Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD26_LEIBR

TriTrypDb:

LbrM.23.1660 , LBRM2903_230027400

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.654
CLV_C14_Caspase3-7	341	345	PF00656	0.563
CLV_C14_Caspase3-7	451	455	PF00656	0.550
CLV_C14_Caspase3-7	579	583	PF00656	0.586
CLV_C14_Caspase3-7	832	836	PF00656	0.546
CLV_NRD_NRD_1	13	15	PF00675	0.596
CLV_NRD_NRD_1	156	158	PF00675	0.588
CLV_NRD_NRD_1	281	283	PF00675	0.539
CLV_NRD_NRD_1	662	664	PF00675	0.421
CLV_NRD_NRD_1	739	741	PF00675	0.430
CLV_PCSK_KEX2_1	12	14	PF00082	0.600
CLV_PCSK_KEX2_1	152	154	PF00082	0.551
CLV_PCSK_KEX2_1	156	158	PF00082	0.578
CLV_PCSK_KEX2_1	281	283	PF00082	0.539
CLV_PCSK_KEX2_1	445	447	PF00082	0.727
CLV_PCSK_KEX2_1	662	664	PF00082	0.425
CLV_PCSK_KEX2_1	739	741	PF00082	0.430
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.445
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.727
CLV_PCSK_SKI1_1	14	18	PF00082	0.550
CLV_PCSK_SKI1_1	221	225	PF00082	0.530
CLV_PCSK_SKI1_1	333	337	PF00082	0.420
CLV_PCSK_SKI1_1	418	422	PF00082	0.618
CLV_PCSK_SKI1_1	430	434	PF00082	0.597
CLV_PCSK_SKI1_1	499	503	PF00082	0.517
CLV_PCSK_SKI1_1	598	602	PF00082	0.462
CLV_PCSK_SKI1_1	655	659	PF00082	0.354
CLV_PCSK_SKI1_1	696	700	PF00082	0.337
CLV_PCSK_SKI1_1	708	712	PF00082	0.357
CLV_PCSK_SKI1_1	806	810	PF00082	0.345
DEG_APCC_DBOX_1	250	258	PF00400	0.549
DEG_APCC_DBOX_1	332	340	PF00400	0.458
DEG_APCC_DBOX_1	707	715	PF00400	0.427
DOC_ANK_TNKS_1	341	348	PF00023	0.501
DOC_CKS1_1	247	252	PF01111	0.502
DOC_MAPK_gen_1	33	42	PF00069	0.421
DOC_MAPK_gen_1	804	812	PF00069	0.280
DOC_MAPK_MEF2A_6	18	27	PF00069	0.611
DOC_MAPK_MEF2A_6	246	254	PF00069	0.641
DOC_MAPK_MEF2A_6	292	300	PF00069	0.387
DOC_MAPK_MEF2A_6	305	313	PF00069	0.437
DOC_PP2B_LxvP_1	311	314	PF13499	0.356
DOC_PP2B_LxvP_1	56	59	PF13499	0.578
DOC_PP4_FxxP_1	485	488	PF00568	0.535
DOC_PP4_FxxP_1	788	791	PF00568	0.375
DOC_SPAK_OSR1_1	282	286	PF12202	0.468
DOC_SPAK_OSR1_1	491	495	PF12202	0.515
DOC_USP7_MATH_1	195	199	PF00917	0.527
DOC_USP7_MATH_1	207	211	PF00917	0.477
DOC_USP7_MATH_1	214	218	PF00917	0.480
DOC_USP7_MATH_1	256	260	PF00917	0.459
DOC_USP7_MATH_1	41	45	PF00917	0.550
DOC_USP7_MATH_1	420	424	PF00917	0.549
DOC_USP7_MATH_1	452	456	PF00917	0.635
DOC_USP7_MATH_1	460	464	PF00917	0.597
DOC_USP7_MATH_1	472	476	PF00917	0.538
DOC_USP7_MATH_1	48	52	PF00917	0.481
DOC_USP7_MATH_1	530	534	PF00917	0.673
DOC_USP7_MATH_1	544	548	PF00917	0.581
DOC_USP7_MATH_1	57	61	PF00917	0.537
DOC_WW_Pin1_4	119	124	PF00397	0.585
DOC_WW_Pin1_4	202	207	PF00397	0.642
DOC_WW_Pin1_4	226	231	PF00397	0.691
DOC_WW_Pin1_4	241	246	PF00397	0.580
