LeishMANIAdb
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Complex I-B15

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Complex I-B15
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HD22_LEIBR
TriTrypDb:
LbrM.23.1620 , LBRM2903_230027000
Length:
143

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HD22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 126 128 PF00675 0.379
CLV_NRD_NRD_1 21 23 PF00675 0.664
CLV_NRD_NRD_1 27 29 PF00675 0.642
CLV_PCSK_KEX2_1 126 128 PF00082 0.379
CLV_PCSK_KEX2_1 134 136 PF00082 0.382
CLV_PCSK_KEX2_1 27 29 PF00082 0.744
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.487
CLV_PCSK_SKI1_1 135 139 PF00082 0.421
CLV_PCSK_SKI1_1 23 27 PF00082 0.685
CLV_PCSK_SKI1_1 34 38 PF00082 0.655
DEG_Nend_UBRbox_2 1 3 PF02207 0.403
DOC_CYCLIN_RxL_1 28 39 PF00134 0.494
DOC_USP7_UBL2_3 34 38 PF12436 0.409
DOC_USP7_UBL2_3 82 86 PF12436 0.589
LIG_Actin_WH2_2 34 51 PF00022 0.477
LIG_deltaCOP1_diTrp_1 90 96 PF00928 0.617
LIG_FHA_1 24 30 PF00498 0.447
LIG_FHA_2 3 9 PF00498 0.373
LIG_LIR_Apic_2 46 50 PF02991 0.394
LIG_LIR_Gen_1 114 123 PF02991 0.590
LIG_LIR_Nem_3 113 119 PF02991 0.603
LIG_LIR_Nem_3 93 99 PF02991 0.617
LIG_PCNA_PIPBox_1 41 50 PF02747 0.433
LIG_Pex14_1 92 96 PF04695 0.621
LIG_SH2_STAT5 116 119 PF00017 0.593
LIG_SH2_STAT5 20 23 PF00017 0.453
LIG_SH2_STAT5 47 50 PF00017 0.478
LIG_SH3_4 34 41 PF00018 0.404
LIG_TYR_ITSM 112 119 PF00017 0.606
MOD_CK2_1 115 121 PF00069 0.606
MOD_GSK3_1 111 118 PF00069 0.614
MOD_NEK2_1 1 6 PF00069 0.390
MOD_NEK2_1 36 41 PF00069 0.389
MOD_NEK2_1 62 67 PF00069 0.475
MOD_PKA_2 48 54 PF00069 0.407
MOD_Plk_1 1 7 PF00069 0.388
MOD_Plk_2-3 115 121 PF00069 0.592
MOD_Plk_2-3 2 8 PF00069 0.379
TRG_ENDOCYTIC_2 116 119 PF00928 0.593
TRG_ER_diArg_1 27 29 PF00400 0.532

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDE3 Leptomonas seymouri 80% 100%
A0A0S4ILZ1 Bodo saltans 55% 100%
A0A1X0NXD3 Trypanosomatidae 62% 96%
A0A3S7WY14 Leishmania donovani 92% 100%
A0A422NJI6 Trypanosoma rangeli 58% 100%
A4I0K9 Leishmania infantum 92% 100%
C9ZVI3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 100%
E9AWH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QB01 Leishmania major 92% 100%
V5BFT8 Trypanosoma cruzi 65% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS