GAF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GAF domain/TIP41-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4HD30_LEIBR

TriTrypDb:

LbrM.23.1700 , LBRM2903_230027800

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD30

Function

Biological processes
Term	Name	Level	Count
GO:0010921	regulation of phosphatase activity	5	11
GO:0019220	regulation of phosphate metabolic process	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031399	regulation of protein modification process	6	11
GO:0035303	regulation of dephosphorylation	7	11
GO:0035304	regulation of protein dephosphorylation	7	11
GO:0043666	regulation of phosphoprotein phosphatase activity	6	11
GO:0050789	regulation of biological process	2	11
GO:0050790	regulation of catalytic activity	3	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051174	regulation of phosphorus metabolic process	5	11
GO:0051246	regulation of protein metabolic process	5	11
GO:0051336	regulation of hydrolase activity	4	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0065009	regulation of molecular function	2	11
GO:0080090	regulation of primary metabolic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	1
GO:0070191	methionine-R-sulfoxide reductase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.581
CLV_PCSK_KEX2_1	34	36	PF00082	0.561
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.568
CLV_PCSK_SKI1_1	272	276	PF00082	0.462
CLV_PCSK_SKI1_1	34	38	PF00082	0.525
DEG_APCC_DBOX_1	266	274	PF00400	0.573
DEG_SPOP_SBC_1	235	239	PF00917	0.727
DOC_CDC14_PxL_1	79	87	PF14671	0.485
DOC_CYCLIN_yCln2_LP_2	342	348	PF00134	0.475
DOC_MAPK_DCC_7	467	477	PF00069	0.559
DOC_MAPK_MEF2A_6	136	145	PF00069	0.449
DOC_MAPK_MEF2A_6	309	316	PF00069	0.454
DOC_MAPK_MEF2A_6	335	344	PF00069	0.501
DOC_MAPK_MEF2A_6	399	407	PF00069	0.501
DOC_PP1_RVXF_1	359	365	PF00149	0.517
DOC_PP1_RVXF_1	69	75	PF00149	0.491
DOC_PP2B_LxvP_1	197	200	PF13499	0.532
DOC_PP2B_LxvP_1	342	345	PF13499	0.350
DOC_PP2B_LxvP_1	6	9	PF13499	0.386
DOC_PP2B_PxIxI_1	472	478	PF00149	0.341
DOC_PP4_FxxP_1	60	63	PF00568	0.505
DOC_PP4_FxxP_1	80	83	PF00568	0.498
DOC_USP7_MATH_1	130	134	PF00917	0.344
DOC_USP7_MATH_1	253	257	PF00917	0.539
DOC_USP7_MATH_1	295	299	PF00917	0.441
DOC_USP7_MATH_1	489	493	PF00917	0.421
DOC_USP7_UBL2_3	247	251	PF12436	0.697
DOC_USP7_UBL2_3	357	361	PF12436	0.569
DOC_WW_Pin1_4	301	306	PF00397	0.498
DOC_WW_Pin1_4	34	39	PF00397	0.476
DOC_WW_Pin1_4	431	436	PF00397	0.400
DOC_WW_Pin1_4	496	501	PF00397	0.497
LIG_14-3-3_CanoR_1	267	271	PF00244	0.397
LIG_14-3-3_CanoR_1	94	102	PF00244	0.413
LIG_Actin_WH2_2	469	484	PF00022	0.540
LIG_APCC_ABBA_1	457	462	PF00400	0.501
LIG_BIR_III_4	389	393	PF00653	0.581
LIG_BRCT_BRCA1_1	32	36	PF00533	0.550
LIG_BRCT_BRCA1_1	351	355	PF00533	0.581
LIG_BRCT_BRCA1_1	433	437	PF00533	0.572
LIG_BRCT_BRCA1_2	351	357	PF00533	0.581
LIG_deltaCOP1_diTrp_1	310	316	PF00928	0.528
LIG_deltaCOP1_diTrp_1	363	370	PF00928	0.466
LIG_EH1_1	315	323	PF00400	0.499
LIG_FHA_1	235	241	PF00498	0.742
LIG_FHA_1	298	304	PF00498	0.427
LIG_FHA_2	107	113	PF00498	0.475
LIG_FHA_2	227	233	PF00498	0.539
LIG_FHA_2	266	272	PF00498	0.473
LIG_FHA_2	273	279	PF00498	0.425
LIG_FXI_DFP_1	408	412	PF00024	0.381
LIG_GBD_Chelix_1	175	183	PF00786	0.298
LIG_Integrin_RGD_1	215	217	PF01839	0.530
LIG_IRF3_LxIS_1	282	289	PF10401	0.572
LIG_LIR_Gen_1	16	25	PF02991	0.365
LIG_LIR_Gen_1	310	321	PF02991	0.480
LIG_LIR_Gen_1	347	358	PF02991	0.508
LIG_LIR_Gen_1	410	418	PF02991	0.581
