Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD34_LEIBR

TriTrypDb:

LbrM.23.1740 , LBRM2903_230028200

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.627
CLV_NRD_NRD_1	222	224	PF00675	0.613
CLV_NRD_NRD_1	282	284	PF00675	0.570
CLV_NRD_NRD_1	31	33	PF00675	0.425
CLV_NRD_NRD_1	423	425	PF00675	0.465
CLV_PCSK_KEX2_1	10	12	PF00082	0.576
CLV_PCSK_KEX2_1	136	138	PF00082	0.627
CLV_PCSK_KEX2_1	222	224	PF00082	0.613
CLV_PCSK_KEX2_1	248	250	PF00082	0.518
CLV_PCSK_KEX2_1	282	284	PF00082	0.570
CLV_PCSK_KEX2_1	31	33	PF00082	0.425
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.419
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.487
CLV_PCSK_SKI1_1	170	174	PF00082	0.525
CLV_PCSK_SKI1_1	307	311	PF00082	0.557
DEG_APCC_DBOX_1	248	256	PF00400	0.502
DEG_APCC_DBOX_1	297	305	PF00400	0.446
DOC_ANK_TNKS_1	18	25	PF00023	0.574
DOC_CYCLIN_RxL_1	134	145	PF00134	0.400
DOC_MAPK_DCC_7	406	415	PF00069	0.567
DOC_MAPK_gen_1	10	16	PF00069	0.562
DOC_MAPK_gen_1	136	142	PF00069	0.390
DOC_MAPK_gen_1	219	228	PF00069	0.611
DOC_MAPK_gen_1	295	303	PF00069	0.462
DOC_MAPK_MEF2A_6	219	228	PF00069	0.611
DOC_MAPK_MEF2A_6	406	415	PF00069	0.567
DOC_MAPK_NFAT4_5	223	231	PF00069	0.605
DOC_MAPK_RevD_3	234	249	PF00069	0.470
DOC_PP2B_LxvP_1	418	421	PF13499	0.488
DOC_PP4_FxxP_1	213	216	PF00568	0.616
DOC_USP7_MATH_1	152	156	PF00917	0.548
DOC_USP7_MATH_1	386	390	PF00917	0.440
DOC_USP7_MATH_1	449	453	PF00917	0.571
DOC_USP7_MATH_1	83	87	PF00917	0.611
DOC_WW_Pin1_4	2	7	PF00397	0.469
DOC_WW_Pin1_4	344	349	PF00397	0.499
LIG_14-3-3_CanoR_1	194	202	PF00244	0.683
LIG_14-3-3_CanoR_1	31	35	PF00244	0.595
LIG_14-3-3_CanoR_1	464	470	PF00244	0.718
LIG_AP2alpha_1	362	366	PF02296	0.443
LIG_APCC_ABBA_1	12	17	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	11	17	PF00400	0.560
LIG_BIR_III_2	100	104	PF00653	0.469
LIG_BRCT_BRCA1_1	449	453	PF00533	0.518
LIG_CtBP_PxDLS_1	410	414	PF00389	0.590
LIG_deltaCOP1_diTrp_1	346	351	PF00928	0.460
LIG_EH1_1	166	174	PF00400	0.371
LIG_FHA_1	151	157	PF00498	0.518
LIG_FHA_1	185	191	PF00498	0.618
LIG_FHA_1	230	236	PF00498	0.450
LIG_FHA_1	298	304	PF00498	0.609
LIG_FHA_1	322	328	PF00498	0.546
LIG_FHA_1	336	342	PF00498	0.616
LIG_FHA_1	353	359	PF00498	0.350
LIG_FHA_1	400	406	PF00498	0.508
LIG_FHA_1	57	63	PF00498	0.574
LIG_FHA_2	180	186	PF00498	0.670
LIG_FHA_2	376	382	PF00498	0.565
LIG_FHA_2	64	70	PF00498	0.527
LIG_LIR_Apic_2	211	216	PF02991	0.612
LIG_LIR_Gen_1	175	183	PF02991	0.530
LIG_LIR_Nem_3	175	179	PF02991	0.531
LIG_LIR_Nem_3	412	418	PF02991	0.562
LIG_NRBOX	454	460	PF00104	0.556
LIG_PCNA_PIPBox_1	40	49	PF02747	0.409
LIG_Pex14_2	362	366	PF04695	0.511
LIG_Pex14_2	393	397	PF04695	0.480
LIG_REV1ctd_RIR_1	13	23	PF16727	0.555
LIG_SH2_CRK	242	246	PF00017	0.566
LIG_SH2_STAT5	146	149	PF00017	0.547
LIG_SH2_STAT5	396	399	PF00017	0.473
LIG_SH2_STAT5	70	73	PF00017	0.455
LIG_SH3_3	413	419	PF00018	0.607
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.437
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.398
LIG_SUMO_SIM_par_1	323	330	PF11976	0.536
LIG_SUMO_SIM_par_1	39	45	PF11976	0.579
MOD_CK1_1	145	151	PF00069	0.566
MOD_CK1_1	332	338	PF00069	0.591
MOD_CK1_1	339	345	PF00069	0.565
MOD_CK1_1	347	353	PF00069	0.444
MOD_CK1_1	49	55	PF00069	0.626
MOD_CK2_1	145	151	PF00069	0.566
MOD_CK2_1	179	185	PF00069	0.587
MOD_CK2_1	288	294	PF00069	0.675
MOD_CK2_1	340	346	PF00069	0.484
MOD_CK2_1	375	381	PF00069	0.558
MOD_CK2_1	63	69	PF00069	0.519
MOD_GlcNHglycan	156	159	PF01048	0.596
MOD_GlcNHglycan	197	200	PF01048	0.619
MOD_GlcNHglycan	330	334	PF01048	0.574
MOD_GlcNHglycan	373	376	PF01048	0.373
MOD_GlcNHglycan	449	452	PF01048	0.552
MOD_GlcNHglycan	460	463	PF01048	0.659
MOD_GlcNHglycan	467	470	PF01048	0.524
MOD_GlcNHglycan	49	52	PF01048	0.559
MOD_GlcNHglycan	56	59	PF01048	0.589
MOD_GlcNHglycan	85	88	PF01048	0.611
MOD_GSK3_1	141	148	PF00069	0.475
MOD_GSK3_1	150	157	PF00069	0.496
MOD_GSK3_1	321	328	PF00069	0.526
MOD_GSK3_1	329	336	PF00069	0.599
MOD_GSK3_1	337	344	PF00069	0.681
MOD_GSK3_1	347	354	PF00069	0.464
MOD_GSK3_1	371	378	PF00069	0.647
MOD_GSK3_1	42	49	PF00069	0.566
MOD_GSK3_1	443	450	PF00069	0.478
MOD_GSK3_1	52	59	PF00069	0.621
MOD_NEK2_1	130	135	PF00069	0.559
MOD_NEK2_1	141	146	PF00069	0.600
MOD_NEK2_1	161	166	PF00069	0.391
MOD_NEK2_1	186	191	PF00069	0.691
MOD_NEK2_1	277	282	PF00069	0.634
MOD_NEK2_1	30	35	PF00069	0.562
MOD_NEK2_1	321	326	PF00069	0.572
MOD_NEK2_1	337	342	PF00069	0.470
MOD_NEK2_1	362	367	PF00069	0.443
MOD_NEK2_1	42	47	PF00069	0.499
MOD_NEK2_1	458	463	PF00069	0.636
MOD_NEK2_1	56	61	PF00069	0.476
MOD_NEK2_1	71	76	PF00069	0.642
MOD_NEK2_2	399	404	PF00069	0.535
MOD_PIKK_1	130	136	PF00454	0.700
MOD_PIKK_1	150	156	PF00454	0.360
MOD_PIKK_1	33	39	PF00454	0.561
MOD_PK_1	118	124	PF00069	0.581
MOD_PKA_1	248	254	PF00069	0.498
MOD_PKA_2	193	199	PF00069	0.574
MOD_PKA_2	248	254	PF00069	0.658
MOD_PKA_2	297	303	PF00069	0.529
MOD_PKA_2	30	36	PF00069	0.639
MOD_Plk_1	315	321	PF00069	0.593
MOD_Plk_1	351	357	PF00069	0.398
MOD_Plk_1	399	405	PF00069	0.513
MOD_Plk_4	118	124	PF00069	0.581
MOD_Plk_4	142	148	PF00069	0.539
MOD_Plk_4	208	214	PF00069	0.689
MOD_Plk_4	235	241	PF00069	0.525
MOD_Plk_4	251	257	PF00069	0.639
MOD_Plk_4	288	294	PF00069	0.714
MOD_Plk_4	299	305	PF00069	0.510
MOD_Plk_4	315	321	PF00069	0.650
MOD_Plk_4	362	368	PF00069	0.377
MOD_ProDKin_1	2	8	PF00069	0.465
MOD_ProDKin_1	344	350	PF00069	0.495
TRG_ENDOCYTIC_2	242	245	PF00928	0.641
TRG_ENDOCYTIC_2	27	30	PF00928	0.568
TRG_ER_diArg_1	221	223	PF00400	0.629
TRG_ER_diArg_1	30	32	PF00400	0.421
TRG_ER_diArg_1	403	406	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G3	Leptomonas seymouri	37%	100%
A0A3Q8ICP2	Leishmania donovani	74%	100%
A4I0M1	Leishmania infantum	73%	100%
E9AWI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QAY8	Leishmania major	74%	100%
V5ARA2	Trypanosoma cruzi	24%	100%