Pre-mRNA-splicing factor SYF1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD39_LEIBR

TriTrypDb:

LbrM.23.1790 , LBRM2903_230028700

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0071007	U2-type catalytic step 2 spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0071014	post-mRNA release spliceosomal complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HD39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD39

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000349	generation of catalytic spliceosome for first transesterification step	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.530
CLV_C14_Caspase3-7	475	479	PF00656	0.552
CLV_NRD_NRD_1	179	181	PF00675	0.276
CLV_NRD_NRD_1	691	693	PF00675	0.552
CLV_NRD_NRD_1	698	700	PF00675	0.437
CLV_NRD_NRD_1	77	79	PF00675	0.393
CLV_NRD_NRD_1	776	778	PF00675	0.445
CLV_PCSK_KEX2_1	149	151	PF00082	0.402
CLV_PCSK_KEX2_1	179	181	PF00082	0.496
CLV_PCSK_KEX2_1	331	333	PF00082	0.424
CLV_PCSK_KEX2_1	375	377	PF00082	0.376
CLV_PCSK_KEX2_1	494	496	PF00082	0.675
CLV_PCSK_KEX2_1	727	729	PF00082	0.421
CLV_PCSK_KEX2_1	77	79	PF00082	0.393
CLV_PCSK_KEX2_1	775	777	PF00082	0.428
CLV_PCSK_KEX2_1	786	788	PF00082	0.542
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.421
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.331
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.376
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.675
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.472
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.638
CLV_PCSK_SKI1_1	126	130	PF00082	0.468
CLV_PCSK_SKI1_1	146	150	PF00082	0.192
CLV_PCSK_SKI1_1	216	220	PF00082	0.485
CLV_PCSK_SKI1_1	477	481	PF00082	0.454
CLV_PCSK_SKI1_1	612	616	PF00082	0.424
CLV_PCSK_SKI1_1	717	721	PF00082	0.364
CLV_Separin_Metazoa	118	122	PF03568	0.555
DEG_APCC_DBOX_1	281	289	PF00400	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DOC_CKS1_1	620	625	PF01111	0.494
DOC_MAPK_gen_1	146	156	PF00069	0.503
DOC_MAPK_gen_1	179	187	PF00069	0.487
DOC_MAPK_gen_1	255	264	PF00069	0.514
DOC_MAPK_gen_1	669	677	PF00069	0.560
DOC_MAPK_gen_1	775	784	PF00069	0.455
DOC_MAPK_MEF2A_6	257	266	PF00069	0.478
DOC_MAPK_MEF2A_6	564	572	PF00069	0.459
DOC_PP1_RVXF_1	214	221	PF00149	0.475
DOC_PP2B_LxvP_1	202	205	PF13499	0.550
DOC_USP7_MATH_1	232	236	PF00917	0.470
DOC_USP7_MATH_1	386	390	PF00917	0.493
DOC_USP7_MATH_1	407	411	PF00917	0.613
DOC_USP7_MATH_1	448	452	PF00917	0.487
DOC_USP7_MATH_1	5	9	PF00917	0.506
DOC_USP7_MATH_1	534	538	PF00917	0.455
DOC_USP7_MATH_1	57	61	PF00917	0.505
DOC_WW_Pin1_4	18	23	PF00397	0.619
DOC_WW_Pin1_4	257	262	PF00397	0.407
DOC_WW_Pin1_4	363	368	PF00397	0.518
