Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HD20_LEIBR

TriTrypDb:

LbrM.23.1590 , LBRM2903_230026600

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HD20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HD20

Function

Biological processes
Term	Name	Level	Count
GO:0006140	regulation of nucleotide metabolic process	5	1
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010155	regulation of proton transport	7	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018023	peptidyl-lysine trimethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0022898	regulation of transmembrane transporter activity	4	1
GO:0030808	regulation of nucleotide biosynthetic process	6	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0032259	methylation	2	1
GO:0032409	regulation of transporter activity	3	1
GO:0032411	positive regulation of transporter activity	4	1
GO:0032412	regulation of monoatomic ion transmembrane transporter activity	5	1
GO:0032414	positive regulation of ion transmembrane transporter activity	5	1
GO:0032879	regulation of localization	3	1
GO:0034762	regulation of transmembrane transport	4	1
GO:0034764	positive regulation of transmembrane transport	5	1
GO:0034765	regulation of monoatomic ion transmembrane transport	5	1
GO:0034767	positive regulation of monoatomic ion transmembrane transport	6	1
GO:0036211	protein modification process	4	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043269	regulation of monoatomic ion transport	5	1
GO:0043270	positive regulation of monoatomic ion transport	5	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044093	positive regulation of molecular function	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051049	regulation of transport	4	1
GO:0051050	positive regulation of transport	4	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051340	regulation of ligase activity	4	1
GO:0051351	positive regulation of ligase activity	5	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1900371	regulation of purine nucleotide biosynthetic process	7	1
GO:1900542	regulation of purine nucleotide metabolic process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903578	regulation of ATP metabolic process	7	1
GO:1904062	regulation of monoatomic cation transmembrane transport	6	1
GO:1904064	positive regulation of cation transmembrane transport	7	1
GO:1905271	regulation of proton-transporting ATP synthase activity, rotational mechanism	5	1
GO:1905273	positive regulation of proton-transporting ATP synthase activity, rotational mechanism	6	1
GO:1905706	regulation of mitochondrial ATP synthesis coupled proton transport	9	1
GO:2001169	regulation of ATP biosynthetic process	8	1
GO:2001257	regulation of cation channel activity	6	1
GO:2001259	positive regulation of cation channel activity	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008168	methyltransferase activity	4	9
GO:0008170	N-methyltransferase activity	5	9
GO:0008276	protein methyltransferase activity	3	9
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	9
GO:0016278	lysine N-methyltransferase activity	6	9
GO:0016279	protein-lysine N-methyltransferase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016741	transferase activity, transferring one-carbon groups	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	84	86	PF00675	0.428
DEG_APCC_DBOX_1	196	204	PF00400	0.377
DOC_MAPK_MEF2A_6	155	163	PF00069	0.472
DOC_PP4_FxxP_1	13	16	PF00568	0.407
DOC_USP7_MATH_1	126	130	PF00917	0.501
DOC_USP7_MATH_1	136	140	PF00917	0.604
DOC_WW_Pin1_4	12	17	PF00397	0.470
DOC_WW_Pin1_4	134	139	PF00397	0.438
LIG_Actin_WH2_2	142	157	PF00022	0.290
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BIR_III_2	97	101	PF00653	0.425
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.416
LIG_FHA_1	145	151	PF00498	0.466
LIG_FHA_1	154	160	PF00498	0.472
LIG_FHA_1	73	79	PF00498	0.390
LIG_FHA_2	110	116	PF00498	0.433
LIG_FHA_2	92	98	PF00498	0.441
LIG_LIR_Apic_2	10	16	PF02991	0.408
LIG_LIR_Apic_2	212	218	PF02991	0.353
LIG_LIR_Nem_3	87	91	PF02991	0.301
LIG_Pex14_2	13	17	PF04695	0.410
LIG_SH2_CRK	185	189	PF00017	0.406
LIG_SH2_STAP1	234	238	PF00017	0.328
LIG_SH2_STAP1	62	66	PF00017	0.263
LIG_SH2_STAT5	182	185	PF00017	0.321
LIG_SH2_STAT5	187	190	PF00017	0.343
LIG_SH2_STAT5	36	39	PF00017	0.445
LIG_SH3_3	132	138	PF00018	0.338
LIG_SH3_3	158	164	PF00018	0.486
LIG_SH3_3	55	61	PF00018	0.541
LIG_Sin3_3	74	81	PF02671	0.303
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.460
LIG_SUMO_SIM_par_1	139	147	PF11976	0.587
LIG_SUMO_SIM_par_1	155	160	PF11976	0.357
LIG_SUMO_SIM_par_1	198	205	PF11976	0.424
LIG_TRAF2_2	5	10	PF00917	0.470
LIG_TYR_ITIM	183	188	PF00017	0.409
MOD_CK1_1	129	135	PF00069	0.510
MOD_CK1_1	137	143	PF00069	0.589
MOD_CK1_1	144	150	PF00069	0.548
MOD_CK1_1	44	50	PF00069	0.436
MOD_GSK3_1	137	144	PF00069	0.516
MOD_GSK3_1	170	177	PF00069	0.480
MOD_GSK3_1	41	48	PF00069	0.430
MOD_GSK3_1	72	79	PF00069	0.436
MOD_N-GLC_1	126	131	PF02516	0.439
MOD_N-GLC_1	42	47	PF02516	0.394
MOD_NEK2_1	120	125	PF00069	0.459
MOD_NEK2_1	131	136	PF00069	0.335
MOD_NEK2_1	220	225	PF00069	0.326
MOD_NEK2_2	126	131	PF00069	0.282
MOD_NEK2_2	170	175	PF00069	0.496
MOD_PIKK_1	148	154	PF00454	0.443
MOD_PKA_2	64	70	PF00069	0.330
MOD_Plk_1	126	132	PF00069	0.558
MOD_Plk_1	220	226	PF00069	0.319
MOD_Plk_1	72	78	PF00069	0.317
MOD_Plk_2-3	153	159	PF00069	0.362
MOD_Plk_4	126	132	PF00069	0.566
MOD_Plk_4	170	176	PF00069	0.559
MOD_Plk_4	36	42	PF00069	0.353
MOD_ProDKin_1	12	18	PF00069	0.464
MOD_ProDKin_1	134	140	PF00069	0.437
TRG_ENDOCYTIC_2	185	188	PF00928	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5N7	Leptomonas seymouri	51%	100%
A0A1X0NWN1	Trypanosomatidae	35%	100%
A0A3S7WXY7	Leishmania donovani	75%	100%
A4I0K6	Leishmania infantum	75%	100%
C9ZVI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QB04	Leishmania major	74%	100%