LeishMANIAdb
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V-type proton ATPase subunit a

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
V-type proton ATPase subunit a
Gene product:
V-type proton ATPase subunit a, putative
Species:
Leishmania braziliensis
UniProt:
A4HD35_LEIBR
TriTrypDb:
LbrM.23.1750 , LBRM2903_230028300
Length:
775

Annotations

LeishMANIAdb annotations

Homologous to animal V-type proton pumps, vacuolar or lysosomal. For some reason, this family expanded in kinetoplastids. Localization: Endosomal (by homology) / Lysosomal (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain 5 21
GO:0016020 membrane 2 21
GO:0032991 protein-containing complex 1 21
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain 3 21
GO:0033179 proton-transporting V-type ATPase, V0 domain 4 21
GO:0098796 membrane protein complex 2 21
GO:0110165 cellular anatomical entity 1 21
GO:0016469 proton-transporting two-sector ATPase complex 3 2
GO:0016471 vacuolar proton-transporting V-type ATPase complex 5 2
GO:0033176 proton-transporting V-type ATPase complex 4 2
GO:0000323 lytic vacuole 6 1
GO:0005764 lysosome 7 1
GO:0005773 vacuole 5 1
GO:0005794 Golgi apparatus 5 1
GO:0020022 acidocalcisome 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HD35
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD35

Function

Biological processes
Term Name Level Count
GO:0006873 intracellular monoatomic ion homeostasis 4 2
GO:0006885 regulation of pH 8 2
GO:0007035 vacuolar acidification 10 2
GO:0009987 cellular process 1 2
GO:0019725 cellular homeostasis 2 2
GO:0030003 intracellular monoatomic cation homeostasis 5 2
GO:0030004 obsolete cellular monovalent inorganic cation homeostasis 6 2
GO:0030641 regulation of cellular pH 7 2
GO:0042592 homeostatic process 3 2
GO:0048878 chemical homeostasis 4 2
GO:0050801 monoatomic ion homeostasis 5 2
GO:0051452 intracellular pH reduction 9 2
GO:0051453 regulation of intracellular pH 8 2
GO:0055067 obsolete monovalent inorganic cation homeostasis 7 2
GO:0055080 monoatomic cation homeostasis 6 2
GO:0055082 intracellular chemical homeostasis 3 2
GO:0065007 biological regulation 1 2
GO:0065008 regulation of biological quality 2 2
GO:0098771 inorganic ion homeostasis 6 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 21
GO:0008324 monoatomic cation transmembrane transporter activity 4 21
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 21
GO:0015075 monoatomic ion transmembrane transporter activity 3 21
GO:0015078 proton transmembrane transporter activity 5 21
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 21
GO:0015399 primary active transmembrane transporter activity 4 21
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 21
GO:0022804 active transmembrane transporter activity 3 21
GO:0022853 active monoatomic ion transmembrane transporter activity 4 21
GO:0022857 transmembrane transporter activity 2 21
GO:0022890 inorganic cation transmembrane transporter activity 4 21
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 21
GO:0042626 ATPase-coupled transmembrane transporter activity 2 21
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 21
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 21
GO:0140657 ATP-dependent activity 1 21
GO:0003824 catalytic activity 1 2
GO:0016787 hydrolase activity 2 2
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2
GO:0019899 enzyme binding 3 2
GO:0051117 ATPase binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 351 355 PF00656 0.271
CLV_C14_Caspase3-7 461 465 PF00656 0.326
CLV_C14_Caspase3-7 84 88 PF00656 0.221
CLV_NRD_NRD_1 271 273 PF00675 0.457
CLV_NRD_NRD_1 61 63 PF00675 0.450
CLV_NRD_NRD_1 67 69 PF00675 0.450
CLV_PCSK_KEX2_1 271 273 PF00082 0.463
CLV_PCSK_KEX2_1 61 63 PF00082 0.450
CLV_PCSK_SKI1_1 194 198 PF00082 0.420
CLV_PCSK_SKI1_1 209 213 PF00082 0.385
CLV_PCSK_SKI1_1 257 261 PF00082 0.467
CLV_PCSK_SKI1_1 278 282 PF00082 0.466
CLV_PCSK_SKI1_1 421 425 PF00082 0.287
CLV_PCSK_SKI1_1 563 567 PF00082 0.523
DEG_APCC_DBOX_1 206 214 PF00400 0.236
DEG_APCC_DBOX_1 256 264 PF00400 0.244
DEG_APCC_DBOX_1 420 428 PF00400 0.301
DOC_CDC14_PxL_1 200 208 PF14671 0.275
DOC_CYCLIN_RxL_1 62 76 PF00134 0.315
DOC_CYCLIN_yClb1_LxF_4 496 501 PF00134 0.266
DOC_MAPK_gen_1 123 132 PF00069 0.233
DOC_MAPK_gen_1 166 176 PF00069 0.287
DOC_MAPK_gen_1 255 263 PF00069 0.278
DOC_MAPK_gen_1 506 515 PF00069 0.238
DOC_MAPK_MEF2A_6 11 20 PF00069 0.335
DOC_MAPK_MEF2A_6 255 263 PF00069 0.326
DOC_MAPK_MEF2A_6 506 515 PF00069 0.250
DOC_MAPK_MEF2A_6 541 548 PF00069 0.271
DOC_PP1_RVXF_1 496 502 PF00149 0.281
DOC_PP1_RVXF_1 535 541 PF00149 0.516
DOC_PP1_RVXF_1 66 73 PF00149 0.324
DOC_PP1_RVXF_1 742 748 PF00149 0.444
DOC_PP4_FxxP_1 201 204 PF00568 0.233
DOC_PP4_FxxP_1 585 588 PF00568 0.244
DOC_USP7_MATH_2 2 8 PF00917 0.390
DOC_WW_Pin1_4 332 337 PF00397 0.326
DOC_WW_Pin1_4 479 484 PF00397 0.268
LIG_14-3-3_CanoR_1 169 174 PF00244 0.179
LIG_14-3-3_CanoR_1 272 281 PF00244 0.300
LIG_14-3-3_CanoR_1 636 640 PF00244 0.385
LIG_Actin_WH2_2 19 35 PF00022 0.344
LIG_APCC_ABBA_1 397 402 PF00400 0.295
LIG_APCC_ABBA_1 620 625 PF00400 0.292
LIG_BRCT_BRCA1_1 133 137 PF00533 0.370
LIG_BRCT_BRCA1_1 414 418 PF00533 0.454
LIG_BRCT_BRCA1_1 549 553 PF00533 0.295
LIG_BRCT_BRCA1_1 692 696 PF00533 0.304
LIG_BRCT_BRCA1_1 697 701 PF00533 0.304
LIG_Clathr_ClatBox_1 702 706 PF01394 0.410
LIG_Clathr_ClatBox_1 730 734 PF01394 0.295
LIG_deltaCOP1_diTrp_1 694 701 PF00928 0.279
LIG_EVH1_2 336 340 PF00568 0.266
LIG_FHA_1 147 153 PF00498 0.227
LIG_FHA_1 244 250 PF00498 0.256