DOC_WW_Pin1_4	292	297	PF00397	0.478
DOC_WW_Pin1_4	351	356	PF00397	0.621
DOC_WW_Pin1_4	406	411	PF00397	0.628
DOC_WW_Pin1_4	484	489	PF00397	0.667
DOC_WW_Pin1_4	540	545	PF00397	0.703
DOC_WW_Pin1_4	674	679	PF00397	0.387
DOC_WW_Pin1_4	686	691	PF00397	0.430
DOC_WW_Pin1_4	756	761	PF00397	0.393
DOC_WW_Pin1_4	835	840	PF00397	0.435
LIG_14-3-3_CanoR_1	350	355	PF00244	0.542
LIG_14-3-3_CanoR_1	438	444	PF00244	0.572
LIG_14-3-3_CanoR_1	446	453	PF00244	0.580
LIG_14-3-3_CanoR_1	499	509	PF00244	0.545
LIG_14-3-3_CanoR_1	556	560	PF00244	0.559
LIG_14-3-3_CanoR_1	799	807	PF00244	0.403
LIG_Actin_WH2_2	67	84	PF00022	0.428
LIG_APCC_ABBA_1	312	317	PF00400	0.461
LIG_APCC_ABBAyCdc20_2	430	436	PF00400	0.684
LIG_BIR_III_4	133	137	PF00653	0.524
LIG_BIR_III_4	365	369	PF00653	0.543
LIG_BIR_III_4	419	423	PF00653	0.657
LIG_BRCT_BRCA1_1	257	261	PF00533	0.389
LIG_BRCT_BRCA1_1	408	412	PF00533	0.538
LIG_BRCT_BRCA1_1	488	492	PF00533	0.517
LIG_deltaCOP1_diTrp_1	404	412	PF00928	0.597
LIG_eIF4E_1	599	605	PF01652	0.385
LIG_FHA_1	130	136	PF00498	0.521
LIG_FHA_1	184	190	PF00498	0.549
LIG_FHA_1	20	26	PF00498	0.610
LIG_FHA_1	214	220	PF00498	0.515
LIG_FHA_1	247	253	PF00498	0.718
LIG_FHA_1	271	277	PF00498	0.366
LIG_FHA_1	381	387	PF00498	0.511
LIG_FHA_1	537	543	PF00498	0.542
LIG_FHA_1	556	562	PF00498	0.595
LIG_FHA_1	721	727	PF00498	0.358
LIG_FHA_1	76	82	PF00498	0.453
LIG_FHA_1	771	777	PF00498	0.428
LIG_FHA_1	807	813	PF00498	0.342
LIG_FHA_2	128	134	PF00498	0.616
LIG_FHA_2	354	360	PF00498	0.622
LIG_FHA_2	399	405	PF00498	0.641
LIG_FHA_2	41	47	PF00498	0.497
LIG_FHA_2	479	485	PF00498	0.679
LIG_FHA_2	566	572	PF00498	0.646
LIG_Integrin_RGD_1	342	344	PF01839	0.502
LIG_LIR_Apic_2	201	206	PF02991	0.654
LIG_LIR_Apic_2	404	410	PF02991	0.592
LIG_LIR_Apic_2	482	488	PF02991	0.539
LIG_LIR_Gen_1	205	214	PF02991	0.501
LIG_LIR_Gen_1	387	398	PF02991	0.489
LIG_LIR_LC3C_4	423	428	PF02991	0.569
LIG_LIR_Nem_3	205	211	PF02991	0.493
LIG_LIR_Nem_3	387	393	PF02991	0.474
LIG_LIR_Nem_3	811	817	PF02991	0.540
LIG_NRBOX	710	716	PF00104	0.352
LIG_PCNA_yPIPBox_3	263	276	PF02747	0.535
LIG_PDZ_Class_3	841	846	PF00595	0.496
LIG_SH2_CRK	203	207	PF00017	0.489
LIG_SH2_NCK_1	203	207	PF00017	0.489
LIG_SH2_PTP2	650	653	PF00017	0.334
LIG_SH2_STAT3	277	280	PF00017	0.521
LIG_SH2_STAT3	96	99	PF00017	0.519
LIG_SH2_STAT5	599	602	PF00017	0.397
LIG_SH2_STAT5	627	630	PF00017	0.369
LIG_SH2_STAT5	641	644	PF00017	0.277
LIG_SH2_STAT5	650	653	PF00017	0.334
LIG_SH2_STAT5	814	817	PF00017	0.348
LIG_SH2_STAT5	96	99	PF00017	0.519
LIG_SH3_2	734	739	PF14604	0.416
LIG_SH3_3	188	194	PF00018	0.568
LIG_SH3_3	459	465	PF00018	0.558
LIG_SH3_3	505	511	PF00018	0.618