DOC_WW_Pin1_4	469	474	PF00397	0.543
DOC_WW_Pin1_4	542	547	PF00397	0.534
DOC_WW_Pin1_4	619	624	PF00397	0.476
LIG_14-3-3_CanoR_1	121	125	PF00244	0.375
LIG_14-3-3_CanoR_1	167	173	PF00244	0.536
LIG_14-3-3_CanoR_1	388	392	PF00244	0.464
LIG_14-3-3_CanoR_1	56	65	PF00244	0.541
LIG_14-3-3_CanoR_1	6	14	PF00244	0.564
LIG_14-3-3_CanoR_1	728	738	PF00244	0.479
LIG_14-3-3_CanoR_1	777	783	PF00244	0.347
LIG_Actin_WH2_2	351	366	PF00022	0.501
LIG_APCC_ABBAyCdc20_2	216	222	PF00400	0.311
LIG_BIR_III_2	290	294	PF00653	0.321
LIG_BIR_III_4	740	744	PF00653	0.578
LIG_BRCT_BRCA1_1	264	268	PF00533	0.456
LIG_BRCT_BRCA1_1	544	548	PF00533	0.503
LIG_BRCT_BRCA1_1	684	688	PF00533	0.429
LIG_BRCT_BRCA1_1	780	784	PF00533	0.479
LIG_BRCT_BRCA1_1	82	86	PF00533	0.305
LIG_BRCT_BRCA1_2	780	786	PF00533	0.462
LIG_Clathr_ClatBox_1	588	592	PF01394	0.466
LIG_CtBP_PxDLS_1	261	265	PF00389	0.487
LIG_deltaCOP1_diTrp_1	442	449	PF00928	0.355
LIG_deltaCOP1_diTrp_1	754	760	PF00928	0.508
LIG_FHA_1	123	129	PF00498	0.431
LIG_FHA_1	239	245	PF00498	0.459
LIG_FHA_1	36	42	PF00498	0.545
LIG_FHA_1	435	441	PF00498	0.431
LIG_FHA_1	583	589	PF00498	0.470
LIG_FHA_1	74	80	PF00498	0.383
LIG_FHA_2	22	28	PF00498	0.569
LIG_FHA_2	388	394	PF00498	0.510
LIG_FHA_2	685	691	PF00498	0.445
LIG_FHA_2	763	769	PF00498	0.499
LIG_GBD_Chelix_1	705	713	PF00786	0.540
LIG_LIR_Apic_2	442	448	PF02991	0.450
LIG_LIR_Gen_1	109	116	PF02991	0.324
LIG_LIR_Gen_1	181	187	PF02991	0.387
LIG_LIR_Gen_1	191	200	PF02991	0.381
LIG_LIR_Gen_1	224	233	PF02991	0.397
LIG_LIR_Gen_1	24	33	PF02991	0.465
LIG_LIR_Gen_1	265	273	PF02991	0.384
LIG_LIR_Gen_1	389	398	PF02991	0.539
LIG_LIR_Gen_1	533	542	PF02991	0.282
LIG_LIR_Gen_1	592	600	PF02991	0.483
LIG_LIR_Gen_1	613	623	PF02991	0.419
LIG_LIR_Gen_1	672	682	PF02991	0.395
LIG_LIR_Gen_1	768	774	PF02991	0.470
LIG_LIR_Gen_1	83	93	PF02991	0.482
LIG_LIR_Nem_3	109	113	PF02991	0.315
LIG_LIR_Nem_3	181	186	PF02991	0.381
LIG_LIR_Nem_3	191	195	PF02991	0.324
LIG_LIR_Nem_3	217	223	PF02991	0.445
LIG_LIR_Nem_3	224	229	PF02991	0.392
LIG_LIR_Nem_3	24	28	PF02991	0.464
LIG_LIR_Nem_3	265	271	PF02991	0.385
LIG_LIR_Nem_3	327	333	PF02991	0.456
LIG_LIR_Nem_3	353	357	PF02991	0.486
LIG_LIR_Nem_3	389	394	PF02991	0.550
LIG_LIR_Nem_3	533	538	PF02991	0.412
LIG_LIR_Nem_3	592	597	PF02991	0.476
LIG_LIR_Nem_3	613	618	PF02991	0.412
LIG_LIR_Nem_3	672	677	PF02991	0.402
LIG_LIR_Nem_3	754	759	PF02991	0.416
LIG_LIR_Nem_3	768	773	PF02991	0.359
LIG_LYPXL_SIV_4	641	649	PF13949	0.525
LIG_NRBOX	284	290	PF00104	0.462
LIG_NRBOX	457	463	PF00104	0.504
LIG_Pex14_1	445	449	PF04695	0.357
LIG_Pex14_2	611	615	PF04695	0.519
LIG_RPA_C_Fungi	25	37	PF08784	0.484
LIG_SH2_CRK	330	334	PF00017	0.441
LIG_SH2_CRK	695	699	PF00017	0.506