LIG_FHA_1 340 346 PF00498 0.244
LIG_FHA_1 588 594 PF00498 0.211
LIG_FHA_1 724 730 PF00498 0.319
LIG_FHA_2 323 329 PF00498 0.238
LIG_FHA_2 564 570 PF00498 0.208
LIG_FHA_2 82 88 PF00498 0.320
LIG_GBD_Chelix_1 522 530 PF00786 0.243
LIG_LIR_Apic_2 450 456 PF02991 0.207
LIG_LIR_Apic_2 582 588 PF02991 0.248
LIG_LIR_Gen_1 103 112 PF02991 0.279
LIG_LIR_Gen_1 114 120 PF02991 0.203
LIG_LIR_Gen_1 346 356 PF02991 0.248
LIG_LIR_Gen_1 392 400 PF02991 0.279
LIG_LIR_Gen_1 412 422 PF02991 0.317
LIG_LIR_Gen_1 500 507 PF02991 0.244
LIG_LIR_Gen_1 527 536 PF02991 0.472
LIG_LIR_Gen_1 552 562 PF02991 0.308
LIG_LIR_Gen_1 653 662 PF02991 0.449
LIG_LIR_Gen_1 676 687 PF02991 0.444
LIG_LIR_Gen_1 698 707 PF02991 0.283
LIG_LIR_Nem_3 103 109 PF02991 0.279
LIG_LIR_Nem_3 114 119 PF02991 0.219
LIG_LIR_Nem_3 180 186 PF02991 0.246
LIG_LIR_Nem_3 195 200 PF02991 0.279
LIG_LIR_Nem_3 346 352 PF02991 0.245
LIG_LIR_Nem_3 373 377 PF02991 0.254
LIG_LIR_Nem_3 392 397 PF02991 0.295
LIG_LIR_Nem_3 412 417 PF02991 0.402
LIG_LIR_Nem_3 500 505 PF02991 0.244
LIG_LIR_Nem_3 527 532 PF02991 0.489
LIG_LIR_Nem_3 552 558 PF02991 0.280
LIG_LIR_Nem_3 653 657 PF02991 0.445
LIG_LIR_Nem_3 676 682 PF02991 0.444
LIG_LIR_Nem_3 693 699 PF02991 0.295
LIG_LYPXL_S_1 467 471 PF13949 0.526
LIG_MYND_1 456 460 PF01753 0.244
LIG_NRBOX 601 607 PF00104 0.155
LIG_NRP_CendR_1 773 775 PF00754 0.345
LIG_PCNA_PIPBox_1 733 742 PF02747 0.444
LIG_Pex14_1 697 701 PF04695 0.279
LIG_Pex14_2 197 201 PF04695 0.233
LIG_Pex14_2 374 378 PF04695 0.244
LIG_Pex14_2 414 418 PF04695 0.415
LIG_Pex14_2 52 56 PF04695 0.275
LIG_Pex14_2 750 754 PF04695 0.444
LIG_PTB_Apo_2 436 443 PF02174 0.295
LIG_PTB_Apo_2 525 532 PF02174 0.304
LIG_PTB_Apo_2 749 756 PF02174 0.450
LIG_PTB_Phospho_1 525 531 PF10480 0.304
LIG_PTB_Phospho_1 749 755 PF10480 0.450
LIG_SH2_CRK 116 120 PF00017 0.244
LIG_SH2_CRK 433 437 PF00017 0.436
LIG_SH2_CRK 481 485 PF00017 0.144
LIG_SH2_CRK 502 506 PF00017 0.244
LIG_SH2_CRK 555 559 PF00017 0.304
LIG_SH2_GRB2like 531 534 PF00017 0.497
LIG_SH2_GRB2like 707 710 PF00017 0.158
LIG_SH2_NCK_1 481 485 PF00017 0.144
LIG_SH2_SRC 106 109 PF00017 0.144
LIG_SH2_SRC 224 227 PF00017 0.237
LIG_SH2_SRC 707 710 PF00017 0.158
LIG_SH2_STAP1 106 110 PF00017 0.326
LIG_SH2_STAT5 200 203 PF00017 0.233
LIG_SH2_STAT5 317 320 PF00017 0.258
LIG_SH2_STAT5 339 342 PF00017 0.248
LIG_SH2_STAT5 376 379 PF00017 0.295
LIG_SH2_STAT5 422 425 PF00017 0.293
LIG_SH2_STAT5 531 534 PF00017 0.416
LIG_SH2_STAT5 623 626 PF00017 0.554
LIG_SH2_STAT5 668 671 PF00017 0.442
LIG_SH2_STAT5 679 682 PF00017 0.438
LIG_SH3_1 453 459 PF00018 0.244
LIG_SH3_3 453 459 PF00018 0.233
LIG_SH3_3 466 472 PF00018 0.270
LIG_SH3_3 477 483 PF00018 0.266
LIG_SH3_3 588 594 PF00018 0.228
LIG_SUMO_SIM_anti_2 128 134 PF11976 0.208
LIG_SUMO_SIM_anti_2 143 149 PF11976 0.390