LIG_SH3_3	520	526	PF00018	0.567
LIG_SH3_3	723	729	PF00018	0.396
LIG_SH3_3	731	737	PF00018	0.541
LIG_SUMO_SIM_anti_2	809	814	PF11976	0.348
LIG_SUMO_SIM_par_1	21	26	PF11976	0.451
LIG_SUMO_SIM_par_1	696	701	PF11976	0.335
LIG_TYR_ITIM	812	817	PF00017	0.343
LIG_WRC_WIRS_1	318	323	PF05994	0.472
LIG_WW_3	553	557	PF00397	0.527
LIG_WW_3	652	656	PF00397	0.344
MOD_CDC14_SPxK_1	677	680	PF00782	0.404
MOD_CDK_SPK_2	226	231	PF00069	0.552
MOD_CDK_SPK_2	241	246	PF00069	0.550
MOD_CDK_SPxK_1	674	680	PF00069	0.394
MOD_CDK_SPxxK_3	246	253	PF00069	0.496
MOD_CDK_SPxxK_3	484	491	PF00069	0.662
MOD_CDK_SPxxK_3	835	842	PF00069	0.423
MOD_CK1_1	119	125	PF00069	0.580
MOD_CK1_1	129	135	PF00069	0.591
MOD_CK1_1	198	204	PF00069	0.572
MOD_CK1_1	210	216	PF00069	0.557
MOD_CK1_1	319	325	PF00069	0.381
MOD_CK1_1	456	462	PF00069	0.633
MOD_CK1_1	479	485	PF00069	0.645
MOD_CK1_1	486	492	PF00069	0.659
MOD_CK1_1	545	551	PF00069	0.627
MOD_CK1_1	619	625	PF00069	0.530
MOD_CK1_1	64	70	PF00069	0.577
MOD_CK1_1	747	753	PF00069	0.450
MOD_CK1_1	759	765	PF00069	0.340
MOD_CK2_1	353	359	PF00069	0.640
MOD_CK2_1	381	387	PF00069	0.587
MOD_CK2_1	398	404	PF00069	0.707
MOD_CK2_1	41	47	PF00069	0.401
MOD_CK2_1	460	466	PF00069	0.721
MOD_CK2_1	468	474	PF00069	0.595
MOD_Cter_Amidation	10	13	PF01082	0.588
MOD_GlcNHglycan	117	121	PF01048	0.540
MOD_GlcNHglycan	186	189	PF01048	0.787
MOD_GlcNHglycan	212	215	PF01048	0.650
MOD_GlcNHglycan	258	261	PF01048	0.441
MOD_GlcNHglycan	383	386	PF01048	0.406
MOD_GlcNHglycan	429	433	PF01048	0.679
MOD_GlcNHglycan	454	458	PF01048	0.648
MOD_GlcNHglycan	462	465	PF01048	0.636
MOD_GlcNHglycan	470	473	PF01048	0.656
MOD_GlcNHglycan	502	505	PF01048	0.548
MOD_GlcNHglycan	547	550	PF01048	0.613
MOD_GlcNHglycan	578	581	PF01048	0.748
MOD_GlcNHglycan	59	62	PF01048	0.682
MOD_GlcNHglycan	618	621	PF01048	0.552
MOD_GlcNHglycan	770	773	PF01048	0.401
MOD_GlcNHglycan	782	785	PF01048	0.522
MOD_GSK3_1	119	126	PF00069	0.620
MOD_GSK3_1	172	179	PF00069	0.634
MOD_GSK3_1	19	26	PF00069	0.612
MOD_GSK3_1	195	202	PF00069	0.706
MOD_GSK3_1	210	217	PF00069	0.573
MOD_GSK3_1	346	353	PF00069	0.691
MOD_GSK3_1	406	413	PF00069	0.773
MOD_GSK3_1	452	459	PF00069	0.661
MOD_GSK3_1	468	475	PF00069	0.713
MOD_GSK3_1	479	486	PF00069	0.620
MOD_GSK3_1	48	55	PF00069	0.562
MOD_GSK3_1	536	543	PF00069	0.693
MOD_GSK3_1	544	551	PF00069	0.611
MOD_GSK3_1	57	64	PF00069	0.634
MOD_GSK3_1	615	622	PF00069	0.493
MOD_GSK3_1	65	72	PF00069	0.569
MOD_GSK3_1	756	763	PF00069	0.378
MOD_N-GLC_1	172	177	PF02516	0.511
MOD_N-GLC_1	479	484	PF02516	0.546
MOD_N-GLC_1	540	545	PF02516	0.797
MOD_NEK2_1	127	132	PF00069	0.521
MOD_NEK2_1	177	182	PF00069	0.529
