Cilia- and flagella-associated protein 53

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor, Mitostatin, putative

Species:

Leishmania braziliensis

UniProt:

A4HD29_LEIBR

TriTrypDb:

LbrM.23.1690 , LBRM2903_230027600

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD29

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.562
CLV_C14_Caspase3-7	286	290	PF00656	0.524
CLV_NRD_NRD_1	100	102	PF00675	0.480
CLV_NRD_NRD_1	105	107	PF00675	0.467
CLV_NRD_NRD_1	16	18	PF00675	0.494
CLV_NRD_NRD_1	165	167	PF00675	0.286
CLV_NRD_NRD_1	199	201	PF00675	0.333
CLV_NRD_NRD_1	217	219	PF00675	0.211
CLV_NRD_NRD_1	245	247	PF00675	0.253
CLV_NRD_NRD_1	308	310	PF00675	0.315
CLV_NRD_NRD_1	325	327	PF00675	0.190
CLV_NRD_NRD_1	345	347	PF00675	0.361
CLV_NRD_NRD_1	370	372	PF00675	0.299
CLV_NRD_NRD_1	387	389	PF00675	0.279
CLV_NRD_NRD_1	412	414	PF00675	0.309
CLV_NRD_NRD_1	442	444	PF00675	0.238
CLV_NRD_NRD_1	73	75	PF00675	0.453
CLV_PCSK_FUR_1	112	116	PF00082	0.581
CLV_PCSK_FUR_1	14	18	PF00082	0.509
CLV_PCSK_FUR_1	410	414	PF00082	0.301
CLV_PCSK_FUR_1	71	75	PF00082	0.506
CLV_PCSK_KEX2_1	100	102	PF00082	0.480
CLV_PCSK_KEX2_1	114	116	PF00082	0.466
CLV_PCSK_KEX2_1	119	121	PF00082	0.471
CLV_PCSK_KEX2_1	16	18	PF00082	0.494
CLV_PCSK_KEX2_1	164	166	PF00082	0.296
CLV_PCSK_KEX2_1	247	249	PF00082	0.234
CLV_PCSK_KEX2_1	270	272	PF00082	0.274
CLV_PCSK_KEX2_1	308	310	PF00082	0.306
CLV_PCSK_KEX2_1	347	349	PF00082	0.278
CLV_PCSK_KEX2_1	358	360	PF00082	0.282
CLV_PCSK_KEX2_1	370	372	PF00082	0.270
CLV_PCSK_KEX2_1	377	379	PF00082	0.239
CLV_PCSK_KEX2_1	412	414	PF00082	0.297
CLV_PCSK_KEX2_1	442	444	PF00082	0.307
CLV_PCSK_KEX2_1	71	73	PF00082	0.453
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.535
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.517
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.381
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.362
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.287
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.287
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.201
CLV_PCSK_PC7_1	115	121	PF00082	0.589
CLV_PCSK_SKI1_1	184	188	PF00082	0.362
CLV_PCSK_SKI1_1	285	289	PF00082	0.287
CLV_PCSK_SKI1_1	359	363	PF00082	0.301
CLV_PCSK_SKI1_1	364	368	PF00082	0.300
CLV_PCSK_SKI1_1	412	416	PF00082	0.341
CLV_PCSK_SKI1_1	51	55	PF00082	0.547
DEG_APCC_DBOX_1	71	79	PF00400	0.443
DOC_CDC14_PxL_1	475	483	PF14671	0.486
DOC_MAPK_gen_1	471	480	PF00069	0.474
DOC_MAPK_MEF2A_6	3	10	PF00069	0.444
DOC_MAPK_NFAT4_5	3	11	PF00069	0.437
DOC_USP7_MATH_1	482	486	PF00917	0.462
DOC_USP7_UBL2_3	197	201	PF12436	0.400
DOC_USP7_UBL2_3	219	223	PF12436	0.581
DOC_USP7_UBL2_3	343	347	PF12436	0.487
LIG_14-3-3_CanoR_1	33	39	PF00244	0.598
LIG_14-3-3_CanoR_1	412	417	PF00244	0.517
LIG_Actin_WH2_2	255	272	PF00022	0.562
LIG_deltaCOP1_diTrp_1	342	352	PF00928	0.491
LIG_eIF4E_1	475	481	PF01652	0.477
LIG_FHA_1	185	191	PF00498	0.428
LIG_FHA_1	328	334	PF00498	0.400
LIG_LIR_Gen_1	152	162	PF02991	0.562
LIG_LIR_Gen_1	276	284	PF02991	0.477
LIG_LIR_Gen_1	55	62	PF02991	0.339
LIG_LIR_Nem_3	152	158	PF02991	0.454
LIG_LIR_Nem_3	230	236	PF02991	0.518