LIG_SUMO_SIM_par_1 108 114 PF11976 0.321
LIG_SUMO_SIM_par_1 12 19 PF11976 0.363
LIG_SUMO_SIM_par_1 143 149 PF11976 0.319
LIG_SUMO_SIM_par_1 522 527 PF11976 0.301
LIG_SUMO_SIM_par_1 701 706 PF11976 0.434
LIG_TRFH_1 584 588 PF08558 0.295
LIG_TYR_ITIM 380 385 PF00017 0.304
LIG_UBA3_1 326 333 PF00899 0.301
LIG_UBA3_1 617 626 PF00899 0.281
LIG_WRC_WIRS_1 696 701 PF05994 0.360
LIG_WW_1 336 339 PF00397 0.338
MOD_CK1_1 290 296 PF00069 0.311
MOD_CK1_1 348 354 PF00069 0.364
MOD_CK1_1 470 476 PF00069 0.351
MOD_CK1_1 490 496 PF00069 0.117
MOD_CK1_1 690 696 PF00069 0.299
MOD_CK2_1 263 269 PF00069 0.178
MOD_CK2_1 322 328 PF00069 0.287
MOD_CK2_1 490 496 PF00069 0.338
MOD_CK2_1 563 569 PF00069 0.283
MOD_CK2_1 573 579 PF00069 0.309
MOD_CK2_1 85 91 PF00069 0.338
MOD_CK2_1 93 99 PF00069 0.372
MOD_GlcNHglycan 140 143 PF01048 0.386
MOD_GlcNHglycan 201 204 PF01048 0.370
MOD_GlcNHglycan 251 254 PF01048 0.301
MOD_GlcNHglycan 289 292 PF01048 0.307
MOD_GlcNHglycan 318 321 PF01048 0.324
MOD_GlcNHglycan 450 453 PF01048 0.303
MOD_GlcNHglycan 48 52 PF01048 0.308
MOD_GlcNHglycan 489 492 PF01048 0.297
MOD_GlcNHglycan 596 599 PF01048 0.426
MOD_GlcNHglycan 6 9 PF01048 0.473
MOD_GlcNHglycan 736 739 PF01048 0.301
MOD_GlcNHglycan 87 90 PF01048 0.361
MOD_GSK3_1 165 172 PF00069 0.282
MOD_GSK3_1 230 237 PF00069 0.315
MOD_GSK3_1 241 248 PF00069 0.317
MOD_GSK3_1 335 342 PF00069 0.265
MOD_GSK3_1 348 355 PF00069 0.310
MOD_GSK3_1 470 477 PF00069 0.331
MOD_GSK3_1 564 571 PF00069 0.321
MOD_GSK3_1 573 580 PF00069 0.260
MOD_GSK3_1 671 678 PF00069 0.300
MOD_GSK3_1 683 690 PF00069 0.285
MOD_GSK3_1 81 88 PF00069 0.247
MOD_N-GLC_1 123 128 PF02516 0.280
MOD_NEK2_1 146 151 PF00069 0.393
MOD_NEK2_1 234 239 PF00069 0.327
MOD_NEK2_1 249 254 PF00069 0.284
MOD_NEK2_1 287 292 PF00069 0.274
MOD_NEK2_1 501 506 PF00069 0.309
MOD_NEK2_1 507 512 PF00069 0.311
MOD_NEK2_1 549 554 PF00069 0.262
MOD_NEK2_1 577 582 PF00069 0.265
MOD_NEK2_1 687 692 PF00069 0.315
MOD_NEK2_1 723 728 PF00069 0.306
MOD_NEK2_1 767 772 PF00069 0.528
MOD_PIKK_1 243 249 PF00454 0.350
MOD_PIKK_1 513 519 PF00454 0.155
MOD_PIKK_1 687 693 PF00454 0.309
MOD_PK_1 169 175 PF00069 0.295
MOD_PKA_2 165 171 PF00069 0.301
MOD_PKA_2 474 480 PF00069 0.340
MOD_PKA_2 635 641 PF00069 0.205
MOD_Plk_1 401 407 PF00069 0.268
MOD_Plk_1 47 53 PF00069 0.310
MOD_Plk_1 91 97 PF00069 0.309
MOD_Plk_2-3 573 579 PF00069 0.236
MOD_Plk_4 169 175 PF00069 0.279
MOD_Plk_4 192 198 PF00069 0.385
MOD_Plk_4 217 223 PF00069 0.273
MOD_Plk_4 322 328 PF00069 0.307
MOD_Plk_4 335 341 PF00069 0.267
MOD_Plk_4 348 354 PF00069 0.267
MOD_Plk_4 389 395 PF00069 0.265
MOD_Plk_4 507 513 PF00069 0.276
MOD_Plk_4 573 579 PF00069 0.250
MOD_Plk_4 675 681 PF00069 0.295
MOD_Plk_4 81 87 PF00069 0.369
MOD_ProDKin_1 332 338 PF00069 0.410
MOD_ProDKin_1 479 485 PF00069 0.329
