Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HD33_LEIBR

TriTrypDb:

LbrM.23.1730 , LBRM2903_230028100

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

A4HD33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD33

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.351
CLV_NRD_NRD_1	230	232	PF00675	0.454
CLV_NRD_NRD_1	30	32	PF00675	0.328
CLV_PCSK_FUR_1	143	147	PF00082	0.408
CLV_PCSK_KEX2_1	145	147	PF00082	0.351
CLV_PCSK_KEX2_1	230	232	PF00082	0.454
CLV_PCSK_KEX2_1	30	32	PF00082	0.328
CLV_PCSK_KEX2_1	37	39	PF00082	0.305
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.320
CLV_PCSK_SKI1_1	153	157	PF00082	0.349
CLV_PCSK_SKI1_1	200	204	PF00082	0.415
CLV_PCSK_SKI1_1	30	34	PF00082	0.397
CLV_PCSK_SKI1_1	43	47	PF00082	0.376
CLV_Separin_Metazoa	241	245	PF03568	0.452
DOC_CDC14_PxL_1	130	138	PF14671	0.371
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.411
DOC_MAPK_MEF2A_6	153	162	PF00069	0.446
DOC_MAPK_MEF2A_6	67	74	PF00069	0.341
DOC_PP2B_LxvP_1	156	159	PF13499	0.406
DOC_PP4_MxPP_1	132	135	PF00568	0.394
DOC_USP7_MATH_1	119	123	PF00917	0.348
DOC_USP7_MATH_1	168	172	PF00917	0.407
DOC_USP7_MATH_1	55	59	PF00917	0.321
DOC_USP7_MATH_1	84	88	PF00917	0.432
DOC_USP7_UBL2_3	23	27	PF12436	0.452
LIG_14-3-3_CanoR_1	102	106	PF00244	0.418
LIG_14-3-3_CanoR_1	12	21	PF00244	0.413
LIG_14-3-3_CanoR_1	146	156	PF00244	0.423
LIG_14-3-3_CanoR_1	181	186	PF00244	0.367
LIG_14-3-3_CanoR_1	230	235	PF00244	0.462
LIG_14-3-3_CanoR_1	38	43	PF00244	0.311
LIG_14-3-3_CanoR_1	67	73	PF00244	0.320
LIG_BRCT_BRCA1_1	258	262	PF00533	0.260
LIG_Clathr_ClatBox_1	69	73	PF01394	0.378
LIG_CtBP_PxDLS_1	159	163	PF00389	0.405
LIG_EH_1	193	197	PF12763	0.294
LIG_EVH1_1	115	119	PF00568	0.333
LIG_FHA_1	14	20	PF00498	0.388
LIG_FHA_1	182	188	PF00498	0.426
LIG_FHA_1	210	216	PF00498	0.366
LIG_FHA_1	31	37	PF00498	0.371
LIG_FHA_1	42	48	PF00498	0.424
LIG_FHA_2	236	242	PF00498	0.322
LIG_FHA_2	3	9	PF00498	0.619
LIG_LIR_Apic_2	111	116	PF02991	0.411
LIG_LIR_Gen_1	58	65	PF02991	0.372
LIG_LIR_Nem_3	28	32	PF02991	0.388
LIG_LIR_Nem_3	58	63	PF02991	0.378
LIG_LIR_Nem_3	64	69	PF02991	0.338
LIG_PCNA_yPIPBox_3	282	292	PF02747	0.327
LIG_PDZ_Class_3	300	305	PF00595	0.537
LIG_SH2_CRK	113	117	PF00017	0.398
LIG_SH2_STAP1	10	14	PF00017	0.460
LIG_SH3_1	113	119	PF00018	0.361
LIG_SH3_1	221	227	PF00018	0.327
LIG_SH3_3	113	119	PF00018	0.439
LIG_SH3_3	136	142	PF00018	0.357
LIG_SH3_3	189	195	PF00018	0.485
LIG_SH3_3	221	227	PF00018	0.392
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.423
LIG_SUMO_SIM_par_1	68	73	PF11976	0.389
LIG_UBA3_1	18	23	PF00899	0.445
LIG_WRC_WIRS_1	182	187	PF05994	0.364
LIG_WRC_WIRS_1	257	262	PF05994	0.258
LIG_WW_2	116	119	PF00397	0.315
MOD_CK2_1	235	241	PF00069	0.461
MOD_CK2_1	91	97	PF00069	0.387
MOD_GlcNHglycan	125	128	PF01048	0.495
MOD_GlcNHglycan	57	60	PF01048	0.376
MOD_GSK3_1	119	126	PF00069	0.317
MOD_GSK3_1	13	20	PF00069	0.444
MOD_GSK3_1	147	154	PF00069	0.405
MOD_GSK3_1	271	278	PF00069	0.454
MOD_GSK3_1	37	44	PF00069	0.432
MOD_GSK3_1	61	68	PF00069	0.441
MOD_N-GLC_1	123	128	PF02516	0.330
MOD_N-GLC_1	151	156	PF02516	0.421
MOD_NEK2_1	123	128	PF00069	0.378
MOD_NEK2_1	209	214	PF00069	0.372
MOD_NEK2_1	271	276	PF00069	0.335
MOD_NEK2_1	45	50	PF00069	0.322
MOD_NEK2_1	65	70	PF00069	0.366
MOD_NEK2_1	72	77	PF00069	0.315
MOD_NEK2_1	91	96	PF00069	0.609
MOD_NEK2_2	108	113	PF00069	0.408
MOD_NMyristoyl	1	7	PF02799	0.506
MOD_PKA_1	230	236	PF00069	0.435
MOD_PKA_1	30	36	PF00069	0.345
MOD_PKA_1	37	43	PF00069	0.354
MOD_PKA_2	101	107	PF00069	0.477
MOD_PKA_2	230	236	PF00069	0.435
MOD_PKA_2	30	36	PF00069	0.336
MOD_PKA_2	37	43	PF00069	0.320
MOD_PKB_1	179	187	PF00069	0.338
MOD_Plk_1	151	157	PF00069	0.425
MOD_Plk_1	188	194	PF00069	0.445
MOD_Plk_4	108	114	PF00069	0.409
MOD_Plk_4	181	187	PF00069	0.489
MOD_Plk_4	246	252	PF00069	0.354
MOD_Plk_4	271	277	PF00069	0.447
MOD_Plk_4	61	67	PF00069	0.368
MOD_SUMO_rev_2	290	296	PF00179	0.486
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.346
TRG_ER_diArg_1	142	145	PF00400	0.361
TRG_ER_diArg_1	229	231	PF00400	0.452
TRG_ER_diArg_1	29	31	PF00400	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL46	Leptomonas seymouri	50%	100%
A0A3Q8ICP4	Leishmania donovani	77%	100%
A0A3R7NP81	Trypanosoma rangeli	36%	100%
A4I0M0	Leishmania infantum	78%	100%
E9AWI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QAY9	Leishmania major	77%	100%