426
CLV_PCSK_SKI1_1	31	35	PF00082	0.452
CLV_PCSK_SKI1_1	77	81	PF00082	0.452
DEG_APCC_DBOX_1	166	174	PF00400	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.707
DEG_SCF_FBW7_1	85	92	PF00400	0.628
DOC_CKS1_1	86	91	PF01111	0.645
DOC_CYCLIN_RxL_1	164	171	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.565
DOC_MAPK_gen_1	263	273	PF00069	0.512
DOC_MAPK_gen_1	75	82	PF00069	0.497
DOC_PP1_RVXF_1	170	176	PF00149	0.429
DOC_PP2B_LxvP_1	51	54	PF13499	0.560
DOC_PP2B_LxvP_1	82	85	PF13499	0.489
DOC_USP7_MATH_1	108	112	PF00917	0.430
DOC_USP7_MATH_1	26	30	PF00917	0.670
DOC_USP7_MATH_1	3	7	PF00917	0.451
DOC_USP7_MATH_1	334	338	PF00917	0.450
DOC_USP7_MATH_1	54	58	PF00917	0.549
DOC_USP7_MATH_1	67	71	PF00917	0.503
DOC_WW_Pin1_4	120	125	PF00397	0.623
DOC_WW_Pin1_4	272	277	PF00397	0.567
DOC_WW_Pin1_4	284	289	PF00397	0.632
DOC_WW_Pin1_4	85	90	PF00397	0.595
LIG_14-3-3_CanoR_1	106	111	PF00244	0.548
LIG_14-3-3_CanoR_1	191	196	PF00244	0.555
LIG_14-3-3_CanoR_1	321	330	PF00244	0.331
LIG_14-3-3_CanoR_1	7	17	PF00244	0.390
LIG_BRCT_BRCA1_1	110	114	PF00533	0.515
LIG_BRCT_BRCA1_1	252	256	PF00533	0.509
LIG_BRCT_BRCA1_1	91	95	PF00533	0.568
LIG_EH_1	155	159	PF12763	0.502
LIG_FHA_1	10	16	PF00498	0.555
LIG_FHA_1	272	278	PF00498	0.359
LIG_FHA_1	53	59	PF00498	0.542
LIG_FHA_2	139	145	PF00498	0.629
LIG_FHA_2	191	197	PF00498	0.572
LIG_FHA_2	310	316	PF00498	0.492
LIG_LIR_Apic_2	29	35	PF02991	0.548
LIG_LIR_Apic_2	81	86	PF02991	0.496
LIG_LIR_Gen_1	193	203	PF02991	0.510
LIG_LIR_Gen_1	253	261	PF02991	0.443
LIG_LIR_Nem_3	193	198	PF02991	0.530
LIG_LIR_Nem_3	253	259	PF02991	0.477
LIG_MAD2	226	234	PF02301	0.459
LIG_Pex14_2	114	118	PF04695	0.520
LIG_Pex14_2	256	260	PF04695	0.413
LIG_SH2_CRK	267	271	PF00017	0.307
LIG_SH2_STAP1	10	14	PF00017	0.379
LIG_SH2_STAT3	323	326	PF00017	0.547
LIG_SH2_STAT3	47	50	PF00017	0.535
LIG_SH2_STAT5	192	195	PF00017	0.476
LIG_SH2_STAT5	258	261	PF00017	0.508
LIG_SH3_1	83	89	PF00018	0.463
LIG_SH3_3	42	48	PF00018	0.614
LIG_SH3_3	83	89	PF00018	0.597
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.474
LIG_WRC_WIRS_1	192	197	PF05994	0.612
MOD_CK1_1	123	129	PF00069	0.586
MOD_CK1_1	178	184	PF00069	0.515
MOD_CK1_1	70	76	PF00069	0.438
MOD_CK1_1	98	104	PF00069	0.375
MOD_CK2_1	106	112	PF00069	0.474
MOD_CK2_1	138	144	PF00069	0.633
MOD_CK2_1	309	315	PF00069	0.501
MOD_DYRK1A_RPxSP_1	120	124	PF00069	0.536
MOD_GlcNHglycan	97	101	PF01048	0.565
MOD_GSK3_1	175	182	PF00069	0.582
MOD_GSK3_1	228	235	PF00069	0.409
MOD_GSK3_1	250	257	PF00069	0.463
MOD_GSK3_1	85	92	PF00069	0.563
MOD_GSK3_1	96	103	PF00069	0.427
MOD_NEK2_1	175	180	PF00069	0.523
MOD_NEK2_1	190	195	PF00069	0.497
MOD_NEK2_1	250	255	PF00069	0.430
MOD_NEK2_1	271	276	PF00069	0.434
MOD_NEK2_1	307	312	PF00069	0.437
MOD_NEK2_1	322	327	PF00069	0.471
MOD_NEK2_1	95	100	PF00069	0.497
MOD_PIKK_1	228	234	PF00454	0.434
MOD_PIKK_1	322	328	PF00454	0.445
MOD_PKA_2	190	196	PF00069	0.558
MOD_PKB_1	104	112	PF00069	0.543
MOD_Plk_1	144	150	PF00069	0.581
MOD_Plk_1	198	204	PF00069	0.469
MOD_Plk_4	144	150	PF00069	0.588
MOD_Plk_4	54	60	PF00069	0.576
MOD_Plk_4	78	84	PF00069	0.523
MOD_ProDKin_1	120	126	PF00069	0.624
MOD_ProDKin_1	272	278	PF00069	0.568
MOD_ProDKin_1	284	290	PF00069	0.625
MOD_ProDKin_1	85	91	PF00069	0.598
TRG_DiLeu_BaEn_1	13	18	PF01217	0.532
TRG_DiLeu_BaEn_4	144	150	PF01217	0.474
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.576
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.554
TRG_ENDOCYTIC_2	192	195	PF00928	0.466
TRG_ENDOCYTIC_2	267	270	PF00928	0.578
TRG_ER_diArg_1	316	318	PF00400	0.378
TRG_ER_diArg_1	319	321	PF00400	0.393
TRG_ER_diArg_1	74	77	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC82	Leptomonas seymouri	51%	100%
A0A1X0NWL6	Trypanosomatidae	29%	100%
A0A3S7WY36	Leishmania donovani	76%	100%
A0A422NJF2	Trypanosoma rangeli	28%	99%
C9ZNR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AH18	Leishmania infantum	76%	100%
E9AWI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QAY2	Leishmania major	76%	100%
V5BFT2	Trypanosoma cruzi	28%	95%