Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD37_LEIBR

TriTrypDb:

LbrM.23.1770 , LBRM2903_230028500

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	545	549	PF00656	0.628
CLV_C14_Caspase3-7	613	617	PF00656	0.515
CLV_NRD_NRD_1	328	330	PF00675	0.349
CLV_NRD_NRD_1	385	387	PF00675	0.570
CLV_NRD_NRD_1	43	45	PF00675	0.558
CLV_NRD_NRD_1	511	513	PF00675	0.466
CLV_NRD_NRD_1	55	57	PF00675	0.399
CLV_NRD_NRD_1	769	771	PF00675	0.314
CLV_PCSK_KEX2_1	328	330	PF00082	0.349
CLV_PCSK_KEX2_1	385	387	PF00082	0.570
CLV_PCSK_KEX2_1	43	45	PF00082	0.501
CLV_PCSK_KEX2_1	511	513	PF00082	0.472
CLV_PCSK_KEX2_1	55	57	PF00082	0.390
CLV_PCSK_KEX2_1	561	563	PF00082	0.536
CLV_PCSK_KEX2_1	769	771	PF00082	0.344
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.536
CLV_PCSK_SKI1_1	236	240	PF00082	0.413
CLV_PCSK_SKI1_1	294	298	PF00082	0.563
CLV_PCSK_SKI1_1	323	327	PF00082	0.585
CLV_PCSK_SKI1_1	373	377	PF00082	0.486
CLV_PCSK_SKI1_1	547	551	PF00082	0.575
CLV_PCSK_SKI1_1	555	559	PF00082	0.524
CLV_PCSK_SKI1_1	688	692	PF00082	0.610
CLV_PCSK_SKI1_1	759	763	PF00082	0.546
DEG_APCC_DBOX_1	224	232	PF00400	0.529
DEG_APCC_DBOX_1	23	31	PF00400	0.414
DEG_APCC_DBOX_1	372	380	PF00400	0.500
DEG_APCC_DBOX_1	499	507	PF00400	0.414
DOC_CDC14_PxL_1	805	813	PF14671	0.432
DOC_CYCLIN_RxL_1	515	528	PF00134	0.276
DOC_CYCLIN_RxL_1	765	777	PF00134	0.491
DOC_CYCLIN_RxL_1	820	828	PF00134	0.532
DOC_MAPK_gen_1	24	32	PF00069	0.600
DOC_MAPK_gen_1	766	776	PF00069	0.263
DOC_MAPK_MEF2A_6	232	239	PF00069	0.567
DOC_MAPK_MEF2A_6	26	34	PF00069	0.472
DOC_MAPK_MEF2A_6	500	507	PF00069	0.471
DOC_MAPK_MEF2A_6	728	736	PF00069	0.426
DOC_MAPK_MEF2A_6	769	776	PF00069	0.421
DOC_MAPK_NFAT4_5	500	508	PF00069	0.514
DOC_MAPK_NFAT4_5	769	777	PF00069	0.269
DOC_PP2B_LxvP_1	494	497	PF13499	0.458
DOC_PP2B_LxvP_1	534	537	PF13499	0.348
DOC_PP2B_LxvP_1	9	12	PF13499	0.575
DOC_PP4_FxxP_1	187	190	PF00568	0.637
DOC_PP4_FxxP_1	478	481	PF00568	0.541
DOC_PP4_FxxP_1	691	694	PF00568	0.656
DOC_SPAK_OSR1_1	61	65	PF12202	0.407
DOC_USP7_MATH_1	108	112	PF00917	0.675
DOC_USP7_MATH_1	121	125	PF00917	0.599
DOC_USP7_MATH_1	304	308	PF00917	0.679
DOC_USP7_MATH_1	319	323	PF00917	0.398
DOC_USP7_MATH_1	435	439	PF00917	0.492
DOC_USP7_MATH_1	540	544	PF00917	0.664
DOC_USP7_MATH_1	721	725	PF00917	0.547
DOC_USP7_UBL2_3	232	236	PF12436	0.322
DOC_WW_Pin1_4	117	122	PF00397	0.507
DOC_WW_Pin1_4	396	401	PF00397	0.431
DOC_WW_Pin1_4	532	537	PF00397	0.544
DOC_WW_Pin1_4	600	605	PF00397	0.527
DOC_WW_Pin1_4	657	662	PF00397	0.568
DOC_WW_Pin1_4	697	702	PF00397	0.489
LIG_14-3-3_CanoR_1	107	113	PF00244	0.706
LIG_14-3-3_CanoR_1	243	248	PF00244	0.528
LIG_14-3-3_CanoR_1	264	268	PF00244	0.414
LIG_14-3-3_CanoR_1	29	35	PF00244	0.528
LIG_14-3-3_CanoR_1	303	309	PF00244	0.688
LIG_14-3-3_CanoR_1	344	349	PF00244	0.641
LIG_14-3-3_CanoR_1	500	506	PF00244	0.528
LIG_14-3-3_CanoR_1	55	62	PF00244	0.404
LIG_14-3-3_CanoR_1	583	588	PF00244	0.498
LIG_14-3-3_CanoR_1	759	764	PF00244	0.529
LIG_14-3-3_CanoR_1	769	775	PF00244	0.516
LIG_Actin_WH2_2	674	690	PF00022	0.539
LIG_AP2alpha_2	351	353	PF02296	0.385
LIG_APCC_ABBA_1	235	240	PF00400	0.566
LIG_APCC_ABBA_1	772	777	PF00400	0.519
LIG_APCC_ABBA_1	802	807	PF00400	0.493
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_eIF4E_1	551	557	PF01652	0.545
LIG_eIF4E_1	805	811	PF01652	0.460
LIG_EVH1_2	183	187	PF00568	0.553
LIG_FHA_1	120	126	PF00498	0.760
LIG_FHA_1	257	263	PF00498	0.513
LIG_FHA_1	31	37	PF00498	0.533
LIG_FHA_1	511	517	PF00498	0.471
LIG_FHA_1	641	647	PF00498	0.457
LIG_FHA_1	66	72	PF00498	0.558
LIG_FHA_1	73	79	PF00498	0.540
LIG_FHA_2	597	603	PF00498	0.577
LIG_FHA_2	713	719	PF00498	0.540
LIG_FHA_2	81	87	PF00498	0.486
LIG_GBD_Chelix_1	287	295	PF00786	0.511
LIG_IRF3_LxIS_1	128	133	PF10401	0.451
LIG_LIR_Apic_2	689	694	PF02991	0.518
LIG_LIR_Gen_1	548	557	PF02991	0.551
LIG_LIR_Gen_1	723	734	PF02991	0.466
LIG_LIR_Gen_1	782	790	PF02991	0.386
LIG_LIR_Nem_3	106	112	PF02991	0.549
LIG_LIR_Nem_3	334	339	PF02991	0.426
LIG_LIR_Nem_3	548	554	PF02991	0.535
LIG_LIR_Nem_3	782	786	PF02991	0.407
LIG_LIR_Nem_3	819	825	PF02991	0.406
LIG_NRBOX	643	649	PF00104	0.483
LIG_PCNA_PIPBox_1	245	254	PF02747	0.491
LIG_Pex14_1	704	708	PF04695	0.470
LIG_SH2_CRK	168	172	PF00017	0.340
LIG_SH2_CRK	551	555	PF00017	0.594
LIG_SH2_SRC	45	48	PF00017	0.469
LIG_SH2_SRC	614	617	PF00017	0.498
LIG_SH2_SRC	805	808	PF00017	0.476
LIG_SH2_STAP1	448	452	PF00017	0.528
LIG_SH2_STAP1	518	522	PF00017	0.541
LIG_SH2_STAP1	611	615	PF00017	0.538
LIG_SH2_STAP1	708	712	PF00017	0.406
LIG_SH2_STAT5	406	409	PF00017	0.406
LIG_SH2_STAT5	45	48	PF00017	0.469
LIG_SH2_STAT5	458	461	PF00017	0.382
LIG_SH2_STAT5	591	594	PF00017	0.547
LIG_SH2_STAT5	614	617	PF00017	0.389
