RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HD23_LEIBR

TriTrypDb:

LbrM.23.1630 , LBRM2903_230027100

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD23

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.553
CLV_C14_Caspase3-7	22	26	PF00656	0.587
CLV_NRD_NRD_1	73	75	PF00675	0.604
CLV_PCSK_KEX2_1	3	5	PF00082	0.604
CLV_PCSK_KEX2_1	73	75	PF00082	0.604
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.601
CLV_PCSK_SKI1_1	106	110	PF00082	0.485
CLV_PCSK_SKI1_1	249	253	PF00082	0.530
CLV_PCSK_SKI1_1	66	70	PF00082	0.510
CLV_PCSK_SKI1_1	74	78	PF00082	0.530
DEG_APCC_DBOX_1	61	69	PF00400	0.443
DEG_APCC_DBOX_1	73	81	PF00400	0.499
DEG_SPOP_SBC_1	26	30	PF00917	0.519
DEG_SPOP_SBC_1	393	397	PF00917	0.606
DOC_CYCLIN_RxL_1	103	110	PF00134	0.479
DOC_CYCLIN_yClb5_NLxxxL_5	257	266	PF00134	0.521
DOC_USP7_MATH_1	10	14	PF00917	0.513
DOC_USP7_MATH_1	16	20	PF00917	0.501
DOC_USP7_MATH_1	26	30	PF00917	0.486
DOC_USP7_MATH_1	393	397	PF00917	0.614
DOC_USP7_MATH_1	398	402	PF00917	0.597
DOC_USP7_UBL2_3	355	359	PF12436	0.543
DOC_WW_Pin1_4	202	207	PF00397	0.699
DOC_WW_Pin1_4	224	229	PF00397	0.630
DOC_WW_Pin1_4	346	351	PF00397	0.516
DOC_WW_Pin1_4	394	399	PF00397	0.482
DOC_WW_Pin1_4	66	71	PF00397	0.482
LIG_14-3-3_CanoR_1	106	112	PF00244	0.492
LIG_14-3-3_CanoR_1	6	14	PF00244	0.655
LIG_BIR_III_2	342	346	PF00653	0.414
LIG_BRCT_BRCA1_1	332	336	PF00533	0.414
LIG_BRCT_BRCA1_1	363	367	PF00533	0.414
LIG_BRCT_BRCA1_2	363	369	PF00533	0.414
LIG_Clathr_ClatBox_1	289	293	PF01394	0.447
LIG_FHA_1	29	35	PF00498	0.631
LIG_FHA_1	322	328	PF00498	0.304
LIG_FHA_1	379	385	PF00498	0.469
LIG_FHA_2	212	218	PF00498	0.688
LIG_FHA_2	248	254	PF00498	0.600
LIG_FHA_2	283	289	PF00498	0.515
LIG_FHA_2	70	76	PF00498	0.469
LIG_FHA_2	85	91	PF00498	0.514
LIG_FHA_2	96	102	PF00498	0.529
LIG_LIR_Gen_1	135	144	PF02991	0.662
LIG_LIR_Gen_1	283	292	PF02991	0.448
LIG_LIR_Gen_1	364	372	PF02991	0.414
LIG_LIR_Nem_3	283	289	PF02991	0.451
LIG_LIR_Nem_3	364	370	PF02991	0.414
LIG_SH2_STAP1	286	290	PF00017	0.452
LIG_SH2_STAT5	137	140	PF00017	0.521
LIG_SH3_1	182	188	PF00018	0.514
LIG_SH3_2	185	190	PF14604	0.521
LIG_SH3_3	171	177	PF00018	0.615
LIG_SH3_3	182	188	PF00018	0.564
LIG_SUMO_SIM_anti_2	214	220	PF11976	0.579
LIG_SUMO_SIM_par_1	27	38	PF11976	0.641
LIG_SUMO_SIM_par_1	287	294	PF11976	0.452
LIG_TRAF2_1	251	254	PF00917	0.584
LIG_TRAF2_1	285	288	PF00917	0.454
LIG_TRAF2_1	35	38	PF00917	0.577
LIG_WRC_WIRS_1	108	113	PF05994	0.694
MOD_CDK_SPxxK_3	224	231	PF00069	0.642
MOD_CDK_SPxxK_3	66	73	PF00069	0.472
MOD_CK1_1	107	113	PF00069	0.496
MOD_CK1_1	234	240	PF00069	0.543
MOD_CK1_1	28	34	PF00069	0.605
MOD_CK1_1	337	343	PF00069	0.476
MOD_CK1_1	396	402	PF00069	0.572
MOD_CK2_1	16	22	PF00069	0.503
MOD_CK2_1	247	253	PF00069	0.609
MOD_CK2_1	282	288	PF00069	0.460
MOD_CK2_1	315	321	PF00069	0.401
MOD_CK2_1	32	38	PF00069	0.583
MOD_CK2_1	84	90	PF00069	0.571
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.477
MOD_GlcNHglycan	233	236	PF01048	0.605
MOD_GlcNHglycan	245	248	PF01048	0.627
MOD_GlcNHglycan	330	335	PF01048	0.305
MOD_GlcNHglycan	398	401	PF01048	0.570
MOD_GlcNHglycan	8	11	PF01048	0.516
MOD_GSK3_1	21	28	PF00069	0.759
MOD_GSK3_1	243	250	PF00069	0.648
MOD_GSK3_1	330	337	PF00069	0.460
MOD_GSK3_1	346	353	PF00069	0.425
MOD_GSK3_1	374	381	PF00069	0.516
MOD_GSK3_1	392	399	PF00069	0.447
MOD_GSK3_1	6	13	PF00069	0.663
MOD_N-GLC_1	297	302	PF02516	0.490
MOD_N-GLC_1	361	366	PF02516	0.321
MOD_NEK2_1	153	158	PF00069	0.549
MOD_NEK2_1	307	312	PF00069	0.482
MOD_NEK2_1	315	320	PF00069	0.468
MOD_NEK2_1	332	337	PF00069	0.409
MOD_NEK2_1	361	366	PF00069	0.421
MOD_NEK2_1	376	381	PF00069	0.396
MOD_NEK2_1	39	44	PF00069	0.632
MOD_NEK2_1	61	66	PF00069	0.457
MOD_PIKK_1	28	34	PF00454	0.661
MOD_PIKK_1	374	380	PF00454	0.516
MOD_PK_1	316	322	PF00069	0.421
MOD_PKA_2	153	159	PF00069	0.660
MOD_PKA_2	189	195	PF00069	0.536
MOD_PKA_2	243	249	PF00069	0.616
MOD_PKA_2	315	321	PF00069	0.537
MOD_PKA_2	61	67	PF00069	0.464
MOD_PKB_1	4	12	PF00069	0.595
MOD_Plk_1	10	16	PF00069	0.661
MOD_Plk_1	282	288	PF00069	0.460
MOD_Plk_1	89	95	PF00069	0.521
MOD_Plk_2-3	282	288	PF00069	0.460
MOD_Plk_4	211	217	PF00069	0.596
MOD_Plk_4	89	95	PF00069	0.532
MOD_ProDKin_1	202	208	PF00069	0.698
MOD_ProDKin_1	224	230	PF00069	0.636
MOD_ProDKin_1	346	352	PF00069	0.516
MOD_ProDKin_1	394	400	PF00069	0.485
MOD_ProDKin_1	66	72	PF00069	0.479
TRG_DiLeu_BaEn_2	174	180	PF01217	0.650
TRG_DiLeu_BaEn_4	287	293	PF01217	0.447
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.577
TRG_ENDOCYTIC_2	137	140	PF00928	0.663
TRG_ENDOCYTIC_2	286	289	PF00928	0.453
TRG_NES_CRM1_1	88	101	PF08389	0.551
TRG_NLS_MonoExtN_4	2	7	PF00514	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS7	Leptomonas seymouri	41%	100%
A0A3Q8IBP7	Leishmania donovani	79%	100%
A4I0L0	Leishmania infantum	79%	100%
E9AWH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QB00	Leishmania major	78%	100%