LIG_LIR_Nem_3	276	280	PF02991	0.477
LIG_LIR_Nem_3	473	478	PF02991	0.469
LIG_LIR_Nem_3	55	59	PF02991	0.544
LIG_NRBOX	74	80	PF00104	0.496
LIG_PCNA_yPIPBox_3	43	57	PF02747	0.584
LIG_Pex14_2	20	24	PF04695	0.639
LIG_PTB_Apo_2	389	396	PF02174	0.400
LIG_RPA_C_Fungi	68	80	PF08784	0.333
LIG_RPA_C_Plants	303	314	PF08784	0.378
LIG_SH2_CRK	234	238	PF00017	0.449
LIG_SH2_CRK	475	479	PF00017	0.411
LIG_SH2_NCK_1	155	159	PF00017	0.223
LIG_SH2_STAP1	175	179	PF00017	0.475
LIG_SH2_STAP1	456	460	PF00017	0.385
LIG_SH2_STAT3	175	178	PF00017	0.449
LIG_SH2_STAT5	198	201	PF00017	0.417
LIG_SH2_STAT5	423	426	PF00017	0.344
LIG_SH3_1	476	482	PF00018	0.454
LIG_SH3_2	479	484	PF14604	0.507
LIG_SH3_3	476	482	PF00018	0.454
LIG_TRAF2_1	391	394	PF00917	0.223
LIG_TYR_ITIM	54	59	PF00017	0.605
LIG_UBA3_1	262	270	PF00899	0.449
MOD_CK1_1	88	94	PF00069	0.665
MOD_CK2_1	16	22	PF00069	0.627
MOD_CK2_1	6	12	PF00069	0.669
MOD_GSK3_1	22	29	PF00069	0.382
MOD_GSK3_1	84	91	PF00069	0.634
MOD_NEK2_1	196	201	PF00069	0.223
MOD_NEK2_1	288	293	PF00069	0.223
MOD_NEK2_1	362	367	PF00069	0.223
MOD_NEK2_1	395	400	PF00069	0.413
MOD_NEK2_1	417	422	PF00069	0.423
MOD_NEK2_1	85	90	PF00069	0.606
MOD_PIKK_1	417	423	PF00454	0.392
MOD_PKA_1	16	22	PF00069	0.627
MOD_PKA_1	412	418	PF00069	0.223
MOD_PKA_2	16	22	PF00069	0.575
MOD_PKA_2	227	233	PF00069	0.475
MOD_PKA_2	412	418	PF00069	0.381
MOD_PKB_1	14	22	PF00069	0.625
MOD_PKB_1	410	418	PF00069	0.223
MOD_Plk_1	26	32	PF00069	0.505
MOD_Plk_1	288	294	PF00069	0.223
MOD_Plk_4	16	22	PF00069	0.627
MOD_Plk_4	412	418	PF00069	0.223
MOD_Plk_4	6	12	PF00069	0.691
MOD_Plk_4	85	91	PF00069	0.576
MOD_SUMO_for_1	113	116	PF00179	0.509
MOD_SUMO_for_1	280	283	PF00179	0.466
MOD_SUMO_for_1	470	473	PF00179	0.396
MOD_SUMO_rev_2	116	121	PF00179	0.594
MOD_SUMO_rev_2	193	199	PF00179	0.223
MOD_SUMO_rev_2	264	272	PF00179	0.437
MOD_SUMO_rev_2	46	53	PF00179	0.521
TRG_DiLeu_BaEn_1	232	237	PF01217	0.449
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.489
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.482
TRG_DiLeu_LyEn_5	232	237	PF01217	0.449
TRG_ENDOCYTIC_2	155	158	PF00928	0.475
TRG_ENDOCYTIC_2	234	237	PF00928	0.449
TRG_ENDOCYTIC_2	277	280	PF00928	0.328
TRG_ENDOCYTIC_2	475	478	PF00928	0.492
TRG_ENDOCYTIC_2	56	59	PF00928	0.580
TRG_ER_diArg_1	14	17	PF00400	0.497
TRG_ER_diArg_1	164	166	PF00400	0.367
TRG_ER_diArg_1	246	249	PF00400	0.417
TRG_ER_diArg_1	308	310	PF00400	0.434
TRG_ER_diArg_1	345	348	PF00400	0.428
TRG_ER_diArg_1	410	413	PF00400	0.356
TRG_ER_diArg_1	71	74	PF00400	0.453
TRG_NLS_MonoExtN_4	197	204	PF00514	0.322
TRG_NLS_MonoExtN_4	482	487	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	388	393	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD5	Leptomonas seymouri	73%	100%
A0A0S4IRE4	Bodo saltans	38%	99%
A0A1X0NWN4	Trypanosomatidae	49%	100%
A0A3Q8IMD7	Leishmania donovani	85%	100%
A0A422NJE4	Trypanosoma rangeli	49%	100%
A4I0L6	Leishmania infantum	85%	100%
C9ZNQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AWH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAZ3	Leishmania major	85%	100%
V5D760	Trypanosoma cruzi	51%	100%