LIG_SH2_STAP1	51	55	PF00017	0.360
LIG_SH2_STAP1	93	97	PF00017	0.359
LIG_SH2_STAT3	71	74	PF00017	0.434
LIG_SH2_STAT5	169	172	PF00017	0.420
LIG_SH2_STAT5	182	185	PF00017	0.335
LIG_SH2_STAT5	446	449	PF00017	0.250
LIG_SH2_STAT5	555	558	PF00017	0.362
LIG_SH2_STAT5	561	564	PF00017	0.388
LIG_SH2_STAT5	594	597	PF00017	0.347
LIG_SH2_STAT5	599	602	PF00017	0.392
LIG_SH2_STAT5	674	677	PF00017	0.533
LIG_SH2_STAT5	68	71	PF00017	0.351
LIG_SH2_STAT5	701	704	PF00017	0.352
LIG_SH3_3	152	158	PF00018	0.379
LIG_SH3_3	508	514	PF00018	0.495
LIG_SH3_3	98	104	PF00018	0.389
LIG_Sin3_3	354	361	PF02671	0.482
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.475
LIG_SUMO_SIM_anti_2	659	664	PF11976	0.476
LIG_SUMO_SIM_par_1	260	265	PF11976	0.489
LIG_SUMO_SIM_par_1	434	442	PF11976	0.266
LIG_SUMO_SIM_par_1	472	478	PF11976	0.552
LIG_SUMO_SIM_par_1	622	628	PF11976	0.459
LIG_TRAF2_1	766	769	PF00917	0.475
LIG_Vh1_VBS_1	447	465	PF01044	0.506
LIG_Vh1_VBS_1	649	667	PF01044	0.481
LIG_WRC_WIRS_1	169	174	PF05994	0.513
LIG_WRC_WIRS_1	313	318	PF05994	0.529
LIG_WRC_WIRS_1	594	599	PF05994	0.470
MOD_CDK_SPK_2	18	23	PF00069	0.619
MOD_CK1_1	21	27	PF00069	0.494
MOD_CK1_1	469	475	PF00069	0.544
MOD_CK1_1	490	496	PF00069	0.702
MOD_CK1_1	729	735	PF00069	0.536
MOD_CK1_1	762	768	PF00069	0.435
MOD_CK2_1	21	27	PF00069	0.577
MOD_CK2_1	221	227	PF00069	0.438
MOD_CK2_1	257	263	PF00069	0.421
MOD_CK2_1	342	348	PF00069	0.443
MOD_CK2_1	534	540	PF00069	0.433
MOD_CK2_1	684	690	PF00069	0.449
MOD_CK2_1	762	768	PF00069	0.440
MOD_CMANNOS	517	520	PF00535	0.461
MOD_CMANNOS	757	760	PF00535	0.391
MOD_Cter_Amidation	784	787	PF01082	0.396
MOD_GlcNHglycan	158	161	PF01048	0.503
MOD_GlcNHglycan	17	21	PF01048	0.595
MOD_GlcNHglycan	434	437	PF01048	0.526
MOD_GlcNHglycan	450	453	PF01048	0.265
MOD_GlcNHglycan	469	472	PF01048	0.499
MOD_GlcNHglycan	485	488	PF01048	0.570
MOD_GlcNHglycan	489	492	PF01048	0.598
MOD_GlcNHglycan	548	551	PF01048	0.426
MOD_GlcNHglycan	630	633	PF01048	0.470
MOD_GlcNHglycan	7	10	PF01048	0.550
MOD_GlcNHglycan	728	731	PF01048	0.514
MOD_GSK3_1	12	19	PF00069	0.568
MOD_GSK3_1	168	175	PF00069	0.513
MOD_GSK3_1	221	228	PF00069	0.400
MOD_GSK3_1	403	410	PF00069	0.479
MOD_GSK3_1	434	441	PF00069	0.335
MOD_GSK3_1	483	490	PF00069	0.626
MOD_GSK3_1	530	537	PF00069	0.411
MOD_GSK3_1	538	545	PF00069	0.393
MOD_GSK3_1	682	689	PF00069	0.438
MOD_GSK3_1	742	749	PF00069	0.487
MOD_GSK3_1	759	766	PF00069	0.273
MOD_GSK3_1	786	793	PF00069	0.579
MOD_N-GLC_1	530	535	PF02516	0.378
MOD_NEK2_1	168	173	PF00069	0.449
MOD_NEK2_1	225	230	PF00069	0.371
MOD_NEK2_1	28	33	PF00069	0.468
MOD_NEK2_1	312	317	PF00069	0.433
MOD_NEK2_1	419	424	PF00069	0.343
MOD_NEK2_1	467	472	PF00069	0.402