LIG_SH2_STAT5	799	802	PF00017	0.471
LIG_SH3_1	598	604	PF00018	0.601
LIG_SH3_3	178	184	PF00018	0.407
LIG_SH3_3	394	400	PF00018	0.400
LIG_SH3_3	598	604	PF00018	0.601
LIG_SH3_3	832	838	PF00018	0.381
LIG_Sin3_3	492	499	PF02671	0.511
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.522
LIG_SUMO_SIM_anti_2	643	649	PF11976	0.445
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.486
LIG_SUMO_SIM_par_1	406	413	PF11976	0.435
LIG_SUMO_SIM_par_1	837	843	PF11976	0.447
LIG_TRAF2_1	203	206	PF00917	0.694
LIG_TRFH_1	363	367	PF08558	0.572
LIG_WRC_WIRS_1	582	587	PF05994	0.522
MOD_CK1_1	110	116	PF00069	0.682
MOD_CK1_1	120	126	PF00069	0.609
MOD_CK1_1	204	210	PF00069	0.633
MOD_CK1_1	307	313	PF00069	0.608
MOD_CK1_1	603	609	PF00069	0.512
MOD_CK1_1	697	703	PF00069	0.454
MOD_CK2_1	199	205	PF00069	0.702
MOD_CK2_1	395	401	PF00069	0.527
MOD_CK2_1	482	488	PF00069	0.609
MOD_CK2_1	596	602	PF00069	0.552
MOD_CK2_1	674	680	PF00069	0.570
MOD_CK2_1	697	703	PF00069	0.307
MOD_CK2_1	713	719	PF00069	0.487
MOD_CK2_1	721	727	PF00069	0.490
MOD_CK2_1	781	787	PF00069	0.530
MOD_CK2_1	80	86	PF00069	0.592
MOD_GlcNHglycan	112	115	PF01048	0.669
MOD_GlcNHglycan	201	204	PF01048	0.723
MOD_GlcNHglycan	205	209	PF01048	0.669
MOD_GlcNHglycan	306	309	PF01048	0.665
MOD_GlcNHglycan	412	415	PF01048	0.467
MOD_GlcNHglycan	431	434	PF01048	0.252
MOD_GlcNHglycan	544	547	PF01048	0.670
MOD_GlcNHglycan	715	718	PF01048	0.519
MOD_GlcNHglycan	754	757	PF01048	0.472
MOD_GlcNHglycan	759	762	PF01048	0.494
MOD_GlcNHglycan	783	786	PF01048	0.460
MOD_GlcNHglycan	787	791	PF01048	0.516
MOD_GSK3_1	103	110	PF00069	0.670
MOD_GSK3_1	117	124	PF00069	0.684
MOD_GSK3_1	197	204	PF00069	0.648
MOD_GSK3_1	282	289	PF00069	0.490
MOD_GSK3_1	294	301	PF00069	0.564
MOD_GSK3_1	307	314	PF00069	0.578
MOD_GSK3_1	577	584	PF00069	0.456
MOD_GSK3_1	596	603	PF00069	0.305
MOD_GSK3_1	692	699	PF00069	0.635
MOD_GSK3_1	7	14	PF00069	0.505
MOD_GSK3_1	812	819	PF00069	0.445
MOD_LATS_1	292	298	PF00433	0.454
MOD_N-GLC_1	501	506	PF02516	0.420
MOD_NEK2_1	130	135	PF00069	0.517
MOD_NEK2_1	238	243	PF00069	0.547
MOD_NEK2_1	286	291	PF00069	0.513
MOD_NEK2_1	510	515	PF00069	0.465
MOD_NEK2_1	550	555	PF00069	0.532
MOD_NEK2_1	556	561	PF00069	0.483
MOD_NEK2_1	577	582	PF00069	0.445
MOD_NEK2_1	696	701	PF00069	0.541
MOD_NEK2_1	764	769	PF00069	0.482
MOD_NEK2_1	781	786	PF00069	0.293