MOD_SUMO_rev_2 328 335 PF00179 0.155
MOD_SUMO_rev_2 490 499 PF00179 0.292
MOD_SUMO_rev_2 625 633 PF00179 0.295
MOD_SUMO_rev_2 64 70 PF00179 0.265
MOD_SUMO_rev_2 93 102 PF00179 0.274
TRG_DiLeu_BaLyEn_6 206 211 PF01217 0.417
TRG_ENDOCYTIC_2 106 109 PF00928 0.338
TRG_ENDOCYTIC_2 116 119 PF00928 0.244
TRG_ENDOCYTIC_2 382 385 PF00928 0.295
TRG_ENDOCYTIC_2 422 425 PF00928 0.295
TRG_ENDOCYTIC_2 433 436 PF00928 0.295
TRG_ENDOCYTIC_2 438 441 PF00928 0.295
TRG_ENDOCYTIC_2 468 471 PF00928 0.415
TRG_ENDOCYTIC_2 481 484 PF00928 0.415
TRG_ENDOCYTIC_2 502 505 PF00928 0.295
TRG_ENDOCYTIC_2 529 532 PF00928 0.364
TRG_ENDOCYTIC_2 555 558 PF00928 0.312
TRG_ENDOCYTIC_2 679 682 PF00928 0.295
TRG_ER_diArg_1 204 207 PF00400 0.284
TRG_ER_diArg_1 254 257 PF00400 0.343
TRG_ER_diArg_1 270 272 PF00400 0.343
TRG_ER_diArg_1 302 305 PF00400 0.423
TRG_ER_diArg_1 60 62 PF00400 0.304
TRG_NES_CRM1_1 734 749 PF08389 0.295
TRG_Pf-PMV_PEXEL_1 71 75 PF00026 0.279

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P622 Leptomonas seymouri 88% 100%
A0A0N1PFQ1 Leptomonas seymouri 42% 84%
A0A0S4JG87 Bodo saltans 46% 86%
A0A0S4JMR5 Bodo saltans 62% 100%
A0A1X0NV83 Trypanosomatidae 38% 92%
A0A1X0NWN0 Trypanosomatidae 74% 100%
A0A3Q8IB62 Leishmania donovani 92% 100%
A0A3Q8IGN1 Leishmania donovani 43% 87%
A0A3R7KUW1 Trypanosoma rangeli 41% 91%
A0A422NJD7 Trypanosoma rangeli 72% 100%
A1A5G6 Xenopus tropicalis 39% 93%
A4HK73 Leishmania braziliensis 42% 86%
A4I0M2 Leishmania infantum 92% 100%
A4I7Q8 Leishmania infantum 42% 87%
C9ZNR3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 99%
E9AWI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B2L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 87%
G5EEK9 Caenorhabditis elegans 33% 89%
G5EGP4 Caenorhabditis elegans 33% 90%
O13742 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 93%
O97681 Bos taurus 35% 91%
P15920 Mus musculus 35% 91%
P25286 Rattus norvegicus 39% 92%
P30628 Caenorhabditis elegans 35% 86%
P32563 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 92%
P37296 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 87%
Q01290 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 34% 91%
Q13488 Homo sapiens 34% 93%
Q29466 Bos taurus 39% 92%
Q4Q5J0 Leishmania major 41% 100%
Q4QAY7 Leishmania major 91% 100%
Q54E04 Dictyostelium discoideum 39% 95%
Q5R422 Pongo abelii 40% 93%
Q8AVM5 Xenopus laevis 39% 93%
Q8RWZ7 Arabidopsis thaliana 38% 95%
Q8W4S4 Arabidopsis thaliana 40% 94%
Q920R6 Mus musculus 38% 93%
Q93050 Homo sapiens 39% 93%
Q9HBG4 Homo sapiens 38% 92%
Q9I8D0 Gallus gallus 38% 92%
Q9SJT7 Arabidopsis thaliana 38% 94%
Q9Y487 Homo sapiens 34% 91%
Q9Z1G4 Mus musculus 39% 92%
V5BQN9 Trypanosoma cruzi 44% 100%
V5D763 Trypanosoma cruzi 73% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS