Pyridoxal phosphate homeostasis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alanine racemase, putative

Species:

Leishmania braziliensis

UniProt:

A4HD32_LEIBR

TriTrypDb:

LbrM.23.1720 , LBRM2903_230028000

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD32

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	5
GO:0019842	vitamin binding	3	12
GO:0030170	pyridoxal phosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0070279	vitamin B6 binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.394
CLV_PCSK_KEX2_1	33	35	PF00082	0.394
CLV_PCSK_SKI1_1	33	37	PF00082	0.335
CLV_PCSK_SKI1_1	93	97	PF00082	0.315
DEG_APCC_DBOX_1	33	41	PF00400	0.420
DEG_APCC_DBOX_1	92	100	PF00400	0.194
DOC_CDC14_PxL_1	96	104	PF14671	0.384
DOC_CYCLIN_RxL_1	90	97	PF00134	0.315
DOC_MAPK_gen_1	122	132	PF00069	0.308
DOC_MAPK_gen_1	33	40	PF00069	0.420
DOC_MAPK_MEF2A_6	125	134	PF00069	0.299
DOC_MAPK_MEF2A_6	170	177	PF00069	0.359
DOC_USP7_MATH_1	27	31	PF00917	0.499
DOC_USP7_UBL2_3	112	116	PF12436	0.200
DOC_WW_Pin1_4	42	47	PF00397	0.308
LIG_14-3-3_CanoR_1	125	131	PF00244	0.276
LIG_14-3-3_CanoR_1	223	231	PF00244	0.343
LIG_14-3-3_CanoR_1	33	38	PF00244	0.367
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_BRCT_BRCA1_1	232	236	PF00533	0.354
LIG_deltaCOP1_diTrp_1	78	83	PF00928	0.296
LIG_FHA_1	151	157	PF00498	0.323
LIG_FHA_1	226	232	PF00498	0.323
LIG_FHA_2	136	142	PF00498	0.299
LIG_LIR_Gen_1	78	87	PF02991	0.312
LIG_LIR_Nem_3	131	136	PF02991	0.315
LIG_LIR_Nem_3	185	190	PF02991	0.300
LIG_LIR_Nem_3	78	84	PF02991	0.312
LIG_SH2_CRK	19	23	PF00017	0.422
LIG_SH2_GRB2like	218	221	PF00017	0.384
LIG_SH2_NCK_1	4	8	PF00017	0.466
LIG_SH2_PTP2	133	136	PF00017	0.315
LIG_SH2_SRC	218	221	PF00017	0.420
LIG_SH2_SRC	4	7	PF00017	0.529
LIG_SH2_STAT5	133	136	PF00017	0.299
LIG_SH2_STAT5	159	162	PF00017	0.356
LIG_SH2_STAT5	180	183	PF00017	0.315
LIG_SH2_STAT5	218	221	PF00017	0.384
LIG_SH2_STAT5	64	67	PF00017	0.299
LIG_TRAF2_1	139	142	PF00917	0.315
LIG_TYR_ITIM	17	22	PF00017	0.527
LIG_UBA3_1	166	170	PF00899	0.445
MOD_CK1_1	126	132	PF00069	0.394
MOD_CK1_1	8	14	PF00069	0.509
MOD_CK2_1	135	141	PF00069	0.299
MOD_CK2_1	142	148	PF00069	0.298
MOD_CK2_1	179	185	PF00069	0.315
MOD_GlcNHglycan	125	128	PF01048	0.319
MOD_GlcNHglycan	138	141	PF01048	0.301
MOD_GlcNHglycan	144	147	PF01048	0.299
MOD_GlcNHglycan	214	217	PF01048	0.356
MOD_GlcNHglycan	29	32	PF01048	0.424
MOD_GSK3_1	136	143	PF00069	0.315
MOD_GSK3_1	208	215	PF00069	0.315
MOD_GSK3_1	36	43	PF00069	0.304
MOD_N-GLC_1	136	141	PF02516	0.299
MOD_NEK2_1	208	213	PF00069	0.296
MOD_NEK2_1	224	229	PF00069	0.231
MOD_NEK2_2	225	230	PF00069	0.361
MOD_NEK2_2	48	53	PF00069	0.435
MOD_PKA_1	33	39	PF00069	0.446
MOD_PKA_2	33	39	PF00069	0.446
MOD_Plk_1	150	156	PF00069	0.420
MOD_Plk_1	208	214	PF00069	0.343
MOD_Plk_4	231	237	PF00069	0.322
MOD_Plk_4	33	39	PF00069	0.384
MOD_Plk_4	48	54	PF00069	0.384
MOD_Plk_4	76	82	PF00069	0.446
MOD_ProDKin_1	42	48	PF00069	0.308
MOD_SUMO_rev_2	139	145	PF00179	0.315
MOD_SUMO_rev_2	67	72	PF00179	0.194
TRG_AP2beta_CARGO_1	185	194	PF09066	0.300
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.417
TRG_ENDOCYTIC_2	133	136	PF00928	0.299
TRG_ENDOCYTIC_2	19	22	PF00928	0.383
TRG_ER_diArg_1	33	35	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.116

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P624	Leptomonas seymouri	80%	99%
A0A0S4JPZ2	Bodo saltans	49%	96%
A0A1X0NWM6	Trypanosomatidae	67%	99%
A0A3Q8ICU4	Leishmania donovani	91%	100%
A0A422NJG5	Trypanosoma rangeli	66%	100%
A4I0L9	Leishmania infantum	91%	100%
C9ZNR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	95%
E9AWI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O24748	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	33%	100%
O25156	Helicobacter pylori (strain ATCC 700392 / 26695)	37%	100%
O31727	Bacillus subtilis (strain 168)	33%	100%
O66631	Aquifex aeolicus (strain VF5)	40%	100%
O94903	Homo sapiens	46%	89%
P24562	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	38%	100%
P38197	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	95%
P44506	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	43%	100%
P52055	Vibrio alginolyticus	42%	100%
P52056	Synechocystis sp. (strain PCC 6803 / Kazusa)	34%	100%
P52057	Caenorhabditis elegans	44%	100%
P57614	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	29%	100%
P67080	Escherichia coli (strain K12)	39%	100%
P67081	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	39%	100%
P67082	Escherichia coli O157:H7	39%	100%
P67084	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	95%
P9WFQ6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	95%
P9WFQ7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	95%
Q1ZXI6	Dictyostelium discoideum	38%	96%
Q3T0G5	Bos taurus	47%	90%
Q4QAZ0	Leishmania major	90%	100%
Q5R4Z1	Pongo abelii	48%	89%
Q89A48	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	30%	100%
Q8K929	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	33%	100%
Q9CCE2	Mycobacterium leprae (strain TN)	30%	95%
Q9CPD5	Pasteurella multocida (strain Pm70)	42%	100%
Q9KUQ4	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	42%	100%
Q9P6Q1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
Q9RUL6	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	34%	100%
Q9Z2Y8	Mus musculus	43%	89%
Q9ZKF2	Helicobacter pylori (strain J99 / ATCC 700824)	36%	100%
V5B6R2	Trypanosoma cruzi	66%	97%