MOD_NEK2_1	500	505	PF00069	0.569
MOD_NEK2_1	538	543	PF00069	0.355
MOD_NEK2_1	58	63	PF00069	0.459
MOD_NEK2_1	636	641	PF00069	0.392
MOD_NEK2_1	649	654	PF00069	0.297
MOD_NEK2_1	682	687	PF00069	0.254
MOD_NEK2_1	759	764	PF00069	0.384
MOD_PIKK_1	136	142	PF00454	0.392
MOD_PIKK_1	742	748	PF00454	0.427
MOD_PK_1	564	570	PF00069	0.485
MOD_PKA_1	786	792	PF00069	0.542
MOD_PKA_2	120	126	PF00069	0.386
MOD_PKA_2	238	244	PF00069	0.481
MOD_PKA_2	29	35	PF00069	0.503
MOD_PKA_2	387	393	PF00069	0.514
MOD_PKA_2	482	488	PF00069	0.585
MOD_PKA_2	5	11	PF00069	0.598
MOD_PKA_2	786	792	PF00069	0.667
MOD_Plk_1	221	227	PF00069	0.401
MOD_Plk_1	262	268	PF00069	0.471
MOD_Plk_1	326	332	PF00069	0.367
MOD_Plk_1	530	536	PF00069	0.294
MOD_Plk_1	658	664	PF00069	0.513
MOD_Plk_1	682	688	PF00069	0.378
MOD_Plk_4	221	227	PF00069	0.407
MOD_Plk_4	297	303	PF00069	0.495
MOD_Plk_4	434	440	PF00069	0.454
MOD_Plk_4	45	51	PF00069	0.548
MOD_Plk_4	534	540	PF00069	0.403
MOD_Plk_4	593	599	PF00069	0.455
MOD_ProDKin_1	18	24	PF00069	0.612
MOD_ProDKin_1	257	263	PF00069	0.407
MOD_ProDKin_1	363	369	PF00069	0.518
MOD_ProDKin_1	469	475	PF00069	0.542
MOD_ProDKin_1	542	548	PF00069	0.531
MOD_ProDKin_1	619	625	PF00069	0.470
TRG_DiLeu_BaEn_1	214	219	PF01217	0.557
TRG_DiLeu_BaEn_1	284	289	PF01217	0.527
TRG_DiLeu_BaEn_1	613	618	PF01217	0.480
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.455
TRG_ENDOCYTIC_2	110	113	PF00928	0.462
TRG_ENDOCYTIC_2	169	172	PF00928	0.425
TRG_ENDOCYTIC_2	182	185	PF00928	0.287
TRG_ENDOCYTIC_2	330	333	PF00928	0.434
TRG_ENDOCYTIC_2	446	449	PF00928	0.250
TRG_ENDOCYTIC_2	594	597	PF00928	0.468
TRG_ENDOCYTIC_2	674	677	PF00928	0.399
TRG_ENDOCYTIC_2	695	698	PF00928	0.506
TRG_ENDOCYTIC_2	756	759	PF00928	0.504
TRG_ER_diArg_1	668	671	PF00400	0.554
TRG_ER_diArg_1	77	79	PF00400	0.453
TRG_ER_diArg_1	775	777	PF00400	0.540
TRG_NES_CRM1_1	243	256	PF08389	0.368
TRG_NES_CRM1_1	296	310	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ1	Leptomonas seymouri	69%	100%
A0A1X0NWW2	Trypanosomatidae	39%	100%
A0A3Q8IBX9	Leishmania donovani	89%	100%
A0A422NJT0	Trypanosoma rangeli	39%	100%
C9ZNR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	87%
E9AH17	Leishmania infantum	90%	100%
E9AWI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAY3	Leishmania major	88%	100%
Q4WVF4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	95%
Q52DF3	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	95%
Q54Z08	Dictyostelium discoideum	22%	93%
Q5BH69	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	93%
Q7SAK5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	96%
Q9P7R9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	100%
V5ARA5	Trypanosoma cruzi	40%	100%