Putative Csl4p homologue

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome component CSL4, putative

Species:

Leishmania braziliensis

UniProt:

A4HD27_LEIBR

TriTrypDb:

LbrM.23.1670 , LBRM2903_230027500

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	11
GO:0005737	cytoplasm	2	10
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	11
GO:1905354	exoribonuclease complex	3	11
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HD27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD27

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0006364	rRNA processing	8	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.548
CLV_NRD_NRD_1	260	262	PF00675	0.434
CLV_PCSK_KEX2_1	260	262	PF00082	0.422
CLV_PCSK_SKI1_1	177	181	PF00082	0.304
CLV_PCSK_SKI1_1	186	190	PF00082	0.389
CLV_PCSK_SKI1_1	54	58	PF00082	0.366
DEG_SPOP_SBC_1	23	27	PF00917	0.549
DEG_SPOP_SBC_1	93	97	PF00917	0.415
DOC_CKS1_1	55	60	PF01111	0.376
DOC_CYCLIN_RxL_1	54	67	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	195	198	PF00134	0.551
DOC_MAPK_gen_1	260	266	PF00069	0.472
DOC_MAPK_MEF2A_6	127	136	PF00069	0.409
DOC_PP2B_LxvP_1	195	198	PF13499	0.438
DOC_PP2B_LxvP_1	63	66	PF13499	0.402
DOC_PP4_FxxP_1	18	21	PF00568	0.484
DOC_USP7_MATH_1	23	27	PF00917	0.532
DOC_USP7_MATH_1	87	91	PF00917	0.531
DOC_USP7_MATH_1	93	97	PF00917	0.619
DOC_WW_Pin1_4	17	22	PF00397	0.523
DOC_WW_Pin1_4	54	59	PF00397	0.470
LIG_14-3-3_CanoR_1	120	124	PF00244	0.574
LIG_14-3-3_CanoR_1	154	161	PF00244	0.525
LIG_BRCT_BRCA1_1	172	176	PF00533	0.586
LIG_BRCT_BRCA1_1	200	204	PF00533	0.442
LIG_CtBP_PxDLS_1	199	203	PF00389	0.456
LIG_EVH1_1	196	200	PF00568	0.337
LIG_FHA_1	267	273	PF00498	0.500
LIG_FHA_2	225	231	PF00498	0.355
LIG_FHA_2	238	244	PF00498	0.417
LIG_FHA_2	66	72	PF00498	0.523
LIG_LIR_Apic_2	15	21	PF02991	0.481
LIG_LIR_Apic_2	53	58	PF02991	0.518
LIG_LIR_Nem_3	173	179	PF02991	0.448
LIG_SH2_PTP2	55	58	PF00017	0.516
LIG_SH2_STAT3	246	249	PF00017	0.549
LIG_SH2_STAT5	51	54	PF00017	0.542
LIG_SH2_STAT5	55	58	PF00017	0.584
LIG_SH3_1	275	281	PF00018	0.471
LIG_SH3_2	187	192	PF14604	0.439
LIG_SH3_3	120	126	PF00018	0.532
LIG_SH3_3	184	190	PF00018	0.408
LIG_SH3_3	194	200	PF00018	0.443
LIG_SH3_3	275	281	PF00018	0.471
LIG_SUMO_SIM_par_1	1	7	PF11976	0.500
LIG_TRAF2_1	35	38	PF00917	0.668
LIG_WRC_WIRS_1	235	240	PF05994	0.441
MOD_CDK_SPK_2	54	59	PF00069	0.364
MOD_CK1_1	114	120	PF00069	0.666
MOD_CK1_1	157	163	PF00069	0.607
MOD_CK1_1	226	232	PF00069	0.534
MOD_CK1_1	237	243	PF00069	0.536
MOD_CK1_1	64	70	PF00069	0.612
MOD_CK2_1	224	230	PF00069	0.349
MOD_CK2_1	237	243	PF00069	0.396
MOD_CK2_1	265	271	PF00069	0.481
MOD_CK2_1	65	71	PF00069	0.541
MOD_Cter_Amidation	258	261	PF01082	0.460
MOD_GlcNHglycan	162	165	PF01048	0.666
MOD_GlcNHglycan	172	175	PF01048	0.505
MOD_GlcNHglycan	63	66	PF01048	0.612
MOD_GlcNHglycan	96	99	PF01048	0.627
MOD_GSK3_1	111	118	PF00069	0.767
MOD_GSK3_1	13	20	PF00069	0.417
MOD_GSK3_1	234	241	PF00069	0.452
MOD_GSK3_1	61	68	PF00069	0.598
MOD_N-GLC_1	170	175	PF02516	0.537
MOD_NEK2_1	134	139	PF00069	0.361
MOD_NEK2_1	265	270	PF00069	0.481
MOD_NEK2_1	61	66	PF00069	0.424
MOD_NEK2_1	94	99	PF00069	0.531
MOD_NEK2_2	13	18	PF00069	0.422
MOD_NEK2_2	87	92	PF00069	0.312
MOD_PIKK_1	213	219	PF00454	0.380
MOD_PKA_2	105	111	PF00069	0.570
MOD_PKA_2	119	125	PF00069	0.619
MOD_PKA_2	134	140	PF00069	0.358
MOD_PKA_2	266	272	PF00069	0.481
MOD_Plk_4	119	125	PF00069	0.537
MOD_Plk_4	13	19	PF00069	0.391
MOD_Plk_4	234	240	PF00069	0.437
MOD_Plk_4	65	71	PF00069	0.550
MOD_Plk_4	87	93	PF00069	0.467
MOD_ProDKin_1	17	23	PF00069	0.538
MOD_ProDKin_1	54	60	PF00069	0.475
MOD_SUMO_for_1	252	255	PF00179	0.466
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.371
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ0	Leptomonas seymouri	60%	95%
A0A0S4IM15	Bodo saltans	36%	96%
A0A3Q8IBW8	Leishmania donovani	80%	99%
A0A422NJG6	Trypanosoma rangeli	42%	100%
A4I0L4	Leishmania infantum	80%	99%
C9ZNQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
E9AWH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QAZ6	Leishmania major	80%	100%
V5AR97	Trypanosoma cruzi	44%	100%