LIG_LIR_LC3C_4	115	119	PF02991	0.392
LIG_LIR_Nem_3	16	21	PF02991	0.360
LIG_LIR_Nem_3	310	316	PF02991	0.493
LIG_LIR_Nem_3	331	337	PF02991	0.510
LIG_LIR_Nem_3	347	353	PF02991	0.401
LIG_LIR_Nem_3	369	373	PF02991	0.497
LIG_LIR_Nem_3	434	440	PF02991	0.489
LIG_PDZ_Class_2	519	524	PF00595	0.393
LIG_Pex14_1	366	370	PF04695	0.476
LIG_Pex14_1	74	78	PF04695	0.335
LIG_Pex14_2	407	411	PF04695	0.501
LIG_Pex14_2	437	441	PF04695	0.501
LIG_REV1ctd_RIR_1	243	251	PF16727	0.707
LIG_SH2_CRK	202	206	PF00017	0.660
LIG_SH2_STAP1	18	22	PF00017	0.448
LIG_SH2_STAP1	202	206	PF00017	0.660
LIG_SH2_STAT3	78	81	PF00017	0.389
LIG_SH2_STAT5	163	166	PF00017	0.223
LIG_SH2_STAT5	78	81	PF00017	0.370
LIG_SH3_3	136	142	PF00018	0.298
LIG_SH3_3	378	384	PF00018	0.492
LIG_SH3_3	429	435	PF00018	0.400
LIG_SH3_3	483	489	PF00018	0.359
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.475
LIG_SUMO_SIM_par_1	141	146	PF11976	0.434
LIG_SUMO_SIM_par_1	149	155	PF11976	0.254
LIG_SUMO_SIM_par_1	298	304	PF11976	0.533
LIG_SUMO_SIM_par_1	474	479	PF11976	0.321
LIG_SxIP_EBH_1	236	247	PF03271	0.721
MOD_CK1_1	113	119	PF00069	0.428
MOD_CK1_1	134	140	PF00069	0.223
MOD_CK1_1	304	310	PF00069	0.578
MOD_CK2_1	10	16	PF00069	0.444
MOD_CK2_1	106	112	PF00069	0.449
MOD_CK2_1	117	123	PF00069	0.421
MOD_CK2_1	132	138	PF00069	0.207
MOD_CK2_1	226	232	PF00069	0.543
MOD_CK2_1	272	278	PF00069	0.495
MOD_CK2_1	304	310	PF00069	0.550
MOD_DYRK1A_RPxSP_1	431	435	PF00069	0.223
MOD_GlcNHglycan	112	115	PF01048	0.389
MOD_GlcNHglycan	202	205	PF01048	0.607
MOD_GlcNHglycan	288	291	PF01048	0.488
MOD_GlcNHglycan	323	326	PF01048	0.412
MOD_GlcNHglycan	346	349	PF01048	0.428
MOD_GlcNHglycan	469	472	PF01048	0.601
MOD_GlcNHglycan	503	506	PF01048	0.523
MOD_GSK3_1	106	113	PF00069	0.463
MOD_GSK3_1	130	137	PF00069	0.344
MOD_GSK3_1	226	233	PF00069	0.653
MOD_GSK3_1	234	241	PF00069	0.587
MOD_GSK3_1	282	289	PF00069	0.561
MOD_GSK3_1	295	302	PF00069	0.477
MOD_GSK3_1	30	37	PF00069	0.521
MOD_GSK3_1	463	470	PF00069	0.437
MOD_N-GLC_1	146	151	PF02516	0.449
MOD_NEK2_1	117	122	PF00069	0.358
MOD_NEK2_1	265	270	PF00069	0.478
MOD_NEK2_1	282	287	PF00069	0.495
MOD_NEK2_1	321	326	PF00069	0.464
MOD_NEK2_1	398	403	PF00069	0.475
MOD_NEK2_1	423	428	PF00069	0.475
MOD_NEK2_1	463	468	PF00069	0.437
MOD_NEK2_2	253	258	PF00069	0.331
MOD_PIKK_1	272	278	PF00454	0.465
MOD_PIKK_1	323	329	PF00454	0.461
MOD_PKA_2	266	272	PF00069	0.436
MOD_Plk_1	208	214	PF00069	0.505
MOD_Plk_1	253	259	PF00069	0.395
MOD_Plk_1	399	405	PF00069	0.336
MOD_Plk_4	113	119	PF00069	0.320
MOD_Plk_4	146	152	PF00069	0.449
MOD_ProDKin_1	301	307	PF00069	0.510
MOD_ProDKin_1	34	40	PF00069	0.470
MOD_ProDKin_1	431	437	PF00069	0.223
MOD_ProDKin_1	496	502	PF00069	0.494
MOD_SUMO_for_1	246	249	PF00179	0.717
MOD_SUMO_for_1	505	508	PF00179	0.449
MOD_SUMO_rev_2	356	362	PF00179	0.455
MOD_SUMO_rev_2	488	498	PF00179	0.587
TRG_DiLeu_BaEn_1	333	338	PF01217	0.537
TRG_ENDOCYTIC_2	18	21	PF00928	0.381
TRG_ENDOCYTIC_2	202	205	PF00928	0.655
TRG_ENDOCYTIC_2	408	411	PF00928	0.449
TRG_ENDOCYTIC_2	430	433	PF00928	0.475
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5N3	Leptomonas seymouri	68%	100%
A0A0S4JL71	Bodo saltans	36%	100%
A0A1X0NWX3	Trypanosomatidae	44%	97%
A0A3S7WY26	Leishmania donovani	83%	100%
A0A422NJH6	Trypanosoma rangeli	44%	95%
A4I0L7	Leishmania infantum	83%	100%
C9ZNQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	91%
E9AWH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QAZ2	Leishmania major	83%	100%
V5BB88	Trypanosoma cruzi	45%	95%