MOD_NEK2_1	199	204	PF00069	0.521
MOD_NEK2_1	23	28	PF00069	0.607
MOD_NEK2_1	255	260	PF00069	0.389
MOD_NEK2_1	290	295	PF00069	0.392
MOD_NEK2_1	40	45	PF00069	0.413
MOD_NEK2_1	411	416	PF00069	0.588
MOD_NEK2_1	492	497	PF00069	0.590
MOD_NEK2_1	500	505	PF00069	0.541
MOD_NEK2_1	52	57	PF00069	0.489
MOD_NEK2_1	591	596	PF00069	0.381
MOD_NEK2_1	66	71	PF00069	0.460
MOD_NEK2_1	90	95	PF00069	0.494
MOD_NEK2_2	123	128	PF00069	0.523
MOD_NEK2_2	207	212	PF00069	0.501
MOD_PIKK_1	236	242	PF00454	0.657
MOD_PIKK_1	420	426	PF00454	0.652
MOD_PIKK_1	524	530	PF00454	0.631
MOD_PIKK_1	536	542	PF00454	0.577
MOD_PIKK_1	657	663	PF00454	0.450
MOD_PIKK_1	717	723	PF00454	0.360
MOD_PIKK_1	75	81	PF00454	0.573
MOD_PIKK_1	763	769	PF00454	0.312
MOD_PKA_2	349	355	PF00069	0.543
MOD_PKA_2	437	443	PF00069	0.706
MOD_PKA_2	447	453	PF00069	0.669
MOD_PKA_2	472	478	PF00069	0.566
MOD_PKA_2	492	498	PF00069	0.623
MOD_PKA_2	555	561	PF00069	0.687
MOD_PKA_2	798	804	PF00069	0.313
MOD_PKA_2	99	105	PF00069	0.581
MOD_PKB_1	804	812	PF00069	0.280
MOD_Plk_1	143	149	PF00069	0.519
MOD_Plk_1	316	322	PF00069	0.348
MOD_Plk_1	358	364	PF00069	0.570
MOD_Plk_1	428	434	PF00069	0.674
MOD_Plk_1	479	485	PF00069	0.546
MOD_Plk_1	581	587	PF00069	0.492
MOD_Plk_4	19	25	PF00069	0.614
MOD_Plk_4	195	201	PF00069	0.521
MOD_Plk_4	214	220	PF00069	0.469
MOD_Plk_4	271	277	PF00069	0.414
MOD_Plk_4	99	105	PF00069	0.581
MOD_ProDKin_1	119	125	PF00069	0.586
MOD_ProDKin_1	202	208	PF00069	0.644
MOD_ProDKin_1	226	232	PF00069	0.691
MOD_ProDKin_1	241	247	PF00069	0.577
MOD_ProDKin_1	292	298	PF00069	0.473
MOD_ProDKin_1	351	357	PF00069	0.621
MOD_ProDKin_1	406	412	PF00069	0.629
MOD_ProDKin_1	484	490	PF00069	0.664
MOD_ProDKin_1	540	546	PF00069	0.703
MOD_ProDKin_1	674	680	PF00069	0.394
MOD_ProDKin_1	686	692	PF00069	0.416
MOD_ProDKin_1	756	762	PF00069	0.387
MOD_ProDKin_1	835	841	PF00069	0.425
TRG_DiLeu_BaEn_1	19	24	PF01217	0.458
TRG_DiLeu_BaEn_3	369	375	PF01217	0.549
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.514
TRG_ENDOCYTIC_2	208	211	PF00928	0.507
TRG_ENDOCYTIC_2	627	630	PF00928	0.415
TRG_ENDOCYTIC_2	814	817	PF00928	0.348
TRG_ER_diArg_1	12	14	PF00400	0.600
TRG_ER_diArg_1	155	157	PF00400	0.583
TRG_ER_diArg_1	250	253	PF00400	0.623
TRG_ER_diArg_1	281	283	PF00400	0.539
TRG_ER_diArg_1	561	564	PF00400	0.539
TRG_ER_diArg_1	739	742	PF00400	0.419
TRG_ER_diArg_1	803	806	PF00400	0.308
TRG_NES_CRM1_1	85	101	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P625	Leptomonas seymouri	44%	98%
A0A3S7WXX2	Leishmania donovani	71%	99%
A4I0L3	Leishmania infantum	71%	99%
E9AWH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QAZ7	Leishmania major	71%	98%