LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD31_LEIBR

TriTrypDb:

LbrM.23.1710 , LBRM2903_230027900

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HD31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD31

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.474
CLV_C14_Caspase3-7	164	168	PF00656	0.757
CLV_C14_Caspase3-7	174	178	PF00656	0.716
CLV_C14_Caspase3-7	201	205	PF00656	0.743
CLV_C14_Caspase3-7	75	79	PF00656	0.390
CLV_NRD_NRD_1	4	6	PF00675	0.370
CLV_PCSK_KEX2_1	210	212	PF00082	0.732
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.732
CLV_Separin_Metazoa	2	6	PF03568	0.378
DEG_Nend_UBRbox_2	1	3	PF02207	0.500
DOC_CDC14_PxL_1	29	37	PF14671	0.430
DOC_CKS1_1	129	134	PF01111	0.575
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.544
DOC_MAPK_gen_1	151	160	PF00069	0.546
DOC_MAPK_MEF2A_6	54	62	PF00069	0.494
DOC_PP2B_LxvP_1	96	99	PF13499	0.533
DOC_USP7_MATH_1	147	151	PF00917	0.444
DOC_USP7_MATH_1	205	209	PF00917	0.571
DOC_USP7_MATH_1	89	93	PF00917	0.548
DOC_WW_Pin1_4	128	133	PF00397	0.582
DOC_WW_Pin1_4	37	42	PF00397	0.547
DOC_WW_Pin1_4	82	87	PF00397	0.573
LIG_14-3-3_CanoR_1	111	117	PF00244	0.493
LIG_14-3-3_CanoR_1	5	11	PF00244	0.360
LIG_BIR_III_2	204	208	PF00653	0.690
LIG_Clathr_ClatBox_1	57	61	PF01394	0.538
LIG_CSL_BTD_1	38	41	PF09270	0.542
LIG_FHA_1	154	160	PF00498	0.672
LIG_FHA_1	44	50	PF00498	0.510
LIG_FHA_2	210	216	PF00498	0.652
LIG_IRF3_LxIS_1	45	52	PF10401	0.265
LIG_LIR_Gen_1	40	50	PF02991	0.418
LIG_LIR_Nem_3	115	119	PF02991	0.442
LIG_LIR_Nem_3	137	142	PF02991	0.415
LIG_LIR_Nem_3	37	42	PF02991	0.429
LIG_NRBOX	44	50	PF00104	0.515
LIG_NRBOX	92	98	PF00104	0.539
LIG_Pex14_2	135	139	PF04695	0.440
LIG_SH2_SRC	172	175	PF00017	0.571
LIG_SH2_STAT5	42	45	PF00017	0.509
LIG_SH3_3	126	132	PF00018	0.576
LIG_SH3_3	30	36	PF00018	0.378
LIG_SH3_3	85	91	PF00018	0.430
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.389
LIG_SUMO_SIM_par_1	120	126	PF11976	0.494
LIG_SUMO_SIM_par_1	144	150	PF11976	0.449
LIG_SUMO_SIM_par_1	46	52	PF11976	0.519
LIG_SUMO_SIM_par_1	56	61	PF11976	0.488
LIG_SUMO_SIM_par_1	72	78	PF11976	0.288
LIG_TRAF2_1	105	108	PF00917	0.588
LIG_TRAF2_1	168	171	PF00917	0.690
LIG_TRAF2_1	197	200	PF00917	0.677
LIG_TRAF2_1	20	23	PF00917	0.545
LIG_UBA3_1	48	56	PF00899	0.534
MOD_CK1_1	163	169	PF00069	0.652
MOD_CK1_1	185	191	PF00069	0.700
MOD_CK1_1	224	230	PF00069	0.515
MOD_CK1_1	40	46	PF00069	0.405
MOD_CK2_1	101	107	PF00069	0.528
MOD_CK2_1	165	171	PF00069	0.656
MOD_CK2_1	173	179	PF00069	0.647
MOD_CK2_1	190	196	PF00069	0.522
MOD_CK2_1	200	206	PF00069	0.666
MOD_CK2_1	209	215	PF00069	0.561
MOD_CK2_1	224	230	PF00069	0.520
MOD_GlcNHglycan	189	192	PF01048	0.777
MOD_GlcNHglycan	206	210	PF01048	0.686
MOD_GlcNHglycan	218	221	PF01048	0.638
MOD_GlcNHglycan	223	227	PF01048	0.538
MOD_GlcNHglycan	29	32	PF01048	0.511
MOD_GSK3_1	149	156	PF00069	0.571
MOD_GSK3_1	173	180	PF00069	0.714
MOD_GSK3_1	182	189	PF00069	0.754
MOD_GSK3_1	205	212	PF00069	0.655
MOD_GSK3_1	221	228	PF00069	0.568
MOD_NEK2_1	112	117	PF00069	0.489
MOD_NEK2_1	27	32	PF00069	0.515
MOD_NEK2_1	4	9	PF00069	0.435
MOD_NEK2_1	49	54	PF00069	0.500
MOD_PIKK_1	182	188	PF00454	0.803
MOD_PIKK_1	22	28	PF00454	0.543
MOD_PKA_2	221	227	PF00069	0.706
MOD_PKA_2	4	10	PF00069	0.359
MOD_PKB_1	151	159	PF00069	0.630
MOD_Plk_1	107	113	PF00069	0.537
MOD_Plk_1	22	28	PF00069	0.469
MOD_Plk_2-3	165	171	PF00069	0.648
MOD_Plk_2-3	173	179	PF00069	0.609
MOD_Plk_2-3	198	204	PF00069	0.721
MOD_Plk_4	134	140	PF00069	0.584
MOD_ProDKin_1	128	134	PF00069	0.579
MOD_ProDKin_1	37	43	PF00069	0.550
MOD_ProDKin_1	82	88	PF00069	0.572
TRG_DiLeu_BaEn_4	107	113	PF01217	0.545
TRG_DiLeu_BaEn_4	22	28	PF01217	0.581
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.521
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.543
TRG_ENDOCYTIC_2	42	45	PF00928	0.509
TRG_NES_CRM1_1	67	78	PF08389	0.403
TRG_NLS_MonoExtC_3	209	215	PF00514	0.759
TRG_NLS_MonoExtN_4	207	214	PF00514	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B1	Leptomonas seymouri	68%	100%
A0A0S4JGB7	Bodo saltans	34%	95%
A0A1X0NX37	Trypanosomatidae	46%	100%
A0A3S5H7C5	Leishmania donovani	86%	100%
A0A422NJD9	Trypanosoma rangeli	53%	76%
A4I0L8	Leishmania infantum	86%	100%
C9ZNR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AWH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAZ1	Leishmania major	85%	100%
V5BFS2	Trypanosoma cruzi	52%	85%