MOD_PIKK_1	380	386	PF00454	0.515
MOD_PIKK_1	45	51	PF00454	0.462
MOD_PIKK_1	603	609	PF00454	0.555
MOD_PK_1	243	249	PF00069	0.627
MOD_PK_1	7	13	PF00069	0.460
MOD_PKA_1	55	61	PF00069	0.404
MOD_PKA_2	194	200	PF00069	0.739
MOD_PKA_2	263	269	PF00069	0.427
MOD_PKA_2	510	516	PF00069	0.483
MOD_PKA_2	54	60	PF00069	0.616
MOD_Plk_1	501	507	PF00069	0.422
MOD_Plk_1	596	602	PF00069	0.595
MOD_Plk_1	80	86	PF00069	0.592
MOD_Plk_4	11	17	PF00069	0.600
MOD_Plk_4	141	147	PF00069	0.486
MOD_Plk_4	243	249	PF00069	0.591
MOD_Plk_4	282	288	PF00069	0.505
MOD_Plk_4	435	441	PF00069	0.500
MOD_Plk_4	501	507	PF00069	0.436
MOD_Plk_4	640	646	PF00069	0.501
MOD_Plk_4	721	727	PF00069	0.532
MOD_Plk_4	759	765	PF00069	0.477
MOD_Plk_4	770	776	PF00069	0.505
MOD_Plk_4	80	86	PF00069	0.483
MOD_ProDKin_1	117	123	PF00069	0.506
MOD_ProDKin_1	396	402	PF00069	0.426
MOD_ProDKin_1	532	538	PF00069	0.557
MOD_ProDKin_1	600	606	PF00069	0.520
MOD_ProDKin_1	657	663	PF00069	0.564
MOD_ProDKin_1	697	703	PF00069	0.482
TRG_DiLeu_BaEn_4	205	211	PF01217	0.468
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.561
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.507
TRG_DiLeu_BaLyEn_6	806	811	PF01217	0.535
TRG_DiLeu_BaLyEn_6	835	840	PF01217	0.495
TRG_ENDOCYTIC_2	101	104	PF00928	0.661
TRG_ENDOCYTIC_2	168	171	PF00928	0.327
TRG_ENDOCYTIC_2	518	521	PF00928	0.549
TRG_ENDOCYTIC_2	551	554	PF00928	0.559
TRG_ENDOCYTIC_2	799	802	PF00928	0.391
TRG_ENDOCYTIC_2	805	808	PF00928	0.391
TRG_ER_diArg_1	23	26	PF00400	0.525
TRG_ER_diArg_1	327	329	PF00400	0.327
TRG_ER_diArg_1	385	387	PF00400	0.570
TRG_ER_diArg_1	43	45	PF00400	0.542
TRG_ER_diArg_1	510	512	PF00400	0.487
TRG_ER_diArg_1	59	62	PF00400	0.383
TRG_ER_diArg_1	648	651	PF00400	0.506
TRG_ER_diArg_1	768	770	PF00400	0.312
TRG_NES_CRM1_1	226	240	PF08389	0.564
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	429	434	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	823	828	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS3	Leptomonas seymouri	49%	100%
A0A1X0NXC2	Trypanosomatidae	24%	100%
A0A3Q8IBR0	Leishmania donovani	86%	100%
A0A3R7RJS0	Trypanosoma rangeli	27%	100%
C9ZNR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AH15	Leishmania infantum	86%	100%
E9AWI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAY5	Leishmania major	85%	100%
V5BFS5	Trypanosoma cruzi	26%	100%