LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HD21_LEIBR
TriTrypDb:
LbrM.23.1610 , LBRM2903_230026900 *
Length:
134

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HD21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 23 25 PF00082 0.632
CLV_PCSK_PC1ET2_1 23 25 PF00082 0.594
CLV_PCSK_SKI1_1 108 112 PF00082 0.567
DEG_Nend_UBRbox_3 1 3 PF02207 0.767
DOC_CDC14_PxL_1 41 49 PF14671 0.644
DOC_MAPK_gen_1 108 118 PF00069 0.557
DOC_USP7_MATH_1 18 22 PF00917 0.545
DOC_USP7_MATH_1 3 7 PF00917 0.717
LIG_14-3-3_CanoR_1 17 23 PF00244 0.729
LIG_14-3-3_CanoR_1 33 43 PF00244 0.628
LIG_14-3-3_CanoR_1 86 95 PF00244 0.392
LIG_LIR_Apic_2 11 16 PF02991 0.687
LIG_LIR_Gen_1 123 133 PF02991 0.416
LIG_LIR_Nem_3 123 128 PF02991 0.431
LIG_SH2_CRK 125 129 PF00017 0.375
LIG_SH2_CRK 13 17 PF00017 0.760
LIG_SH2_SRC 43 46 PF00017 0.676
LIG_SH2_STAT5 13 16 PF00017 0.759
LIG_SH2_STAT5 43 46 PF00017 0.676
LIG_SH3_1 39 45 PF00018 0.550
LIG_SH3_3 39 45 PF00018 0.606
MOD_CK2_1 34 40 PF00069 0.622
MOD_GlcNHglycan 5 8 PF01048 0.740
MOD_GlcNHglycan 55 58 PF01048 0.490
MOD_N-GLC_1 18 23 PF02516 0.759
MOD_PKA_2 34 40 PF00069 0.657
MOD_PKA_2 85 91 PF00069 0.611
MOD_Plk_1 18 24 PF00069 0.761
TRG_ENDOCYTIC_2 125 128 PF00928 0.574
TRG_ER_diArg_1 102 105 PF00400 0.534
TRG_ER_diArg_1 33 36 PF00400 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL49 Leptomonas seymouri 56% 95%
A0A3Q8IFY5 Leishmania donovani 79% 100%
A0A3R7LAA1 Trypanosoma rangeli 33% 100%
A4I0K8 Leishmania infantum 79% 100%
E9AWG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
Q4QB02 Leishmania major 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS